JP2014533115A5 - - Google Patents

Info

Publication number

JP2014533115A5

JP2014533115A5 JP2014541350A JP2014541350A JP2014533115A5 JP 2014533115 A5 JP2014533115 A5 JP 2014533115A5 JP 2014541350 A JP2014541350 A JP 2014541350A JP 2014541350 A JP2014541350 A JP 2014541350A JP 2014533115 A5 JP2014533115 A5 JP 2014533115A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

polypeptide

adamts13

vwf

Prior art date

2012-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 18
• 229920001184 polypeptide Polymers 0.000 description 16
• 108090000765 processed proteins & peptides Proteins 0.000 description 16
• 102000004196 processed proteins & peptides Human genes 0.000 description 16
• 150000001413 amino acids Chemical class 0.000 description 12
• 239000000758 substrate Substances 0.000 description 12
• 108010047303 von Willebrand Factor Proteins 0.000 description 10
• 102100036537 von Willebrand factor Human genes 0.000 description 10
• 229960001134 von willebrand factor Drugs 0.000 description 10
• 239000012634 fragment Substances 0.000 description 8
• 102000005741 Metalloproteases Human genes 0.000 description 5
• 108010006035 Metalloproteases Proteins 0.000 description 5
• 230000000694 effects Effects 0.000 description 5
• 108060008245 Thrombospondin Proteins 0.000 description 4
• 102000002938 Thrombospondin Human genes 0.000 description 4
• 101800000620 Disintegrin-like Proteins 0.000 description 3
• 101150045640 VWF gene Proteins 0.000 description 3
• 125000003275 alpha amino acid group Chemical group 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 2
• 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 2
• 238000003776 cleavage reaction Methods 0.000 description 2
• 239000007857 degradation product Substances 0.000 description 2
• 239000007850 fluorescent dye Substances 0.000 description 2
• 230000007017 scission Effects 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 1
• 108091005804 Peptidases Proteins 0.000 description 1
• 239000004365 Protease Substances 0.000 description 1
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
• 125000000539 amino acid group Chemical group 0.000 description 1
• 210000004900 c-terminal fragment Anatomy 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000000338 in vitro Methods 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 239000013641 positive control Substances 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1