JP2014532636A5 - - Google Patents

Info

Publication number

JP2014532636A5

JP2014532636A5 JP2014537693A JP2014537693A JP2014532636A5 JP 2014532636 A5 JP2014532636 A5 JP 2014532636A5 JP 2014537693 A JP2014537693 A JP 2014537693A JP 2014537693 A JP2014537693 A JP 2014537693A JP 2014532636 A5 JP2014532636 A5 JP 2014532636A5

Authority

JP

Japan

Prior art keywords

treatment

group

medicament

virus

compound

Prior art date

2012-10-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 230000009385 viral infection Effects 0.000 claims 10
• 208000036142 Viral infection Diseases 0.000 claims 9
• 239000003814 drug Substances 0.000 claims 8
• 150000001875 compounds Chemical class 0.000 claims 6
• 241000725303 Human immunodeficiency virus Species 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 241000713772 Human immunodeficiency virus 1 Species 0.000 claims 2
• VTAPXODOLMOLNK-PCYKNENESA-N [(2s,3r,4s,5r)-2-(6-aminopurin-9-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-phenylmethanone Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@]1(C(=O)C=2C=CC=CC=2)O[C@H](CO)[C@@H](O)[C@H]1O VTAPXODOLMOLNK-PCYKNENESA-N 0.000 claims 2
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 108020004705 Codon Proteins 0.000 claims 1
• 241000711549 Hepacivirus C Species 0.000 claims 1
• 241000700721 Hepatitis B virus Species 0.000 claims 1
• 102100034343 Integrase Human genes 0.000 claims 1
• 229910003827 NRaRb Inorganic materials 0.000 claims 1
• 229940122313 Nucleoside reverse transcriptase inhibitor Drugs 0.000 claims 1
• 229910019142 PO4 Inorganic materials 0.000 claims 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
• 239000004473 Threonine Substances 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 125000003277 amino group Chemical group 0.000 claims 1
• 229940124522 antiretrovirals Drugs 0.000 claims 1
• 239000003903 antiretrovirus agent Substances 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 239000001177 diphosphate Substances 0.000 claims 1
• XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims 1
• 235000011180 diphosphates Nutrition 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000001188 haloalkyl group Chemical group 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 150000004712 monophosphates Chemical class 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical class [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 1
• 239000000651 prodrug Substances 0.000 claims 1
• 229940002612 prodrug Drugs 0.000 claims 1
• 239000003419 rna directed dna polymerase inhibitor Substances 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 239000001226 triphosphate Substances 0.000 claims 1
• 235000011178 triphosphate Nutrition 0.000 claims 1
• UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 claims 1
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
• 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 241001529453 unidentified herpesvirus Species 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1
• 0 CP(*)(NC(*)C(O*)=O)=O Chemical compound CP(*)(NC(*)C(O*)=O)=O 0.000 description 1