JP2015500663A5 - - Google Patents
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- JP2015500663A5 JP2015500663A5 JP2014548982A JP2014548982A JP2015500663A5 JP 2015500663 A5 JP2015500663 A5 JP 2015500663A5 JP 2014548982 A JP2014548982 A JP 2014548982A JP 2014548982 A JP2014548982 A JP 2014548982A JP 2015500663 A5 JP2015500663 A5 JP 2015500663A5
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- JP
- Japan
- Prior art keywords
- enzyme
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- produced
- pcoa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 41
- 102000004190 Enzymes Human genes 0.000 claims 30
- 108090000790 Enzymes Proteins 0.000 claims 30
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 claims 14
- 239000013592 cell lysate Substances 0.000 claims 12
- LYCRXMTYUZDUGA-UYRKPTJQSA-N pimeloyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CCCCCC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LYCRXMTYUZDUGA-UYRKPTJQSA-N 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 5
- 230000037361 pathway Effects 0.000 claims 5
- 108010000700 Acetolactate synthase Proteins 0.000 claims 4
- 108030002325 Carboxylate reductases Proteins 0.000 claims 4
- 108090000364 Ligases Proteins 0.000 claims 4
- 102000003960 Ligases Human genes 0.000 claims 4
- 102000005488 Thioesterase Human genes 0.000 claims 4
- 108090000992 Transferases Proteins 0.000 claims 4
- 102000004357 Transferases Human genes 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 4
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims 4
- 229960002685 biotin Drugs 0.000 claims 4
- 235000020958 biotin Nutrition 0.000 claims 4
- 239000011616 biotin Substances 0.000 claims 4
- NZNMSOFKMUBTKW-UHFFFAOYSA-M cyclohexanecarboxylate Chemical compound [O-]C(=O)C1CCCCC1 NZNMSOFKMUBTKW-UHFFFAOYSA-M 0.000 claims 4
- 239000000047 product Substances 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108020002982 thioesterase Proteins 0.000 claims 4
- 108090000340 Transaminases Proteins 0.000 claims 3
- 102000003929 Transaminases Human genes 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 238000006114 decarboxylation reaction Methods 0.000 claims 3
- 238000006356 dehydrogenation reaction Methods 0.000 claims 3
- PWSKHLMYTZNYKO-UHFFFAOYSA-N heptane-1,7-diamine Chemical compound NCCCCCCCN PWSKHLMYTZNYKO-UHFFFAOYSA-N 0.000 claims 3
- XDOLZJYETYVRKV-UHFFFAOYSA-N 7-Aminoheptanoic acid Chemical compound NCCCCCCC(O)=O XDOLZJYETYVRKV-UHFFFAOYSA-N 0.000 claims 2
- 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 2
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 2
- 241000203069 Archaea Species 0.000 claims 2
- 102100026278 Cysteine sulfinic acid decarboxylase Human genes 0.000 claims 2
- 108030001081 D-amino-acid transaminases Proteins 0.000 claims 2
- 101710088194 Dehydrogenase Proteins 0.000 claims 2
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 claims 2
- 102000004316 Oxidoreductases Human genes 0.000 claims 2
- 108090000854 Oxidoreductases Proteins 0.000 claims 2
- 150000001299 aldehydes Chemical class 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- 230000006652 catabolic pathway Effects 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- JBJSVEVEEGOEBZ-SCZZXKLOSA-N coenzyme B Chemical compound OP(=O)(O)O[C@H](C)[C@@H](C(O)=O)NC(=O)CCCCCCS JBJSVEVEEGOEBZ-SCZZXKLOSA-N 0.000 claims 2
- 230000005494 condensation Effects 0.000 claims 2
- 238000009833 condensation Methods 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 claims 2
- 230000000696 methanogenic effect Effects 0.000 claims 2
- 108010064775 protein C activator peptide Proteins 0.000 claims 2
- HAGOOZVJLSSXGZ-UHFFFAOYSA-N 2-oxosuberic acid Chemical compound OC(=O)CCCCCC(=O)C(O)=O HAGOOZVJLSSXGZ-UHFFFAOYSA-N 0.000 claims 1
- 108030001028 5-aminovalerate transaminases Proteins 0.000 claims 1
- UGLZOVSJRNQLCS-UHFFFAOYSA-N 7-aminoheptanal Chemical compound NCCCCCCC=O UGLZOVSJRNQLCS-UHFFFAOYSA-N 0.000 claims 1
- 108010049445 Acetylornithine transaminase Proteins 0.000 claims 1
- 108030001147 Adenosylmethionine-8-amino-7-oxononanoate transaminases Proteins 0.000 claims 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 claims 1
- 102100022279 Aldehyde dehydrogenase family 3 member B2 Human genes 0.000 claims 1
- 108030004471 Butanal dehydrogenases Proteins 0.000 claims 1
- 108090000489 Carboxy-Lyases Proteins 0.000 claims 1
- 108700035525 EC 1.2.1.76 Proteins 0.000 claims 1
- 108010049380 Glutarate-semialdehyde dehydrogenase Proteins 0.000 claims 1
- 108010057617 Lactaldehyde dehydrogenase Proteins 0.000 claims 1
- 108090000691 Ornithine aminotransferases Proteins 0.000 claims 1
- 102000004132 Ornithine aminotransferases Human genes 0.000 claims 1
- 241000736131 Sphingomonas Species 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 150000004716 alpha keto acids Chemical class 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 101150026728 tesB gene Proteins 0.000 claims 1
- 150000007970 thio esters Chemical class 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578272P | 2011-12-21 | 2011-12-21 | |
| US201161578265P | 2011-12-21 | 2011-12-21 | |
| US201161578289P | 2011-12-21 | 2011-12-21 | |
| US61/578,272 | 2011-12-21 | ||
| US61/578,289 | 2011-12-21 | ||
| US61/578,265 | 2011-12-21 | ||
| PCT/US2012/044984 WO2013003744A2 (en) | 2011-06-30 | 2012-06-29 | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters |
| USPCT/US2012/044984 | 2012-06-29 | ||
| PCT/US2012/071472 WO2013096898A2 (en) | 2011-12-21 | 2012-12-21 | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017034360A Division JP2017131229A (ja) | 2011-12-21 | 2017-02-27 | ナイロン−７、ナイロン−７，７、およびポリエステルを生産するための生物変換方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500663A JP2015500663A (ja) | 2015-01-08 |
| JP2015500663A5 true JP2015500663A5 (https=) | 2016-02-12 |
Family
ID=48669717
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548982A Pending JP2015500663A (ja) | 2011-12-21 | 2012-12-21 | ナイロン−７、ナイロン−７，７、およびポリエステルを生産するための生物変換方法 |
| JP2017034360A Pending JP2017131229A (ja) | 2011-12-21 | 2017-02-27 | ナイロン−７、ナイロン−７，７、およびポリエステルを生産するための生物変換方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017034360A Pending JP2017131229A (ja) | 2011-12-21 | 2017-02-27 | ナイロン−７、ナイロン−７，７、およびポリエステルを生産するための生物変換方法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2794897A2 (https=) |
| JP (2) | JP2015500663A (https=) |
| CN (1) | CN104126012A (https=) |
| BR (1) | BR112014015077A2 (https=) |
| WO (1) | WO2013096898A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2720997A1 (en) | 2011-06-17 | 2014-04-23 | Invista Technologies S.à.r.l. | Use of hydrolases to increase monomer content in waste stream |
| EP2726627A2 (en) * | 2011-06-30 | 2014-05-07 | Invista Technologies S.à.r.l. | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters |
| US9102960B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| US9102958B2 (en) | 2011-12-16 | 2015-08-11 | Invista North America S.á.r.l. | Methods of producing 6-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| US9790525B2 (en) | 2012-12-14 | 2017-10-17 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via CoA-dependent carbon chain elongation associated with carbon storage |
| EP2938734A2 (en) * | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via aromatic compounds |
| WO2014105793A1 (en) * | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals from long chain fatty acids via oxidative cleavage |
| CN105408487A (zh) * | 2012-12-31 | 2016-03-16 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产7碳化学物的方法 |
| EP2938736A2 (en) * | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via c1 carbon chain elongation associated with coenzyme b synthesis |
| CN105073214A (zh) | 2012-12-31 | 2015-11-18 | 英威达技术有限责任公司 | 通过甲酯保护的碳链延伸生产6碳化学物的方法 |
| EP2938731A2 (en) * | 2012-12-31 | 2015-11-04 | Invista Technologies S.A R.L. | Methods of producing 7-carbon chemicals via carbon chain elongation associated with cyclohexane carboxylate synthesis |
| WO2014105797A2 (en) * | 2012-12-31 | 2014-07-03 | Invista North America S.A.R.L. | Methods of producing 7-carbon chemicals via pyruvate and succinate semialdehyde aldol condensation |
| US9745607B2 (en) | 2014-05-15 | 2017-08-29 | Invista North America S.A.R.L. | Methods of producing 6-carbon chemicals using 2,6-diaminopimelate as precursor to 2-aminopimelate |
| US20170152531A1 (en) | 2014-06-16 | 2017-06-01 | North America S.A.R.L. | Process for producing glutarate and glutaric acid methyl ester |
| CN106795535A (zh) | 2014-06-16 | 2017-05-31 | 英威达技术有限责任公司 | 用于生物合成化合物的方法，试剂和细胞 |
| US9988654B2 (en) | 2014-06-16 | 2018-06-05 | Invista North America S.A.R.L. | Methods, reagents and cells for biosynthesizing compounds |
| US9957535B2 (en) | 2014-06-16 | 2018-05-01 | Invista North America S.A.R.L. | Methods, reagents and cells for biosynthesizing compounds |
| EP3224366A1 (en) * | 2014-11-26 | 2017-10-04 | Invista Technologies S.A.R.L. | Methods and materials for producing 7-carbon chemicals via a c9 route |
| CN108998430B (zh) * | 2018-06-29 | 2020-11-13 | 浙江工业大学 | 一种界面自组装羰基还原酶及在(r)-3-羟基-3-苯基丙酸乙酯合成中的应用 |
| CN116790698B (zh) * | 2023-06-21 | 2024-06-18 | 南京大学 | 基于氧化脱羧酶的硫醛合成方法及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3719561A (en) * | 1966-08-26 | 1973-03-06 | Kyowa Hakko Kogyo Kk | Process for producing diaminopimelic acid |
| FR2921364B1 (fr) * | 2007-09-20 | 2009-11-06 | Arkema France | Procede de coproduction de 7-oxoheptanoate de methyle et d'acide undecylenique a partir d'acide ricinoleique |
| US8569023B2 (en) * | 2008-03-28 | 2013-10-29 | The Regents Of The University Of California | Producing dicarboxylic acids using polyketide synthases |
| US8192976B2 (en) * | 2008-12-12 | 2012-06-05 | Celexion, Llc | Biological synthesis of difunctional alkanes from carbohydrate feedstocks |
| WO2010104391A2 (en) * | 2009-03-11 | 2010-09-16 | Dsm Ip Assets B.V. | Preparation of adipic acid |
| EA201200454A1 (ru) * | 2009-09-11 | 2013-01-30 | ДСМ АйПи АССЕТС Б.В. | Получение альфа-кетопимелиновой кислоты |
| TW201127961A (en) * | 2009-09-11 | 2011-08-16 | Dsm Ip Assets Bv | Preparation of a compound comprising an amine group from an alpha-keto acid |
| WO2012031910A2 (en) * | 2010-09-10 | 2012-03-15 | Dsm Ip Assets B.V. | Method for preparing alpha-ketopimelic acid by c1-elongation |
| EP2726627A2 (en) * | 2011-06-30 | 2014-05-07 | Invista Technologies S.à.r.l. | Bioconversion process for producing nylon-7, nylon-7,7 and polyesters |
-
2012
- 2012-12-21 CN CN201280070432.9A patent/CN104126012A/zh active Pending
- 2012-12-21 BR BR112014015077-0A patent/BR112014015077A2/pt not_active IP Right Cessation
- 2012-12-21 WO PCT/US2012/071472 patent/WO2013096898A2/en not_active Ceased
- 2012-12-21 EP EP12816586.7A patent/EP2794897A2/en not_active Withdrawn
- 2012-12-21 JP JP2014548982A patent/JP2015500663A/ja active Pending
-
2017
- 2017-02-27 JP JP2017034360A patent/JP2017131229A/ja active Pending
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