JP2015507200A5 - - Google Patents
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- Publication number
- JP2015507200A5 JP2015507200A5 JP2014555836A JP2014555836A JP2015507200A5 JP 2015507200 A5 JP2015507200 A5 JP 2015507200A5 JP 2014555836 A JP2014555836 A JP 2014555836A JP 2014555836 A JP2014555836 A JP 2014555836A JP 2015507200 A5 JP2015507200 A5 JP 2015507200A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- peptide
- cell
- fragment
- galactosidase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261595525P | 2012-02-06 | 2012-02-06 | |
| US61/595,525 | 2012-02-06 | ||
| PCT/US2013/024789 WO2013119579A1 (en) | 2012-02-06 | 2013-02-05 | Detection of intracellular binding events by measuring protein abundance |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015507200A JP2015507200A (ja) | 2015-03-05 |
| JP2015507200A5 true JP2015507200A5 (enExample) | 2015-08-06 |
| JP6141327B2 JP6141327B2 (ja) | 2017-06-07 |
Family
ID=48903215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014555836A Active JP6141327B2 (ja) | 2012-02-06 | 2013-02-05 | タンパク質存在量の測定による細胞内結合事象の検出 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8945853B2 (enExample) |
| EP (2) | EP3367096B1 (enExample) |
| JP (1) | JP6141327B2 (enExample) |
| CA (1) | CA2863774C (enExample) |
| WO (1) | WO2013119579A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3183580B1 (en) * | 2014-08-21 | 2025-03-26 | Eurofins DiscoverX Corporation | Homogenous thermal shift ligand binding assay |
| GB201814451D0 (en) * | 2018-09-05 | 2018-10-17 | Valerie Nicholas Carl Kristoffer | Methods |
| CN113785072A (zh) * | 2019-03-28 | 2021-12-10 | 欧陆迪斯卡沃爱克斯制品有限责任公司 | 启动子区域分析方法和用于实施该方法的细胞 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4378428A (en) | 1981-03-30 | 1983-03-29 | Baker Instruments Corporation | Method for carrying out non-isotopic immunoassays, labeled analytes and kits for use in such assays |
| US4708929A (en) | 1984-10-29 | 1987-11-24 | Microgenics Corporation | Methods for protein binding enzyme complementation assays |
| US5604091A (en) | 1984-03-01 | 1997-02-18 | Microgenics Corporation | Methods for protein binding enzyme complementation |
| JPH0779717B2 (ja) | 1984-10-29 | 1995-08-30 | マイクロジエニツクス コ−ポレ−シヨン | タンパク質結合酵素相補性検定に関する方法 |
| CA1335707C (en) * | 1989-08-15 | 1995-05-30 | Pyare Khanna | Drug screening assay |
| US5444161A (en) | 1989-08-16 | 1995-08-22 | Microgenics Corporation | Substrates for β-galactosidase |
| US5543264A (en) | 1990-06-29 | 1996-08-06 | Associated Universities, Inc. | Co-factor activated recombinant adenovirus proteinases |
| US6828099B2 (en) | 1998-02-02 | 2004-12-07 | Odyssey Thera Inc. | Protein fragment complementation assay (PCA) for the detection of protein-protein, protein-small molecule and protein nucleic acid interactions based on the E. coli TEM-1 β-Lactamase |
| AU6045900A (en) | 1999-05-25 | 2000-12-12 | Panorama Research, Inc. | Interaction-activated proteins |
| US7220552B1 (en) | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
| US7589167B2 (en) | 2000-02-22 | 2009-09-15 | J. David Gladstone Institutes | ZA loops of bromodomains |
| US20040137480A1 (en) | 2001-08-30 | 2004-07-15 | Eglen Richard M. | Monitoring intracellular proteins |
| AU2002332724A1 (en) * | 2001-08-30 | 2003-03-18 | Discoverx, Inc. | Genetic construct intracellular monitoring system |
| CA2478395A1 (en) | 2002-04-08 | 2003-10-23 | Sunesis Pharmaceuticals, Inc. | Methods for identifying allosteric sites |
| JP2007521021A (ja) | 2003-11-06 | 2007-08-02 | ディスカヴァーエックス インコーポレイテッド | 細胞膜タンパク質の検定 |
| EP2400030B1 (en) | 2004-05-18 | 2016-01-20 | The Board of Trustees of the Leland Stanford Junior University | Detection of protein translocation by beta-galactosidase reporter fragment complementation |
| US7842815B2 (en) | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
| JP5303448B2 (ja) | 2006-03-13 | 2013-10-02 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | 親和性が減少した酵素の相補性レポーター系を用いた分子相互作用の検出 |
| ES2321359B1 (es) * | 2006-06-07 | 2010-03-03 | Centro De Investigacion Cooperativa De Biociencias- Cic Biogune | Proteinas de fusion de p53 sin actividad de transcripcion y sus aplicaciones. |
| EP2099925B1 (en) | 2006-12-26 | 2013-02-13 | The Board of Trustees of The Leland Stanford Junior University | Detection of sub-cellular compartment localization of a cell-surface receptor to an endosome using a reduced affinity enzyme complementation reporter system |
| US8101373B2 (en) | 2007-10-12 | 2012-01-24 | Discoverx Corporation | β-galactosidase donor fragments |
| US8530636B2 (en) | 2008-05-07 | 2013-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for regulating protein function in cells in vivo using synthetic small molecules |
| US20100120063A1 (en) | 2008-10-10 | 2010-05-13 | Discoverx Corporation | GPCR Arrestin Assays |
| US8211655B2 (en) | 2009-02-12 | 2012-07-03 | Discoverx Corporation | Wild-type receptor assays |
| US8080796B1 (en) | 2010-06-30 | 2011-12-20 | Ut-Battelle, Llc | Standoff spectroscopy using a conditioned target |
| EP2487183A1 (en) | 2011-01-18 | 2012-08-15 | Helmholtz-Zentrum für Infektionsforschung GmbH | Ubiquitin-isopeptide probes |
| WO2012178079A1 (en) | 2011-06-23 | 2012-12-27 | Discoverx Corporation | Monitoring protein trafficking using beta-galactosidase reporter fragment complementation |
-
2013
- 2013-02-05 WO PCT/US2013/024789 patent/WO2013119579A1/en not_active Ceased
- 2013-02-05 EP EP18156334.7A patent/EP3367096B1/en active Active
- 2013-02-05 US US13/759,691 patent/US8945853B2/en active Active
- 2013-02-05 EP EP13746491.3A patent/EP2812695A4/en not_active Ceased
- 2013-02-05 CA CA2863774A patent/CA2863774C/en active Active
- 2013-02-05 JP JP2014555836A patent/JP6141327B2/ja active Active
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