JP2015507916A - グルタミン酸安定化インスリン類似体 - Google Patents

グルタミン酸安定化インスリン類似体 Download PDF

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Publication number
JP2015507916A
JP2015507916A JP2014553515A JP2014553515A JP2015507916A JP 2015507916 A JP2015507916 A JP 2015507916A JP 2014553515 A JP2014553515 A JP 2014553515A JP 2014553515 A JP2014553515 A JP 2014553515A JP 2015507916 A JP2015507916 A JP 2015507916A
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JP
Japan
Prior art keywords
insulin
glu
phe
insulin analogue
analog
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Pending
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JP2014553515A
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Japanese (ja)
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JP2015507916A5 (https=
Inventor
ワイス、マイケル、エー．
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Case Western Reserve University
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Case Western Reserve University
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Publication of JP2015507916A publication Critical patent/JP2015507916A/ja
Publication of JP2015507916A5 publication Critical patent/JP2015507916A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014553515A 2012-01-20 2013-01-22 グルタミン酸安定化インスリン類似体 Pending JP2015507916A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589271P 2012-01-20 2012-01-20
US61/589,271 2012-01-20
PCT/US2013/022551 WO2013110069A1 (en) 2012-01-20 2013-01-22 Glutamic acid-stabilized insulin analogues

Publications (2)

Publication Number Publication Date
JP2015507916A true JP2015507916A (ja) 2015-03-16
JP2015507916A5 JP2015507916A5 (https=) 2016-03-10

Family

ID=48799748

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014553515A Pending JP2015507916A (ja) 2012-01-20 2013-01-22 グルタミン酸安定化インスリン類似体

Country Status (6)

Country Link
US (1) US20150299286A1 (https=)
EP (1) EP2804621A4 (https=)
JP (1) JP2015507916A (https=)
CN (1) CN104168911A (https=)
CA (1) CA2898730A1 (https=)
WO (1) WO2013110069A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506366A (ja) * 2012-11-05 2016-03-03 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 長時間作用型単鎖インスリン類似体
JP2018170813A (ja) * 2018-08-13 2018-11-01 株式会社Ｎｔｔドコモ ユーザ装置、基地局、及びキャリアアグリゲーション制御方法

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102351111B1 (ko) * 2014-01-13 2022-01-14 써멀린 다이어비티즈, 엘엘씨 초속효성 인슐린 제형 및 약제학적 전달 시스템
CR20160376A (es) 2014-01-20 2016-10-07 Hanmi Pharm Ind Co Ltd Insulina de acción prolongada y uso de la misma
AR100639A1 (es) 2014-05-29 2016-10-19 Hanmi Pharm Ind Co Ltd Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada
AR100695A1 (es) 2014-05-30 2016-10-26 Hanmi Pharm Ind Co Ltd Composición para el tratamiento de diabetes mellitus que comprende insulina y un agonista dual glp-1 / glucagón
WO2016105545A2 (en) * 2014-12-24 2016-06-30 Case Western Reserve University Insulin analogues with enhanced stabilized and reduced mitogenicity
HK1247836A1 (zh) * 2015-03-13 2018-10-05 Case Western Reserve University 含有葡萄糖调节的构象转换器的胰岛素类似物
UY36870A (es) 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
WO2017070617A1 (en) * 2015-10-21 2017-04-27 Case Western Reserve University Diol-modified insulin analogues containing a glucose-regulated conformational switch
JP7158378B2 (ja) 2016-09-23 2022-10-21 ハンミ ファーマシューティカル カンパニー リミテッド インスリン受容体との結合力が減少された、インスリンアナログ及びその用途
CA3294636A1 (en) * 2016-11-21 2026-02-10 Case Western Reserve University Rapid-acting insulin analogues of enhanced stability
KR102629006B1 (ko) 2017-03-23 2024-01-25 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
CZ310198B6 (cs) * 2021-07-07 2024-11-13 Ústav organické chemie a biochemie AV ČR, v. v. i. Deriváty inzulínu se zvýšenou tepelnou stabilitou

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003528149A (ja) * 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
JP2005519041A (ja) * 2001-12-20 2005-06-30 イーライ・リリー・アンド・カンパニー 長期作用を備えたインスリン分子
JP2006516536A (ja) * 2002-10-29 2006-07-06 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリン類似体の結晶およびそれらの製造方法
JP2009512709A (ja) * 2005-10-20 2009-03-26 エムディーアールエヌエー，インコーポレイテッド 速効型インスリンの経鼻投与
US20110077196A1 (en) * 2009-09-17 2011-03-31 Case Western Reserve University Non-standard insulin analogues
JP2011529692A (ja) * 2008-07-31 2011-12-15 ケイス、ウエスタン、リザーブ、ユニバーシティ ハロゲン安定化インスリン

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
US7193035B2 (en) * 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
KR20120129875A (ko) * 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
JP5789515B2 (ja) * 2008-12-19 2015-10-07 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ インスリン類似体

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003528149A (ja) * 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
JP2005519041A (ja) * 2001-12-20 2005-06-30 イーライ・リリー・アンド・カンパニー 長期作用を備えたインスリン分子
JP2006516536A (ja) * 2002-10-29 2006-07-06 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリン類似体の結晶およびそれらの製造方法
JP2009512709A (ja) * 2005-10-20 2009-03-26 エムディーアールエヌエー，インコーポレイテッド 速効型インスリンの経鼻投与
JP2011529692A (ja) * 2008-07-31 2011-12-15 ケイス、ウエスタン、リザーブ、ユニバーシティ ハロゲン安定化インスリン
US20110077196A1 (en) * 2009-09-17 2011-03-31 Case Western Reserve University Non-standard insulin analogues

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DIABETES, OBESITY AND METABOLISM, vol. 11, no. 1, JPN6016045247, 2009, pages 5 - 19, ISSN: 0003445804 *
J. BIOL. CHEM., vol. 276, no. 43, JPN6016045246, 2001, pages 40018 - 40024, ISSN: 0003445803 *
J. MOL. BIOL., vol. 315, no. 2, JPN6016045245, 2002, pages 103 - 111, ISSN: 0003445802 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016506366A (ja) * 2012-11-05 2016-03-03 ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ 長時間作用型単鎖インスリン類似体
JP2018170813A (ja) * 2018-08-13 2018-11-01 株式会社Ｎｔｔドコモ ユーザ装置、基地局、及びキャリアアグリゲーション制御方法

Also Published As

Publication number Publication date
EP2804621A1 (en) 2014-11-26
CA2898730A1 (en) 2013-07-25
WO2013110069A1 (en) 2013-07-25
US20150299286A1 (en) 2015-10-22
EP2804621A4 (en) 2015-11-18
CN104168911A (zh) 2014-11-26

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