JP6419576B2 - プロテアーゼａｄａｍｔｓ１３を切断するフォン・ヴィレブランド因子の検出用ポリペプチド基体 - Google Patents

プロテアーゼａｄａｍｔｓ１３を切断するフォン・ヴィレブランド因子の検出用ポリペプチド基体 Download PDF

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JP6419576B2
JP6419576B2 JP2014541350A JP2014541350A JP6419576B2 JP 6419576 B2 JP6419576 B2 JP 6419576B2 JP 2014541350 A JP2014541350 A JP 2014541350A JP 2014541350 A JP2014541350 A JP 2014541350A JP 6419576 B2 JP6419576 B2 JP 6419576B2
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adamts13
seq
polypeptide substrate
amino acid
substrate
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JP2014533115A (ja
JP2014533115A5 (enExample
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パオロ ヴィセンティン，ジャン
パオロ ヴィセンティン，ジャン
シー． チャンス，シュゼット
シー． チャンス，シュゼット
ウィトシック，エリザベス
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イムコア ジーティーアイ ダイアグノスティクス インコーポレイテッド
イムコア ジーティーアイ ダイアグノスティクス インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
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  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2014541350A 2011-11-11 2012-11-09 プロテアーゼａｄａｍｔｓ１３を切断するフォン・ヴィレブランド因子の検出用ポリペプチド基体 Active JP6419576B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161558927P 2011-11-11 2011-11-11
US61/558,927 2011-11-11
PCT/US2012/064526 WO2013071168A1 (en) 2011-11-11 2012-11-09 Polypeptide substrate for the detection of von willebrand factor cleaving protease adamts13

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JP2014533115A JP2014533115A (ja) 2014-12-11
JP2014533115A5 JP2014533115A5 (enExample) 2018-02-15
JP6419576B2 true JP6419576B2 (ja) 2018-11-07

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US (3) US9513290B2 (enExample)
EP (1) EP2776461B1 (enExample)
JP (1) JP6419576B2 (enExample)
AU (1) AU2012335087B2 (enExample)
CA (1) CA2855498A1 (enExample)
WO (1) WO2013071168A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10858689B2 (en) 2016-10-11 2020-12-08 Laboratory Corporation Of America Holdings Methods and systems for determining ADAMTS13 enzyme activity

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7002727B2 (ja) * 2016-01-08 2022-02-15 Ｋｍバイオロジクス株式会社 Ａｄａｍｔｓ１３を主成分とする診断薬および医薬品
CN106596936B (zh) * 2016-12-19 2019-05-31 吴江华药生物技术有限公司 体外定量测定vWF-CP酶活性的方法、检测试剂盒及制备方法
CN111153962B (zh) * 2020-01-15 2021-09-28 苏州智影特生物医药技术有限公司 一种血栓性血小板减少性紫癜病诊断探针及其制备方法和应用
EP4279607A1 (de) 2022-05-20 2023-11-22 Siemens Healthcare Diagnostics Products GmbH Enzym-verstärkter adamts-13 aktivitätstest
WO2024153750A1 (en) * 2023-01-18 2024-07-25 Enzyre B.V. Luminescent detection of adamts13

Family Cites Families (2)

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Publication number Priority date Publication date Assignee Title
US5556771A (en) 1995-02-10 1996-09-17 Gen-Probe Incorporated Stabilized compositions of reverse transcriptase and RNA polymerase for nucleic acid amplification
US8663912B2 (en) * 2011-07-18 2014-03-04 Washington University Fluorogenic substrate for ADAMTS13

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10858689B2 (en) 2016-10-11 2020-12-08 Laboratory Corporation Of America Holdings Methods and systems for determining ADAMTS13 enzyme activity
US11959124B2 (en) 2016-10-11 2024-04-16 Laboratory Corporation Of America Holdings Methods and systems for determining ADAMTS13 enzyme activity
US12442030B2 (en) 2016-10-11 2025-10-14 Laboratory Corporation Of America Holdings Methods and systems for determining ADAMTS13 enzyme activity

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CA2855498A1 (en) 2013-05-16
JP2014533115A (ja) 2014-12-11
US20190185905A1 (en) 2019-06-20
EP2776461B1 (en) 2018-02-28
US20170145471A1 (en) 2017-05-25
US20150147764A1 (en) 2015-05-28
EP2776461A1 (en) 2014-09-17
US10538802B2 (en) 2020-01-21
WO2013071168A1 (en) 2013-05-16
US10202633B2 (en) 2019-02-12
AU2012335087B2 (en) 2017-06-29
US9513290B2 (en) 2016-12-06
AU2012335087A1 (en) 2014-06-19

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