JP2015501328A5 - - Google Patents
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- Publication number
- JP2015501328A5 JP2015501328A5 JP2014539406A JP2014539406A JP2015501328A5 JP 2015501328 A5 JP2015501328 A5 JP 2015501328A5 JP 2014539406 A JP2014539406 A JP 2014539406A JP 2014539406 A JP2014539406 A JP 2014539406A JP 2015501328 A5 JP2015501328 A5 JP 2015501328A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- microdroplet
- droplet
- polymerizable amphiphilic
- bilayer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims 23
- 210000003000 inclusion body Anatomy 0.000 claims 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 13
- 230000002093 peripheral effect Effects 0.000 claims 13
- 108010052285 Membrane Proteins Proteins 0.000 claims 9
- 229940079593 drug Drugs 0.000 claims 9
- 150000002632 lipids Chemical class 0.000 claims 7
- 102000018697 Membrane Proteins Human genes 0.000 claims 6
- 239000002609 medium Substances 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- UKDDQGWMHWQMBI-UHFFFAOYSA-O 1,2-diphytanoyl-sn-glycero-3-phosphocholine Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)CC(=O)OCC(COP(O)(=O)OCC[N+](C)(C)C)OC(=O)CC(C)CCCC(C)CCCC(C)CCCC(C)C UKDDQGWMHWQMBI-UHFFFAOYSA-O 0.000 claims 5
- 239000012736 aqueous medium Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 229940039227 diagnostic agent Drugs 0.000 claims 5
- 239000000032 diagnostic agent Substances 0.000 claims 5
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 4
- 239000012190 activator Substances 0.000 claims 4
- 239000002872 contrast media Substances 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 230000000937 inactivator Effects 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 238000002648 combination therapy Methods 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000012052 hydrophilic carrier Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- MWRBNPKJOOWZPW-NYVOMTAGSA-N 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine zwitterion Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC MWRBNPKJOOWZPW-NYVOMTAGSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000012491 analyte Substances 0.000 claims 1
- 239000012062 aqueous buffer Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000001687 destabilization Effects 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000005684 electric field Effects 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 238000011835 investigation Methods 0.000 claims 1
- 239000002608 ionic liquid Substances 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000007704 transition Effects 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1119032.9A GB201119032D0 (en) | 2011-11-03 | 2011-11-03 | Multisomes: encapsulated droplet networks |
| GB1119032.9 | 2011-11-03 | ||
| US201261592062P | 2012-01-30 | 2012-01-30 | |
| US61/592,062 | 2012-01-30 | ||
| PCT/GB2012/052736 WO2013064837A1 (en) | 2011-11-03 | 2012-11-02 | Multisomes: encapsulated droplet networks |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501328A JP2015501328A (ja) | 2015-01-15 |
| JP2015501328A5 true JP2015501328A5 (https=) | 2015-12-17 |
| JP6234371B2 JP6234371B2 (ja) | 2017-11-22 |
Family
ID=45375781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014539406A Active JP6234371B2 (ja) | 2011-11-03 | 2012-11-02 | マルチソーム:封入された微小滴ネットワーク |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US10548852B2 (https=) |
| EP (1) | EP2773451A1 (https=) |
| JP (1) | JP6234371B2 (https=) |
| KR (1) | KR102038450B1 (https=) |
| CN (1) | CN104053497B (https=) |
| AU (1) | AU2012330894B2 (https=) |
| BR (1) | BR112014010811B1 (https=) |
| CA (1) | CA2853966C (https=) |
| GB (1) | GB201119032D0 (https=) |
| IN (1) | IN2014CN03680A (https=) |
| WO (1) | WO2013064837A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201119032D0 (en) | 2011-11-03 | 2011-12-14 | Isis Innovation | Multisomes: encapsulated droplet networks |
| GB201219196D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Droplet assembly method |
| GB201219201D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Hydrogel network |
| EP2928610A2 (en) | 2012-12-07 | 2015-10-14 | Isis Innovation Limited | Droplet assembly by 3d printing |
| US9427737B2 (en) * | 2012-12-14 | 2016-08-30 | Bio-Rad Laboratories, Inc. | Methods and compositions for using oils for analysis and detection of molecules |
| FR3000688B1 (fr) * | 2013-01-08 | 2016-09-30 | Centre Nat De La Rech Scient - Cnrs - | Procede pour activer une reaction chimique, melange activable par ce procede et dispostiif pour la mise en oeuvre de ce procede |
| US9758535B2 (en) | 2013-03-15 | 2017-09-12 | Bio-Rad Laboratories, Inc. | Silicone surfactants for emulsion assays |
| HK1220390A1 (zh) * | 2013-08-29 | 2017-05-05 | Teva Pharmaceutical Industries Ltd. | 包括恩曲他滨,替诺福韦,达芦那韦和利托那韦的单位剂型以及包含达芦那韦和利托那韦的单体片剂 |
| CA2942877A1 (en) * | 2014-04-08 | 2015-10-15 | Nitzan SHAHAR | Unit dosage form comprising emtricitabine, tenofovir, darunavir and ritonavir |
| ES2789000T3 (es) | 2014-10-10 | 2020-10-23 | Quantapore Inc | Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente |
| US10641764B2 (en) | 2015-07-02 | 2020-05-05 | The University Of Massachusetts | Membrane and droplet-interface bilayer systems and methods |
| EP3387108B1 (en) | 2015-12-08 | 2022-05-25 | Quantapore, Inc. | Method of translocating nucleic acids through nanopores |
| EP3423570A1 (en) | 2016-03-01 | 2019-01-09 | Oxford University Innovation Limited | Phase transfer of a cargo laden scaffold |
| GB201603591D0 (en) * | 2016-03-01 | 2016-04-13 | Isis Innovation | Improved promotors and compositions |
| GB201615741D0 (en) * | 2016-09-15 | 2016-11-02 | Univ College Cardiff Consultants Ltd | Artificial cells |
| GB2561157A (en) * | 2017-03-27 | 2018-10-10 | Univ Oxford Innovation Ltd | Compartmentalised gel matrix and method of production |
| CN110961055B (zh) * | 2019-12-06 | 2021-01-05 | 锦州医科大学 | 离子液体聚合微球及其制备方法和应用 |
| KR20220159986A (ko) * | 2020-03-26 | 2022-12-05 | 고쿠리쓰다이가쿠호진 규슈다이가쿠 | 이온 액체, 용매, 제제 및 경피흡수제 |
| CN112588218B (zh) * | 2020-12-11 | 2021-09-21 | 中国科学院力学研究所 | 一种实现液滴快速自发旋转的方法 |
| CN114250190A (zh) * | 2021-12-22 | 2022-03-29 | 北京京东方技术开发有限公司 | 封装细胞及其制备方法 |
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| GB201219201D0 (en) | 2012-10-25 | 2012-12-12 | Isis Innovation | Hydrogel network |
| EP2911771B1 (en) | 2012-10-26 | 2017-01-18 | Oxford Nanopore Technologies Limited | Droplet interfaces |
| EP2928610A2 (en) | 2012-12-07 | 2015-10-14 | Isis Innovation Limited | Droplet assembly by 3d printing |
-
2011
- 2011-11-03 GB GBGB1119032.9A patent/GB201119032D0/en not_active Ceased
-
2012
- 2012-11-02 IN IN3680CHN2014 patent/IN2014CN03680A/en unknown
- 2012-11-02 AU AU2012330894A patent/AU2012330894B2/en active Active
- 2012-11-02 US US14/354,706 patent/US10548852B2/en active Active
- 2012-11-02 WO PCT/GB2012/052736 patent/WO2013064837A1/en not_active Ceased
- 2012-11-02 BR BR112014010811-0A patent/BR112014010811B1/pt active IP Right Grant
- 2012-11-02 EP EP12784659.0A patent/EP2773451A1/en active Pending
- 2012-11-02 CN CN201280065007.0A patent/CN104053497B/zh active Active
- 2012-11-02 CA CA2853966A patent/CA2853966C/en active Active
- 2012-11-02 KR KR1020147015197A patent/KR102038450B1/ko active Active
- 2012-11-02 JP JP2014539406A patent/JP6234371B2/ja active Active
-
2019
- 2019-12-19 US US16/721,302 patent/US11406603B2/en active Active
-
2022
- 2022-06-29 US US17/853,000 patent/US11998642B2/en active Active
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