JP2015513919A5 - - Google Patents
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- Publication number
- JP2015513919A5 JP2015513919A5 JP2015505732A JP2015505732A JP2015513919A5 JP 2015513919 A5 JP2015513919 A5 JP 2015513919A5 JP 2015505732 A JP2015505732 A JP 2015505732A JP 2015505732 A JP2015505732 A JP 2015505732A JP 2015513919 A5 JP2015513919 A5 JP 2015513919A5
- Authority
- JP
- Japan
- Prior art keywords
- pancreatic cancer
- cancer cell
- aptamer
- molecules
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 25
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 25
- 201000002528 pancreatic cancer Diseases 0.000 claims 25
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 25
- 210000004027 cell Anatomy 0.000 claims 18
- 108091023037 Aptamer Proteins 0.000 claims 14
- 229940124597 therapeutic agent Drugs 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 3
- 239000000032 diagnostic agent Substances 0.000 claims 3
- 229940039227 diagnostic agent Drugs 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000009164 Islet Cell Adenoma Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108091027967 Small hairpin RNA Proteins 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 239000012830 cancer therapeutic Substances 0.000 claims 2
- 201000000052 gastrinoma Diseases 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 108091070501 miRNA Proteins 0.000 claims 2
- 239000002679 microRNA Substances 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 239000004055 small Interfering RNA Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010068873 Adenosquamous cell carcinoma Diseases 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 208000007569 Giant Cell Tumors Diseases 0.000 claims 1
- 206010018404 Glucagonoma Diseases 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 206010073150 Multiple endocrine neoplasia Type 1 Diseases 0.000 claims 1
- 206010041329 Somatostatinoma Diseases 0.000 claims 1
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 claims 1
- 102400000015 Vasoactive intestinal peptide Human genes 0.000 claims 1
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 1
- 208000006336 acinar cell carcinoma Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 201000008395 adenosquamous carcinoma Diseases 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000000975 dye Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 206010022498 insulinoma Diseases 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 claims 1
- 201000002529 islet cell tumor Diseases 0.000 claims 1
- 208000010492 mucinous cystadenocarcinoma Diseases 0.000 claims 1
- 208000022669 mucinous neoplasm Diseases 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 208000021255 pancreatic insulinoma Diseases 0.000 claims 1
- 208000022102 pancreatic neuroendocrine neoplasm Diseases 0.000 claims 1
- 208000002820 pancreatoblastoma Diseases 0.000 claims 1
- 239000012857 radioactive material Substances 0.000 claims 1
- 208000011581 secondary neoplasm Diseases 0.000 claims 1
- 208000004548 serous cystadenocarcinoma Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000005945 translocation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261622375P | 2012-04-10 | 2012-04-10 | |
| US61/622,375 | 2012-04-10 | ||
| PCT/US2013/031074 WO2013154735A1 (en) | 2012-04-10 | 2013-03-13 | Rna aptamers for therapeutic and diagnostic delivery to pancreatic cancer cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015513919A JP2015513919A (ja) | 2015-05-18 |
| JP2015513919A5 true JP2015513919A5 (https=) | 2016-04-28 |
Family
ID=49328023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505732A Pending JP2015513919A (ja) | 2012-04-10 | 2013-03-13 | 膵癌細胞への治療的送達および診断的送達のためのｒｎａアプタマー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9464293B2 (https=) |
| EP (1) | EP2836501B1 (https=) |
| JP (1) | JP2015513919A (https=) |
| AU (1) | AU2013246419A1 (https=) |
| CA (1) | CA2870288A1 (https=) |
| WO (1) | WO2013154735A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102121086B1 (ko) | 2012-11-01 | 2020-06-09 | 팩터 바이오사이언스 인크. | 세포에서 단백질을 발현시키는 방법들과 생성물들 |
| WO2014144744A1 (en) * | 2013-03-15 | 2014-09-18 | The Trustees Of Columbia University In The City Of New York | Aptamer methods and compositions |
| EP3024497B1 (en) * | 2013-07-26 | 2021-01-13 | University of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| EP3149167B1 (en) * | 2014-05-30 | 2019-09-04 | Academia Sinica | Aptamer targeting mage-a3 peptide and uses thereof |
| CN107106697B (zh) * | 2014-10-15 | 2021-06-18 | 希望之城 | Pdgfr rna适体 |
| US10550394B2 (en) | 2015-03-31 | 2020-02-04 | City Of Hope | Anti-cancer RNA aptamers |
| JP7041517B2 (ja) * | 2015-10-30 | 2022-03-24 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 癌細胞に結合するｄｎａアプタマー |
| US11219635B2 (en) | 2016-02-19 | 2022-01-11 | City Of Hope | Bi-specific aptamer |
| US11845938B2 (en) | 2016-03-31 | 2023-12-19 | City Of Hope | Aptamer compositions and the use thereof |
| KR20200068647A (ko) | 2017-08-11 | 2020-06-15 | 시티 오브 호프 | 트랜스페린 수용체 (TfR)에 대한 RNA 앱타머 |
| US20200181264A1 (en) * | 2017-08-11 | 2020-06-11 | City Of Hope | Bispecific antigen-binding molecule |
| PL3502552T3 (pl) * | 2017-12-21 | 2022-12-12 | Marelli Automotive Lighting Italy S.p.A. | Lampa pojazdu z częściami o różnych poziomach luminancji |
| US11225665B2 (en) | 2019-06-20 | 2022-01-18 | City Of Hope | P38 map kinase inhibitors |
| KR102294694B1 (ko) * | 2019-07-18 | 2021-08-30 | 국립암센터 | 신규한 dna 앱타머 및 이의 용도 |
| BR112023022439A2 (pt) | 2021-04-26 | 2023-12-26 | Celanese Eva Performance Polymers Llc | Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular |
| CN119855910A (zh) | 2022-07-06 | 2025-04-18 | 美国微哲默理有限责任公司 | 用于治疗胰腺癌的组合物和方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030073207A1 (en) * | 1997-01-31 | 2003-04-17 | Saghir Akhtar | Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors |
| WO1999065928A2 (en) * | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Polynucleotide population isolated from non-metastatic and metastatic breast tumor tissues |
| US20030064946A1 (en) * | 2000-08-09 | 2003-04-03 | Mcswiggen James | Method and reagent for the inhibition of calcium activated chloride channel-1 (CLCA-1) |
| EP1499895B1 (en) | 2002-04-22 | 2008-05-07 | University Of Florida | Functionalized nanoparticles and methods of use |
| US7115374B2 (en) * | 2002-10-16 | 2006-10-03 | Gen-Probe Incorporated | Compositions and methods for detecting West Nile virus |
| US7655785B1 (en) * | 2002-11-14 | 2010-02-02 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
| US20100254901A1 (en) | 2005-07-28 | 2010-10-07 | Smith Cassandra L | Compositions comprising nucleic acid aptamers |
| GB2437727B (en) | 2006-05-04 | 2011-04-20 | Univ Open | Aptamers directed to MUC1 |
| WO2007128109A1 (en) * | 2006-05-04 | 2007-11-15 | University Health Network | Aptamers that recognize the carbohydrate n-acetylgalactosamine (galnac) |
| WO2007137117A2 (en) | 2006-05-17 | 2007-11-29 | Massachusetts Institute Of Technology | Aptamer-directed drug delivery |
| US20090169613A1 (en) * | 2007-11-09 | 2009-07-02 | Reznik Boris N | Targeting of tumor stem cells through selective silencing of boris expression |
| US7875711B2 (en) * | 2008-04-17 | 2011-01-25 | Alnylam Pharamaceuticals, Inc. | Compositions and methods for inhibiting expression of XBP-1 gene |
| EP2481800B1 (en) * | 2009-06-01 | 2018-02-21 | Sungkyunkwan University Foundation For Corporate Collaboration | Nucleic acid aptamer specifically binding to pancreatic cancer cells or tissues and use thereof |
-
2013
- 2013-03-13 EP EP13775956.9A patent/EP2836501B1/en not_active Not-in-force
- 2013-03-13 JP JP2015505732A patent/JP2015513919A/ja active Pending
- 2013-03-13 AU AU2013246419A patent/AU2013246419A1/en not_active Abandoned
- 2013-03-13 WO PCT/US2013/031074 patent/WO2013154735A1/en not_active Ceased
- 2013-03-13 US US14/391,997 patent/US9464293B2/en active Active
- 2013-03-13 CA CA2870288A patent/CA2870288A1/en not_active Abandoned
-
2016
- 2016-03-28 US US15/082,621 patent/US20160201059A1/en not_active Abandoned
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