JP2015503552A - チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体 - Google Patents

チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体 Download PDF

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JP2015503552A
JP2015503552A JP2014550009A JP2014550009A JP2015503552A JP 2015503552 A JP2015503552 A JP 2015503552A JP 2014550009 A JP2014550009 A JP 2014550009A JP 2014550009 A JP2014550009 A JP 2014550009A JP 2015503552 A JP2015503552 A JP 2015503552A
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phenyl
disease
pyridin
imidazo
chloro
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JP2015503552A5 (cg-RX-API-DMAC7.html
Inventor
イ・キョンイク
シム・ジェイ
キム・ホソク
ハ・テヒ
ス・クィヒョン
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ハンミ ファーム． シーオー．， エルティーディー．
ハンミ ファーム． シーオー．， エルティーディー．
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Publication of JP2015503552A publication Critical patent/JP2015503552A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Bioinformatics & Cheminformatics (AREA)
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  • Epidemiology (AREA)
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  • Diabetes (AREA)
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  • Dermatology (AREA)
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  • Otolaryngology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
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  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
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  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
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JP2014550009A 2011-12-28 2012-12-27 チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体 Ceased JP2015503552A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2011-0144450 2011-12-28
KR1020110144450A KR20130076046A (ko) 2011-12-28 2011-12-28 타이로신 카이네이즈 억제 활성을 갖는 신규 이미다조피리딘 유도체
PCT/KR2012/011570 WO2013100631A1 (en) 2011-12-28 2012-12-27 Novel imidazopyridine derivatives as a tyrosine kinase inhibitor

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JP2015503552A true JP2015503552A (ja) 2015-02-02
JP2015503552A5 JP2015503552A5 (cg-RX-API-DMAC7.html) 2016-02-12

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JP2014550009A Ceased JP2015503552A (ja) 2011-12-28 2012-12-27 チロシンキナーゼ阻害剤としての新規イミダゾピリジン誘導体

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US (1) US20150299185A1 (cg-RX-API-DMAC7.html)
EP (1) EP2797909A4 (cg-RX-API-DMAC7.html)
JP (1) JP2015503552A (cg-RX-API-DMAC7.html)
KR (1) KR20130076046A (cg-RX-API-DMAC7.html)
CN (1) CN104024243A (cg-RX-API-DMAC7.html)
AU (1) AU2012363557A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014016146A8 (cg-RX-API-DMAC7.html)
CA (1) CA2859664A1 (cg-RX-API-DMAC7.html)
HK (1) HK1200811A1 (cg-RX-API-DMAC7.html)
IL (1) IL233415A0 (cg-RX-API-DMAC7.html)
MX (1) MX2014007976A (cg-RX-API-DMAC7.html)
RU (1) RU2014131068A (cg-RX-API-DMAC7.html)
WO (1) WO2013100631A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201405505B (cg-RX-API-DMAC7.html)

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CN105837572B (zh) * 2015-02-02 2019-04-19 四川大学 N-取代苯基酰胺衍生物及其制备方法和用途
CN109563092B (zh) * 2016-07-11 2021-09-14 坎塞拉有限公司 可用作哺乳动物酪氨酸激酶ror1活性的抑制剂的2-苯基咪唑并[4,5-b]吡啶-7-胺衍生物
CN110545826A (zh) 2016-12-03 2019-12-06 朱诺治疗学股份有限公司 用于与激酶抑制剂组合使用治疗性t细胞的方法和组合物
JP7592029B2 (ja) * 2019-05-28 2024-11-29 マンカインド ファーマ リミテッド ヤヌスキナーゼ１の阻害のための新規化合物
US20240100172A1 (en) 2020-12-21 2024-03-28 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2022199561A1 (zh) * 2021-03-23 2022-09-29 杭州阿诺生物医药科技有限公司 Hpk1激酶抑制剂化合物

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JP2009523845A (ja) * 2006-01-23 2009-06-25 クリスタルゲノミクス インコーポレーテッド たんぱく質キナーゼの活性を阻害するイミダゾピリジン誘導体、これの製造方法およびこれを含む薬学組成物
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BRPI0707245A2 (pt) * 2006-01-23 2011-04-26 Crystalgenomics Inc derivados de imidazopiridina que inibem a atividade de proteìna quinase, método para a preparação destes e composição farmacêutica contendo os mesmos
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Publication number Priority date Publication date Assignee Title
JP2001518470A (ja) * 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド 新規な血管形成阻害剤
JP2009523845A (ja) * 2006-01-23 2009-06-25 クリスタルゲノミクス インコーポレーテッド たんぱく質キナーゼの活性を阻害するイミダゾピリジン誘導体、これの製造方法およびこれを含む薬学組成物
WO2010129053A2 (en) * 2009-05-05 2010-11-11 Dana Farber Cancer Institute Egfr inhibitors and methods of treating disorders
JP2013529630A (ja) * 2010-06-23 2013-07-22 ハンミ・サイエンス・カンパニー・リミテッド チロシンキナーゼ活性阻害作用を有する新規な縮合ピリミジン誘導体
CN102827186A (zh) * 2011-06-16 2012-12-19 中国科学院上海药物研究所 一类吡啶并五元杂环衍生物及其制备方法和用途

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AU2012363557A1 (en) 2014-07-17
BR112014016146A2 (pt) 2017-06-13
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EP2797909A4 (en) 2015-06-10
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CN104024243A (zh) 2014-09-03
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