JP2015515968A5 - - Google Patents
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- Publication number
- JP2015515968A5 JP2015515968A5 JP2015509432A JP2015509432A JP2015515968A5 JP 2015515968 A5 JP2015515968 A5 JP 2015515968A5 JP 2015509432 A JP2015509432 A JP 2015509432A JP 2015509432 A JP2015509432 A JP 2015509432A JP 2015515968 A5 JP2015515968 A5 JP 2015515968A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- microparticle
- microparticles
- carrier polymer
- polyinosin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 62
- 239000011859 microparticle Substances 0.000 claims description 46
- 229920000642 polymer Polymers 0.000 claims description 21
- 239000002253 acid Substances 0.000 claims description 17
- 229940115272 polyinosinic:polycytidylic acid Drugs 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 10
- 229920002472 Starch Polymers 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 229940072056 alginate Drugs 0.000 claims description 4
- 235000010443 alginic acid Nutrition 0.000 claims description 4
- 229920000615 alginic acid Polymers 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 206010057190 Respiratory tract infections Diseases 0.000 claims description 3
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims 8
- 208000036142 Viral infection Diseases 0.000 claims 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 241000430519 Human rhinovirus sp. Species 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 206010061494 Rhinovirus infection Diseases 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 229920002261 Corn starch Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 239000008120 corn starch Substances 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12166595.4 | 2012-05-03 | ||
| EP12166595 | 2012-05-03 | ||
| PCT/EP2013/059079 WO2013164380A1 (en) | 2012-05-03 | 2013-05-02 | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015515968A JP2015515968A (ja) | 2015-06-04 |
| JP2015515968A5 true JP2015515968A5 (OSRAM) | 2016-06-30 |
| JP6349304B2 JP6349304B2 (ja) | 2018-06-27 |
Family
ID=48430695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015509432A Expired - Fee Related JP6349304B2 (ja) | 2012-05-03 | 2013-05-02 | 上気道感染症の処置のためのポリイノシン−ポリシチジル酸（ポリ（ｉ：ｃ））製剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9682096B2 (OSRAM) |
| EP (1) | EP2846767B1 (OSRAM) |
| JP (1) | JP6349304B2 (OSRAM) |
| KR (1) | KR102240042B1 (OSRAM) |
| CN (1) | CN104394846B (OSRAM) |
| AU (1) | AU2013255885C1 (OSRAM) |
| BR (1) | BR112014026957A8 (OSRAM) |
| CA (1) | CA2866230C (OSRAM) |
| CL (1) | CL2014002929A1 (OSRAM) |
| CO (1) | CO7101247A2 (OSRAM) |
| ES (1) | ES2911116T3 (OSRAM) |
| IN (1) | IN2014MN02359A (OSRAM) |
| MX (1) | MX2014013256A (OSRAM) |
| NZ (1) | NZ630040A (OSRAM) |
| RU (1) | RU2650636C2 (OSRAM) |
| SG (2) | SG11201406208QA (OSRAM) |
| WO (1) | WO2013164380A1 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6349304B2 (ja) | 2012-05-03 | 2018-06-27 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 上気道感染症の処置のためのポリイノシン−ポリシチジル酸（ポリ（ｉ：ｃ））製剤 |
| CA2929142A1 (en) * | 2013-11-06 | 2015-05-14 | Janssen Sciences Ireland Uc | Polylnosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
| GB201415381D0 (en) * | 2014-08-29 | 2014-10-15 | Algipharma As | Inhalable powder formulations of alginate oligomers |
| KR20180004233A (ko) * | 2015-05-11 | 2018-01-10 | 얀센 사이언시즈 아일랜드 유씨 | 상기도 감염의 예방 및/또는 치료를 위한 폴리이노신-폴리사이티딜산 (Poly (I:C)) 완두 전분 제형 |
| ES2715251B1 (es) | 2015-11-17 | 2020-09-07 | Bioncotech Therapeutics S L | Novedosa composicion farmaceutica que comprende particulas que comprenden un complejo de un polirribonucleotido de doble cadena y una polialquilenimina |
| AU2016365219A1 (en) * | 2015-11-30 | 2018-07-05 | Novus Therapeutics, Inc. | Compositions and methods for otologic prophylaxis and treatment |
| US20200060972A1 (en) | 2016-11-16 | 2020-02-27 | Janssen Sciences Ireland Unlimited Company | Formulations of polyinosinic acid and polycytidylic acid for the prevention of upper respiratory tract infections |
| US10849921B2 (en) | 2017-05-17 | 2020-12-01 | Bioncotech Therapeutics Sl | Pharmaceutical composition comprising particles comprising a complex of a double-stranded polyribonucleotide and a polyalkyleneimine |
| US12226477B2 (en) * | 2018-06-29 | 2025-02-18 | Beijing Yisheng Biotechnology Co., Ltd. | Methods for preparing complex for enhancing immune response |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| CA2079509C (en) | 1991-10-01 | 2002-05-14 | Shigeyuki Takada | Prolonged release microparticle preparation and production of the same |
| GB9606188D0 (en) * | 1996-03-23 | 1996-05-29 | Danbiosyst Uk | Pollysaccharide microspheres for the pulmonary delivery of drugs |
| AR012448A1 (es) | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
| CA2203843C (en) | 1997-04-28 | 2013-07-23 | Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence | Liposome-encapsulated poly iclc |
| MA25590A1 (fr) * | 1998-09-14 | 2002-12-31 | Inhale Therapeutic Syst | Agent actif de delivraison de poudre seche |
| CA2424892A1 (en) * | 2000-10-06 | 2002-04-11 | Jagotec Ag | Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight |
| US20040248837A1 (en) * | 2002-11-01 | 2004-12-09 | Eyal Raz | Methods of treating pulmonary fibrotic disorders |
| WO2004073729A1 (ja) | 2003-02-21 | 2004-09-02 | Translational Research Ltd. | 薬物の経鼻投与用組成物 |
| CN1867355A (zh) | 2003-08-11 | 2006-11-22 | 财团法人阪大微生物病研究会 | 包含诱导粘膜免疫的佐剂的新型疫苗 |
| AU2004314706A1 (en) * | 2003-12-11 | 2005-08-11 | University Of Miami | Immunotherapy compositions, method of making and method of use thereof |
| CN101229378A (zh) | 2005-05-05 | 2008-07-30 | 国家淀粉及化学投资控股公司 | 用于送递活性剂的组合物 |
| ATE539767T1 (de) | 2005-06-08 | 2012-01-15 | Yisheng Biopharma Singapore Pte Ltd | Adjuvans auf basis von polyinosinsäure/polycytidylsäure |
| US20070166239A1 (en) * | 2006-01-13 | 2007-07-19 | Haixiang Lin | Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant |
| GB0607534D0 (en) | 2006-04-13 | 2006-05-24 | Univ London Pharmacy | Colonic drug delivery formulation |
| EP2046740B1 (en) | 2006-07-22 | 2012-05-23 | Oxagen Limited | Compounds having crth2 antagonist activity |
| CL2007002218A1 (es) | 2006-08-03 | 2008-03-14 | Celgene Corp Soc Organizada Ba | Uso de 3-(4-amino-1-oxo-1,3-dihidro-isoindol-2-il)-piperidina 2,6-diona para la preparacion de un medicamento util para el tratamiento de linfoma de celula de capa. |
| AR067997A1 (es) * | 2007-08-24 | 2009-10-28 | Novartis Ag | Compuestos organicos |
| JP2009209086A (ja) * | 2008-03-04 | 2009-09-17 | Masami Moriyama | 粘膜投与型ワクチン |
| UA90013C2 (ru) * | 2008-03-19 | 2010-03-25 | Давид Анатолійович Нога | Фармацевтическая композиция, содержащая инсулин, и способ его получения |
| EP2116602A1 (en) | 2008-05-07 | 2009-11-11 | Institut Gustave Roussy | Combination products for treating cancer |
| CN102281870B (zh) * | 2008-12-10 | 2015-03-04 | 安徽中人科技有限责任公司 | 新型控释组合物 |
| CN101491503A (zh) | 2008-12-17 | 2009-07-29 | 天津瑞普生物技术股份有限公司 | 一种用于宠物的聚肌胞滴丸及其制备方法 |
| SI3098239T1 (sl) | 2008-12-22 | 2020-03-31 | Targimmune Therapeutics Ag | Egfr-homing vektor dvoverižne rna za sistemsko zdravljenje raka |
| CN101757018A (zh) * | 2008-12-24 | 2010-06-30 | 天津瑞普生物技术股份有限公司 | 一种用于畜禽的聚肌胞干粉及其制备方法 |
| AU2010232180B2 (en) | 2009-03-31 | 2016-09-22 | Japan As Represented By The Director-General Of National Institute Of Infectious Diseases | Method for prophylaxis of influenza using vaccine for intranasal administration |
| EP2598145A1 (en) | 2010-07-28 | 2013-06-05 | Boehringer Ingelheim International GmbH | Pharmaceutical composition for treatment of respiratory and inflammatory diseases |
| US8431155B1 (en) | 2012-04-30 | 2013-04-30 | Veroscience Llc | Bromocriptine formulations |
| JP6349304B2 (ja) | 2012-05-03 | 2018-06-27 | ヤンセン・サイエンシズ・アイルランド・ユーシー | 上気道感染症の処置のためのポリイノシン−ポリシチジル酸（ポリ（ｉ：ｃ））製剤 |
| CA2929142A1 (en) | 2013-11-06 | 2015-05-14 | Janssen Sciences Ireland Uc | Polylnosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections |
-
2013
- 2013-05-02 JP JP2015509432A patent/JP6349304B2/ja not_active Expired - Fee Related
- 2013-05-02 KR KR1020147028656A patent/KR102240042B1/ko not_active Expired - Fee Related
- 2013-05-02 CA CA2866230A patent/CA2866230C/en active Active
- 2013-05-02 SG SG11201406208QA patent/SG11201406208QA/en unknown
- 2013-05-02 EP EP13722334.3A patent/EP2846767B1/en active Active
- 2013-05-02 CN CN201380023084.4A patent/CN104394846B/zh not_active Expired - Fee Related
- 2013-05-02 AU AU2013255885A patent/AU2013255885C1/en not_active Ceased
- 2013-05-02 RU RU2014148544A patent/RU2650636C2/ru active
- 2013-05-02 MX MX2014013256A patent/MX2014013256A/es unknown
- 2013-05-02 SG SG10201607288VA patent/SG10201607288VA/en unknown
- 2013-05-02 WO PCT/EP2013/059079 patent/WO2013164380A1/en not_active Ceased
- 2013-05-02 IN IN2359MUN2014 patent/IN2014MN02359A/en unknown
- 2013-05-02 NZ NZ630040A patent/NZ630040A/en not_active IP Right Cessation
- 2013-05-02 US US14/398,573 patent/US9682096B2/en not_active Expired - Fee Related
- 2013-05-02 ES ES13722334T patent/ES2911116T3/es active Active
- 2013-05-02 BR BR112014026957A patent/BR112014026957A8/pt not_active Application Discontinuation
-
2014
- 2014-10-15 CO CO14228077A patent/CO7101247A2/es unknown
- 2014-10-29 CL CL2014002929A patent/CL2014002929A1/es unknown
-
2016
- 2016-06-13 US US15/180,603 patent/US9987300B2/en active Active
-
2018
- 2018-05-07 US US15/972,840 patent/US10485816B2/en active Active
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