JP2015078151A - 尿路感染症の予防又は治療 - Google Patents
尿路感染症の予防又は治療 Download PDFInfo
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- JP2015078151A JP2015078151A JP2013215980A JP2013215980A JP2015078151A JP 2015078151 A JP2015078151 A JP 2015078151A JP 2013215980 A JP2013215980 A JP 2013215980A JP 2013215980 A JP2013215980 A JP 2013215980A JP 2015078151 A JP2015078151 A JP 2015078151A
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- mannose
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- tract infection
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
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Abstract
【解決手段】
D-マンノース若しくはその誘導体又はクランベリー果実成分を含有する、予防又は治療剤が提供される。
【選択図】なし
Description
[1]SGLT2阻害剤の投与を受ける糖尿病患者に使用される、尿路感染症の予防又は治療剤であって、D-マンノース若しくはその誘導体又はクランベリー果実成分を含有する、予防又は治療剤。
[2]SGLT2阻害剤の投与を受ける糖尿病患者に使用される、尿路感染症の予防又は治療剤であって、D-マンノース若しくはその誘導体を含有し、クランベリー果実成分と併用される、予防又は治療剤。
[3]前記誘導体がD-マンニトール又はα−メチル−D-マンノシドである、[1]又は[2]に記載の予防又は治療剤。
[4]前記クランベリー果実成分がキナ酸及び/又はプロアントシアニジンである、[1]〜[3]のいずれか一項に記載の予防又は治療剤。
[5]SGLT2阻害剤の投与を受ける糖尿病患者に対して、D-マンノース若しくはその誘導体、及び/又はクランベリー果実成分を投与するステップを含む、尿路感染症の予防又は治療法。
SGLT2治療の投薬と同時にD-マンノース1g/日を経口で2週間〜4週間内服する。SGLT2投与数十分で尿中の尿糖が増加する(図1)。それを栄養に24〜48時間で大腸菌が増殖する(図2)。増殖する前にマンノースを経口投与することによって数十分で尿中マンノース濃度が上昇し、上記の機序で大腸菌の増殖、生体内侵入を防ぐことができる(図3)。
SGLT2治療の投薬と同時にマンノース1g/日を経口で2週間〜4週間内服する。これに併せて、クランベリーシュース1缶(200ml)/日を併用する。SGLT2投与数十分で尿中の尿糖が増加する。それを栄養に24〜48時間で大腸菌が増殖する。大腸菌の増殖する前にD-マンノース及びクランベリージュースを経口投与することによって数十分で尿中濃度が上昇し、上記の機序で大腸菌の増殖、生体内侵入を防ぐことができる。作用機序の異なる、D-マンノース及びクランベリー果実成分を併用することにより、一層効果的な尿路感染症の予防/治療が期待できる。
Claims (5)
- SGLT2阻害剤の投与を受ける糖尿病患者に使用される、尿路感染症の予防又は治療剤であって、D-マンノース若しくはその誘導体又はクランベリー果実成分を含有する、予防又は治療剤。
- SGLT2阻害剤の投与を受ける糖尿病患者に使用される、尿路感染症の予防又は治療剤であって、D-マンノース若しくはその誘導体を含有し、クランベリー果実成分と併用される、予防又は治療剤。
- 前記誘導体がD-マンニトール又はα−メチル−D-マンノシドである、請求項1又は2に記載の予防又は治療剤。
- 前記クランベリー果実成分がキナ酸及び/又はプロアントシアニジンである、請求項1〜3のいずれか一項に記載の予防又は治療剤。
- SGLT2阻害剤の投与を受ける糖尿病患者に対して、D-マンノース若しくはその誘導体、及び/又はクランベリー果実成分を投与するステップを含む、尿路感染症の予防又は治療法。
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KR101835263B1 (ko) | 2017-02-08 | 2018-03-06 | 고려대학교 산학협력단 | 요로감염증 예방 및 치료를 위한 항균 조성물 |
WO2024034495A1 (ja) * | 2022-08-09 | 2024-02-15 | 株式会社サナス | 1-デオキシマンノースを含有する尿路感染症予防・治療剤 |
EP4324465A1 (en) * | 2022-08-15 | 2024-02-21 | Gedea Biotech AB | Compounds for use in the treatment of a microbial infection in the urogenital system |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101835263B1 (ko) | 2017-02-08 | 2018-03-06 | 고려대학교 산학협력단 | 요로감염증 예방 및 치료를 위한 항균 조성물 |
WO2024034495A1 (ja) * | 2022-08-09 | 2024-02-15 | 株式会社サナス | 1-デオキシマンノースを含有する尿路感染症予防・治療剤 |
EP4324465A1 (en) * | 2022-08-15 | 2024-02-21 | Gedea Biotech AB | Compounds for use in the treatment of a microbial infection in the urogenital system |
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