JP2015507070A5 - - Google Patents
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- Publication number
- JP2015507070A5 JP2015507070A5 JP2014557055A JP2014557055A JP2015507070A5 JP 2015507070 A5 JP2015507070 A5 JP 2015507070A5 JP 2014557055 A JP2014557055 A JP 2014557055A JP 2014557055 A JP2014557055 A JP 2014557055A JP 2015507070 A5 JP2015507070 A5 JP 2015507070A5
- Authority
- JP
- Japan
- Prior art keywords
- glycosaminoglycan
- metal salt
- metal
- molecular weight
- gold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052751 metal Inorganic materials 0.000 claims 24
- 239000002184 metal Substances 0.000 claims 24
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 20
- 150000003839 salts Chemical class 0.000 claims 17
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 9
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 8
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 8
- 229910052737 gold Inorganic materials 0.000 claims 8
- 239000010931 gold Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 8
- 229910052709 silver Inorganic materials 0.000 claims 8
- 239000004332 silver Substances 0.000 claims 8
- 239000002537 cosmetic Substances 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 3
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 229940059329 chondroitin sulfate Drugs 0.000 claims 3
- 229920002674 hyaluronan Polymers 0.000 claims 3
- 229960003160 hyaluronic acid Drugs 0.000 claims 3
- 239000012286 potassium permanganate Substances 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 208000002874 Acne Vulgaris Diseases 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 208000032544 Cicatrix Diseases 0.000 claims 1
- 229920000045 Dermatan sulfate Polymers 0.000 claims 1
- 229920002971 Heparan sulfate Polymers 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 229920000288 Keratan sulfate Polymers 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 206010000496 acne Diseases 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 238000004061 bleaching Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
- 229940051593 dermatan sulfate Drugs 0.000 claims 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 230000000813 microbial effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 230000037387 scars Effects 0.000 claims 1
- 230000036620 skin dryness Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229940010747 sodium hyaluronate Drugs 0.000 claims 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ESP201230247 | 2012-02-17 | ||
| ES201230247 | 2012-02-17 | ||
| PCT/EP2013/053087 WO2013121001A1 (en) | 2012-02-17 | 2013-02-15 | Partially depolymerized glycosaminoglycan silver and gold salts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015507070A JP2015507070A (ja) | 2015-03-05 |
| JP2015507070A5 true JP2015507070A5 (https=) | 2016-04-07 |
Family
ID=47716061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014557055A Pending JP2015507070A (ja) | 2012-02-17 | 2013-02-15 | 部分的に解重合したグリコサミノグリカン銀及び金塩 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150011501A1 (https=) |
| EP (1) | EP2814848B1 (https=) |
| JP (1) | JP2015507070A (https=) |
| CN (1) | CN104125964B (https=) |
| BR (1) | BR112014019795A8 (https=) |
| CA (1) | CA2861052A1 (https=) |
| ES (1) | ES2648414T3 (https=) |
| MX (1) | MX2014009410A (https=) |
| RU (1) | RU2014137454A (https=) |
| WO (1) | WO2013121001A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103788222B (zh) * | 2014-01-08 | 2016-08-31 | 中国科学院昆明植物研究所 | Fuc3S4S取代的低聚糖胺聚糖及其制备方法 |
| TWI567097B (zh) * | 2015-04-21 | 2017-01-21 | 王式禹 | 一種水溶性抗菌壓克力高分子銀鹽之製備方法 |
| WO2018234407A1 (en) * | 2017-06-20 | 2018-12-27 | Sakura Italia S.R.L. | Composition containing silver metal nanoparticles and a hyaluronate salt as intermediate in the preparation of topical pharmaceutical formulations |
| CN113456662B (zh) * | 2019-09-30 | 2022-12-09 | 中检科医药科技(北京)集团有限公司 | 低分子量硫酸软骨素在制备日化产品和外用制剂中的用途 |
| IL295232A (en) * | 2020-02-10 | 2022-10-01 | Univ Utah Res Found | High molecular weight heparin compositions and methods for diagnosing, treating and monitoring eosinophil mediated inflammatory diseases |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3405120A (en) * | 1966-01-27 | 1968-10-08 | Green Cross Corp | Low molecular chondroitin sulfate and method for manufacturing the same |
| IT1214609B (it) * | 1985-05-17 | 1990-01-18 | Opocrin Spa | Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono. |
| AU600483B2 (en) | 1986-03-14 | 1990-08-16 | Bio-Technology General Corporation | Heavy metal salts of hyaluronic acid |
| US4746504A (en) * | 1986-03-14 | 1988-05-24 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
| IT1213384B (it) * | 1986-11-24 | 1989-12-20 | Lab Derivati Organici Mediolan | Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare. |
| IT1256236B (it) * | 1992-12-23 | 1995-11-29 | Mediolanum Farmaceutici Srl | Oligosaccaridi aventi attivita' biologica e procedimento per la loro preparazione di glicosaminoglicani |
| US6017901A (en) * | 1995-05-10 | 2000-01-25 | Fidia Advanced Bioplymers S.R.L. | Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions |
| EP1582531A1 (en) * | 2004-03-24 | 2005-10-05 | Aventis Pharma S.A. | Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products |
| JP4576583B2 (ja) * | 2005-03-22 | 2010-11-10 | キユーピー株式会社 | ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物 |
| CN1269846C (zh) | 2005-04-20 | 2006-08-16 | 凌沛学 | 肝素银的制备及其应用 |
| CN1269845C (zh) | 2005-04-29 | 2006-08-16 | 凌沛学 | 硫酸软骨素银及其治疗烧烫伤的应用 |
| JP2006327955A (ja) * | 2005-05-24 | 2006-12-07 | Taisho Pharmaceut Co Ltd | 低分子量コンドロイチン硫酸を含む医薬 |
| CN100540569C (zh) * | 2006-12-15 | 2009-09-16 | 由守谊 | 一种低分子量硫酸软骨素的制备方法 |
| JP2009155486A (ja) * | 2007-12-27 | 2009-07-16 | Kikkoman Corp | 低分子化ヒアルロン酸とその製造法 |
| JP2009284826A (ja) * | 2008-05-29 | 2009-12-10 | Mitsubishi Rayon Co Ltd | ヒアルロン酸の製造方法 |
| US8314078B2 (en) * | 2009-06-15 | 2012-11-20 | Vascular Vision Pharmaceutical Co. | Silver nanoparticles as anti-microbial |
| US8435795B2 (en) * | 2010-01-19 | 2013-05-07 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
-
2013
- 2013-02-15 ES ES13704450.9T patent/ES2648414T3/es active Active
- 2013-02-15 EP EP13704450.9A patent/EP2814848B1/en not_active Not-in-force
- 2013-02-15 CA CA2861052A patent/CA2861052A1/en not_active Abandoned
- 2013-02-15 RU RU2014137454A patent/RU2014137454A/ru not_active Application Discontinuation
- 2013-02-15 BR BR112014019795A patent/BR112014019795A8/pt not_active Application Discontinuation
- 2013-02-15 US US14/375,306 patent/US20150011501A1/en not_active Abandoned
- 2013-02-15 CN CN201380009874.7A patent/CN104125964B/zh not_active Expired - Fee Related
- 2013-02-15 JP JP2014557055A patent/JP2015507070A/ja active Pending
- 2013-02-15 WO PCT/EP2013/053087 patent/WO2013121001A1/en not_active Ceased
- 2013-02-15 MX MX2014009410A patent/MX2014009410A/es unknown
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