JP2015507611A5 - - Google Patents
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- Publication number
- JP2015507611A5 JP2015507611A5 JP2014546031A JP2014546031A JP2015507611A5 JP 2015507611 A5 JP2015507611 A5 JP 2015507611A5 JP 2014546031 A JP2014546031 A JP 2014546031A JP 2014546031 A JP2014546031 A JP 2014546031A JP 2015507611 A5 JP2015507611 A5 JP 2015507611A5
- Authority
- JP
- Japan
- Prior art keywords
- aromatic
- dmt
- phe
- lys
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims description 9
- 239000012472 biological sample Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 230000037050 permeability transition Effects 0.000 claims description 6
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
- 230000002407 ATP formation Effects 0.000 claims description 3
- 210000003470 mitochondria Anatomy 0.000 claims description 3
- 210000001700 mitochondrial membrane Anatomy 0.000 claims description 3
- 230000004792 oxidative damage Effects 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- SFVLTCAESLKEHH-WKAQUBQDSA-N (2s)-6-amino-2-[[(2s)-2-[[(2r)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-n-[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide Chemical compound CC1=CC(O)=CC(C)=C1C[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)CC1=CC=CC=C1 SFVLTCAESLKEHH-WKAQUBQDSA-N 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004255 ion exchange chromatography Methods 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 238000004007 reversed phase HPLC Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 230000002438 mitochondrial effect Effects 0.000 claims 3
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569120P | 2011-12-09 | 2011-12-09 | |
| US61/569,120 | 2011-12-09 | ||
| PCT/US2012/067984 WO2013086020A1 (en) | 2011-12-09 | 2012-12-05 | Aromatic-cationic peptides and uses of same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017212657A Division JP2018035190A (ja) | 2011-12-09 | 2017-11-02 | 芳香族カチオン性ペプチドおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015507611A JP2015507611A (ja) | 2015-03-12 |
| JP2015507611A5 true JP2015507611A5 (https=) | 2016-01-28 |
Family
ID=48574838
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546031A Pending JP2015507611A (ja) | 2011-12-09 | 2012-12-05 | 芳香族カチオン性ペプチドおよびその使用 |
| JP2017212657A Withdrawn JP2018035190A (ja) | 2011-12-09 | 2017-11-02 | 芳香族カチオン性ペプチドおよびその使用 |
| JP2019085146A Pending JP2019137691A (ja) | 2011-12-09 | 2019-04-26 | 芳香族カチオン性ペプチドおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017212657A Withdrawn JP2018035190A (ja) | 2011-12-09 | 2017-11-02 | 芳香族カチオン性ペプチドおよびその使用 |
| JP2019085146A Pending JP2019137691A (ja) | 2011-12-09 | 2019-04-26 | 芳香族カチオン性ペプチドおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20140294796A1 (https=) |
| EP (4) | EP3009141A1 (https=) |
| JP (3) | JP2015507611A (https=) |
| CN (3) | CN109160936A (https=) |
| AU (3) | AU2012347931A1 (https=) |
| CA (1) | CA2858550A1 (https=) |
| HK (1) | HK1223550A1 (https=) |
| WO (1) | WO2013086020A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012315586B2 (en) | 2011-09-29 | 2017-07-20 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| EP3009141A1 (en) | 2011-12-09 | 2016-04-20 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| CA2870200A1 (en) * | 2012-04-12 | 2013-10-17 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| JP6480921B2 (ja) * | 2013-09-27 | 2019-03-13 | コーネル ユニヴァーシティー | コレステロール誘発性ミトコンドリア機能不全を治療するための芳香族カチオン性ペプチドの使用 |
| EP3060573B1 (en) | 2013-10-23 | 2019-07-17 | Kaneka Corporation | Tetrapeptide compound and method for producing same |
| EP3071591B1 (en) * | 2014-01-22 | 2021-05-05 | Agency For Science, Technology And Research | Antimicrobial peptidomimetics |
| EP3149035A4 (en) * | 2014-05-28 | 2018-05-16 | Stealth BioTherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
| EP3160984B1 (en) | 2014-06-25 | 2021-04-14 | Flamma S.P.A. | Process for preparing d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| US9464111B2 (en) | 2014-06-26 | 2016-10-11 | L'oreal | Short peptides and a method of use as an antioxidant |
| WO2016001042A1 (en) | 2014-06-30 | 2016-01-07 | Flamma S.P.A. | Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| KR102643923B1 (ko) * | 2014-12-23 | 2024-03-05 | 이매틱스 바이오테크놀로지스 게엠베하 | 간세포 암종(hcc) 및 기타 암들에 대한 면역요법에서의 사용을 위한 신규 펩티드 및 펩티드의 조합 |
| US10633415B2 (en) | 2015-03-06 | 2020-04-28 | Stealth Biotherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| WO2016200364A1 (en) * | 2015-06-08 | 2016-12-15 | Stealth Peptides International, Inc. | THERAPEUTIC COMPOSITIONS INCLUDING SkQ COMPOUNDS AND USES THEREOF |
| CA3006698A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| CN109069572A (zh) * | 2015-12-31 | 2018-12-21 | 康德生物医疗技术公司 | 包含肽的治疗性组合物和其用途 |
| CA3020393A1 (en) * | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
| WO2018134265A1 (en) | 2017-01-17 | 2018-07-26 | Forrest Michael David | Therapeutic inhibitors of the reverse mode of atp synthase |
| WO2019012149A1 (en) | 2017-07-13 | 2019-01-17 | Forrest Michael David | THERAPEUTIC MODULATORS OF THE INVERSE MODE OF ATP SYNTHASE |
| US12404300B2 (en) | 2018-12-18 | 2025-09-02 | Stealth Biotherapeutics Inc. | Mitochondria-targeting peptides |
| CA3173936A1 (en) * | 2020-06-22 | 2021-12-30 | Guozhu ZHENG | Prodrugs of mitochondria-targeting oligopeptides |
| US20230279052A1 (en) * | 2020-06-22 | 2023-09-07 | Stealth Biotherapeutics Inc. | Prodrugs of mitochondria-targeting oligopeptides |
| US11932080B2 (en) | 2020-08-20 | 2024-03-19 | Denso International America, Inc. | Diagnostic and recirculation control systems and methods |
| US12251991B2 (en) | 2020-08-20 | 2025-03-18 | Denso International America, Inc. | Humidity control for olfaction sensors |
| US11760170B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Olfaction sensor preservation systems and methods |
| US11760169B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Particulate control systems and methods for olfaction sensors |
| US11813926B2 (en) | 2020-08-20 | 2023-11-14 | Denso International America, Inc. | Binding agent and olfaction sensor |
| US11828210B2 (en) | 2020-08-20 | 2023-11-28 | Denso International America, Inc. | Diagnostic systems and methods of vehicles using olfaction |
| US12377711B2 (en) | 2020-08-20 | 2025-08-05 | Denso International America, Inc. | Vehicle feature control systems and methods based on smoking |
| US12269315B2 (en) | 2020-08-20 | 2025-04-08 | Denso International America, Inc. | Systems and methods for measuring and managing odor brought into rental vehicles |
| US11881093B2 (en) | 2020-08-20 | 2024-01-23 | Denso International America, Inc. | Systems and methods for identifying smoking in vehicles |
| US11636870B2 (en) | 2020-08-20 | 2023-04-25 | Denso International America, Inc. | Smoking cessation systems and methods |
| US12017506B2 (en) | 2020-08-20 | 2024-06-25 | Denso International America, Inc. | Passenger cabin air control systems and methods |
| US20250325469A1 (en) | 2021-01-24 | 2025-10-23 | Michael David FORREST | Inhibitors of atp synthase - cosmetic and therapeutic uses |
| WO2025226064A1 (ko) * | 2024-04-25 | 2025-10-30 | (주)카멜바이오사이언스 | 유비퀴틴 리가아제의 리간드 화합물 및 이를 포함하는 protac 분자 |
| WO2025226057A1 (ko) * | 2024-04-25 | 2025-10-30 | (주)카멜바이오사이언스 | 유비퀴틴 리가아제의 리간드 화합물 및 이를 포함하는 protac 분자 |
| CN118883772B (zh) * | 2024-09-26 | 2025-01-24 | 首都医科大学附属北京朝阳医院 | 3-硝基丙酸的检测方法及其应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US8038984B2 (en) * | 1998-06-20 | 2011-10-18 | Washington University | Membrane-permeant peptide complexes for treatment of sepsis |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| CN101440124B (zh) * | 2003-02-04 | 2012-07-18 | 科内尔研究基金会 | 用于防止线粒体通透性改变的方法 |
| SI2656854T1 (sl) * | 2003-02-04 | 2015-09-30 | Cornell Research Foundation, Inc. | Uporabe aromatsko-kationskega peptida |
| JP4879020B2 (ja) * | 2003-05-01 | 2012-02-15 | コーネル リサーチ ファウンデイション インコーポレイテッド | 細胞に分子を送達する方法及び担体複合体 |
| WO2005040205A1 (en) * | 2003-10-28 | 2005-05-06 | Protemix Discovery Limited | Peptides with anti-obesity activity and other related uses |
| EP3103467A1 (en) * | 2008-02-07 | 2016-12-14 | Cornell University | Methods for preventing or treating insulin resistance |
| DK2262520T3 (en) * | 2008-02-26 | 2017-08-07 | Univ Cornell | COMPOSITIONS FOR PREVENTION AND TREATMENT OF Kidney Injury |
| PL2470191T3 (pl) * | 2009-08-24 | 2014-09-30 | Stealth Peptides Int Inc | Sposoby i kompozycje do profilaktyki lub leczenia stanów okulistycznych |
| EP3266462A1 (en) * | 2009-12-31 | 2018-01-10 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| CN103751763A (zh) * | 2009-12-31 | 2014-04-30 | 康肽德生物医药技术有限公司 | 用于预防或治疗血管阻塞损伤的方法 |
| AU2011207432A1 (en) * | 2010-01-25 | 2012-08-02 | Cornell University | Aromatic-cationic peptides and uses of same |
| EP3332795A1 (en) * | 2010-02-26 | 2018-06-13 | Cornell University Cornell Center For Technology, Enterprise & Commercialization ("CCTEC") | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| US20110245183A1 (en) * | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| US20110245182A1 (en) * | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| JP2013532124A (ja) * | 2010-05-03 | 2013-08-15 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 芳香族系陽イオンペプチド及びその使用 |
| JP6319738B2 (ja) * | 2010-07-09 | 2018-05-09 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 虚血／再灌流障害に続くノーリフローの予防又は処置方法 |
| AU2012315586B2 (en) * | 2011-09-29 | 2017-07-20 | Mayo Foundation For Medical Education And Research | Aromatic-cationic peptides and methods for using same |
| EP3009141A1 (en) * | 2011-12-09 | 2016-04-20 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| JP6317324B2 (ja) * | 2012-03-30 | 2018-04-25 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 神経障害を予防および処置するための方法および組成物 |
| HK1210953A1 (en) * | 2012-08-02 | 2016-05-13 | Stealth Peptides International, Inc. | Methods for treatment of atherosclerosis |
| CN110339339A (zh) * | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
| EP3626252A1 (en) * | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| US10047395B2 (en) * | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| WO2014210062A1 (en) * | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods for the regulation of matrix metalloproteinase expression |
| WO2015009414A1 (en) * | 2013-06-26 | 2015-01-22 | Stealth Peptides International, Inc. | Methods and compositions for regulating srca2a expression levels in myocardial infarction |
| WO2014210056A1 (en) | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| WO2015017861A1 (en) * | 2013-08-02 | 2015-02-05 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment of friedreich's ataxia |
| CA2932408A1 (en) * | 2013-12-02 | 2015-06-11 | Stealth Biotherapeutics Corp | Compositions and methods for treating vitiligo |
| WO2015183995A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| US10627392B2 (en) * | 2014-06-17 | 2020-04-21 | Stealth Biotherapeutics Corp | Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening |
| WO2016029027A2 (en) * | 2014-08-21 | 2016-02-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention and treatment of disease |
-
2012
- 2012-12-05 EP EP15177562.4A patent/EP3009141A1/en not_active Withdrawn
- 2012-12-05 EP EP19202295.2A patent/EP3656394A1/en not_active Withdrawn
- 2012-12-05 JP JP2014546031A patent/JP2015507611A/ja active Pending
- 2012-12-05 WO PCT/US2012/067984 patent/WO2013086020A1/en not_active Ceased
- 2012-12-05 CN CN201810783561.1A patent/CN109160936A/zh not_active Withdrawn
- 2012-12-05 US US14/363,035 patent/US20140294796A1/en not_active Abandoned
- 2012-12-05 CA CA2858550A patent/CA2858550A1/en not_active Abandoned
- 2012-12-05 EP EP18190582.9A patent/EP3466439A1/en not_active Withdrawn
- 2012-12-05 AU AU2012347931A patent/AU2012347931A1/en not_active Abandoned
- 2012-12-05 CN CN201280066416.2A patent/CN104105499A/zh active Pending
- 2012-12-05 EP EP12855211.4A patent/EP2788013A4/en not_active Withdrawn
- 2012-12-05 CN CN201710524414.8A patent/CN107312066A/zh active Pending
-
2016
- 2016-10-13 HK HK16111817.0A patent/HK1223550A1/en unknown
-
2017
- 2017-11-02 JP JP2017212657A patent/JP2018035190A/ja not_active Withdrawn
- 2017-12-11 AU AU2017276158A patent/AU2017276158A1/en not_active Abandoned
-
2018
- 2018-01-09 US US15/865,434 patent/US20180362579A1/en not_active Abandoned
-
2019
- 2019-04-26 JP JP2019085146A patent/JP2019137691A/ja active Pending
- 2019-11-15 AU AU2019264653A patent/AU2019264653A1/en not_active Abandoned
-
2020
- 2020-03-13 US US16/818,560 patent/US12065511B2/en active Active
-
2024
- 2024-07-09 US US18/766,897 patent/US20250002530A1/en active Pending
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