JP2015500328A5 - - Google Patents
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- Publication number
- JP2015500328A5 JP2015500328A5 JP2014546670A JP2014546670A JP2015500328A5 JP 2015500328 A5 JP2015500328 A5 JP 2015500328A5 JP 2014546670 A JP2014546670 A JP 2014546670A JP 2014546670 A JP2014546670 A JP 2014546670A JP 2015500328 A5 JP2015500328 A5 JP 2015500328A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- tumor
- brain
- minicells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002246 antineoplastic agent Substances 0.000 claims description 24
- 206010028980 Neoplasm Diseases 0.000 claims description 15
- 229940034982 antineoplastic agent Drugs 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 11
- 229940127089 cytotoxic agent Drugs 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 9
- 239000003446 ligand Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000006907 apoptotic process Effects 0.000 claims description 5
- 108091033319 polynucleotide Proteins 0.000 claims description 5
- 102000040430 polynucleotide Human genes 0.000 claims description 5
- 239000002157 polynucleotide Substances 0.000 claims description 5
- 150000001720 carbohydrates Chemical class 0.000 claims description 4
- 239000002158 endotoxin Substances 0.000 claims description 4
- 235000014633 carbohydrates Nutrition 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 3
- 230000025084 cell cycle arrest Effects 0.000 claims description 3
- 238000002512 chemotherapy Methods 0.000 claims description 3
- PNDPGZBMCMUPRI-HVTJNCQCSA-N 10043-66-0 Chemical compound [131I][131I] PNDPGZBMCMUPRI-HVTJNCQCSA-N 0.000 claims description 2
- 108020005544 Antisense RNA Proteins 0.000 claims description 2
- 241000894006 Bacteria Species 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- GYHNNYVSQQEPJS-OIOBTWANSA-N Gallium-67 Chemical compound [67Ga] GYHNNYVSQQEPJS-OIOBTWANSA-N 0.000 claims description 2
- ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 claims description 2
- 108091007460 Long intergenic noncoding RNA Proteins 0.000 claims description 2
- IGLNJRXAVVLDKE-OIOBTWANSA-N Rubidium-82 Chemical compound [82Rb] IGLNJRXAVVLDKE-OIOBTWANSA-N 0.000 claims description 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims description 2
- FHNFHKCVQCLJFQ-NJFSPNSNSA-N Xenon-133 Chemical compound [133Xe] FHNFHKCVQCLJFQ-NJFSPNSNSA-N 0.000 claims description 2
- VWQVUPCCIRVNHF-OUBTZVSYSA-N Yttrium-90 Chemical group [90Y] VWQVUPCCIRVNHF-OUBTZVSYSA-N 0.000 claims description 2
- 239000003184 complementary RNA Substances 0.000 claims description 2
- YCKRFDGAMUMZLT-BJUDXGSMSA-N fluorine-18 atom Chemical compound [18F] YCKRFDGAMUMZLT-BJUDXGSMSA-N 0.000 claims description 2
- 229940006110 gallium-67 Drugs 0.000 claims description 2
- 229940055742 indium-111 Drugs 0.000 claims description 2
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims description 2
- 108091070501 miRNA Proteins 0.000 claims description 2
- 239000002679 microRNA Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 239000002924 silencing RNA Substances 0.000 claims description 2
- 239000004055 small Interfering RNA Substances 0.000 claims description 2
- 229940056501 technetium 99m Drugs 0.000 claims description 2
- BKVIYDNLLOSFOA-OIOBTWANSA-N thallium-201 Chemical compound [201Tl] BKVIYDNLLOSFOA-OIOBTWANSA-N 0.000 claims description 2
- 229940106670 xenon-133 Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 208000003174 Brain Neoplasms Diseases 0.000 claims 13
- 230000033115 angiogenesis Effects 0.000 claims 6
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 208000003200 Adenoma Diseases 0.000 claims 2
- 206010001233 Adenoma benign Diseases 0.000 claims 2
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 208000009798 Craniopharyngioma Diseases 0.000 claims 2
- 206010014967 Ependymoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 201000010133 Oligodendroglioma Diseases 0.000 claims 2
- 206010057249 Phagocytosis Diseases 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 210000004556 brain Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 230000008782 phagocytosis Effects 0.000 claims 2
- 230000001817 pituitary effect Effects 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108010001857 Cell Surface Receptors Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000006240 membrane receptors Human genes 0.000 claims 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 241001474374 Blennius Species 0.000 description 1
- 235000014653 Carica parviflora Nutrition 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- GZQKNULLWNGMCW-PWQABINMSA-N lipid A (E. coli) Chemical compound O1[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)[C@@H](NC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)[C@@H]1OC[C@@H]1[C@@H](O)[C@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OP(O)(O)=O)O1 GZQKNULLWNGMCW-PWQABINMSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 230000005747 tumor angiogenesis Effects 0.000 description 1
- 230000004565 tumor cell growth Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569907P | 2011-12-13 | 2011-12-13 | |
| US61/569,907 | 2011-12-13 | ||
| PCT/IB2012/002950 WO2013088250A1 (en) | 2011-12-13 | 2012-12-12 | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017158959A Division JP6594383B2 (ja) | 2011-12-13 | 2017-08-22 | 治療薬を脳腫瘍に送達するための細菌由来のインタクトなミニセル |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500328A JP2015500328A (ja) | 2015-01-05 |
| JP2015500328A5 true JP2015500328A5 (https=) | 2016-02-04 |
| JP6522340B2 JP6522340B2 (ja) | 2019-05-29 |
Family
ID=48611925
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014546670A Active JP6522340B2 (ja) | 2011-12-13 | 2012-12-12 | 治療薬を脳腫瘍に送達するための細菌由来のインタクトなミニセル |
| JP2017158959A Active JP6594383B2 (ja) | 2011-12-13 | 2017-08-22 | 治療薬を脳腫瘍に送達するための細菌由来のインタクトなミニセル |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017158959A Active JP6594383B2 (ja) | 2011-12-13 | 2017-08-22 | 治療薬を脳腫瘍に送達するための細菌由来のインタクトなミニセル |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9844598B2 (https=) |
| EP (1) | EP2790668B1 (https=) |
| JP (2) | JP6522340B2 (https=) |
| KR (2) | KR20140102294A (https=) |
| CN (2) | CN109125286A (https=) |
| AU (2) | AU2012351743B2 (https=) |
| CA (1) | CA2858315C (https=) |
| CY (1) | CY1123824T1 (https=) |
| DK (1) | DK2790668T3 (https=) |
| ES (1) | ES2843402T3 (https=) |
| HR (1) | HRP20201930T1 (https=) |
| HU (1) | HUE052136T2 (https=) |
| IL (1) | IL233031B (https=) |
| LT (1) | LT2790668T (https=) |
| MX (2) | MX385832B (https=) |
| PT (1) | PT2790668T (https=) |
| RS (1) | RS61161B1 (https=) |
| RU (1) | RU2664698C2 (https=) |
| SG (2) | SG11201403062YA (https=) |
| SI (1) | SI2790668T1 (https=) |
| SM (1) | SMT202000676T1 (https=) |
| TW (1) | TWI627966B (https=) |
| WO (1) | WO2013088250A1 (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060403A2 (en) * | 2003-01-06 | 2004-07-22 | Angiochem Inc. | Aprotinin and anglos as carriers across the blood-brain barrier |
| US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| MX355683B (es) | 2008-04-18 | 2018-04-26 | Angiochem Inc | Composiciones farmacéuticas de paclitaxel, análogos de paclitaxel o conjugados de paclitaxel, y métodos relacionados de preparación y uso. |
| WO2010043049A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
| CA2740316A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Conjugates of glp-1 agonists and uses thereof |
| CA2745524C (en) | 2008-12-05 | 2020-06-09 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| US8853353B2 (en) | 2008-12-17 | 2014-10-07 | Angiochem, Inc. | Membrane type-1 matrix metalloprotein inhibitors and uses thereof |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| RU2012103240A (ru) | 2009-07-02 | 2013-08-10 | Ангиокем Инк. | Мультимерные пептидные конъюгаты и их применение |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| RU2664698C2 (ru) | 2011-12-13 | 2018-08-21 | Энджинеик Молекьюлар Деливери Пти Лтд | Полученные из бактерий интактные мини-клетки для доставки лекарственных средств к опухолям мозга |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| WO2015034925A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| EP3041934A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| AP2016009153A0 (en) * | 2013-10-04 | 2016-04-30 | Engeneic Molecular Delivery Pty Ltd | Combination tumor treatment with drug-loaded, bispecific ligand-targeted minicells and interferon-gamma |
| JP6626085B2 (ja) * | 2014-07-15 | 2019-12-25 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 骨髄由来抑制細胞の抑制及び免疫チェックポイント阻害の方法 |
| US20170204152A1 (en) | 2014-07-16 | 2017-07-20 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3171895A1 (en) | 2014-07-23 | 2017-05-31 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| AU2015326407C1 (en) * | 2014-10-03 | 2021-06-24 | Engeneic Molecular Delivery Pty Ltd | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| PL3394093T3 (pl) | 2015-12-23 | 2022-05-16 | Modernatx, Inc. | Metody stosowania polinukleotydów kodujących ligand ox40 |
| MA43587A (fr) | 2016-01-10 | 2018-11-14 | Modernatx Inc | Arnm thérapeutiques codant pour des anticorps anti-ctla-4 |
| JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
| EP3775258A4 (en) | 2018-03-28 | 2022-01-26 | Board of Regents, The University of Texas System | IDENTIFICATION OF EPIGENETIC ALTERATIONS IN DNA ISOLATED FROM EXOSOMES |
| DE102018220892A1 (de) * | 2018-12-04 | 2020-06-04 | Robert Bosch Gmbh | Vorrichtung und Verfahren zur Generierung von Labelobjekten für die Umgebung eines Fahrzeugs |
| US20220031862A1 (en) * | 2018-12-10 | 2022-02-03 | Flagship Pioneering Innovations Vi, Llc | Achromosomal dynamic active systems |
| US20220202950A1 (en) * | 2019-05-01 | 2022-06-30 | Engeneic Molecular Delivery Pty Ltd | Compositions comprising bacterially derived intact minicells for theranostic applications |
| CN114641310A (zh) * | 2019-06-21 | 2022-06-17 | 德克萨斯大学系统董事会 | 治疗癌症和其他疾病的靶向α3β1整合素 |
| CN111001014B (zh) * | 2019-12-12 | 2022-04-22 | 四川大学华西医院 | 一种基于固定细菌做载体的抗肿瘤药物及其应用 |
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| JPH0222340Y2 (https=) | 1986-11-18 | 1990-06-15 | ||
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| AU4056000A (en) | 1999-04-02 | 2000-10-23 | Center For Molecular Medicine And Immunology | Method of detecting endometriosis |
| US6342219B1 (en) * | 1999-04-28 | 2002-01-29 | Board Of Regents, The University Of Texas System | Antibody compositions for selectively inhibiting VEGF |
| FR2793684B1 (fr) | 1999-05-17 | 2001-08-10 | Ethypharm Lab Prod Ethiques | Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant |
| US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| US20030203411A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Methods of minicell-based delivery |
| JP4458846B2 (ja) | 2001-10-15 | 2010-04-28 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏにおけるＤＮＡ導入および遺伝子療法のためのベクターとしての完全なミニ細胞 |
| US7332585B2 (en) * | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US20040005700A1 (en) * | 2002-05-28 | 2004-01-08 | Surber Mark W. | Poroplasts |
| EP1507562B1 (en) | 2002-05-29 | 2010-03-24 | Immunomedics, Inc. | Compositions for radioimmunotherapy of brain |
| JP5138867B2 (ja) | 2002-08-01 | 2013-02-06 | イミューノメディクス、インコーポレイテッド | α−フェトタンパク質Ｉｍｍｕ３１抗体および融合タンパク質ならびにその使用方法 |
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| DK1694361T3 (da) * | 2003-12-09 | 2011-06-06 | Engeneic Molecular Delivery Pty Ltd | Målrettet levering til ikke-phagocytiske pattedyrceller via bakterielt afledte intakte miniceller |
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| HUE024999T2 (en) * | 2004-08-26 | 2016-02-29 | Engeneic Molecular Delivery Pty Ltd | Introducing functional nucleic acids into mammalian cells with bacterial intact minicells |
| WO2006099445A2 (en) | 2005-03-14 | 2006-09-21 | Massachusetts Institute Of Technology | Nanocells for diagnosis and treatment of diseases and disorders |
| CA2646329C (en) | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| US9878043B2 (en) * | 2006-06-23 | 2018-01-30 | Engeneic Molecular Delivery Pty Ltd | Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells |
| JP2010507645A (ja) * | 2006-10-25 | 2010-03-11 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 前立腺癌を検出するための造影剤 |
| HRP20150328T1 (hr) | 2007-03-30 | 2015-05-22 | Engeneic Molecular Delivery Pty Ltd. | Bakterijski dobivene, intaktne mini-stanice koje obuhvaä†aju funkcionalnu nukleinsku kiselinu, bez plazmida, za in vivo dopremu do stanica sisavaca |
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| CA2827443C (en) * | 2011-02-15 | 2021-07-06 | Vaxiion Therapeutics, Inc. | Therapeutic compositions and methods for antibody and fc-containing targeting molecule-based targeted delivery of bioactive molecules by bacterial minicells |
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| EP3826654A4 (en) | 2018-07-23 | 2022-07-06 | EnGeneIC Molecular Delivery Pty Ltd | COMPOSITIONS COMPRISING MINICELLS OF BACTERIAL ORIGIN AND THEIR METHODS OF USE |
-
2012
- 2012-12-12 RU RU2014128338A patent/RU2664698C2/ru active
- 2012-12-12 PT PT128574522T patent/PT2790668T/pt unknown
- 2012-12-12 CA CA2858315A patent/CA2858315C/en active Active
- 2012-12-12 US US13/711,848 patent/US9844598B2/en active Active
- 2012-12-12 LT LTEP12857452.2T patent/LT2790668T/lt unknown
- 2012-12-12 KR KR1020147019228A patent/KR20140102294A/ko not_active Ceased
- 2012-12-12 MX MX2018011664A patent/MX385832B/es unknown
- 2012-12-12 HR HRP20201930TT patent/HRP20201930T1/hr unknown
- 2012-12-12 SG SG11201403062YA patent/SG11201403062YA/en unknown
- 2012-12-12 EP EP12857452.2A patent/EP2790668B1/en active Active
- 2012-12-12 RS RS20201489A patent/RS61161B1/sr unknown
- 2012-12-12 AU AU2012351743A patent/AU2012351743B2/en active Active
- 2012-12-12 SM SM20200676T patent/SMT202000676T1/it unknown
- 2012-12-12 SG SG10201601349XA patent/SG10201601349XA/en unknown
- 2012-12-12 MX MX2014006967A patent/MX359410B/es active IP Right Grant
- 2012-12-12 JP JP2014546670A patent/JP6522340B2/ja active Active
- 2012-12-12 HU HUE12857452A patent/HUE052136T2/hu unknown
- 2012-12-12 WO PCT/IB2012/002950 patent/WO2013088250A1/en not_active Ceased
- 2012-12-12 SI SI201231862T patent/SI2790668T1/sl unknown
- 2012-12-12 DK DK12857452.2T patent/DK2790668T3/da active
- 2012-12-12 CN CN201811227385.XA patent/CN109125286A/zh active Pending
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