JP2015509803A - センサー - Google Patents

センサー Download PDF

Info

Publication number
JP2015509803A
JP2015509803A JP2014561505A JP2014561505A JP2015509803A JP 2015509803 A JP2015509803 A JP 2015509803A JP 2014561505 A JP2014561505 A JP 2014561505A JP 2014561505 A JP2014561505 A JP 2014561505A JP 2015509803 A JP2015509803 A JP 2015509803A
Authority
JP
Japan
Prior art keywords
ros
sensor
membrane
analyte
barrier layer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014561505A
Other languages
English (en)
Japanese (ja)
Inventor
パターソン、ウィリアムス
バーウェル、ニック
カルバート、ブルース
クレーン、バリー、コリン
Original Assignee
ライトシップ メディカル リミテッド
ライトシップ メディカル リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライトシップ メディカル リミテッド, ライトシップ メディカル リミテッド filed Critical ライトシップ メディカル リミテッド
Publication of JP2015509803A publication Critical patent/JP2015509803A/ja
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/206664—Ozone or peroxide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
JP2014561505A 2012-03-15 2013-02-20 センサー Pending JP2015509803A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261611239P 2012-03-15 2012-03-15
US61/611,239 2012-03-15
PCT/GB2013/050407 WO2013136044A2 (en) 2012-03-15 2013-02-20 Sensor

Publications (1)

Publication Number Publication Date
JP2015509803A true JP2015509803A (ja) 2015-04-02

Family

ID=47833300

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014561505A Pending JP2015509803A (ja) 2012-03-15 2013-02-20 センサー

Country Status (8)

Country Link
US (3) US8940542B2 (enExample)
EP (1) EP2825095A2 (enExample)
JP (1) JP2015509803A (enExample)
CN (1) CN104168827A (enExample)
AU (1) AU2013234126A1 (enExample)
CA (2) CA2867092C (enExample)
IN (1) IN2014DN07535A (enExample)
WO (1) WO2013136044A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015513108A (ja) * 2012-04-10 2015-04-30 ライトシップ メディカル リミテッド センサ用較正器
US11963767B2 (en) 2018-12-28 2024-04-23 Dexcom, Inc. Analyte sensor with impedance determination

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9681824B2 (en) 2011-03-15 2017-06-20 Senseonics, Incorporated Integrated catalytic protection of oxidation sensitive materials
CN104168827A (zh) 2012-03-15 2014-11-26 灯船医药有限公司 传感器
US11109779B2 (en) 2012-12-28 2021-09-07 Senseonics, Incorporated Chemical modification of analyte permeable membrane for enhanced oxidative stability
CN105628756B (zh) * 2015-12-30 2018-09-21 南京工业大学 一种血液同步分离与传感膜的制备方法
CN110346341A (zh) * 2019-08-08 2019-10-18 生态环境部华南环境科学研究所 一种活性氧含量自动检测系统
US12186076B2 (en) 2021-02-09 2025-01-07 Medtronic, Inc. Optical based glucose sensor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005315871A (ja) * 2004-03-31 2005-11-10 Terumo Corp 体内物質測定用構成物、体内物質測定用構成物の製造方法、および埋込型物質センサー
US20070191701A1 (en) * 2004-02-09 2007-08-16 Abbott Diabetes Care, Inc. Analyte Sensor, and Associated System and Method Employing a Catalytic Agent
US20110236989A1 (en) * 2010-02-08 2011-09-29 Glumetrics, Inc. Antioxidant protection of a chemical sensor

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63291596A (ja) * 1987-05-22 1988-11-29 Meidensha Electric Mfg Co Ltd 生体試料中のグルコ−スの測定方法
US6387672B1 (en) 2000-12-04 2002-05-14 Beckman Coulter, Inc. Photo-induced electron transfer fluorescent sensor molecules
SE0200269D0 (sv) * 2002-01-31 2002-01-31 Ellem Bioteknik Ab Material for implantation
WO2004007756A1 (en) 2002-07-12 2004-01-22 Novo Nordisk A/S Minimising calibration problems of in vivo glucose sensors
US7761130B2 (en) * 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US7699964B2 (en) 2004-02-09 2010-04-20 Abbott Diabetes Care Inc. Membrane suitable for use in an analyte sensor, analyte sensor, and associated method
US7450980B2 (en) 2004-03-31 2008-11-11 Terumo Kabushiki Kaisha Intracorporeal substance measuring assembly
US8541146B2 (en) * 2005-01-12 2013-09-24 Toyota Motor Engineering & Manufacturing North America, Inc. Photocatalytic methods for preparation of electrocatalyst materials
ITFI20050002A1 (it) * 2005-01-11 2006-07-12 Acta Spa Assemblati mambrana-elettrodi per celle a combustibile, loro fabbricazione ed uso e celle a combustibile che le contegono
US20070014726A1 (en) 2005-07-18 2007-01-18 Sensors For Medicine And Science Oxidation-resistant indicator macromolecule
US20070154466A1 (en) 2005-12-30 2007-07-05 Jan Weber Internal medical devices containing peroxide-converting catalysts
US7851225B2 (en) 2006-11-30 2010-12-14 Sensors For Medicine And Science, Inc. Oxidation resistant indicator molecules
WO2008098087A2 (en) 2007-02-06 2008-08-14 Glumetrics, Inc. Optical systems and methods for rationmetric measurement of blood glucose concentration
WO2008141241A1 (en) 2007-05-10 2008-11-20 Glumetrics, Inc. Equilibrium non-consuming fluorescence sensor for real time intravascular glucose measurement
GB0715590D0 (en) 2007-08-09 2007-09-19 Glysure Ltd Sensing apparatus
EP2217316A4 (en) 2007-11-21 2013-01-16 Glumetrics Inc USE OF AN INTRAVASCULAR EQUILIBRIUM SENSOR FOR CLOSE GLYCEMIC CONTROL
GB0906318D0 (en) 2009-04-09 2009-05-20 Glysure Ltd Fluorophore and fluorescent sensor compound containing same
US20100298674A1 (en) 2009-04-21 2010-11-25 Sensors For Medicine & Science, Inc. Protective shell for an in vivo sensor made from resorbable polymer
WO2010123896A2 (en) * 2009-04-21 2010-10-28 Washington University Palladium-platinum nanostructures and methods for their preparation
US9130074B2 (en) 2009-04-21 2015-09-08 Tetrasun, Inc. High-efficiency solar cell structures and methods of manufacture
JP6008370B2 (ja) * 2010-02-16 2016-10-19 ライトシップ メディカル リミテッド グルコースセンサ用障壁層
EP2537033A1 (en) 2010-02-19 2012-12-26 Lightship Medical Limited Indicator system for fibre optic sensor
EP2545373B1 (en) 2010-03-11 2022-08-24 Medtronic Minimed, Inc. Measuring analyte concentration incorporating temperature and ph correction
US9970940B2 (en) * 2011-08-17 2018-05-15 Lightship Medical Limited Barrier layer for glucose sensor
CN104168827A (zh) * 2012-03-15 2014-11-26 灯船医药有限公司 传感器

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070191701A1 (en) * 2004-02-09 2007-08-16 Abbott Diabetes Care, Inc. Analyte Sensor, and Associated System and Method Employing a Catalytic Agent
JP2005315871A (ja) * 2004-03-31 2005-11-10 Terumo Corp 体内物質測定用構成物、体内物質測定用構成物の製造方法、および埋込型物質センサー
US20110236989A1 (en) * 2010-02-08 2011-09-29 Glumetrics, Inc. Antioxidant protection of a chemical sensor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015513108A (ja) * 2012-04-10 2015-04-30 ライトシップ メディカル リミテッド センサ用較正器
US11963767B2 (en) 2018-12-28 2024-04-23 Dexcom, Inc. Analyte sensor with impedance determination
US12029560B2 (en) * 2018-12-28 2024-07-09 Dexcom, Inc. Analyte sensor with impedance determination
US12114975B2 (en) 2018-12-28 2024-10-15 Dexcom, Inc. Analyte sensor with impedance determination
US12383173B2 (en) 2018-12-28 2025-08-12 Dexcom, Inc. Analyte sensor with impedance determination

Also Published As

Publication number Publication date
US8940542B2 (en) 2015-01-27
US20140234982A1 (en) 2014-08-21
US20150219663A1 (en) 2015-08-06
CA2867092C (en) 2022-12-13
US20170010274A1 (en) 2017-01-12
WO2013136044A2 (en) 2013-09-19
IN2014DN07535A (enExample) 2015-04-24
CN104168827A (zh) 2014-11-26
US9797909B2 (en) 2017-10-24
EP2825095A2 (en) 2015-01-21
AU2013234126A1 (en) 2014-09-25
CA3095821C (en) 2023-03-14
US9476886B2 (en) 2016-10-25
CA2867092A1 (en) 2013-09-19
WO2013136044A3 (en) 2013-12-27
CA3095821A1 (en) 2013-09-19

Similar Documents

Publication Publication Date Title
JP2015509803A (ja) センサー
Zhao et al. Silk/polyols/GOD microneedle based electrochemical biosensor for continuous glucose monitoring
US9309550B2 (en) Analyte sensors having nanostructured electrodes and methods for making and using them
Yezer et al. Cellulose acetate–chitosan based electrospun nanofibers for bio-functionalized surface design in biosensing
Navarro-Villoslada et al. Fiber-optic luminescent sensors with composite oxygen-sensitive layers and anti-biofouling coatings
Wickramasinghe et al. Current problems and potential techniques in in vivo glucose monitoring
CN116626123A (zh) 单个细胞胞内纳米ph探针
Baharifar et al. The Potentials and Applications of Cellulose Acetate in biosensor technology
Balaconis et al. Glucose-sensitive nanofiber scaffolds with an improved sensing design for physiological conditions
Nam et al. A glucose-responsive microgel-based soft etalon as an epidermal glucose colorimetric sensor
WO2015061371A1 (en) Compositions and methods for measurement of analytes
Sun et al. A label-free electrochemical aptasensor for sensitive thrombin detection in whole blood
FR3035221A1 (fr) Biocapteurs electrochimiques implantables
EP2744909B1 (en) Method for preparing a barrier layer for a glucose sensor
CN109897630B (zh) 一种纳米线、其制备方法、包含该纳米线的比率型荧光化学传感器及应用
KR102198384B1 (ko) Poss-마이크로 니들 및 이를 포함하는 마이크로 니들 패치
US8454509B1 (en) Nanostructured composite material and biosensor comprising it
IES20070774A2 (en) Monitoring target endogenous species in the brain
US20190357825A1 (en) Optical sensor
Chu et al. Facile Fabrication of Highly Sensitive Pt-black Electrochemical Sensor for L-Glutamate Detection
Ghannouchi et al. New Amperometric Glucose Biosensors Based On Nafion Nanofibers
Radomska et al. Protein engineering for biosensors
Burugapalli et al. Nanomaterials in glucose sensing
Singh Enhancement of the Response Range and Longevity of Microparticle-based Glucose Sensors
Wang Electrospun membranes for implantable glucose biosensors

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160108

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20161216

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20161222

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170324

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170824