JP2015501784A5 - - Google Patents
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- Publication number
- JP2015501784A5 JP2015501784A5 JP2014540115A JP2014540115A JP2015501784A5 JP 2015501784 A5 JP2015501784 A5 JP 2015501784A5 JP 2014540115 A JP2014540115 A JP 2014540115A JP 2014540115 A JP2014540115 A JP 2014540115A JP 2015501784 A5 JP2015501784 A5 JP 2015501784A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- disease
- methyl
- cycloalkyl
- syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)[n]1c2cc(Br)cc(C(NCc3c(C)cc(*)nc3OC)=O)c2c(C)c1 Chemical compound CC(C)[n]1c2cc(Br)cc(C(NCc3c(C)cc(*)nc3OC)=O)c2c(C)c1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161555650P | 2011-11-04 | 2011-11-04 | |
| US61/555,650 | 2011-11-04 | ||
| PCT/US2012/063235 WO2013067296A1 (en) | 2011-11-04 | 2012-11-02 | Method of treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501784A JP2015501784A (ja) | 2015-01-19 |
| JP2015501784A5 true JP2015501784A5 (enExample) | 2015-12-24 |
| JP6005753B2 JP6005753B2 (ja) | 2016-10-12 |
Family
ID=48192800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014540115A Expired - Fee Related JP6005753B2 (ja) | 2011-11-04 | 2012-11-02 | 治療の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9242962B2 (enExample) |
| EP (1) | EP2773754B1 (enExample) |
| JP (1) | JP6005753B2 (enExample) |
| KR (1) | KR20140095073A (enExample) |
| CN (1) | CN104039956A (enExample) |
| AU (1) | AU2012332297B2 (enExample) |
| BR (1) | BR112014010803A2 (enExample) |
| CA (1) | CA2854447A1 (enExample) |
| ES (1) | ES2600161T3 (enExample) |
| RU (1) | RU2621148C2 (enExample) |
| WO (1) | WO2013067296A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9051269B2 (en) | 2011-11-18 | 2015-06-09 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| JP5989805B2 (ja) | 2012-02-10 | 2016-09-07 | コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | メチル基変更酵素の調節物質、組成物及びその使用 |
| CA2894222A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
| US9745305B2 (en) | 2013-03-15 | 2017-08-29 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| US9045477B2 (en) | 2013-03-15 | 2015-06-02 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
| US9969716B2 (en) | 2013-08-15 | 2018-05-15 | Constellation Pharmaceuticals, Inc. | Indole derivatives as modulators of methyl modifying enzymes, compositions and uses thereof |
| US9822103B2 (en) | 2013-11-22 | 2017-11-21 | Bristol-Myers Squibb Company | Inhibitors of lysine methyl transferase |
| WO2015120372A2 (en) * | 2014-02-10 | 2015-08-13 | University Of Rochester | Compositions and methods to inhibit ezh2 for the treatment of cardiovascular diseases |
| EP3114125A1 (en) * | 2014-03-07 | 2017-01-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| LT3121175T (lt) * | 2014-03-17 | 2020-03-10 | Daiichi Sankyo Company, Limited | 1,3-benzodioksazolo dariniai, kaip ezh1 ir (arba) ezh2 inhibitoriai |
| BR112017008840A2 (pt) * | 2014-10-28 | 2017-12-19 | Glaxosmithkline Ip No 2 Ltd | intensificador de inibidores do homólogo 2 de zeste |
| US20190000860A1 (en) * | 2014-11-06 | 2019-01-03 | Dana-Farber Cancer Institute, Inc. | Use of compositions modulating chromatin structure for graft versus host disease (gvhd) |
| WO2016073956A1 (en) | 2014-11-06 | 2016-05-12 | Dana-Farber Cancer Institute, Inc. | Ezh2 inhibitors and uses thereof |
| AR102767A1 (es) | 2014-12-05 | 2017-03-22 | Lilly Co Eli | Inhibidores de ezh2 |
| WO2017023671A1 (en) * | 2015-08-03 | 2017-02-09 | Constellation Pharmaceuticals, Inc. | Ezh2 inhibitors and modulation of regulatory t-cell function |
| TW201718598A (zh) | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| US10577350B2 (en) | 2015-08-28 | 2020-03-03 | Constellation Pharmaceuticals, Inc. | Crystalline forms of (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide |
| CN105541801B (zh) * | 2016-01-18 | 2018-07-17 | 常州大学 | Ezh2甲基转移酶抑制剂gsk126的合成方法 |
| JP7493304B2 (ja) | 2016-04-22 | 2024-05-31 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | Ｅｚｈ２インヒビターおよびそれらの使用 |
| EP3472166A1 (en) * | 2016-06-20 | 2019-04-24 | Novartis AG | Imidazopyrimidine compounds useful for the treatment of cancer |
| KR102351782B1 (ko) * | 2016-09-07 | 2022-01-17 | 상하이 하이헤 파마수티컬 컴퍼니 리미티드 | 피리도 5원 방향족 고리계 화합물, 이의 제조 방법 및 용도 |
| CN109843870A (zh) | 2016-10-19 | 2019-06-04 | 星座制药公司 | Ezh2抑制剂的合成 |
| WO2018137639A1 (zh) * | 2017-01-25 | 2018-08-02 | 恩瑞生物医药科技（上海）有限公司 | 一种组蛋白甲基转移酶ezh2抑制剂、其制备方法及其医药用途 |
| EP3823671B1 (en) | 2018-07-09 | 2024-02-07 | Fondation Asile Des Aveugles | Inhibition of prc2 subunits to treat eye disorders |
| TWI837231B (zh) | 2018-11-29 | 2024-04-01 | 日商第一三共股份有限公司 | 含有ｅｚｈ１／２雙重抑制劑之醫藥組合及其用途 |
| US20220016111A1 (en) * | 2018-12-21 | 2022-01-20 | The Walter And Eliza Hall Institute Of Medical Research | Methods of Treating Inflammation |
| CN109761960B (zh) * | 2019-02-25 | 2021-08-31 | 江苏豪森药业集团有限公司 | 抗耐药抗肿瘤egfr抑制剂的制备方法 |
| CN111961034A (zh) * | 2019-05-20 | 2020-11-20 | 浙江同源康医药股份有限公司 | 用作ret激酶抑制剂的化合物及其应用 |
| MX2022001019A (es) * | 2019-07-31 | 2022-02-22 | Ribon Therapeutics Inc | Amidas heterobiciclicas como inhibidoras del cumulo de diferenciacion 38 (cd38). |
| CN114555112A (zh) | 2019-08-22 | 2022-05-27 | 朱诺治疗学股份有限公司 | T细胞疗法和zeste增强子同源物2(ezh2)抑制剂的组合疗法及相关方法 |
| CN119303087A (zh) * | 2019-12-25 | 2025-01-14 | 日本新药株式会社 | 慢性前列腺炎/慢性盆腔疼痛综合征的预防和/或治疗剂 |
| HRP20251111T1 (hr) | 2021-01-29 | 2025-11-21 | Boehringer Ingelheim International Gmbh | Azakinolini kao inhibitori cd38 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2584713B1 (fr) | 1985-07-11 | 1988-09-09 | Roussel Uclaf | Nouveaux derives de l'indole carboxamide, leurs sels, procede et intermediaires de preparation, application a titre de medicaments et compositions les renfermant |
| DE10022925A1 (de) | 2000-05-11 | 2001-11-15 | Basf Ag | Substituierte Indole als PARP-Inhibitoren |
| WO2004112719A2 (en) | 2003-06-19 | 2004-12-29 | Smithkline Beecham Corporation | Chemical compounds |
| US20050059682A1 (en) | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
| JP4861976B2 (ja) * | 2004-03-11 | 2012-01-25 | アクテリオン ファーマシューティカルズ リミテッド | インドール−１−イル酢酸誘導体 |
| WO2007053114A1 (en) * | 2005-10-31 | 2007-05-10 | S*Bio Pte Ltd | Method of predicting a response to hdac inhibitors |
| WO2008109534A1 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting ezh2 gene expression and uses thereof |
| WO2009006577A2 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
| US20110064664A1 (en) * | 2007-10-08 | 2011-03-17 | The Board Of Regents Of The University Of Texas System | Methods and compositions involving chitosan nanoparticles |
| AR070398A1 (es) | 2008-02-22 | 2010-03-31 | Gruenenthal Chemie | Derivados sustituidos de indol |
| EP2331543A4 (en) | 2008-09-26 | 2013-06-19 | Agency Science Tech & Res | 3-deazaneplanocin DERIVATIVES |
| WO2010051550A1 (en) * | 2008-10-31 | 2010-05-06 | University Of Rochester | Methods of diagnosing and treating fibrosis |
| CA2751563A1 (en) * | 2009-02-04 | 2010-08-12 | Jelena Mann | Methods of inhibiting fibrogenesis and treating fibrotic disease |
| JP5864546B2 (ja) | 2010-05-07 | 2016-02-17 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | インダゾール |
| WO2012005805A1 (en) | 2010-05-07 | 2012-01-12 | Glaxosmithkline Llc | Azaindazoles |
| EA023788B1 (ru) * | 2010-05-07 | 2016-07-29 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Производные индола и фармацевтические композиции на их основе |
| WO2012118812A2 (en) * | 2011-02-28 | 2012-09-07 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
-
2012
- 2012-11-02 CN CN201280066115.XA patent/CN104039956A/zh active Pending
- 2012-11-02 KR KR1020147014677A patent/KR20140095073A/ko not_active Withdrawn
- 2012-11-02 BR BR112014010803A patent/BR112014010803A2/pt not_active IP Right Cessation
- 2012-11-02 JP JP2014540115A patent/JP6005753B2/ja not_active Expired - Fee Related
- 2012-11-02 AU AU2012332297A patent/AU2012332297B2/en not_active Ceased
- 2012-11-02 RU RU2014122546A patent/RU2621148C2/ru not_active IP Right Cessation
- 2012-11-02 ES ES12845460.0T patent/ES2600161T3/es active Active
- 2012-11-02 WO PCT/US2012/063235 patent/WO2013067296A1/en not_active Ceased
- 2012-11-02 US US14/355,964 patent/US9242962B2/en not_active Expired - Fee Related
- 2012-11-02 EP EP12845460.0A patent/EP2773754B1/en active Active
- 2012-11-02 CA CA2854447A patent/CA2854447A1/en not_active Abandoned
-
2015
- 2015-11-30 US US14/953,546 patent/US9446041B2/en not_active Expired - Fee Related
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