JP2015507070A - 部分的に解重合したグリコサミノグリカン銀及び金塩 - Google Patents

部分的に解重合したグリコサミノグリカン銀及び金塩 Download PDF

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Publication number
JP2015507070A
JP2015507070A JP2014557055A JP2014557055A JP2015507070A JP 2015507070 A JP2015507070 A JP 2015507070A JP 2014557055 A JP2014557055 A JP 2014557055A JP 2014557055 A JP2014557055 A JP 2014557055A JP 2015507070 A JP2015507070 A JP 2015507070A
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Prior art keywords
glycosaminoglycan
silver
metal salt
molecular weight
gold
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JP2014557055A
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Japanese (ja)
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JP2015507070A5 (https=
Inventor
イー サルガド， フランセスク フロレス
イー サルガド， フランセスク フロレス
ヒメネス， アントニオ フランシスコ ベニテス
ヒメネス， アントニオ フランシスコ ベニテス
イー リエロラ， マルガリータ コスタ
イー リエロラ， マルガリータ コスタ
イー コスタ， ロヘル フロレス
イー コスタ， ロヘル フロレス
イー コスタ， ライア フロレス
イー コスタ， ライア フロレス
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キムフレクサー エセ．エレ．
キムフレクサー エセ．エレ．
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Publication of JP2015507070A publication Critical patent/JP2015507070A/ja
Publication of JP2015507070A5 publication Critical patent/JP2015507070A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014557055A 2012-02-17 2013-02-15 部分的に解重合したグリコサミノグリカン銀及び金塩 Pending JP2015507070A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ESP201230247 2012-02-17
ES201230247 2012-02-17
PCT/EP2013/053087 WO2013121001A1 (en) 2012-02-17 2013-02-15 Partially depolymerized glycosaminoglycan silver and gold salts

Publications (2)

Publication Number Publication Date
JP2015507070A true JP2015507070A (ja) 2015-03-05
JP2015507070A5 JP2015507070A5 (https=) 2016-04-07

Family

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JP2014557055A Pending JP2015507070A (ja) 2012-02-17 2013-02-15 部分的に解重合したグリコサミノグリカン銀及び金塩

Country Status (10)

Country Link
US (1) US20150011501A1 (https=)
EP (1) EP2814848B1 (https=)
JP (1) JP2015507070A (https=)
CN (1) CN104125964B (https=)
BR (1) BR112014019795A8 (https=)
CA (1) CA2861052A1 (https=)
ES (1) ES2648414T3 (https=)
MX (1) MX2014009410A (https=)
RU (1) RU2014137454A (https=)
WO (1) WO2013121001A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023513548A (ja) * 2020-02-10 2023-03-31 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 好酸球介在性炎症疾患を診断、治療およびモニタリングするための高分子量ヘパリン組成物および方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103788222B (zh) * 2014-01-08 2016-08-31 中国科学院昆明植物研究所 Fuc3S4S取代的低聚糖胺聚糖及其制备方法
TWI567097B (zh) * 2015-04-21 2017-01-21 王式禹 一種水溶性抗菌壓克力高分子銀鹽之製備方法
WO2018234407A1 (en) * 2017-06-20 2018-12-27 Sakura Italia S.R.L. Composition containing silver metal nanoparticles and a hyaluronate salt as intermediate in the preparation of topical pharmaceutical formulations
CN113456662B (zh) * 2019-09-30 2022-12-09 中检科医药科技(北京)集团有限公司 低分子量硫酸软骨素在制备日化产品和外用制剂中的用途

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005517A1 (en) * 1986-03-14 1987-09-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid useful as antimicrobial agents
JPS63500184A (ja) * 1985-05-17 1988-01-21 オポクリン・エッセ・ピ・ア・ラボラトリオ・ファルマコバイオロギコ 抗血栓、線維素溶解、抗炎症活性を有する解重合硫酸ヘキソサミノグルカン、それらの製造方法および関連する医薬組成物
JPS63213502A (ja) * 1986-11-24 1988-09-06 ラボラトーリ・デリヴァーティ・オルガニチ・エス．ピー．エイ． 低分子量グルコサミノグルカンの制御製造方法
WO2005090411A1 (en) * 2004-03-24 2005-09-29 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
CN1687141A (zh) * 2005-04-29 2005-10-26 凌沛学 硫酸软骨素银及其治疗烧烫伤的应用
JP2006265287A (ja) * 2005-03-22 2006-10-05 Q P Corp 低分子ヒアルロン酸および／またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
JP2006327955A (ja) * 2005-05-24 2006-12-07 Taisho Pharmaceut Co Ltd 低分子量コンドロイチン硫酸を含む医薬
EP1878754A1 (en) * 2005-04-20 2008-01-16 LING, Peixue Preparation and application of heparin silver
JP2009155486A (ja) * 2007-12-27 2009-07-16 Kikkoman Corp 低分子化ヒアルロン酸とその製造法
JP2009284826A (ja) * 2008-05-29 2009-12-10 Mitsubishi Rayon Co Ltd ヒアルロン酸の製造方法
US20100317617A1 (en) * 2009-06-15 2010-12-16 Vascular Vision Pharmaceutical Co. Silver nanoparticles as anti-microbial
US20110207919A1 (en) * 2010-01-19 2011-08-25 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

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US3405120A (en) * 1966-01-27 1968-10-08 Green Cross Corp Low molecular chondroitin sulfate and method for manufacturing the same
US4746504A (en) * 1986-03-14 1988-05-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
IT1256236B (it) * 1992-12-23 1995-11-29 Mediolanum Farmaceutici Srl Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani
US6017901A (en) * 1995-05-10 2000-01-25 Fidia Advanced Bioplymers S.R.L. Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions
CN100540569C (zh) * 2006-12-15 2009-09-16 由守谊 一种低分子量硫酸软骨素的制备方法

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63500184A (ja) * 1985-05-17 1988-01-21 オポクリン・エッセ・ピ・ア・ラボラトリオ・ファルマコバイオロギコ 抗血栓、線維素溶解、抗炎症活性を有する解重合硫酸ヘキソサミノグルカン、それらの製造方法および関連する医薬組成物
WO1987005517A1 (en) * 1986-03-14 1987-09-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid useful as antimicrobial agents
JPS63213502A (ja) * 1986-11-24 1988-09-06 ラボラトーリ・デリヴァーティ・オルガニチ・エス．ピー．エイ． 低分子量グルコサミノグルカンの制御製造方法
WO2005090411A1 (en) * 2004-03-24 2005-09-29 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
JP2006265287A (ja) * 2005-03-22 2006-10-05 Q P Corp 低分子ヒアルロン酸および／またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
EP1878754A1 (en) * 2005-04-20 2008-01-16 LING, Peixue Preparation and application of heparin silver
CN1687141A (zh) * 2005-04-29 2005-10-26 凌沛学 硫酸软骨素银及其治疗烧烫伤的应用
JP2006327955A (ja) * 2005-05-24 2006-12-07 Taisho Pharmaceut Co Ltd 低分子量コンドロイチン硫酸を含む医薬
JP2009155486A (ja) * 2007-12-27 2009-07-16 Kikkoman Corp 低分子化ヒアルロン酸とその製造法
JP2009284826A (ja) * 2008-05-29 2009-12-10 Mitsubishi Rayon Co Ltd ヒアルロン酸の製造方法
US20100317617A1 (en) * 2009-06-15 2010-12-16 Vascular Vision Pharmaceutical Co. Silver nanoparticles as anti-microbial
US20110207919A1 (en) * 2010-01-19 2011-08-25 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023513548A (ja) * 2020-02-10 2023-03-31 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション 好酸球介在性炎症疾患を診断、治療およびモニタリングするための高分子量ヘパリン組成物および方法

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Publication number Publication date
WO2013121001A1 (en) 2013-08-22
CN104125964B (zh) 2016-11-16
CA2861052A1 (en) 2013-08-22
EP2814848B1 (en) 2017-09-06
US20150011501A1 (en) 2015-01-08
CN104125964A (zh) 2014-10-29
EP2814848A1 (en) 2014-12-24
RU2014137454A (ru) 2016-04-10
BR112014019795A2 (https=) 2017-06-20
BR112014019795A8 (pt) 2017-07-11
MX2014009410A (es) 2015-01-14
ES2648414T3 (es) 2018-01-02

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