JP2015502916A - エンドセリン受容体拮抗薬の調製法 - Google Patents
エンドセリン受容体拮抗薬の調製法 Download PDFInfo
- Publication number
- JP2015502916A JP2015502916A JP2014536322A JP2014536322A JP2015502916A JP 2015502916 A JP2015502916 A JP 2015502916A JP 2014536322 A JP2014536322 A JP 2014536322A JP 2014536322 A JP2014536322 A JP 2014536322A JP 2015502916 A JP2015502916 A JP 2015502916A
- Authority
- JP
- Japan
- Prior art keywords
- kred
- formula
- compound
- solvent
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC([C@](C(*)(C1=CC=CCC1)c1ccccc1)OC(*1)*=C(*)C=C1P)=O Chemical compound CCC([C@](C(*)(C1=CC=CCC1)c1ccccc1)OC(*1)*=C(*)C=C1P)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2943/MUM/2011 | 2011-10-19 | ||
| IN2943MU2011 | 2011-10-19 | ||
| PCT/GB2012/000798 WO2013057468A1 (en) | 2011-10-19 | 2012-10-19 | Process for the preparation of an endothelin receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2015502916A true JP2015502916A (ja) | 2015-01-29 |
Family
ID=47116083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014536322A Pending JP2015502916A (ja) | 2011-10-19 | 2012-10-19 | エンドセリン受容体拮抗薬の調製法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140256004A1 (enExample) |
| EP (1) | EP2768811A1 (enExample) |
| JP (1) | JP2015502916A (enExample) |
| KR (1) | KR20140091700A (enExample) |
| AU (1) | AU2012324612A1 (enExample) |
| BR (1) | BR112014009437A2 (enExample) |
| CA (1) | CA2852810A1 (enExample) |
| IN (1) | IN2014MN00850A (enExample) |
| WO (1) | WO2013057468A1 (enExample) |
| ZA (1) | ZA201403245B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103709106A (zh) * | 2013-12-06 | 2014-04-09 | 石家庄博策生物科技有限公司 | 一种立体选择性制备安立生坦的方法 |
| US9133488B2 (en) | 2013-12-30 | 2015-09-15 | University Of Alaska Fairbanks | Synthetic methods and compounds related thereto |
| CN106011194A (zh) * | 2016-06-14 | 2016-10-12 | 西安大唐制药集团有限公司 | 一种安立生坦的制备方法 |
| CN110437063B (zh) * | 2018-05-03 | 2022-04-29 | 常州恒邦药业有限公司 | 安立生坦关键中间体的制备方法 |
| CN111057725B (zh) * | 2019-07-01 | 2023-08-18 | 弈柯莱生物科技(上海)股份有限公司 | 酮还原酶在制备(s)-1,1-二(4-氟苯基)-2-丙醇的用途及制备 |
| CN110423741B (zh) * | 2019-07-16 | 2021-08-17 | 浙江工业大学 | 羰基还原酶-辅酶nadp+共固定化酶及其制备与应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005017135A1 (en) * | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| WO2010070658A2 (en) * | 2008-11-05 | 2010-06-24 | Msn Laboratories Limited | Improved process for the preparation of endothelin receptor antagonists |
| WO2010091877A2 (en) * | 2009-02-13 | 2010-08-19 | Ratiopharm Gmbh | Process for producing ambrisentan |
| WO2011004402A2 (en) * | 2009-07-10 | 2011-01-13 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan and novel intermediates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| EP0918090A3 (en) | 1997-11-04 | 2002-08-28 | Eli Lilly And Company | Ketoreductase gene and protein from yeast |
| DE19850301A1 (de) | 1998-10-30 | 2000-05-04 | Basf Ag | Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren |
-
2012
- 2012-10-19 EP EP12780256.9A patent/EP2768811A1/en not_active Withdrawn
- 2012-10-19 IN IN850MUN2014 patent/IN2014MN00850A/en unknown
- 2012-10-19 BR BR112014009437A patent/BR112014009437A2/pt not_active Application Discontinuation
- 2012-10-19 AU AU2012324612A patent/AU2012324612A1/en not_active Abandoned
- 2012-10-19 KR KR1020147013040A patent/KR20140091700A/ko not_active Withdrawn
- 2012-10-19 WO PCT/GB2012/000798 patent/WO2013057468A1/en not_active Ceased
- 2012-10-19 JP JP2014536322A patent/JP2015502916A/ja active Pending
- 2012-10-19 CA CA2852810A patent/CA2852810A1/en not_active Abandoned
- 2012-10-19 US US14/352,917 patent/US20140256004A1/en not_active Abandoned
-
2014
- 2014-05-06 ZA ZA2014/03245A patent/ZA201403245B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005017135A1 (en) * | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| WO2010070658A2 (en) * | 2008-11-05 | 2010-06-24 | Msn Laboratories Limited | Improved process for the preparation of endothelin receptor antagonists |
| WO2010091877A2 (en) * | 2009-02-13 | 2010-08-19 | Ratiopharm Gmbh | Process for producing ambrisentan |
| WO2011004402A2 (en) * | 2009-07-10 | 2011-01-13 | Cadila Healthcare Limited | Improved process for the preparation of ambrisentan and novel intermediates thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140256004A1 (en) | 2014-09-11 |
| BR112014009437A2 (pt) | 2017-04-11 |
| WO2013057468A1 (en) | 2013-04-25 |
| IN2014MN00850A (enExample) | 2015-04-17 |
| CA2852810A1 (en) | 2013-04-25 |
| KR20140091700A (ko) | 2014-07-22 |
| EP2768811A1 (en) | 2014-08-27 |
| AU2012324612A1 (en) | 2014-05-15 |
| ZA201403245B (en) | 2015-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11767292B2 (en) | Process for making beta 3 agonists and intermediates | |
| US20140256004A1 (en) | Process for the Preparation of an Endothelin Receptor Antagonist | |
| JP6511448B2 (ja) | キラルな２−アリールモルホリン類の調製のためのプロセス | |
| US20240336603A1 (en) | Process for the preparation of a cyp11a1 inhibitor and intermediates thereof | |
| US20080248537A1 (en) | Biocatalytic asymmetric reduction in preparation of (s)-n-[5-(1,2-dihydroxy-ethyl)-pyrazinyl]-2,2-dimethyl-propionamide | |
| JP2019205429A (ja) | ロスバスタチンカルシウム及びその中間体の製造方法 | |
| WO2018207888A1 (ja) | ラメルテオンの製造法 | |
| US20120123128A1 (en) | Process for production of optically active nipecotamide | |
| JPWO2016056658A1 (ja) | スタチン系化合物の精製方法 | |
| CN115820754A (zh) | 一种潜手性二羧酸酯去对称化方法 | |
| CA3102474C (en) | Enzymatic process for the preparation of droxidopa | |
| CN111836899B (zh) | 制备用于通过酶还原合成光学活性β-氨基醇的中间体的方法以及合成中间体 | |
| CN108192932B (zh) | 一种手性醇的酶催化制备方法 | |
| CN101137637A (zh) | 制备(r)-4,4-二烷氧基-吡喃-3-醇例如(r)-4,4-二甲氧基-吡喃-3-醇的方法 | |
| US20040077061A1 (en) | Enzymatic resolution of aryl and thio-substituted acids | |
| JPWO2003040382A1 (ja) | 光学活性クロマン誘導体の製造法および中間体 | |
| JP5503930B2 (ja) | ３−アミノ−１−ｔｅｒｔ−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩 | |
| JP2001064209A (ja) | 選択的還元方法 | |
| US20050153408A1 (en) | Process for preparation of 2-aminotetralin derivatives and intermediates thereof | |
| CN115678936A (zh) | 一种选择性合成手性醇及环氧化合物的方法 | |
| JP2013110980A (ja) | 光学活性なコハク酸イミド誘導体の製造方法 | |
| JP2009019021A (ja) | ホモイソクエン酸脱水素酵素の阻害剤 | |
| WO2000003999A1 (fr) | Procede pour la preparation de 5-(1-methylethyl) -6-(phenylmethyl)pyrimidine-2,4(1h,3h)-dione |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150903 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160621 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20170228 |