JP2015507635A5 - - Google Patents
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- Publication number
- JP2015507635A5 JP2015507635A5 JP2014550538A JP2014550538A JP2015507635A5 JP 2015507635 A5 JP2015507635 A5 JP 2015507635A5 JP 2014550538 A JP2014550538 A JP 2014550538A JP 2014550538 A JP2014550538 A JP 2014550538A JP 2015507635 A5 JP2015507635 A5 JP 2015507635A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- alkyl
- pharmaceutically acceptable
- alkylene
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- -1 cycloheteroalkyl Chemical group 0.000 claims 2
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000006850 spacer group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005085 alkoxycarbonylalkoxy group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 229910052805 deuterium Inorganic materials 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000005226 heteroaryloxycarbonyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940124530 sulfonamide Drugs 0.000 claims 1
- 150000003456 sulfonamides Chemical class 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 229910052722 tritium Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582201P | 2011-12-30 | 2011-12-30 | |
| US61/582,201 | 2011-12-30 | ||
| PCT/US2012/072283 WO2013102195A1 (en) | 2011-12-30 | 2012-12-31 | Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076091A Division JP2018138566A (ja) | 2011-12-30 | 2018-04-11 | 組成物、合成およびフェニルシクロアルキルメチルアミン誘導体を使用する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015507635A JP2015507635A (ja) | 2015-03-12 |
| JP2015507635A5 true JP2015507635A5 (enExample) | 2016-01-28 |
Family
ID=48698693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014550538A Pending JP2015507635A (ja) | 2011-12-30 | 2012-12-31 | 組成物、合成およびフェニルシクロアルキルメチルアミン誘導体を使用する方法 |
| JP2018076091A Pending JP2018138566A (ja) | 2011-12-30 | 2018-04-11 | 組成物、合成およびフェニルシクロアルキルメチルアミン誘導体を使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076091A Pending JP2018138566A (ja) | 2011-12-30 | 2018-04-11 | 組成物、合成およびフェニルシクロアルキルメチルアミン誘導体を使用する方法 |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US9238625B2 (enExample) |
| EP (1) | EP2797870B1 (enExample) |
| JP (2) | JP2015507635A (enExample) |
| KR (1) | KR20140110014A (enExample) |
| CN (1) | CN104039753B (enExample) |
| AU (1) | AU2012362105B2 (enExample) |
| BR (1) | BR112014016122A8 (enExample) |
| CA (1) | CA2858837C (enExample) |
| CO (1) | CO7071125A2 (enExample) |
| ES (1) | ES2726807T3 (enExample) |
| IL (1) | IL233083A0 (enExample) |
| IN (1) | IN2014MN01407A (enExample) |
| MX (1) | MX352874B (enExample) |
| MY (1) | MY170643A (enExample) |
| PH (1) | PH12014501313A1 (enExample) |
| RU (1) | RU2642074C2 (enExample) |
| SG (1) | SG11201403165SA (enExample) |
| UA (1) | UA114807C2 (enExample) |
| WO (1) | WO2013102195A1 (enExample) |
| ZA (1) | ZA201404711B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2797870B1 (en) | 2011-12-30 | 2019-02-20 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using 1-[1-phenyl-cyclobutyl]isobutylamine derivatives |
| JP7734917B2 (ja) | 2019-01-28 | 2025-09-08 | ミトコンドリア エモーション， インク． | トランス－４－ヒドロキシシクロヘキシルフェニルアミドマイトフュージン活性化物質及びその使用方法 |
| JP7473565B2 (ja) | 2019-01-28 | 2024-04-23 | ミトコンドリア エモーション， インク． | マイトフュージン活性化物質及びその使用方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| IE52768B1 (en) * | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
| ZA836848B (en) * | 1982-09-30 | 1984-05-30 | Boots Co Plc | Therapeutic agents |
| IE56000B1 (en) * | 1982-09-30 | 1991-03-13 | Boots Co Plc | 1-arylcyclobutylalkylamine compounds |
| US5015664A (en) | 1984-01-26 | 1991-05-14 | Oral D | Orally effective ion chelators related to deferoxamine |
| GB8501192D0 (en) | 1985-01-17 | 1985-02-20 | Boots Co Plc | Therapeutic agents |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| ZA925185B (en) * | 1991-07-18 | 1993-04-29 | Hoffmann La Roche | Dithianes. |
| US5596019A (en) | 1995-06-07 | 1997-01-21 | Bristol-Myers Squibb Company | N-acyl-cycloalkylamine derivatives as melatonergics |
| GB9619757D0 (en) | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
| GB9619961D0 (en) | 1996-09-25 | 1996-11-13 | Knoll Ag | Medical treatment |
| US6476078B2 (en) | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| US6323242B1 (en) | 1998-12-02 | 2001-11-27 | Peter Sterling Mueller | Treatment of disorders secondary to organic impairments |
| GB9914744D0 (en) | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| GB9914742D0 (en) | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| AU2002210816A1 (en) | 2000-11-02 | 2002-05-15 | Torrent Pharmaceuticals Ltd | Process for preparation of beta-phenethylamine derivative |
| EE05643B1 (et) | 2001-02-24 | 2013-04-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina |
| WO2002083631A1 (en) | 2001-04-13 | 2002-10-24 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
| GB0230134D0 (en) | 2002-12-24 | 2003-01-29 | Amedis Pharm Ltd | Compounds and their use |
| WO2004096202A1 (en) | 2003-04-28 | 2004-11-11 | Cipla Limited | Pharmaceutical formulation comprising anti-obesity agent and acidulant |
| TW201245229A (en) | 2003-10-14 | 2012-11-16 | Hoffmann La Roche | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of HCV replication |
| EP1595873A1 (de) * | 2004-05-13 | 2005-11-16 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen |
| ES2646326T3 (es) * | 2005-08-03 | 2017-12-13 | Sprout Pharmaceuticals, Inc. | Uso de flibanserina en el tratamiento de la obesidad |
| EP1976513B1 (en) | 2006-01-06 | 2016-08-24 | Sunovion Pharmaceuticals Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| JP2007254409A (ja) * | 2006-03-24 | 2007-10-04 | Taisho Pharmaceut Co Ltd | イミダゾリジノン誘導体 |
| NZ572381A (en) | 2006-04-28 | 2011-01-28 | Shionogi & Co | Amine derivative having npy y5 receptor antagonist activity |
| EP2066329B1 (en) * | 2006-09-15 | 2017-09-06 | Reviva Pharmaceuticals, Inc. | Synthesis, methods of using, and compositions of cyclobutylmethylamines |
| SA08290668B1 (ar) | 2007-10-25 | 2012-02-12 | شيونوجي آند كو.، ليمتد | مشتقات أمين لها نشاط مضاد لمستقبل npy y5 واستخداماتها |
| CN101970430B (zh) | 2007-11-01 | 2013-05-08 | 埃科特莱茵药品有限公司 | 嘧啶衍生物 |
| BRPI1013868A2 (pt) * | 2009-04-21 | 2016-04-05 | Astellas Pharma Inc | composto diaciletilenodiamina |
| US8227618B2 (en) * | 2009-04-23 | 2012-07-24 | Shionogi & Co., Ltd. | Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof |
| WO2012003501A2 (en) * | 2010-07-02 | 2012-01-05 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| EP2797870B1 (en) | 2011-12-30 | 2019-02-20 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using 1-[1-phenyl-cyclobutyl]isobutylamine derivatives |
-
2012
- 2012-12-31 EP EP12863137.1A patent/EP2797870B1/en active Active
- 2012-12-31 JP JP2014550538A patent/JP2015507635A/ja active Pending
- 2012-12-31 SG SG11201403165SA patent/SG11201403165SA/en unknown
- 2012-12-31 UA UAA201407974A patent/UA114807C2/uk unknown
- 2012-12-31 MY MYPI2014001866A patent/MY170643A/en unknown
- 2012-12-31 KR KR1020147020986A patent/KR20140110014A/ko not_active Ceased
- 2012-12-31 AU AU2012362105A patent/AU2012362105B2/en active Active
- 2012-12-31 CN CN201280064358.XA patent/CN104039753B/zh active Active
- 2012-12-31 ES ES12863137T patent/ES2726807T3/es active Active
- 2012-12-31 US US13/731,670 patent/US9238625B2/en active Active
- 2012-12-31 CA CA2858837A patent/CA2858837C/en active Active
- 2012-12-31 MX MX2014007879A patent/MX352874B/es active IP Right Grant
- 2012-12-31 BR BR112014016122A patent/BR112014016122A8/pt not_active Application Discontinuation
- 2012-12-31 WO PCT/US2012/072283 patent/WO2013102195A1/en not_active Ceased
- 2012-12-31 RU RU2014129416A patent/RU2642074C2/ru active
- 2012-12-31 IN IN1407MUN2014 patent/IN2014MN01407A/en unknown
-
2014
- 2014-06-09 PH PH12014501313A patent/PH12014501313A1/en unknown
- 2014-06-12 IL IL233083A patent/IL233083A0/en not_active IP Right Cessation
- 2014-06-26 ZA ZA2014/04711A patent/ZA201404711B/en unknown
- 2014-07-02 CO CO14141800A patent/CO7071125A2/es unknown
-
2015
- 2015-12-31 US US14/986,267 patent/US9695116B2/en active Active
-
2017
- 2017-06-30 US US15/639,135 patent/US10035761B2/en active Active
-
2018
- 2018-04-11 JP JP2018076091A patent/JP2018138566A/ja active Pending