JP2015502973A5 - - Google Patents
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- Publication number
- JP2015502973A5 JP2015502973A5 JP2014548200A JP2014548200A JP2015502973A5 JP 2015502973 A5 JP2015502973 A5 JP 2015502973A5 JP 2014548200 A JP2014548200 A JP 2014548200A JP 2014548200 A JP2014548200 A JP 2014548200A JP 2015502973 A5 JP2015502973 A5 JP 2015502973A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- pharmaceutical composition
- multiple sclerosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 23
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 8
- 206010025135 lupus erythematosus Diseases 0.000 claims description 6
- 201000006417 multiple sclerosis Diseases 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 101150042851 rapK gene Proteins 0.000 claims description 4
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 4
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 4
- 229960002930 sirolimus Drugs 0.000 claims description 4
- 239000007858 starting material Substances 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 229930001119 polyketide Natural products 0.000 claims description 2
- 150000003881 polyketide derivatives Chemical class 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1122305.4A GB201122305D0 (en) | 2011-12-23 | 2011-12-23 | Novel compound |
| GB1122305.4 | 2011-12-23 | ||
| PCT/GB2012/053228 WO2013093493A1 (en) | 2011-12-23 | 2012-12-21 | Novel rapamycin analogue |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502973A JP2015502973A (ja) | 2015-01-29 |
| JP2015502973A5 true JP2015502973A5 (https=) | 2016-02-12 |
| JP6268341B2 JP6268341B2 (ja) | 2018-01-31 |
Family
ID=45573035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548200A Expired - Fee Related JP6268341B2 (ja) | 2011-12-23 | 2012-12-21 | 新規なラパマイシン類似体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9382266B2 (https=) |
| EP (1) | EP2797929B1 (https=) |
| JP (1) | JP6268341B2 (https=) |
| DK (1) | DK2797929T3 (https=) |
| ES (1) | ES2664246T3 (https=) |
| GB (1) | GB201122305D0 (https=) |
| NO (1) | NO2797929T3 (https=) |
| PL (1) | PL2797929T3 (https=) |
| WO (1) | WO2013093493A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
| JP2020507632A (ja) * | 2017-02-10 | 2020-03-12 | マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. | ラパマイシン類似体 |
| US20210369684A1 (en) * | 2018-02-09 | 2021-12-02 | Torcept Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of neurodegnerative conditions |
| US20210024542A1 (en) * | 2018-02-09 | 2021-01-28 | Torcept Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of cancer |
| WO2019157374A1 (en) * | 2018-02-09 | 2019-08-15 | Mount Tam Therapeutics, Inc. | Rapamycin analog for prevention and/or treatment of neurodegenerative conditions |
| EP4118431A1 (de) | 2020-03-12 | 2023-01-18 | Heinrich-Heine-Universität Düsseldorf | Inhibition von fkbp1a zur therapie des triple-negativen mammakarzinoms |
| DE102020203224A1 (de) | 2020-03-12 | 2021-09-16 | Heinrich-Heine-Universität Düsseldorf | Inhibition von FKBP1A zur Therapie des Triple-negativen Mammakarzinoms |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5023262A (en) | 1990-08-14 | 1991-06-11 | American Home Products Corporation | Hydrogenated rapamycin derivatives |
| US5221670A (en) | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
| US5138051A (en) | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
| WO1992021341A1 (en) | 1991-05-31 | 1992-12-10 | Pfizer Inc. | Use of rapamycin prodrugs as immunosuppressant agents |
| ZA935112B (en) | 1992-07-17 | 1994-02-08 | Smithkline Beecham Corp | Rapamycin derivatives |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
| US5349060A (en) * | 1993-01-07 | 1994-09-20 | American Home Products Corporation | Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents |
| GB9302016D0 (en) | 1993-02-02 | 1993-03-17 | Sandoz Ltd | Compounds |
| GB9318144D0 (en) | 1993-09-01 | 1993-10-20 | Sandoz Ltd | Organic compounds |
| US5391730A (en) | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
| US5373014A (en) | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
| US5378836A (en) | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
| US5912253A (en) | 1993-12-17 | 1999-06-15 | Novartis Ag | Rapamycin derivatives |
| US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US5563145A (en) | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
| EP0833828B1 (en) | 1995-06-09 | 2002-11-20 | Novartis AG | Rapamycin derivatives |
| US5780462A (en) | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
| EP1208847B8 (en) | 1996-07-30 | 2007-02-14 | Novartis AG | Pharmaceutical compositions for the treatment of transplant rejection, as well as autoimmune or inflammatory conditions |
| US6015815A (en) | 1997-09-26 | 2000-01-18 | Abbott Laboratories | Tetrazole-containing rapamycin analogs with shortened half-lives |
| US6776796B2 (en) | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
| CA2492153C (en) * | 2002-07-16 | 2012-05-08 | Biotica Technology Limited | Production of polyketide fkbp-ligand analogues |
| GB0417852D0 (en) * | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| CN101836980A (zh) * | 2005-03-11 | 2010-09-22 | 比奥蒂卡科技有限公司 | 39-去甲氧基雷帕霉素及其类似物的医药用途 |
| GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
| GB0504995D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Use of a compound |
| WO2010004304A1 (en) * | 2008-06-17 | 2010-01-14 | Biotica Technology Limited | Novel compounds and methods for their production |
| GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
-
2011
- 2011-12-23 GB GBGB1122305.4A patent/GB201122305D0/en not_active Ceased
-
2012
- 2012-12-21 DK DK12806101.7T patent/DK2797929T3/en active
- 2012-12-21 EP EP12806101.7A patent/EP2797929B1/en active Active
- 2012-12-21 NO NO12806101A patent/NO2797929T3/no unknown
- 2012-12-21 WO PCT/GB2012/053228 patent/WO2013093493A1/en not_active Ceased
- 2012-12-21 US US14/367,181 patent/US9382266B2/en active Active
- 2012-12-21 PL PL12806101T patent/PL2797929T3/pl unknown
- 2012-12-21 ES ES12806101.7T patent/ES2664246T3/es active Active
- 2012-12-21 JP JP2014548200A patent/JP6268341B2/ja not_active Expired - Fee Related