JP2015502951A5 - - Google Patents
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- JP2015502951A5 JP2015502951A5 JP2014545355A JP2014545355A JP2015502951A5 JP 2015502951 A5 JP2015502951 A5 JP 2015502951A5 JP 2014545355 A JP2014545355 A JP 2014545355A JP 2014545355 A JP2014545355 A JP 2014545355A JP 2015502951 A5 JP2015502951 A5 JP 2015502951A5
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- JP
- Japan
- Prior art keywords
- use according
- ring
- pharmaceutical composition
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 12
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims 8
- -1 3,3,7-trimethyl-2,3-dihydro-1-benzofuran-4-yl Chemical group 0.000 claims 7
- 208000016354 hearing loss disease Diseases 0.000 claims 6
- 230000002265 prevention Effects 0.000 claims 5
- 208000001914 Fragile X syndrome Diseases 0.000 claims 3
- 201000000980 schizophrenia Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- UTNAZRUUEYLOJF-CYBMUJFWSA-N (5r)-5-ethyl-3-[2-[(3,3,7-trimethyl-2h-1-benzofuran-4-yl)oxy]pyrimidin-5-yl]imidazolidine-2,4-dione Chemical compound O=C1[C@@H](CC)NC(=O)N1C(C=N1)=CN=C1OC1=CC=C(C)C2=C1C(C)(C)CO2 UTNAZRUUEYLOJF-CYBMUJFWSA-N 0.000 claims 1
- YHKIKNMCENTLLI-CQSZACIVSA-N (5r)-5-ethyl-3-[6-[(3,3,7-trimethyl-2h-1-benzofuran-4-yl)oxy]pyridin-3-yl]imidazolidine-2,4-dione Chemical compound O=C1[C@@H](CC)NC(=O)N1C(C=N1)=CC=C1OC1=CC=C(C)C2=C1C(C)(C)CO2 YHKIKNMCENTLLI-CQSZACIVSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 206010036626 Presbyacusis Diseases 0.000 claims 1
- 208000009205 Tinnitus Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 231100000888 hearing loss Toxicity 0.000 claims 1
- 230000010370 hearing loss Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 231100000886 tinnitus Toxicity 0.000 claims 1
- BRWPNRPKCXINGP-UHFFFAOYSA-N CCC(C1OC1N1C)NC1=O Chemical compound CCC(C1OC1N1C)NC1=O BRWPNRPKCXINGP-UHFFFAOYSA-N 0.000 description 1
- 0 CCC([C@](*)(C1OC1N1C)NC1=O)=C Chemical compound CCC([C@](*)(C1OC1N1C)NC1=O)=C 0.000 description 1
- XHPQMYVMTQWHGY-SCSAIBSYSA-N CC[C@H](C(N1C)=O)NC1=O Chemical compound CC[C@H](C(N1C)=O)NC1=O XHPQMYVMTQWHGY-SCSAIBSYSA-N 0.000 description 1
- UYZMWRYXBKPYPJ-MRVPVSSYSA-N CC[C@](C)(COCN1C)NC1=O Chemical compound CC[C@](C)(COCN1C)NC1=O UYZMWRYXBKPYPJ-MRVPVSSYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2011/052414 WO2012076877A1 (en) | 2010-12-06 | 2011-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
| GBPCT/GB2011/052414 | 2011-12-06 | ||
| PCT/GB2012/053045 WO2013083994A1 (en) | 2011-12-06 | 2012-12-06 | Hydantoin derivatives useful as kv3 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502951A JP2015502951A (ja) | 2015-01-29 |
| JP2015502951A5 true JP2015502951A5 (https=) | 2016-04-14 |
| JP5985651B2 JP5985651B2 (ja) | 2016-09-06 |
Family
ID=47429936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545355A Active JP5985651B2 (ja) | 2011-12-06 | 2012-12-06 | Ｋｖ３阻害剤として有用なヒダントイン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2788339B1 (https=) |
| JP (1) | JP5985651B2 (https=) |
| KR (1) | KR20140098850A (https=) |
| CN (1) | CN103974944B (https=) |
| AU (1) | AU2012349847B2 (https=) |
| CA (1) | CA2856654C (https=) |
| DK (1) | DK2788339T3 (https=) |
| ES (1) | ES2576628T3 (https=) |
| IL (2) | IL232612B (https=) |
| IN (1) | IN2014CN04014A (https=) |
| MX (1) | MX356813B (https=) |
| PL (1) | PL2788339T3 (https=) |
| WO (1) | WO2013083994A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103596943B (zh) | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
| US9669030B2 (en) | 2012-05-22 | 2017-06-06 | Autifony Therapeutics Limited | Hydantoin derivatives as Kv3 inhibitors |
| US9422252B2 (en) | 2012-05-22 | 2016-08-23 | Autifony Therapeutics Limited | Triazoles as Kv3 inhibitors |
| WO2013182851A1 (en) * | 2012-06-06 | 2013-12-12 | Autifony Therapeutics Limited | Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required |
| GB201521751D0 (en) | 2015-12-10 | 2016-01-27 | Autifony Therapeutics Ltd | Novel uses |
| GB201613163D0 (en) | 2016-07-29 | 2016-09-14 | Autifony Therapeutics Ltd | Novel compounds |
| WO2018220762A1 (ja) * | 2017-05-31 | 2018-12-06 | 大塚製薬株式会社 | ピリミジン化合物 |
| US12090146B2 (en) | 2018-09-21 | 2024-09-17 | Bionomics Limited | Substituted-pyridinyl compounds and uses thereof |
| US12358901B2 (en) | 2018-10-16 | 2025-07-15 | Autifony Therapeutics Limited | KV3 modulators |
| KR102854594B1 (ko) | 2018-10-16 | 2025-09-02 | 오티포니 세라피틱스 리미티드 | 신규한 화합물 |
| MY210184A (en) * | 2018-11-30 | 2025-08-31 | Otsuka Pharma Co Ltd | Heterocyclic compounds for the treatment of epilepsy |
| BR112022013339A2 (pt) * | 2020-02-06 | 2022-09-13 | Autifony Therapeutics Ltd | Moduladores de kv3 |
| KR20240046748A (ko) | 2021-08-10 | 2024-04-09 | 오티포니 세라피틱스 리미티드 | 칼륨 채널 조절제 |
| WO2024121552A1 (en) | 2022-12-06 | 2024-06-13 | Autifony Therapeutics Limited | Compounds for the treatment of centra nervous system disorders |
| CN117448440B (zh) * | 2023-10-23 | 2024-11-01 | 中国人民解放军空军军医大学 | Kv3在制备诊断或治疗创伤后应激障碍异常恐惧记忆消退产品中的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675403A (en) * | 1985-10-16 | 1987-06-23 | American Home Products Corporation | 3-Aminoalkyl derivatives of 5,5-disubstituted hydantoins with psychotropic activity |
| DK123493D0 (da) * | 1993-11-01 | 1993-11-01 | Lundbeck & Co As H | Compounds |
| EP2379534A1 (en) * | 2008-12-22 | 2011-10-26 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
| EP2509961B1 (en) * | 2009-12-11 | 2016-03-09 | Autifony Therapeutics Limited | Imidazolidinedione derivatives |
| WO2011073114A1 (en) * | 2009-12-14 | 2011-06-23 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| EA023768B1 (ru) * | 2010-12-06 | 2016-07-29 | Отифони Терапеутикс Лимитед | ПРОИЗВОДНЫЕ ГИДАНТОИНА, ПОЛЕЗНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ Kv3-КАНАЛОВ |
| CN103596943B (zh) * | 2011-06-07 | 2016-10-12 | 奥蒂福尼疗法有限公司 | 用作kv3抑制剂的乙内酰脲衍生物 |
-
2012
- 2012-12-06 EP EP12806092.8A patent/EP2788339B1/en active Active
- 2012-12-06 IN IN4014CHN2014 patent/IN2014CN04014A/en unknown
- 2012-12-06 JP JP2014545355A patent/JP5985651B2/ja active Active
- 2012-12-06 KR KR1020147018643A patent/KR20140098850A/ko not_active Ceased
- 2012-12-06 PL PL12806092.8T patent/PL2788339T3/pl unknown
- 2012-12-06 ES ES12806092.8T patent/ES2576628T3/es active Active
- 2012-12-06 CA CA2856654A patent/CA2856654C/en active Active
- 2012-12-06 WO PCT/GB2012/053045 patent/WO2013083994A1/en not_active Ceased
- 2012-12-06 DK DK12806092.8T patent/DK2788339T3/en active
- 2012-12-06 CN CN201280059633.9A patent/CN103974944B/zh active Active
- 2012-12-06 MX MX2014006753A patent/MX356813B/es active IP Right Grant
- 2012-12-06 AU AU2012349847A patent/AU2012349847B2/en active Active
-
2014
- 2014-05-14 IL IL232612A patent/IL232612B/en active IP Right Grant
-
2018
- 2018-04-15 IL IL258704A patent/IL258704B/en active IP Right Grant
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