JP2015503329A5 - - Google Patents
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- JP2015503329A5 JP2015503329A5 JP2014548973A JP2014548973A JP2015503329A5 JP 2015503329 A5 JP2015503329 A5 JP 2015503329A5 JP 2014548973 A JP2014548973 A JP 2014548973A JP 2014548973 A JP2014548973 A JP 2014548973A JP 2015503329 A5 JP2015503329 A5 JP 2015503329A5
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- JP
- Japan
- Prior art keywords
- feed
- cell culture
- medium
- supplement composition
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 22
- 239000013589 supplement Substances 0.000 claims 19
- 239000002609 medium Substances 0.000 claims 15
- 239000006143 cell culture medium Substances 0.000 claims 11
- 238000004113 cell culture Methods 0.000 claims 6
- 239000012592 cell culture supplement Substances 0.000 claims 6
- 239000006052 feed supplement Substances 0.000 claims 6
- -1 dextran sulfate Polymers 0.000 claims 5
- 239000011324 bead Substances 0.000 claims 4
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 230000005251 gamma ray Effects 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 239000003094 microcapsule Substances 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920002732 Polyanhydride Polymers 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 229920001710 Polyorthoester Polymers 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004793 Polystyrene Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 229940059329 chondroitin sulfate Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 229960002086 dextran Drugs 0.000 claims 1
- 229960000633 dextran sulfate Drugs 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000008393 encapsulating agent Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229940014259 gelatin Drugs 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 238000005469 granulation Methods 0.000 claims 1
- 230000003179 granulation Effects 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910021645 metal ion Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229920001432 poly(L-lactide) Polymers 0.000 claims 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000004633 polyglycolic acid Substances 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 239000004926 polymethyl methacrylate Substances 0.000 claims 1
- 229920002714 polyornithine Polymers 0.000 claims 1
- 108010055896 polyornithine Proteins 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229920002223 polystyrene Polymers 0.000 claims 1
- 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 235000013619 trace mineral Nutrition 0.000 claims 1
- 239000011573 trace mineral Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161579432P | 2011-12-22 | 2011-12-22 | |
| US61/579,432 | 2011-12-22 | ||
| PCT/US2012/071411 WO2013096858A1 (en) | 2011-12-22 | 2012-12-21 | Cell culture media and methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017181983A Division JP6457041B2 (ja) | 2011-12-22 | 2017-09-22 | 細胞培地および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015503329A JP2015503329A (ja) | 2015-02-02 |
| JP2015503329A5 true JP2015503329A5 (https=) | 2016-01-28 |
| JP6216327B2 JP6216327B2 (ja) | 2017-10-18 |
Family
ID=47557531
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548973A Active JP6216327B2 (ja) | 2011-12-22 | 2012-12-21 | 細胞培地および方法 |
| JP2017181983A Active JP6457041B2 (ja) | 2011-12-22 | 2017-09-22 | 細胞培地および方法 |
| JP2018236870A Active JP6843824B2 (ja) | 2011-12-22 | 2018-12-19 | 細胞培地および方法 |
| JP2021026972A Active JP7217765B2 (ja) | 2011-12-22 | 2021-02-24 | 細胞培地および方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017181983A Active JP6457041B2 (ja) | 2011-12-22 | 2017-09-22 | 細胞培地および方法 |
| JP2018236870A Active JP6843824B2 (ja) | 2011-12-22 | 2018-12-19 | 細胞培地および方法 |
| JP2021026972A Active JP7217765B2 (ja) | 2011-12-22 | 2021-02-24 | 細胞培地および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US9410118B2 (https=) |
| EP (2) | EP3702442B1 (https=) |
| JP (4) | JP6216327B2 (https=) |
| KR (1) | KR102039494B1 (https=) |
| CN (2) | CN104080905B (https=) |
| WO (1) | WO2013096858A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102007997B1 (ko) * | 2011-02-07 | 2019-08-07 | 라이프 테크놀로지스 코포레이션 | 감수성 화합물을 안정화시키는 조성물 및 방법 |
| CN104080905B (zh) * | 2011-12-22 | 2016-11-16 | 生命技术公司 | 细胞培养基和方法 |
| CA2917745A1 (en) * | 2013-07-11 | 2015-01-15 | Merck Patent Gmbh | A dry cell culture medium comprising a polymer-embedded component |
| CN112662611B (zh) * | 2014-01-23 | 2024-10-29 | 日产化学工业株式会社 | 培养基组合物 |
| US20150275167A1 (en) * | 2014-03-28 | 2015-10-01 | Corning Incorporated | Composition and method for cell culture sustained release |
| RU2016144057A (ru) * | 2014-04-10 | 2018-05-15 | Байер Хелскеа Ллк | Смешанный состав порошка среды и способ получения жидкой среды для культуры клеток |
| US10900021B2 (en) * | 2015-06-08 | 2021-01-26 | Corning Incorporated | Drying formulation for hydrogel microcarriers |
| EP3377645B1 (en) * | 2015-11-20 | 2023-10-04 | Qiagen GmbH | Method of preparing sterilized compositions for stabilization of extracellular nucleic acids |
| KR20180091923A (ko) * | 2015-12-17 | 2018-08-16 | 라이프 테크놀로지스 코포레이션 | 세포 배양에 이용되는 펠릿 및 이의 제조 방법 |
| RU2762292C2 (ru) * | 2015-12-30 | 2021-12-17 | Лайф Текнолоджиз Корпорейшн | Слоистые частицы клеточной культуры и способы их получения |
| CN106222236A (zh) * | 2016-07-27 | 2016-12-14 | 郑州点石生物技术有限公司 | 血液中微生物检测试剂及其制备方法 |
| CN109395095B (zh) * | 2017-09-18 | 2021-09-24 | 武汉原生原代生物医药科技有限公司 | 体内用生物膜及其制备方法和用途 |
| CN112469814A (zh) * | 2018-07-27 | 2021-03-09 | 味之素株式会社 | 动物细胞的悬浮培养用添加物、悬浮培养用培养基和悬浮培养方法 |
| EP4182438A1 (en) * | 2020-07-14 | 2023-05-24 | Corning Incorporated | Rapidly dissolving cell culture media powder and methods of making the same |
| CN111849879A (zh) * | 2020-08-07 | 2020-10-30 | 张娇 | 一种细胞培养基及细胞培养方法 |
| CN112553116A (zh) * | 2020-12-23 | 2021-03-26 | 邢箫 | 一种益生菌培养基及益生菌制剂 |
| AU2023374004A1 (en) * | 2022-10-31 | 2025-05-01 | Samsung Bioepis Co., Ltd. | Method for preparing high-concentration liquid medium |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0299205B1 (en) * | 1987-06-19 | 1992-04-15 | Temple University - Of The Commonwealth System Higher Education | Sustained release microcapsules and method for the production thereof |
| JPS6413986A (en) * | 1987-07-08 | 1989-01-18 | Mitsuiwa Eng Kk | Microcapsule for cultivating cell and production thereof |
| EP0626170A3 (en) * | 1993-05-10 | 1996-03-27 | Sandoz Ltd | Stabilization of pharmacologically active compounds in delayed release agents. |
| US6281015B1 (en) * | 1994-12-16 | 2001-08-28 | Children's Medical Center Corp. | Localized delivery of factors enhancing survival of transplanted cells |
| EP1482031B1 (en) * | 1996-08-30 | 2015-10-28 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
| US6383810B2 (en) | 1997-02-14 | 2002-05-07 | Invitrogen Corporation | Dry powder cells and cell culture reagents and methods of production thereof |
| ES2169980B1 (es) * | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
| JP2002114667A (ja) * | 2000-10-11 | 2002-04-16 | Ltt Institute Co Ltd | 徐放性製剤用組成物、その製造法および徐放性マイクロカプセル製剤 |
| JP2004521615A (ja) * | 2000-11-06 | 2004-07-22 | インヴィトロジェン コーポレーション | 乾燥粉末細胞および細胞培養試薬およびその生産の方法 |
| DE60100389T2 (de) * | 2001-07-11 | 2004-05-19 | Apr Applied Pharma Research S.A. | Fettlösliche Substanzen enthaltende Granulate und Verfahren zu ihrer Herstellung |
| EP2253699A1 (en) * | 2001-11-30 | 2010-11-24 | Life Technologies Corporation | Dry powder cell culture products containing lipid and methods of production thereof |
| US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
| WO2004060447A2 (en) | 2002-12-31 | 2004-07-22 | Ultra-Sonic Technologies, L.L.C. | Transdermal delivery using encapsulated agent activated by ultrasound and/or heat |
| US7482152B2 (en) | 2004-01-08 | 2009-01-27 | Melur Ramasubramanian | Methods and devices for microencapsulation of cells |
| US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
| RU2008136886A (ru) * | 2006-02-15 | 2010-03-20 | Ботанокап Лтд. (Il) | Применение микроинкапсулированных эфирных масел |
| JP5784619B2 (ja) * | 2009-10-21 | 2015-09-24 | ドウ ファーマシューティカル サイエンシーズ、インク． | 過酸化ベンゾイルを含む粉末を湿潤させるための方法 |
| US20110262965A1 (en) | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
| WO2011136274A1 (ja) * | 2010-04-28 | 2011-11-03 | 株式会社フジクラ | 光ファイバケーブル |
| CN102971296B (zh) * | 2010-04-30 | 2015-11-25 | 百时美施贵宝公司 | 包含n-(4-(2-氨基-3-氯吡啶-4-基氧基)-3-氟苯基)-4-乙氧基-1-(4-氟苯基)-2-氧代-1，2-二氢吡啶-3-羧酰胺的药物组合物 |
| KR102007997B1 (ko) * | 2011-02-07 | 2019-08-07 | 라이프 테크놀로지스 코포레이션 | 감수성 화합물을 안정화시키는 조성물 및 방법 |
| CN104080905B (zh) * | 2011-12-22 | 2016-11-16 | 生命技术公司 | 细胞培养基和方法 |
-
2012
- 2012-12-21 CN CN201280068225.XA patent/CN104080905B/zh active Active
- 2012-12-21 WO PCT/US2012/071411 patent/WO2013096858A1/en not_active Ceased
- 2012-12-21 EP EP20170574.6A patent/EP3702442B1/en active Active
- 2012-12-21 EP EP12814100.9A patent/EP2794853B1/en active Active
- 2012-12-21 US US14/367,413 patent/US9410118B2/en active Active
- 2012-12-21 JP JP2014548973A patent/JP6216327B2/ja active Active
- 2012-12-21 CN CN201611042079.XA patent/CN106635949B/zh active Active
- 2012-12-21 KR KR1020147019999A patent/KR102039494B1/ko active Active
-
2016
- 2016-06-30 US US15/198,237 patent/US10066200B2/en active Active
-
2017
- 2017-09-22 JP JP2017181983A patent/JP6457041B2/ja active Active
-
2018
- 2018-08-03 US US16/054,601 patent/US20180346872A1/en not_active Abandoned
- 2018-12-19 JP JP2018236870A patent/JP6843824B2/ja active Active
-
2020
- 2020-07-01 US US16/918,838 patent/US12203095B2/en active Active
-
2021
- 2021-02-24 JP JP2021026972A patent/JP7217765B2/ja active Active
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