JP2015502958A5 - - Google Patents
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- JP2015502958A5 JP2015502958A5 JP2014546103A JP2014546103A JP2015502958A5 JP 2015502958 A5 JP2015502958 A5 JP 2015502958A5 JP 2014546103 A JP2014546103 A JP 2014546103A JP 2014546103 A JP2014546103 A JP 2014546103A JP 2015502958 A5 JP2015502958 A5 JP 2015502958A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- effective amount
- therapeutically effective
- pathway inhibitor
- administering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108091007472 MAP kinase family Proteins 0.000 claims 3
- 102000004331 Mitogen-Activated Protein Kinases Human genes 0.000 claims 3
- 108090000823 Mitogen-Activated Protein Kinases Proteins 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 229940121396 Wnt pathway inhibitors Drugs 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161568844P | 2011-12-09 | 2011-12-09 | |
US61/568,844 | 2011-12-09 | ||
US201261698030P | 2012-09-07 | 2012-09-07 | |
US61/698,030 | 2012-09-07 | ||
PCT/US2012/068351 WO2013086260A2 (fr) | 2011-12-09 | 2012-12-07 | Thérapie d'association pour le traitement du cancer |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015502958A JP2015502958A (ja) | 2015-01-29 |
JP2015502958A5 true JP2015502958A5 (fr) | 2016-02-04 |
Family
ID=48575059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014546103A Pending JP2015502958A (ja) | 2011-12-09 | 2012-12-07 | がんの処置のための併用療法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20150132301A1 (fr) |
EP (1) | EP2788378A4 (fr) |
JP (1) | JP2015502958A (fr) |
WO (1) | WO2013086260A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3281640A1 (fr) | 2011-06-17 | 2018-02-14 | President and Fellows of Harvard College | Frizzled 2 en tant que cible pour des anticorps thérapeutiques dans le traitement du cancer |
JP2016510411A (ja) | 2013-02-04 | 2016-04-07 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Wnt経路インヒビターによる処置の方法およびモニタリング |
WO2015009851A1 (fr) * | 2013-07-16 | 2015-01-22 | Icahn School Of Medicine At Mount Sinai | Procédés permettant de traiter le cancer chez des sujets atteints d'un dysfonctionnement métabolique |
WO2015013579A1 (fr) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions permettant d'améliorer l'avantage thérapeutique du bisantrène |
EP3077546A4 (fr) * | 2013-12-02 | 2017-04-26 | Oncomed Pharmaceuticals, Inc. | Identification de biomarqueurs predictifs associes a des inhibiteurs de la voie wnt |
WO2015145388A2 (fr) * | 2014-03-27 | 2015-10-01 | Novartis Ag | Procédés de traitement de cancers colorectaux avec mutations en amont de la voie wnt |
EP2975047A1 (fr) * | 2014-07-18 | 2016-01-20 | Université de Lausanne | Polypeptides Wnt7a et leur utilisation |
US20180244783A1 (en) * | 2015-08-31 | 2018-08-30 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
EP3596463A4 (fr) * | 2017-03-16 | 2021-03-03 | The Board of Trustees of the Leland Stanford Junior University | Méthodes diagnostiques et thérapeutiques pour des cancers kras-positifs |
CN107441045B (zh) * | 2017-07-21 | 2018-10-19 | 广州源生医药科技有限公司 | 用于递送Wnt信号通路抑制剂的脂质体制剂及其制备方法 |
CN117677398A (zh) * | 2021-07-27 | 2024-03-08 | 东丽株式会社 | 用于癌的治疗和/或预防的药品 |
US20230383360A1 (en) * | 2021-12-16 | 2023-11-30 | D2G Oncology, Inc. | Biomarkers for predicting responsiveness to mek inhibitor monotherapy and combination therapy |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL142481A0 (en) * | 2001-04-05 | 2002-03-10 | Yissum Res Dev Co | A method for identifying consitutively active mutants of mitogen activated protein kinases (mapk) and uses thereof |
JP5133071B2 (ja) * | 2006-02-09 | 2013-01-30 | 第一三共株式会社 | 抗癌医薬組成物 |
KR20090071603A (ko) * | 2006-09-19 | 2009-07-01 | 노파르티스 아게 | Raf 억제제에 대한 표적 조절, 효능, 진단 및/또는 예후의 바이오마커 |
JP5363350B2 (ja) * | 2007-03-19 | 2013-12-11 | 武田薬品工業株式会社 | Mapk/erkキナーゼ阻害剤 |
US20090082328A1 (en) * | 2007-05-11 | 2009-03-26 | Bayer Schering Pharma Aktiengesellschaft | Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity |
EP2164850B1 (fr) * | 2007-06-12 | 2016-01-13 | Genentech, Inc. | Azaindoles n-substitués et procédés d'utilisation |
CN101801966A (zh) * | 2007-07-18 | 2010-08-11 | 诺瓦提斯公司 | 双环杂芳基化合物和它们作为激酶抑制剂的用途 |
CA2924436A1 (fr) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Combinaisons pharmaceutiques de n-3(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide comme inhibiteurs de mek et methodes d'utilisation |
CN103479604B (zh) * | 2007-07-30 | 2016-08-10 | 阿迪生物科学公司 | 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 |
US20100267626A1 (en) * | 2007-11-05 | 2010-10-21 | Novartis Ag | Methods and compositions for measuring wnt activation and for treating wnt-related cancers |
WO2009064675A1 (fr) * | 2007-11-12 | 2009-05-22 | Takeda Pharmaceutical Company Limited | Inhibiteurs de la mapk/erk kinase |
WO2010037041A2 (fr) * | 2008-09-26 | 2010-04-01 | Oncomed Pharmaceuticals, Inc. | Agents se liant aux récepteurs frizzled et leurs utilisations |
CN103948600A (zh) * | 2009-03-11 | 2014-07-30 | 阿迪生物科学公司 | 用于治疗特定癌症的包含rdea119/bay869766的药物组合 |
US8466155B2 (en) * | 2009-10-02 | 2013-06-18 | Boehringer Ingelheim International Gmbh | Pyrimidines |
TWI535445B (zh) * | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
UY33227A (es) * | 2010-02-19 | 2011-09-30 | Novartis Ag | Compuestos de pirrolopirimidina como inhibidores de la cdk4/6 |
ES2714875T3 (es) * | 2010-03-09 | 2019-05-30 | Dana Farber Cancer Inst Inc | Métodos de diagnóstico y tratamiento del cáncer en pacientes que presentan o desarrollan resistencia a una primera terapia del cáncer |
CA2794674A1 (fr) * | 2010-04-01 | 2011-10-06 | Oncomed Pharmaceuticals, Inc. | Agents de liaison aux recepteurs frizzled et leurs utilisations |
US20120231965A1 (en) * | 2011-02-03 | 2012-09-13 | Prometheus Laboratories Inc. | Drug selection for colorectal cancer therapy using antibody-based arrays |
MA34948B1 (fr) * | 2011-02-07 | 2014-03-01 | Plexxikon Inc | Composes et procedes de modulation de kinase, et leurs indications |
-
2012
- 2012-12-07 EP EP12854925.0A patent/EP2788378A4/fr not_active Withdrawn
- 2012-12-07 JP JP2014546103A patent/JP2015502958A/ja active Pending
- 2012-12-07 WO PCT/US2012/068351 patent/WO2013086260A2/fr active Application Filing
- 2012-12-07 US US14/362,991 patent/US20150132301A1/en not_active Abandoned
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