EP3077546A4 - Identification de biomarqueurs predictifs associes a des inhibiteurs de la voie wnt - Google Patents
Identification de biomarqueurs predictifs associes a des inhibiteurs de la voie wnt Download PDFInfo
- Publication number
- EP3077546A4 EP3077546A4 EP14867583.8A EP14867583A EP3077546A4 EP 3077546 A4 EP3077546 A4 EP 3077546A4 EP 14867583 A EP14867583 A EP 14867583A EP 3077546 A4 EP3077546 A4 EP 3077546A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- identification
- wnt pathway
- pathway inhibitors
- biomarkers associated
- predictive biomarkers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361910663P | 2013-12-02 | 2013-12-02 | |
US201461975339P | 2014-04-04 | 2014-04-04 | |
PCT/US2014/068097 WO2015084808A1 (fr) | 2013-12-02 | 2014-12-02 | Identification de biomarqueurs predictifs associes a des inhibiteurs de la voie wnt |
Publications (2)
Publication Number | Publication Date |
---|---|
EP3077546A1 EP3077546A1 (fr) | 2016-10-12 |
EP3077546A4 true EP3077546A4 (fr) | 2017-04-26 |
Family
ID=53274023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP14867583.8A Withdrawn EP3077546A4 (fr) | 2013-12-02 | 2014-12-02 | Identification de biomarqueurs predictifs associes a des inhibiteurs de la voie wnt |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP3077546A4 (fr) |
JP (1) | JP2017501137A (fr) |
CN (1) | CN105829547A (fr) |
AU (1) | AU2014357354A1 (fr) |
CA (1) | CA2931975A1 (fr) |
HK (1) | HK1223657A1 (fr) |
MX (1) | MX2016007066A (fr) |
TW (1) | TW201610168A (fr) |
WO (1) | WO2015084808A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
US9359444B2 (en) | 2013-02-04 | 2016-06-07 | Oncomed Pharmaceuticals Inc. | Methods and monitoring of treatment with a Wnt pathway inhibitor |
WO2017023971A1 (fr) * | 2015-08-03 | 2017-02-09 | Oncomed Pharmaceuticals, Inc. | Identification de biomarqueurs prédictifs associés à des inhibiteurs de la voie wnt |
MX2018003179A (es) * | 2015-09-16 | 2018-08-21 | Tobira Therapeutics Inc | Terapia de combinación con cenicriviroc para el tratamiento de fibrosis. |
MX2019004940A (es) * | 2016-10-26 | 2019-09-26 | Leap Therapeutics Inc | Uso de beta-catenina como un biomarcador para el tratamiento de canceres que usan el anticuerpo anti-dkk-1. |
CN106990245B (zh) * | 2017-04-05 | 2018-07-31 | 东南大学 | 检测pitx1表达量的试剂在制备胃癌预后评估试剂盒中的应用 |
CN110835372B (zh) * | 2019-11-06 | 2020-12-01 | 上海健康医学院 | 一种靶向Frizzled7单克隆抗体及其制备方法与应用 |
CN111735949B (zh) * | 2020-07-17 | 2023-07-21 | 北京信诺卫康科技有限公司 | Wnt7a和CA125联合用作早期卵巢癌生物标志物以及试剂盒 |
CN115337400A (zh) * | 2021-05-13 | 2022-11-15 | 中国科学院分子细胞科学卓越创新中心 | 诊断和治疗肿瘤的试剂及其用途 |
CN113293212A (zh) * | 2021-06-17 | 2021-08-24 | 深圳华因康基因科技有限公司 | 一种检测神经母细胞瘤复发转移基因fzd2扩增的引物探针及其应用 |
WO2023113013A1 (fr) * | 2021-12-17 | 2023-06-22 | 国立大学法人京都大学 | Procédé de sélection d'un gène destiné à être utilisé dans l'estimation de la possibilité d'apparition d'une maladie, et procédé d'estimation de la possibilité d'apparition d'une maladie |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010101793A2 (fr) * | 2009-03-06 | 2010-09-10 | University Of South Alabama | Méthodes et compositions pour le diagnostic, le pronostic et le traitement du cancer |
US7982013B2 (en) * | 2008-09-26 | 2011-07-19 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
WO2013086260A2 (fr) * | 2011-12-09 | 2013-06-13 | Oncomed Pharmaceuticals, Inc. | Thérapie d'association pour le traitement du cancer |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
EP0546073B1 (fr) | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | production et utilisation des animaux non humains transgeniques capable de produire des anticorps heterologues |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
JP2003518920A (ja) * | 1999-07-02 | 2003-06-17 | カイロン コーポレイション | 新規なヒト遺伝子および遺伝子発現産物 |
US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
JP4336498B2 (ja) | 2000-12-12 | 2009-09-30 | メディミューン,エルエルシー | 延長した半減期を有する分子ならびにその組成物および用途 |
GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
US20040247593A1 (en) * | 2002-10-04 | 2004-12-09 | Regents Of The University Of California, | Methods for treating cancer by inhibiting Wnt signaling |
US7365168B2 (en) | 2002-10-15 | 2008-04-29 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
EP1697415A1 (fr) | 2003-11-12 | 2006-09-06 | Biogen Idec MA Inc. | Variants de polypeptide se liant au recepteur fc neonatal (fcrn), proteines de liaison fc dimeres et techniques associees |
US20080187954A1 (en) | 2004-03-10 | 2008-08-07 | Lonza Ltd. | Method For Producing Antibodies |
WO2006024497A1 (fr) | 2004-08-30 | 2006-03-09 | Lonza Biologics Plc. | Chromatographie par echange d'ions et affinite pour la purification d'anticorps |
CA2628255C (fr) | 2005-10-31 | 2016-04-19 | The Regents Of The University Of Michigan | Compositions et methodes pour traiter et diagnostiquer un cancer |
US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
CA2662041A1 (fr) | 2006-09-08 | 2008-03-13 | Genentech, Inc. | Antagonistes de wnt et leur utilisation pour le diagnostic et le traitement de troubles a mediation wnt |
MX2009003229A (es) | 2006-09-29 | 2009-06-18 | Oncomed Pharm Inc | Composiciones y metodos para diagnosticar y tratar cancer. |
EP2084296B1 (fr) * | 2006-09-29 | 2015-08-05 | Agendia N.V. | Essai diagnostique extremement productif au moyen de jeux ordonnes |
US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
WO2009092010A1 (fr) | 2008-01-18 | 2009-07-23 | Gagnon Peter S | Purification améliorée de biomolécules phosphorylées et non phosphorylées par chromatographie sur hydroxyapatite |
US20100169025A1 (en) * | 2008-10-10 | 2010-07-01 | Arthur William T | Methods and gene expression signature for wnt/b-catenin signaling pathway |
TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
CA2786745A1 (fr) | 2010-01-12 | 2011-07-21 | Oncomed Pharmaceuticals, Inc. | Agents de liaison a wnt et leurs utilisations |
-
2014
- 2014-12-02 CN CN201480065718.7A patent/CN105829547A/zh active Pending
- 2014-12-02 EP EP14867583.8A patent/EP3077546A4/fr not_active Withdrawn
- 2014-12-02 WO PCT/US2014/068097 patent/WO2015084808A1/fr active Application Filing
- 2014-12-02 TW TW103141799A patent/TW201610168A/zh unknown
- 2014-12-02 CA CA2931975A patent/CA2931975A1/fr not_active Abandoned
- 2014-12-02 MX MX2016007066A patent/MX2016007066A/es unknown
- 2014-12-02 AU AU2014357354A patent/AU2014357354A1/en not_active Abandoned
- 2014-12-02 JP JP2016535646A patent/JP2017501137A/ja active Pending
-
2016
- 2016-10-17 HK HK16111927.7A patent/HK1223657A1/zh unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7982013B2 (en) * | 2008-09-26 | 2011-07-19 | Oncomed Pharmaceuticals, Inc. | Frizzled-binding agents and uses thereof |
WO2010101793A2 (fr) * | 2009-03-06 | 2010-09-10 | University Of South Alabama | Méthodes et compositions pour le diagnostic, le pronostic et le traitement du cancer |
WO2013086260A2 (fr) * | 2011-12-09 | 2013-06-13 | Oncomed Pharmaceuticals, Inc. | Thérapie d'association pour le traitement du cancer |
Non-Patent Citations (3)
Title |
---|
FORGET M-A ET AL: "The Wnt pathway regulator DKKI is preferentially expressed in hormone-resistant breast tumours and in some common cancer types", BRITISH JOURNAL OF CANCER, NATURE PUBLISHING GROUP, GB, vol. 96, 1 January 2007 (2007-01-01), pages 646 - 653, XP003026724, ISSN: 0007-0920, [retrieved on 20070123], DOI: 10.1038/SJ.BJC.6603579 * |
See also references of WO2015084808A1 * |
WISSMANN C ET AL: "WIFI, A COMPONENT OF THE WNT PATHWAY, IS DOWN-REGULATED IN PROSTATE, BREAST, LUNG, AND BLADDER CANCER", JOURNAL OF PATHOLOGY, JOHN WILEY & SONS LTD, GB, vol. 201, no. 2, 1 January 2003 (2003-01-01), pages 204 - 212, XP008054942, ISSN: 0022-3417, DOI: 10.1002/PATH.1449 * |
Also Published As
Publication number | Publication date |
---|---|
CN105829547A (zh) | 2016-08-03 |
WO2015084808A4 (fr) | 2015-08-13 |
CA2931975A1 (fr) | 2015-06-11 |
AU2014357354A1 (en) | 2016-06-09 |
JP2017501137A (ja) | 2017-01-12 |
MX2016007066A (es) | 2016-09-08 |
HK1223657A1 (zh) | 2017-08-04 |
EP3077546A1 (fr) | 2016-10-12 |
WO2015084808A1 (fr) | 2015-06-11 |
TW201610168A (zh) | 2016-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20160621 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
AX | Request for extension of the european patent |
Extension state: BA ME |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20170329 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61P 35/00 20060101ALI20170323BHEP Ipc: A61K 38/00 20060101ALI20170323BHEP Ipc: C12Q 1/68 20060101AFI20170323BHEP |
|
17Q | First examination report despatched |
Effective date: 20180904 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20190702 |