JP2015513561A - 三環ヌクレオシドおよびこれらから調製したオリゴマー化合物 - Google Patents
三環ヌクレオシドおよびこれらから調製したオリゴマー化合物 Download PDFInfo
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- JP2015513561A JP2015513561A JP2014561475A JP2014561475A JP2015513561A JP 2015513561 A JP2015513561 A JP 2015513561A JP 2014561475 A JP2014561475 A JP 2014561475A JP 2014561475 A JP2014561475 A JP 2014561475A JP 2015513561 A JP2015513561 A JP 2015513561A
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- 125000003835 nucleoside group Chemical group 0.000 title claims abstract description 64
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- 125000001424 substituent group Chemical group 0.000 claims description 50
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- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 28
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical group O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 27
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 26
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical group CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 26
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12159716.5A EP2639238A1 (en) | 2012-03-15 | 2012-03-15 | Tricyclic nucleosides and oligomeric compounds prepared therefrom |
| EP12159716.5 | 2012-03-15 | ||
| PCT/EP2013/055498 WO2013135900A1 (en) | 2012-03-15 | 2013-03-15 | Tricyclic nucleosides and oligomeric compounds prepared therefrom |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2018020638A Division JP2018109015A (ja) | 2012-03-15 | 2018-02-08 | 三環ヌクレオシドおよびこれらから調製したオリゴマー化合物 |
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| JP2015513561A true JP2015513561A (ja) | 2015-05-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014561475A Pending JP2015513561A (ja) | 2012-03-15 | 2013-03-15 | 三環ヌクレオシドおよびこれらから調製したオリゴマー化合物 |
| JP2018020638A Pending JP2018109015A (ja) | 2012-03-15 | 2018-02-08 | 三環ヌクレオシドおよびこれらから調製したオリゴマー化合物 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2018020638A Pending JP2018109015A (ja) | 2012-03-15 | 2018-02-08 | 三環ヌクレオシドおよびこれらから調製したオリゴマー化合物 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190141184A (ko) * | 2017-04-20 | 2019-12-23 | 신테나 아게 | 트리시클로-dna 뉴클레오시드를 포함하는 변형 올리고머 화합물 및 그의 용도 |
| JP2021510714A (ja) * | 2018-01-19 | 2021-04-30 | シンセナ アーゲー | トリシクロ−ｄｎａヌクレオシド前駆体およびそれを調製するためのプロセス |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA3017853A1 (en) | 2016-03-14 | 2017-09-21 | Somalogic, Inc. | Compounds and methods for the synthesis of 5-(n-protectedtryptaminocarboxyamide)-2'-deoxyuridine phosphoramidite for incorporation into a nucleic acid |
| WO2018055577A1 (en) | 2016-09-23 | 2018-03-29 | Synthena Ag | Mixed tricyclo-dna, 2'-modified rna oligonucleotide compositions and uses thereof |
| EP3330276A1 (en) | 2016-11-30 | 2018-06-06 | Universität Bern | Novel bicyclic nucleosides and oligomers prepared therefrom |
| WO2018193428A1 (en) | 2017-04-20 | 2018-10-25 | Synthena Ag | Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof |
| EP3978608A1 (en) | 2020-10-05 | 2022-04-06 | SQY Therapeutics | Oligomeric compound for dystrophin rescue in dmd patients throughout skipping of exon-51 |
| US20240002853A1 (en) | 2020-11-23 | 2024-01-04 | Alpha Anomeric Sas | Nucleic acid duplexes |
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| WO2012170347A1 (en) * | 2011-06-09 | 2012-12-13 | Isis Pharmaceuticals, Inc. | Bicyclic nucleosides and oligomeric compounds prepared therefrom |
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2012
- 2012-03-15 EP EP12159716.5A patent/EP2639238A1/en not_active Withdrawn
-
2013
- 2013-03-15 JP JP2014561475A patent/JP2015513561A/ja active Pending
- 2013-03-15 IN IN1838MUN2014 patent/IN2014MN01838A/en unknown
- 2013-03-15 AU AU2013234303A patent/AU2013234303B2/en not_active Ceased
- 2013-03-15 CA CA2866800A patent/CA2866800A1/en not_active Abandoned
- 2013-03-15 EP EP13712184.4A patent/EP2834257A1/en not_active Ceased
- 2013-03-15 WO PCT/EP2013/055498 patent/WO2013135900A1/en active Application Filing
- 2013-03-15 US US14/385,050 patent/US9249178B2/en not_active Expired - Fee Related
- 2013-03-15 EP EP18203872.9A patent/EP3459962A1/en not_active Withdrawn
- 2013-03-15 CN CN201380025398.8A patent/CN104321334A/zh active Pending
-
2016
- 2016-01-05 US US14/987,937 patent/US20160122372A1/en not_active Abandoned
-
2018
- 2018-02-08 JP JP2018020638A patent/JP2018109015A/ja active Pending
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190141184A (ko) * | 2017-04-20 | 2019-12-23 | 신테나 아게 | 트리시클로-dna 뉴클레오시드를 포함하는 변형 올리고머 화합물 및 그의 용도 |
| JP2020517613A (ja) * | 2017-04-20 | 2020-06-18 | シンセナ アーゲー | トリシクロｄｎａヌクレオシドを含む改変オリゴマー化合物およびその使用 |
| JP2022136147A (ja) * | 2017-04-20 | 2022-09-15 | シンセナ アーゲー | トリシクロｄｎａヌクレオシドを含む改変オリゴマー化合物およびその使用 |
| KR102778110B1 (ko) * | 2017-04-20 | 2025-03-10 | 신테나 아게 | 트리시클로-dna 뉴클레오시드를 포함하는 변형 올리고머 화합물 및 그의 용도 |
| JP2021510714A (ja) * | 2018-01-19 | 2021-04-30 | シンセナ アーゲー | トリシクロ−ｄｎａヌクレオシド前駆体およびそれを調製するためのプロセス |
| JP7652567B2 (ja) | 2018-01-19 | 2025-03-27 | シンセナ アーゲー | トリシクロ－ｄｎａヌクレオシド前駆体およびそれを調製するためのプロセス |
| US12319667B2 (en) | 2018-01-19 | 2025-06-03 | Synthena Ag | Tricyclo-DNA nucleoside precursors and processes for preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150141637A1 (en) | 2015-05-21 |
| CA2866800A1 (en) | 2013-09-19 |
| WO2013135900A1 (en) | 2013-09-19 |
| JP2018109015A (ja) | 2018-07-12 |
| EP2639238A1 (en) | 2013-09-18 |
| EP2834257A1 (en) | 2015-02-11 |
| US9249178B2 (en) | 2016-02-02 |
| US20160122372A1 (en) | 2016-05-05 |
| EP3459962A1 (en) | 2019-03-27 |
| IN2014MN01838A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 2015-07-03 |
| AU2013234303B2 (en) | 2017-09-14 |
| CN104321334A (zh) | 2015-01-28 |
| AU2013234303A1 (en) | 2014-10-02 |
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