JP2015107945A5 - - Google Patents
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- JP2015107945A5 JP2015107945A5 JP2013252443A JP2013252443A JP2015107945A5 JP 2015107945 A5 JP2015107945 A5 JP 2015107945A5 JP 2013252443 A JP2013252443 A JP 2013252443A JP 2013252443 A JP2013252443 A JP 2013252443A JP 2015107945 A5 JP2015107945 A5 JP 2015107945A5
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- Japan
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- hydrogen atom
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- 239000000203 mixture Substances 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 14
- 210000002569 neuron Anatomy 0.000 claims description 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 230000004663 cell proliferation Effects 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 230000004766 neurogenesis Effects 0.000 claims description 6
- 239000000651 prodrug Substances 0.000 claims description 6
- 229940002612 prodrug Drugs 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 230000003213 activating effect Effects 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 2
- 125000001931 aliphatic group Chemical group 0.000 claims description 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000006165 cyclic alkyl group Chemical group 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
- 125000002950 monocyclic group Chemical group 0.000 claims description 2
- 125000003367 polycyclic group Chemical group 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims description 2
- 125000004953 trihalomethyl group Chemical group 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 102100028554 Dual specificity tyrosine-phosphorylation-regulated kinase 1A Human genes 0.000 claims 2
- 101000838016 Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 1A Proteins 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- MOVHBYQABFWGEO-LCYFTJDESA-N CCN(C(C1C=COC1(C)C=C1)=C1S1)/C1=C/C(C)=O Chemical compound CCN(C(C1C=COC1(C)C=C1)=C1S1)/C1=C/C(C)=O MOVHBYQABFWGEO-LCYFTJDESA-N 0.000 description 1
- IZNKZNXIXHLRGY-JYRVWZFOSA-N CCN1c(c2c(cc3)OCC2)c3S/C1=C\C(C)=O Chemical compound CCN1c(c2c(cc3)OCC2)c3S/C1=C\C(C)=O IZNKZNXIXHLRGY-JYRVWZFOSA-N 0.000 description 1
- WJCUXFRHZYIEOR-YVLHZVERSA-N CCN1c(c2c(cc3)[o]c4c2ccc(C)c4)c3S/C1=C\C(C)=O Chemical compound CCN1c(c2c(cc3)[o]c4c2ccc(C)c4)c3S/C1=C\C(C)=O WJCUXFRHZYIEOR-YVLHZVERSA-N 0.000 description 1
- QIAFGVQZUDBBOX-YBEGLDIGSA-N CCN1c(c2c(cc3)[o]c4ccccc24)c3S/C1=C\C(C)=O Chemical compound CCN1c(c2c(cc3)[o]c4ccccc24)c3S/C1=C\C(C)=O QIAFGVQZUDBBOX-YBEGLDIGSA-N 0.000 description 1
- NHDNXYLLAQDNEW-PXNMLYILSA-N CCN1c2c(c(cc(cc3)Cl)c3[o]3)c3ccc2S/C1=C\C(C)=O Chemical compound CCN1c2c(c(cc(cc3)Cl)c3[o]3)c3ccc2S/C1=C\C(C)=O NHDNXYLLAQDNEW-PXNMLYILSA-N 0.000 description 1
- RUQRAQTVHSATEP-PXNMLYILSA-N CCN1c2c(c(ccc(Cl)c3)c3[o]3)c3ccc2S/C1=C\C(C)=O Chemical compound CCN1c2c(c(ccc(Cl)c3)c3[o]3)c3ccc2S/C1=C\C(C)=O RUQRAQTVHSATEP-PXNMLYILSA-N 0.000 description 1
- KAOGHERYRZIKQY-YVLHZVERSA-N CCN1c2c(c3cc(C)ccc3[o]3)c3ccc2S/C1=C\C(C)=O Chemical compound CCN1c2c(c3cc(C)ccc3[o]3)c3ccc2S/C1=C\C(C)=O KAOGHERYRZIKQY-YVLHZVERSA-N 0.000 description 1
- 0 Cc(nccc1c2ccc3OC)c1[n]c2c3C#C[Si](C)(C)* Chemical compound Cc(nccc1c2ccc3OC)c1[n]c2c3C#C[Si](C)(C)* 0.000 description 1
- NRBGMOGXBQRJJI-UHFFFAOYSA-N Cc1c2[nH]c(c(-c3cc(C(F)(F)F)ccc3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(-c3cc(C(F)(F)F)ccc3)c(cc3)OC)c3c2ccn1 NRBGMOGXBQRJJI-UHFFFAOYSA-N 0.000 description 1
- XRKAGOQTYZDWCD-UHFFFAOYSA-N Cc1c2[nH]c(c(-c3ccc(C(F)(F)F)cc3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(-c3ccc(C(F)(F)F)cc3)c(cc3)OC)c3c2ccn1 XRKAGOQTYZDWCD-UHFFFAOYSA-N 0.000 description 1
- FZIYPGBZXZEVAD-UHFFFAOYSA-N Cc1c2[nH]c(c(C#CC3(CC(C4)C5)CC5CC4C3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(C#CC3(CC(C4)C5)CC5CC4C3)c(cc3)OC)c3c2ccn1 FZIYPGBZXZEVAD-UHFFFAOYSA-N 0.000 description 1
- HNEPVENUEAVPDF-UHFFFAOYSA-N Cc1c2[nH]c(c(C#CC3(CCCCC3)O)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(C#CC3(CCCCC3)O)c(cc3)OC)c3c2ccn1 HNEPVENUEAVPDF-UHFFFAOYSA-N 0.000 description 1
- NNBDGHSCJXGLIV-UHFFFAOYSA-N Cc1c2[nH]c(c(C#Cc3ccccc3)c(cc3)OC)c3c2ccn1 Chemical compound Cc1c2[nH]c(c(C#Cc3ccccc3)c(cc3)OC)c3c2ccn1 NNBDGHSCJXGLIV-UHFFFAOYSA-N 0.000 description 1
- XSJFNYCFKORWJZ-UHFFFAOYSA-N Cc1cc(C)cc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 Chemical compound Cc1cc(C)cc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 XSJFNYCFKORWJZ-UHFFFAOYSA-N 0.000 description 1
- IIUIFEXOMDUOPE-UHFFFAOYSA-N Cc1cccc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 Chemical compound Cc1cccc(-c(c2c(cc3)c4ccnc(C)c4[nH]2)c3OC)c1 IIUIFEXOMDUOPE-UHFFFAOYSA-N 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013252443A JP2015107945A (ja) | 2013-12-05 | 2013-12-05 | 神経新生に関する化合物及び医薬組成物 |
| PCT/JP2014/082035 WO2015083750A1 (ja) | 2013-12-05 | 2014-12-03 | 神経新生に関する化合物及び医薬組成物 |
| US15/101,862 US20160303089A1 (en) | 2013-12-05 | 2014-12-03 | Compound pertaining to neuropoiesis and drug composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013252443A JP2015107945A (ja) | 2013-12-05 | 2013-12-05 | 神経新生に関する化合物及び医薬組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015107945A JP2015107945A (ja) | 2015-06-11 |
| JP2015107945A5 true JP2015107945A5 (cg-RX-API-DMAC7.html) | 2017-01-19 |
Family
ID=53273511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013252443A Pending JP2015107945A (ja) | 2013-12-05 | 2013-12-05 | 神経新生に関する化合物及び医薬組成物 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20160303089A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2015107945A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015083750A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6231691B2 (ja) * | 2013-09-12 | 2017-11-15 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドール−カルボキサミド誘導体 |
| JP7054524B2 (ja) * | 2016-08-31 | 2022-04-14 | 国立大学法人京都大学 | 神経新生を活性化するための組成物 |
| EP3318563A1 (en) | 2016-11-07 | 2018-05-09 | Sanofi | Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders |
| CN110312528B (zh) | 2017-02-20 | 2022-02-18 | 国立大学法人京都大学 | 用于起因于剪接异常的遗传性疾病的药物组合物及治疗方法 |
| JPWO2021153665A1 (cg-RX-API-DMAC7.html) * | 2020-01-30 | 2021-08-05 | ||
| EP4129340B1 (en) * | 2020-04-01 | 2025-12-03 | Kyoto University | Suppression of neuroinflammation and composition and method therefor |
| JP7706775B2 (ja) * | 2020-09-18 | 2025-07-14 | カルナバイオサイエンス株式会社 | アミン誘導体 |
| WO2022186089A1 (ja) * | 2021-03-03 | 2022-09-09 | 国立大学法人京都大学 | 神経変性疾患治療のためのポリヌクレオチド、ベクター、細胞、医薬組成物及びスクリーニング方法 |
| WO2022255411A1 (ja) | 2021-06-01 | 2022-12-08 | 国立大学法人京都大学 | 自然免疫応答を増強させる方法 |
| WO2023008470A1 (ja) * | 2021-07-28 | 2023-02-02 | 住友ファーマ株式会社 | 縮環アミン誘導体 |
| JPWO2023008472A1 (cg-RX-API-DMAC7.html) * | 2021-07-28 | 2023-02-02 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004029070A2 (en) * | 2002-09-24 | 2004-04-08 | Isis Pharmaceutical, Inc. | Methods for blocking adipocyte differentiation and triglyceride accumulation with dual-specificity tyrosine- (y) - phosphorylation regulated kinase 4 (dyrk4) inhibitors |
| EP2164494A4 (en) * | 2007-06-01 | 2010-06-02 | Glaxosmithkline Llc | Methods of Treatment |
| KR20100010894A (ko) * | 2008-07-23 | 2010-02-02 | 가부시키가이샤 키노파마 | Ｄｙｒｋ를 저해하는 화합물을 함유하는 의약 조성물 |
| CA2774558A1 (en) * | 2009-09-22 | 2011-03-31 | Neuronascent, Inc. | Methods and pharmaceutical compositions for treating down syndrome |
| WO2011068990A1 (en) * | 2009-12-04 | 2011-06-09 | Medipropharma, Inc. | Compositions and methods for inhibiting dyrk1a to treat central nervous system diseases and disorders |
| US20130231360A1 (en) * | 2010-04-22 | 2013-09-05 | The Brigham And Women S Hospital, Inc. | Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases |
| KR102006749B1 (ko) * | 2011-08-19 | 2019-08-02 | 디악쏘니 | Dyrk1 억제제 및 이의 용도 |
| US20150133467A1 (en) * | 2012-06-06 | 2015-05-14 | Kyoto University | Screening method, protein instability and/or stability inducers, and protein activity assessment |
| CN106986865B (zh) * | 2012-07-30 | 2020-02-28 | 国立大学法人京都大学 | 关于精神神经疾病或恶性肿瘤的化合物及医药组合物 |
-
2013
- 2013-12-05 JP JP2013252443A patent/JP2015107945A/ja active Pending
-
2014
- 2014-12-03 WO PCT/JP2014/082035 patent/WO2015083750A1/ja not_active Ceased
- 2014-12-03 US US15/101,862 patent/US20160303089A1/en not_active Abandoned
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