JP2015514213A5 - - Google Patents
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- Publication number
- JP2015514213A5 JP2015514213A5 JP2015503398A JP2015503398A JP2015514213A5 JP 2015514213 A5 JP2015514213 A5 JP 2015514213A5 JP 2015503398 A JP2015503398 A JP 2015503398A JP 2015503398 A JP2015503398 A JP 2015503398A JP 2015514213 A5 JP2015514213 A5 JP 2015514213A5
- Authority
- JP
- Japan
- Prior art keywords
- image
- biological sample
- interest
- protocol
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 24
- 239000012472 biological sample Substances 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 238000010166 immunofluorescence Methods 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 239000002131 composite material Substances 0.000 claims 2
- 238000001917 fluorescence detection Methods 0.000 claims 2
- 238000002509 fluorescent in situ hybridization Methods 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 230000000877 morphologic effect Effects 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 1
- 210000003855 cell nucleus Anatomy 0.000 claims 1
- 238000004043 dyeing Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000007850 in situ PCR Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 238000002331 protein detection Methods 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 238000010186 staining Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261618282P | 2012-03-30 | 2012-03-30 | |
| US61/618,282 | 2012-03-30 | ||
| PCT/US2013/033286 WO2013148458A1 (en) | 2012-03-30 | 2013-03-21 | Methods for generating an image of a biological sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514213A JP2015514213A (ja) | 2015-05-18 |
| JP2015514213A5 true JP2015514213A5 (enExample) | 2016-05-12 |
| JP6348481B2 JP6348481B2 (ja) | 2018-06-27 |
Family
ID=48096230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503398A Active JP6348481B2 (ja) | 2012-03-30 | 2013-03-21 | 組織試料の画像を生成するための方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US11573235B2 (enExample) |
| EP (1) | EP2831559A1 (enExample) |
| JP (1) | JP6348481B2 (enExample) |
| KR (1) | KR20140145141A (enExample) |
| CN (1) | CN104520689A (enExample) |
| AU (1) | AU2013240137B2 (enExample) |
| CA (1) | CA2867359A1 (enExample) |
| IN (1) | IN2014DN07533A (enExample) |
| RU (1) | RU2014137125A (enExample) |
| SG (1) | SG11201406104QA (enExample) |
| WO (1) | WO2013148458A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10088658B2 (en) | 2013-03-18 | 2018-10-02 | General Electric Company | Referencing in multi-acquisition slide imaging |
| JP6604960B2 (ja) * | 2014-02-21 | 2019-11-13 | ベンタナ メディカル システムズ， インコーポレイテッド | バイオマーカー陽性の腫瘍細胞を識別するための医用画像解析 |
| JP6802153B2 (ja) | 2014-09-03 | 2020-12-16 | ヴェンタナ メディカル システムズ， インク． | 免疫スコアを計算するためのシステム及び方法 |
| EP3326149B1 (en) | 2015-07-17 | 2025-01-22 | Koninklijke Philips N.V. | Registration of histopathology images |
| EP3391285B1 (en) * | 2015-12-18 | 2020-10-21 | Abbott Laboratories | Methods and systems for assessing histological stains |
| EP3203413A1 (en) * | 2016-02-08 | 2017-08-09 | Ecole Polytechnique Federale De Lausanne (Epfl) | Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof |
| US10846509B2 (en) | 2016-06-10 | 2020-11-24 | Luminex Corporation | Method to combine brightfield and fluorescent channels for cell image segmentation and morphological analysis using images obtained from imaging flow cytometer (IFC) |
| TWI611170B (zh) * | 2016-10-05 | 2018-01-11 | 閤康生物科技股份有限公司 | 樣品製備系統及製備方法 |
| US9738937B1 (en) * | 2017-03-31 | 2017-08-22 | Cellmax, Ltd. | Identifying candidate cells using image analysis |
| WO2018187629A1 (en) * | 2017-04-07 | 2018-10-11 | Avelas Biosciences, Inc. | Ratiometric fluorescence imaging methods |
| US10684199B2 (en) | 2017-07-27 | 2020-06-16 | Agilent Technologies, Inc. | Preparation of tissue sections using fluorescence-based detection |
| RU2717944C1 (ru) * | 2019-05-24 | 2020-03-27 | Валентин Григорьевич Никитаев | Способ определения степени злокачественности аденокарциномы предстательной железы |
| US11525782B2 (en) * | 2019-09-03 | 2022-12-13 | Tianma Japan, Ltd. | Fluorescent image analyzer |
| CN113933134B (zh) * | 2020-07-14 | 2026-06-12 | 深圳迈瑞生物医疗电子股份有限公司 | 一种用于样本染色的染色方法以及相关设备 |
| TWI838592B (zh) * | 2020-11-06 | 2024-04-11 | 廣達電腦股份有限公司 | 圈選系統 |
| CA3209737A1 (en) * | 2021-02-01 | 2022-08-04 | Agilent Technologies, Inc. | Analysis of embedded tissue samples using fluorescence-based detection |
| EP4341664A1 (en) * | 2021-05-19 | 2024-03-27 | Leica Microsystems CMS GmbH | Method and apparatus for imaging a biological sample |
| KR102441907B1 (ko) * | 2021-07-08 | 2022-09-08 | 가톨릭대학교 산학협력단 | 암 진단을 위한 이미지 분류 장치 및 이미지 분류 방법 |
| CN114388057B (zh) * | 2022-01-13 | 2024-09-27 | 水木未来(北京)科技有限公司 | 电镜可解析性评估方法及装置、电子设备和存储介质 |
| US20250216394A1 (en) * | 2022-01-28 | 2025-07-03 | University Of Southern California | Liquid biopsy analytes to define cancer stages |
| US12700249B2 (en) | 2023-07-06 | 2026-08-04 | Pictor Labs, Inc. | Systems and methods for training machine learning on noisy and inaccurate immunostains |
| EP4768596A1 (en) * | 2024-12-30 | 2026-07-01 | Leica Microsystems CMS GmbH | LABEL, MARKER AND METHOD FOR ANALYZING BIOLOGICAL SAMPLES |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5364856A (en) | 1991-03-28 | 1994-11-15 | Eli Lilly And Company | 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles |
| US6404906B2 (en) | 1997-03-03 | 2002-06-11 | Bacus Research Laboratories,Inc. | Method and apparatus for acquiring and reconstructing magnified specimen images from a computer-controlled microscope |
| US7691598B2 (en) * | 2001-03-30 | 2010-04-06 | Nanoprobes, Inc. | Method for detecting a target molecule by metal deposition |
| US7219016B2 (en) | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
| US7504222B2 (en) * | 2001-10-31 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20040136969A1 (en) * | 2002-10-02 | 2004-07-15 | New York University | Adult bone marrow derived stem cells |
| US20080138816A1 (en) * | 2005-05-20 | 2008-06-12 | Amnis Corporation | Methods for preparing and analyzing cells having chromosomal abnormalities |
| US8131476B2 (en) * | 2006-08-07 | 2012-03-06 | General Electric Company | System and method for co-registering multi-channel images of a tissue micro array |
| US8060348B2 (en) | 2006-08-07 | 2011-11-15 | General Electric Company | Systems for analyzing tissue samples |
| DE602007008581D1 (de) | 2006-08-25 | 2010-09-30 | Cliniques Universitaires Saint | Verfahren zur bestimmung des antigengehalts in einer probe unter verwendung eines immunhistochemischen doppelnachweises |
| US7629125B2 (en) | 2006-11-16 | 2009-12-08 | General Electric Company | Sequential analysis of biological samples |
| US8019134B2 (en) * | 2006-11-16 | 2011-09-13 | Definiens Ag | Automatic image analysis and quantification for fluorescence in situ hybridization |
| US7741045B2 (en) | 2006-11-16 | 2010-06-22 | General Electric Company | Sequential analysis of biological samples |
| WO2008153743A2 (en) * | 2007-05-21 | 2008-12-18 | Dana Farber Cancer Institute | Compositions and methods for cancer gene discovery |
| AU2008258859A1 (en) * | 2007-06-06 | 2008-12-11 | F.Hoffmann-La Roche Ag | Composition of a first non-labeled monoclonal antibody binding to a tumor antigen and a non-cross reactive second monoclonal antibody labeled with a NIR fluorescence label |
| US20090258365A1 (en) * | 2008-03-25 | 2009-10-15 | Terstappen Leon W M M | METHOD FOR DETECTING IGF1R/Chr 15 in CIRCULATING TUMOR CELLS USING FISH |
| WO2010005991A2 (en) | 2008-07-07 | 2010-01-14 | The Board Of Regents Of The University Of Texas System | Circulating tumor and tumor stem cell detection using genomic specific probes |
| CN102165489B (zh) | 2008-09-16 | 2015-11-25 | 赫斯托克斯公司 | 生物标志物表达的可再现量化 |
| US8269827B2 (en) * | 2009-09-29 | 2012-09-18 | General Electric Company | System and methods for mapping fluorescent images into a bright field color space |
| US8639013B2 (en) | 2011-08-17 | 2014-01-28 | General Electric Company | System and methods for generating a brightfield image using fluorescent images |
| US8568991B2 (en) | 2011-12-23 | 2013-10-29 | General Electric Company | Photoactivated chemical bleaching of dyes |
-
2013
- 2013-03-21 KR KR1020147027571A patent/KR20140145141A/ko not_active Withdrawn
- 2013-03-21 EP EP13716556.9A patent/EP2831559A1/en not_active Withdrawn
- 2013-03-21 US US14/388,057 patent/US11573235B2/en active Active
- 2013-03-21 CN CN201380017701.XA patent/CN104520689A/zh active Pending
- 2013-03-21 IN IN7533DEN2014 patent/IN2014DN07533A/en unknown
- 2013-03-21 AU AU2013240137A patent/AU2013240137B2/en active Active
- 2013-03-21 CA CA2867359A patent/CA2867359A1/en not_active Abandoned
- 2013-03-21 SG SG11201406104QA patent/SG11201406104QA/en unknown
- 2013-03-21 WO PCT/US2013/033286 patent/WO2013148458A1/en not_active Ceased
- 2013-03-21 JP JP2015503398A patent/JP6348481B2/ja active Active
- 2013-03-21 RU RU2014137125A patent/RU2014137125A/ru not_active Application Discontinuation
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