JP2015507611A5 - - Google Patents
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- JP2015507611A5 JP2015507611A5 JP2014546031A JP2014546031A JP2015507611A5 JP 2015507611 A5 JP2015507611 A5 JP 2015507611A5 JP 2014546031 A JP2014546031 A JP 2014546031A JP 2014546031 A JP2014546031 A JP 2014546031A JP 2015507611 A5 JP2015507611 A5 JP 2015507611A5
- Authority
- JP
- Japan
- Prior art keywords
- aromatic
- dmt
- phe
- lys
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 22
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims description 9
- 239000012472 biological sample Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 230000037050 permeability transition Effects 0.000 claims description 6
- 238000004128 high performance liquid chromatography Methods 0.000 claims description 4
- 230000002407 ATP formation Effects 0.000 claims description 3
- 210000003470 mitochondria Anatomy 0.000 claims description 3
- 210000001700 mitochondrial membrane Anatomy 0.000 claims description 3
- 230000004792 oxidative damage Effects 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- SFVLTCAESLKEHH-WKAQUBQDSA-N (2s)-6-amino-2-[[(2s)-2-[[(2r)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-n-[(2s)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide Chemical compound CC1=CC(O)=CC(C)=C1C[C@H](NC(=O)[C@H](N)CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N)=O)CC1=CC=CC=C1 SFVLTCAESLKEHH-WKAQUBQDSA-N 0.000 claims description 2
- 238000001574 biopsy Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 238000004255 ion exchange chromatography Methods 0.000 claims description 2
- 238000004949 mass spectrometry Methods 0.000 claims description 2
- 238000004007 reversed phase HPLC Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 230000002438 mitochondrial effect Effects 0.000 claims 3
- 125000002091 cationic group Chemical group 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569120P | 2011-12-09 | 2011-12-09 | |
| US61/569,120 | 2011-12-09 | ||
| PCT/US2012/067984 WO2013086020A1 (en) | 2011-12-09 | 2012-12-05 | Aromatic-cationic peptides and uses of same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017212657A Division JP2018035190A (ja) | 2011-12-09 | 2017-11-02 | 芳香族カチオン性ペプチドおよびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015507611A JP2015507611A (ja) | 2015-03-12 |
| JP2015507611A5 true JP2015507611A5 (https=) | 2016-01-28 |
Family
ID=48574838
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546031A Pending JP2015507611A (ja) | 2011-12-09 | 2012-12-05 | 芳香族カチオン性ペプチドおよびその使用 |
| JP2017212657A Withdrawn JP2018035190A (ja) | 2011-12-09 | 2017-11-02 | 芳香族カチオン性ペプチドおよびその使用 |
| JP2019085146A Pending JP2019137691A (ja) | 2011-12-09 | 2019-04-26 | 芳香族カチオン性ペプチドおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017212657A Withdrawn JP2018035190A (ja) | 2011-12-09 | 2017-11-02 | 芳香族カチオン性ペプチドおよびその使用 |
| JP2019085146A Pending JP2019137691A (ja) | 2011-12-09 | 2019-04-26 | 芳香族カチオン性ペプチドおよびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20140294796A1 (https=) |
| EP (4) | EP2788013A4 (https=) |
| JP (3) | JP2015507611A (https=) |
| CN (3) | CN104105499A (https=) |
| AU (3) | AU2012347931A1 (https=) |
| CA (1) | CA2858550A1 (https=) |
| HK (1) | HK1223550A1 (https=) |
| WO (1) | WO2013086020A1 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106913860A (zh) | 2011-09-29 | 2017-07-04 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| EP2788013A4 (en) * | 2011-12-09 | 2015-08-19 | Stealth Peptides Int Inc | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
| CN105753939A (zh) * | 2012-04-12 | 2016-07-13 | 康德生物医疗技术公司 | 芳香族阳离子肽及其用途 |
| WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| CA2925475A1 (en) * | 2013-09-27 | 2015-04-02 | Cornell University | Use of aromatic-cationic peptides to treat cholesterol-induced mitochondrial dysfunction |
| JP2016539931A (ja) * | 2013-10-23 | 2016-12-22 | 株式会社カネカ | テトラペプチド化合物及びその製造方法 |
| EP3071591B1 (en) * | 2014-01-22 | 2021-05-05 | Agency For Science, Technology And Research | Antimicrobial peptidomimetics |
| EP3502132A1 (en) * | 2014-05-28 | 2019-06-26 | Stealth BioTherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
| EP3160984B1 (en) | 2014-06-25 | 2021-04-14 | Flamma S.P.A. | Process for preparing d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| US9464111B2 (en) * | 2014-06-26 | 2016-10-11 | L'oreal | Short peptides and a method of use as an antioxidant |
| WO2016001042A1 (en) | 2014-06-30 | 2016-01-07 | Flamma S.P.A. | Process for the production of d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide |
| MA49156A (fr) * | 2014-12-23 | 2020-03-25 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides à utiliser dans l'immunothérapie contre le carcinome hépatocellulaire (hcc) et d'autres cancers |
| EP3265109B1 (en) | 2015-03-06 | 2020-10-21 | Stealth BioTherapeutics Corp | Processes for preparing pharmaceutically relevant peptides |
| WO2016200364A1 (en) * | 2015-06-08 | 2016-12-15 | Stealth Peptides International, Inc. | THERAPEUTIC COMPOSITIONS INCLUDING SkQ COMPOUNDS AND USES THEREOF |
| CA3006698A1 (en) * | 2015-11-30 | 2017-06-08 | Peter Schiller | Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome |
| CN109069572A (zh) * | 2015-12-31 | 2018-12-21 | 康德生物医疗技术公司 | 包含肽的治疗性组合物和其用途 |
| WO2017180535A1 (en) * | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
| US12410143B2 (en) | 2017-01-17 | 2025-09-09 | Michael David FORREST | Therapeutic inhibitors of the reverse mode of ATP synthase |
| BR112019028172A2 (pt) | 2017-07-13 | 2020-10-06 | Michael David Forrest | moduladores terapêuticos do modo reverso da atp sintase |
| IL284006B2 (en) * | 2018-12-18 | 2024-12-01 | Stealth Biotherapeutics Corp | Mitochondria-targeting peptides |
| US20230227499A1 (en) * | 2020-06-22 | 2023-07-20 | Stealth Biotherapeutics Inc. | Prodrugs of mitochondria-targeting oligopeptides |
| WO2021262710A1 (en) * | 2020-06-22 | 2021-12-30 | Stealth Biotherapeutics Corp. | Prodrugs of mitochodria-targeting oligopeptides |
| US11636870B2 (en) | 2020-08-20 | 2023-04-25 | Denso International America, Inc. | Smoking cessation systems and methods |
| US11760170B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Olfaction sensor preservation systems and methods |
| US12251991B2 (en) | 2020-08-20 | 2025-03-18 | Denso International America, Inc. | Humidity control for olfaction sensors |
| US11813926B2 (en) | 2020-08-20 | 2023-11-14 | Denso International America, Inc. | Binding agent and olfaction sensor |
| US11881093B2 (en) | 2020-08-20 | 2024-01-23 | Denso International America, Inc. | Systems and methods for identifying smoking in vehicles |
| US12017506B2 (en) | 2020-08-20 | 2024-06-25 | Denso International America, Inc. | Passenger cabin air control systems and methods |
| US11760169B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Particulate control systems and methods for olfaction sensors |
| US12377711B2 (en) | 2020-08-20 | 2025-08-05 | Denso International America, Inc. | Vehicle feature control systems and methods based on smoking |
| US11828210B2 (en) | 2020-08-20 | 2023-11-28 | Denso International America, Inc. | Diagnostic systems and methods of vehicles using olfaction |
| US12269315B2 (en) | 2020-08-20 | 2025-04-08 | Denso International America, Inc. | Systems and methods for measuring and managing odor brought into rental vehicles |
| US11932080B2 (en) | 2020-08-20 | 2024-03-19 | Denso International America, Inc. | Diagnostic and recirculation control systems and methods |
| MX2023007788A (es) | 2021-01-24 | 2023-11-17 | Michael David Forrest | Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos. |
| KR20250157275A (ko) * | 2024-04-25 | 2025-11-04 | (주)카멜바이오사이언스 | 유비퀴틴 리가아제의 리간드 화합물 및 이를 포함하는 protac 분자 |
| WO2025226057A1 (ko) * | 2024-04-25 | 2025-10-30 | (주)카멜바이오사이언스 | 유비퀴틴 리가아제의 리간드 화합물 및 이를 포함하는 protac 분자 |
| CN118883772B (zh) * | 2024-09-26 | 2025-01-24 | 首都医科大学附属北京朝阳医院 | 3-硝基丙酸的检测方法及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| US8038984B2 (en) * | 1998-06-20 | 2011-10-18 | Washington University | Membrane-permeant peptide complexes for treatment of sepsis |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| CN101440124B (zh) * | 2003-02-04 | 2012-07-18 | 科内尔研究基金会 | 用于防止线粒体通透性改变的方法 |
| EP1599216B9 (en) * | 2003-02-04 | 2015-02-11 | Cornell Research Foundation, Inc. | Methods for preventing mitochondrial permeability transition |
| PL2604286T3 (pl) * | 2003-05-01 | 2015-03-31 | Cornell Res Foundation Inc | Sposoby i kompleksy nośnikowe do transportu cząsteczek do komórek |
| WO2005040205A1 (en) * | 2003-10-28 | 2005-05-06 | Protemix Discovery Limited | Peptides with anti-obesity activity and other related uses |
| EP2712620A1 (en) * | 2008-02-07 | 2014-04-02 | Cornell University | Methods for Preventing or Treating Insulin Resistance |
| EP3741381B1 (en) * | 2008-02-26 | 2024-04-24 | Cornell University | A peptide for use for prevention and treatment of acute renal injury |
| ES2964555T3 (es) * | 2009-08-24 | 2024-04-08 | Stealth Biotherapeutics Inc | Péptido para uso en la prevención o tratamiento de la degeneración macular |
| EP3090754A1 (en) * | 2009-12-31 | 2016-11-09 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of vessel occlusion injury |
| EP3266462A1 (en) * | 2009-12-31 | 2018-01-10 | Stealth Peptides International, Inc. | Methods for performing a coronary artery bypass graft procedure |
| CA2787331A1 (en) * | 2010-01-25 | 2011-07-28 | Hazel H. Szeto | Aromatic-cationic peptides and uses of same |
| JP2013521231A (ja) * | 2010-02-26 | 2013-06-10 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション インコーポレイテッド | ミトコンドリア標的化抗酸化剤は機械的人工呼吸誘発性横隔膜機能障害および骨格筋萎縮を防止する |
| EP3375449A1 (en) * | 2010-03-15 | 2018-09-19 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| US20110245182A1 (en) * | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| US20110245183A1 (en) * | 2010-04-06 | 2011-10-06 | Perricone Nicholas V | Topical Uses of Szeto-Schiller Peptides |
| EP3290433A1 (en) * | 2010-05-03 | 2018-03-07 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| EP2590664B1 (en) * | 2010-07-09 | 2019-03-27 | Stealth Peptides International, Inc. | Methods for the prevention or treatment of no-reflow following ischemia/reperfusion injury |
| CN106913860A (zh) * | 2011-09-29 | 2017-07-04 | 梅约医学教育与研究基金会 | 芳族阳离子肽和使用它们的方法 |
| EP2788013A4 (en) * | 2011-12-09 | 2015-08-19 | Stealth Peptides Int Inc | AROMATIC-CATIONIC PEPTIDES AND USES THEREOF |
| CN104271146A (zh) * | 2012-03-30 | 2015-01-07 | 康肽德生物医药技术有限公司 | 用于预防和治疗神经病的方法和组合物 |
| JP2015529655A (ja) * | 2012-08-02 | 2015-10-08 | ステルス ペプチドズ インターナショナル インコーポレイテッド | アテローム性硬化症の処置方法 |
| ES2755134T3 (es) * | 2013-03-01 | 2020-04-21 | Stealth Biotherapeutics Corp | Métodos para el tratamiento de enfermedad mitocondrial |
| US9687519B2 (en) * | 2013-03-01 | 2017-06-27 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| WO2014210062A1 (en) * | 2013-06-26 | 2014-12-31 | Stealth Peptides International, Inc. | Methods for the regulation of matrix metalloproteinase expression |
| CA2916977A1 (en) * | 2013-06-26 | 2014-12-31 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| CA2916486A1 (en) * | 2013-06-26 | 2015-01-22 | Stealth Biotherapeutics Corp | Methods and compositions comprising an aromatic peptide for regulating serca2a expression levels in myocardinal infarction |
| WO2014210056A1 (en) | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| WO2015017861A1 (en) * | 2013-08-02 | 2015-02-05 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment of friedreich's ataxia |
| JP2016540762A (ja) * | 2013-12-02 | 2016-12-28 | ステルス バイオセラピューティックス コープ | 白斑の治療のための組成物及び方法 |
| WO2015183995A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof |
| US10627392B2 (en) * | 2014-06-17 | 2020-04-21 | Stealth Biotherapeutics Corp | Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening |
| CA2958585C (en) * | 2014-08-21 | 2024-01-09 | Stealth Biotherapeutics Corp | Use of peptide d-arg-2',6'-dmt-lys-phe-nh2 for the treatment of alport syndrome |
-
2012
- 2012-12-05 EP EP12855211.4A patent/EP2788013A4/en not_active Withdrawn
- 2012-12-05 EP EP15177562.4A patent/EP3009141A1/en not_active Withdrawn
- 2012-12-05 CN CN201280066416.2A patent/CN104105499A/zh active Pending
- 2012-12-05 EP EP18190582.9A patent/EP3466439A1/en not_active Withdrawn
- 2012-12-05 CA CA2858550A patent/CA2858550A1/en not_active Abandoned
- 2012-12-05 CN CN201710524414.8A patent/CN107312066A/zh active Pending
- 2012-12-05 JP JP2014546031A patent/JP2015507611A/ja active Pending
- 2012-12-05 WO PCT/US2012/067984 patent/WO2013086020A1/en not_active Ceased
- 2012-12-05 CN CN201810783561.1A patent/CN109160936A/zh not_active Withdrawn
- 2012-12-05 AU AU2012347931A patent/AU2012347931A1/en not_active Abandoned
- 2012-12-05 EP EP19202295.2A patent/EP3656394A1/en not_active Withdrawn
- 2012-12-05 US US14/363,035 patent/US20140294796A1/en not_active Abandoned
-
2016
- 2016-10-13 HK HK16111817.0A patent/HK1223550A1/en unknown
-
2017
- 2017-11-02 JP JP2017212657A patent/JP2018035190A/ja not_active Withdrawn
- 2017-12-11 AU AU2017276158A patent/AU2017276158A1/en not_active Abandoned
-
2018
- 2018-01-09 US US15/865,434 patent/US20180362579A1/en not_active Abandoned
-
2019
- 2019-04-26 JP JP2019085146A patent/JP2019137691A/ja active Pending
- 2019-11-15 AU AU2019264653A patent/AU2019264653A1/en not_active Abandoned
-
2020
- 2020-03-13 US US16/818,560 patent/US12065511B2/en active Active
-
2024
- 2024-07-09 US US18/766,897 patent/US20250002530A1/en active Pending
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