HRP20201930T1 - Intaktne mini - stanice izvedene od bakterija za dovođenje terapeutskih agenasa tumorima na mozgu - Google Patents
Intaktne mini - stanice izvedene od bakterija za dovođenje terapeutskih agenasa tumorima na mozgu Download PDFInfo
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- HRP20201930T1 HRP20201930T1 HRP20201930TT HRP20201930T HRP20201930T1 HR P20201930 T1 HRP20201930 T1 HR P20201930T1 HR P20201930T T HRP20201930T T HR P20201930TT HR P20201930 T HRP20201930 T HR P20201930T HR P20201930 T1 HRP20201930 T1 HR P20201930T1
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- 208000003174 Brain Neoplasms Diseases 0.000 title claims 6
- 239000003814 drug Substances 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 21
- 239000002246 antineoplastic agent Substances 0.000 claims 5
- 229940034982 antineoplastic agent Drugs 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229940044683 chemotherapy drug Drugs 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 230000006907 apoptotic process Effects 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108020005544 Antisense RNA Proteins 0.000 claims 1
- 206010003571 Astrocytoma Diseases 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 208000009798 Craniopharyngioma Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 108091007460 Long intergenic noncoding RNA Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012247 Oligodendroglial tumor Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 208000007641 Pinealoma Diseases 0.000 claims 1
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 1
- 108091027967 Small hairpin RNA Proteins 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000025084 cell cycle arrest Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000030883 malignant astrocytoma Diseases 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 108091070501 miRNA Proteins 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 230000000242 pagocytic effect Effects 0.000 claims 1
- 208000024724 pineal body neoplasm Diseases 0.000 claims 1
- 208000010916 pituitary tumor Diseases 0.000 claims 1
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 239000004055 small Interfering RNA Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000007910 systemic administration Methods 0.000 claims 1
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Claims (16)
1. Sastav za korištenje u liječenju tumora na mozgu putem sistemskog davanja, naznačen time da sastav obuhvaća mnoštvo intaktnih mini - stanica izvedenih od bakterija, i naznačen time da:
(A) svaka mini – stanica iz navedenog mnoštva (i) sadrži antitijelo koje specifično prepoznaje antigen tumorskih stanica i (ii) obuhvaća antineoplastično sredstvo; i
(B) tumor na mozgu ima krvne žile s otvorima u stijenkama kroz koje mini - stanice mogu pasivno ekstravazirati.
2. Sastav za korištenje prema zahtjevu 1, naznačen time da je navedeno antineoplastično sredstvo radionuklid.
3. Sastav za korištenje prema zahtjevu 2, naznačen time da navedeni sastav sadrži otprilike 30 Gy do otprilike 100 Gy radioaktivnosti.
4. Sastav za korištenje prema zahtjevu 1, naznačen time da navedeno antineoplastično sredstvo kemoterapijski lijek.
5. Sastav za korištenje prema zahtjevu 4, naznačen time da navedeni kemoterapijski lijek ima molekularnu težinu od više nego otprilike 400 Daltona.
6. Sastav za korištenje prema bilo kojem od zahtjeva 4 i 5, naznačen time da navedeni sastav sadrži najvište otprilike 1 mg navedenog kemoterapijskog lijeka.
7. Sastav za korištenje prema zahtjevu 1, naznačen time da je navedeno antineoplastično sredstvo funkcionalna nukleinska kiselina ili polinukleotid koji kodira funkcionalnu nukleinsku kiselinu.
8. Sastav za korištenje prema zahtjevu 7, naznačen time da navedena funkcionalna nukleinska kiselina inhibira gen koji potiče proliferaciju tumorskih stanica , angiogenezu ili otpornost na kemoterapiju i/ili inhibira apoptozu ili zaustavljanje staničnog ciklusa.
9. Sastav za korištenje prema zahtjevu 7, naznačen time da je navedena funkcionana nukleinska kiselina odabrana od siRNA, miRNA, shRNA, lincRNA, protusmislene RNA, ili ribozima.
10. Sastav za korištenje prema zahtjevu 1, naznačen time da je navedeno neoplastično sredstvo polinukleotid koji kodira gen koji potiče apoptozu.
11. Sastav za korištenje prema bilo kojem od zahtjeva 1 do 10, naznačen time da svaka mini - stanica od navedenog mnoštva obuhvaća ligand koji ima posebnost na nefagocitni receptor površine stanice sisavaca.
12. Sastav za korištenje prema zahtjevu 11, naznačen time da je navedeni receptor antigen tumorske stanice.
13. Sastav za korištenje prema bilo kojem od zahtjeva 1 do 12, naznačen time da navedeni sastav sadrži manje od otprilike 10 EU slobodnih endotoksina.
14. Sastav za korištenje prema bilo kojem od zahtjeva 1 do 13, naznačen time da navedeni sastav sadrži najviše 1 matičnu bakterijsku stanicu na 108 mini - stanica.
15. Sastav za korištenje prema bilo kojem od zahtjeva 1 do 14, naznačen time da je navedeni tumor na mozgu odabran od glioblastoma, astrocitnog tumora, oligodendroglijalnog tumora, ependimoma, kraniofaringioma, tumora hipofize, primarnog limfoma mozga, tumora epifize, primarni tumor matičnih stanica na mozgu, i kombinacije navedenih.
16. Sastav za korištenje prema zahtjevu 15, naznačen time da je navedeni tumor na mozgu metastatski tumor na mozgu.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161569907P | 2011-12-13 | 2011-12-13 | |
| EP12857452.2A EP2790668B1 (en) | 2011-12-13 | 2012-12-12 | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
| PCT/IB2012/002950 WO2013088250A1 (en) | 2011-12-13 | 2012-12-12 | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201930T1 true HRP20201930T1 (hr) | 2021-02-05 |
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ID=48611925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201930TT HRP20201930T1 (hr) | 2011-12-13 | 2020-12-03 | Intaktne mini - stanice izvedene od bakterija za dovođenje terapeutskih agenasa tumorima na mozgu |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US9844598B2 (hr) |
| EP (1) | EP2790668B1 (hr) |
| JP (2) | JP6522340B2 (hr) |
| KR (2) | KR102046042B1 (hr) |
| CN (2) | CN104114153A (hr) |
| AU (2) | AU2012351743B2 (hr) |
| CA (1) | CA2858315C (hr) |
| CY (1) | CY1123824T1 (hr) |
| DK (1) | DK2790668T3 (hr) |
| ES (1) | ES2843402T3 (hr) |
| HK (1) | HK1201473A1 (hr) |
| HR (1) | HRP20201930T1 (hr) |
| HU (1) | HUE052136T2 (hr) |
| IL (1) | IL233031B (hr) |
| LT (1) | LT2790668T (hr) |
| MX (1) | MX359410B (hr) |
| PT (1) | PT2790668T (hr) |
| RS (1) | RS61161B1 (hr) |
| RU (1) | RU2664698C2 (hr) |
| SG (2) | SG11201403062YA (hr) |
| SI (1) | SI2790668T1 (hr) |
| TW (1) | TWI627966B (hr) |
| WO (1) | WO2013088250A1 (hr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2516056C (en) * | 2003-01-06 | 2012-05-29 | Angiochem Inc. | Aprotinin and analogs as carriers across the blood-brain barrier |
| US9365634B2 (en) * | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
| EP2279008B1 (en) | 2008-04-18 | 2019-03-06 | Angiochem Inc. | Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use |
| BRPI0920209A2 (pt) | 2008-10-15 | 2015-12-22 | Angiochem Inc | conjugados de agonistas de glp-1 e usos dos mesmos |
| WO2010043049A1 (en) | 2008-10-15 | 2010-04-22 | Angiochem Inc. | Etoposide and doxorubicin conjugates for drug delivery |
| MX2011005963A (es) | 2008-12-05 | 2011-09-01 | Angiochem Inc | Conjugados de neurotensina o analogos de neurotensina y sus usos. |
| JP2012512185A (ja) | 2008-12-17 | 2012-05-31 | アンジオケム インコーポレーテッド | 膜１型マトリックス金属タンパク質阻害剤およびその使用 |
| MX2011011023A (es) | 2009-04-20 | 2012-01-20 | Angiochem Inc | Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2. |
| CN102596993A (zh) | 2009-07-02 | 2012-07-18 | 安吉奥开米公司 | 多聚体肽结合物以及其应用 |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| WO2012045082A2 (en) | 2010-10-01 | 2012-04-05 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3682905B1 (en) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| SG11201403062YA (en) * | 2011-12-13 | 2014-07-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
| DK2791160T3 (da) | 2011-12-16 | 2022-05-30 | Modernatx Inc | Modificerede mrna-sammensætninger |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| HRP20220607T1 (hr) | 2012-11-26 | 2022-06-24 | Modernatx, Inc. | Terminalno modificirana rna |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| JP2016530294A (ja) | 2013-09-03 | 2016-09-29 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | キメラポリヌクレオチド |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| MX2016004285A (es) | 2013-10-04 | 2016-07-08 | Engeneic Molecular Delivery Pty Ltd | Tratamiento de tumor por combinacion con minicelulas dirigidas a ligando, biespecificas, cargadas con farmacos e interferon-gamma. |
| CN107072984B (zh) * | 2014-07-15 | 2021-10-01 | 约翰·霍普金斯大学 | 源自骨髓的抑制细胞的抑制和免疫检查点阻断 |
| CA2955250A1 (en) | 2014-07-16 | 2016-01-21 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| US20170210788A1 (en) | 2014-07-23 | 2017-07-27 | Modernatx, Inc. | Modified polynucleotides for the production of intrabodies |
| EP3200765A4 (en) * | 2014-10-03 | 2018-05-30 | EnGeneIC Molecular Delivery Pty Ltd | Enhanced loading of intact, bacterially derived vesicles with small molecule compounds |
| JP6823055B2 (ja) | 2015-06-15 | 2021-01-27 | アンジオケム インコーポレーテッド | 軟髄膜癌腫症の治療方法 |
| SI3394093T1 (sl) | 2015-12-23 | 2022-05-31 | Modernatx, Inc. | Metode uporabe liganda OX40, ki kodira polinukleotid |
| US20190241658A1 (en) | 2016-01-10 | 2019-08-08 | Modernatx, Inc. | Therapeutic mRNAs encoding anti CTLA-4 antibodies |
| JP7285220B2 (ja) | 2017-05-18 | 2023-06-01 | モデルナティエックス インコーポレイテッド | 連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子 |
| DE102018220892A1 (de) * | 2018-12-04 | 2020-06-04 | Robert Bosch Gmbh | Vorrichtung und Verfahren zur Generierung von Labelobjekten für die Umgebung eines Fahrzeugs |
| SG11202105822WA (en) * | 2018-12-10 | 2021-06-29 | Flagship Pioneering Innovations Vi Llc | Achromosomal dynamic active systems |
| AU2020296004A1 (en) * | 2019-06-21 | 2022-01-27 | Board Of Regents, The University Of Texas System | Targeting alpha3beta1 integrin for treatment of cancer and other diseases |
| CN111001014B (zh) * | 2019-12-12 | 2022-04-22 | 四川大学华西医院 | 一种基于固定细菌做载体的抗肿瘤药物及其应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0222340Y2 (hr) | 1986-11-18 | 1990-06-15 | ||
| US6962702B2 (en) | 1998-06-22 | 2005-11-08 | Immunomedics Inc. | Production and use of novel peptide-based agents for use with bi-specific antibodies |
| AU4056000A (en) | 1999-04-02 | 2000-10-23 | Center For Molecular Medicine And Immunology | Method of detecting endometriosis |
| EP1185559A2 (en) | 1999-04-28 | 2002-03-13 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| FR2793684B1 (fr) | 1999-05-17 | 2001-08-10 | Ethypharm Lab Prod Ethiques | Utilisation de microspheres biodegradables liberant un agent anticancereux pour le traitement du glioblastome, procede de preparation de ces microspheres et suspension les contenant |
| US20030194798A1 (en) * | 2001-05-24 | 2003-10-16 | Surber Mark W. | Minicell compositions and methods |
| US20030203411A1 (en) * | 2001-06-05 | 2003-10-30 | Sabbadini Roger A. | Methods of minicell-based delivery |
| CA2463631C (en) * | 2001-10-15 | 2012-07-03 | Engeneic Gene Therapy Pty Limited | Intact minicells as vectors for dna transfer and gene therapy in vitro and in vivo |
| US7332585B2 (en) * | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US20040005700A1 (en) | 2002-05-28 | 2004-01-08 | Surber Mark W. | Poroplasts |
| DE60331827D1 (de) | 2002-05-29 | 2010-05-06 | Immunomedics Inc | Zusammensetzungen für die radioimmuntherapie von gehirn-tumoren |
| AU2003248982B2 (en) | 2002-08-01 | 2009-12-10 | Immunomedics, Inc. | Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof |
| US7611885B2 (en) | 2003-06-24 | 2009-11-03 | Engeneic Molecular Delivery Pty, Ltd. | Pharmaceutically compatible method for purifying intact bacterial minicells |
| PL1694361T3 (pl) | 2003-12-09 | 2011-08-31 | Engeneic Molecular Delivery Pty Ltd | Ukierunkowane dostarczanie genów do niefagocytujących komórek ssaczych z zastosowaniem nienaruszonych minikomórek pochodzących od bakterii |
| US8772013B2 (en) | 2004-02-02 | 2014-07-08 | Engeneic Molecular Delivery Pty Ltd | Methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
| CN102028953B (zh) | 2004-02-02 | 2013-10-30 | 恩杰内克分子递送有限公司 | 经细菌来源的完整微细胞在体外和体内将药物靶向递送至哺乳动物细胞的组合物和方法 |
| US7837998B2 (en) * | 2004-05-21 | 2010-11-23 | Nathaniel Lallatin | Anti-cancer activity of an anti-thymidine kinase monoclonal antibody |
| ES2535235T3 (es) | 2004-08-26 | 2015-05-07 | Engeneic Molecular Delivery Pty Ltd | Administración de ácidos nucleicos funcionales a células de mamífero a través de minicélulas intactas obtenidas a partir de bacterias |
| US20070065359A1 (en) | 2005-03-14 | 2007-03-22 | Shiladitya Sengupta | Nanocells for diagnosis and treatment of diseases and disorders |
| CA2646329C (en) | 2006-03-20 | 2018-07-03 | The Regents Of The University Of California | Engineered anti-prostate stem cell antigen (psca) antibodies for cancer targeting |
| PL2712618T3 (pl) * | 2006-06-23 | 2017-07-31 | Engeneic Molecular Delivery Pty Ltd. | Ukierunkowane dostarczanie leków, terapeutycznych kwasów nukleinowych i funkcjonalnych kwasów nukleinowych do komórek ssaczych przez nienaruszone, uśmiercone komórki bakteryjne |
| US20100215581A1 (en) | 2006-10-25 | 2010-08-26 | Koninklijke Philips Electronics N.V. | Contrast agents for detecting prostate cancer |
| CA2933978C (en) | 2007-03-30 | 2018-08-21 | Engeneic Molecular Delivery Pty. Ltd. | Bacterially-derived, intact minicells that encompass plasmid-free functional nucleic acid for in vivo delivery to mammalian cells |
| KR101813824B1 (ko) * | 2008-06-25 | 2017-12-29 | 벡션 테라퓨틱스 엘엘씨 | 조절된 유전자 자살 메커니즘 조성물 및 방법 |
| EP3059247B1 (en) * | 2008-12-05 | 2017-09-20 | Abraxis BioScience, LLC | Sparc binding peptides and uses thereof |
| CN103097417B (zh) | 2010-04-20 | 2019-04-09 | 根马布股份公司 | 含异二聚体抗体fc的蛋白及其制备方法 |
| DK2675474T3 (en) * | 2011-02-15 | 2019-04-23 | Vaxiion Therapeutics Llc | THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES |
| SG11201403062YA (en) | 2011-12-13 | 2014-07-30 | Engeneic Molecular Delivery Pty Ltd | Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors |
| JP2021532106A (ja) | 2018-07-23 | 2021-11-25 | エンジーンアイシー モレキュラー デリバリー ピーティーワイ リミテッド | 細菌由来ミニ細胞を含む組成物およびそれを使用する方法 |
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