CA2867359A1 - Methods for generating an image of a biological sample - Google Patents

Methods for generating an image of a biological sample Download PDF

Info

Publication number
CA2867359A1
CA2867359A1 CA2867359A CA2867359A CA2867359A1 CA 2867359 A1 CA2867359 A1 CA 2867359A1 CA 2867359 A CA2867359 A CA 2867359A CA 2867359 A CA2867359 A CA 2867359A CA 2867359 A1 CA2867359 A1 CA 2867359A1
Authority
CA
Canada
Prior art keywords
image
sample
biological sample
interest
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2867359A
Other languages
English (en)
French (fr)
Inventor
Antti E. SEPPO
Fiona Ginty
Kevin B. Kenny
David Lavan Henderson
Michael J. Gerdes
Adriana I. Larriera Moreno
Xiaofeng Liu
Alex D. Corwin
Stephen E. Zingelewicz
Thomas Ha
Natalie R. Jun
Ainura KYSHTOOBAYEVE
Denise A. HOLLMAN-HEWGLEY
Ying Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Global Life Sciences Solutions USA LLC
Original Assignee
Clarient Diagnostic Services Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clarient Diagnostic Services Inc filed Critical Clarient Diagnostic Services Inc
Publication of CA2867359A1 publication Critical patent/CA2867359A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30096—Tumor; Lesion

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Multimedia (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Sampling And Sample Adjustment (AREA)
CA2867359A 2012-03-30 2013-03-21 Methods for generating an image of a biological sample Abandoned CA2867359A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261618282P 2012-03-30 2012-03-30
US61/618,282 2012-03-30
PCT/US2013/033286 WO2013148458A1 (en) 2012-03-30 2013-03-21 Methods for generating an image of a biological sample

Publications (1)

Publication Number Publication Date
CA2867359A1 true CA2867359A1 (en) 2013-10-03

Family

ID=48096230

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2867359A Abandoned CA2867359A1 (en) 2012-03-30 2013-03-21 Methods for generating an image of a biological sample

Country Status (11)

Country Link
US (1) US11573235B2 (enExample)
EP (1) EP2831559A1 (enExample)
JP (1) JP6348481B2 (enExample)
KR (1) KR20140145141A (enExample)
CN (1) CN104520689A (enExample)
AU (1) AU2013240137B2 (enExample)
CA (1) CA2867359A1 (enExample)
IN (1) IN2014DN07533A (enExample)
RU (1) RU2014137125A (enExample)
SG (1) SG11201406104QA (enExample)
WO (1) WO2013148458A1 (enExample)

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JP6802153B2 (ja) 2014-09-03 2020-12-16 ヴェンタナ メディカル システムズ， インク． 免疫スコアを計算するためのシステム及び方法
EP3326149B1 (en) 2015-07-17 2025-01-22 Koninklijke Philips N.V. Registration of histopathology images
EP3391285B1 (en) * 2015-12-18 2020-10-21 Abbott Laboratories Methods and systems for assessing histological stains
EP3203413A1 (en) * 2016-02-08 2017-08-09 Ecole Polytechnique Federale De Lausanne (Epfl) Method for quantitative measurement of a biomarker by in situ immunofluorescence and uses thereof
US10846509B2 (en) 2016-06-10 2020-11-24 Luminex Corporation Method to combine brightfield and fluorescent channels for cell image segmentation and morphological analysis using images obtained from imaging flow cytometer (IFC)
TWI611170B (zh) * 2016-10-05 2018-01-11 閤康生物科技股份有限公司 樣品製備系統及製備方法
US9738937B1 (en) * 2017-03-31 2017-08-22 Cellmax, Ltd. Identifying candidate cells using image analysis
WO2018187629A1 (en) * 2017-04-07 2018-10-11 Avelas Biosciences, Inc. Ratiometric fluorescence imaging methods
US10684199B2 (en) 2017-07-27 2020-06-16 Agilent Technologies, Inc. Preparation of tissue sections using fluorescence-based detection
RU2717944C1 (ru) * 2019-05-24 2020-03-27 Валентин Григорьевич Никитаев Способ определения степени злокачественности аденокарциномы предстательной железы
US11525782B2 (en) * 2019-09-03 2022-12-13 Tianma Japan, Ltd. Fluorescent image analyzer
CN113933134B (zh) * 2020-07-14 2026-06-12 深圳迈瑞生物医疗电子股份有限公司 一种用于样本染色的染色方法以及相关设备
TWI838592B (zh) * 2020-11-06 2024-04-11 廣達電腦股份有限公司 圈選系統
CA3209737A1 (en) * 2021-02-01 2022-08-04 Agilent Technologies, Inc. Analysis of embedded tissue samples using fluorescence-based detection
EP4341664A1 (en) * 2021-05-19 2024-03-27 Leica Microsystems CMS GmbH Method and apparatus for imaging a biological sample
KR102441907B1 (ko) * 2021-07-08 2022-09-08 가톨릭대학교 산학협력단 암 진단을 위한 이미지 분류 장치 및 이미지 분류 방법
CN114388057B (zh) * 2022-01-13 2024-09-27 水木未来(北京)科技有限公司 电镜可解析性评估方法及装置、电子设备和存储介质
US20250216394A1 (en) * 2022-01-28 2025-07-03 University Of Southern California Liquid biopsy analytes to define cancer stages
US12700249B2 (en) 2023-07-06 2026-08-04 Pictor Labs, Inc. Systems and methods for training machine learning on noisy and inaccurate immunostains
EP4768596A1 (en) * 2024-12-30 2026-07-01 Leica Microsystems CMS GmbH LABEL, MARKER AND METHOD FOR ANALYZING BIOLOGICAL SAMPLES

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Also Published As

Publication number Publication date
US20150050650A1 (en) 2015-02-19
AU2013240137A1 (en) 2014-10-02
JP6348481B2 (ja) 2018-06-27
RU2014137125A (ru) 2016-05-27
WO2013148458A1 (en) 2013-10-03
EP2831559A1 (en) 2015-02-04
CN104520689A (zh) 2015-04-15
JP2015514213A (ja) 2015-05-18
KR20140145141A (ko) 2014-12-22
IN2014DN07533A (enExample) 2015-04-24
US11573235B2 (en) 2023-02-07
SG11201406104QA (en) 2014-10-30
AU2013240137B2 (en) 2017-04-20

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20180321