JP2014532179A5 - - Google Patents
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- Publication number
- JP2014532179A5 JP2014532179A5 JP2014533519A JP2014533519A JP2014532179A5 JP 2014532179 A5 JP2014532179 A5 JP 2014532179A5 JP 2014533519 A JP2014533519 A JP 2014533519A JP 2014533519 A JP2014533519 A JP 2014533519A JP 2014532179 A5 JP2014532179 A5 JP 2014532179A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen
- blood ammonia
- subject
- dosage
- ammonia level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 28
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 24
- 229910021529 ammonia Inorganic materials 0.000 claims 14
- 239000008280 blood Substances 0.000 claims 12
- 210000004369 blood Anatomy 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 12
- OBKXEAXTFZPCHS-UHFFFAOYSA-N 4-phenylbutyric acid Chemical compound OC(=O)CCCC1=CC=CC=C1 OBKXEAXTFZPCHS-UHFFFAOYSA-N 0.000 claims 6
- 229950009215 phenylbutanoic acid Drugs 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 230000014759 maintenance of location Effects 0.000 claims 3
- 230000005856 abnormality Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960002815 glycerol phenylbutyrate Drugs 0.000 claims 2
- ZSDBFLMJVAGKOU-UHFFFAOYSA-N glycerol phenylbutyrate Chemical compound C=1C=CC=CC=1CCCC(=O)OCC(OC(=O)CCCC=1C=CC=CC=1)COC(=O)CCCC1=CC=CC=C1 ZSDBFLMJVAGKOU-UHFFFAOYSA-N 0.000 claims 2
- 230000002000 scavenging effect Effects 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 238000005096 rolling process Methods 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims 1
- 235000010234 sodium benzoate Nutrition 0.000 claims 1
- 239000004299 sodium benzoate Substances 0.000 claims 1
- 230000004143 urea cycle Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161542100P | 2011-09-30 | 2011-09-30 | |
| US61/542,100 | 2011-09-30 | ||
| US201161564668P | 2011-11-29 | 2011-11-29 | |
| US61/564,668 | 2011-11-29 | ||
| PCT/US2012/028620 WO2013048558A2 (en) | 2011-09-30 | 2012-03-09 | Methods of therapeutic monitoring of nitrogen scavenging drugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000550A Division JP6425746B2 (ja) | 2011-09-30 | 2017-01-05 | 窒素捕集薬の治療監視の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014532179A JP2014532179A (ja) | 2014-12-04 |
| JP2014532179A5 true JP2014532179A5 (https=) | 2015-04-30 |
| JP6073898B2 JP6073898B2 (ja) | 2017-02-01 |
Family
ID=47892277
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014533519A Active JP6073898B2 (ja) | 2011-09-30 | 2012-03-09 | 窒素捕集薬の治療監視の方法 |
| JP2017000550A Active JP6425746B2 (ja) | 2011-09-30 | 2017-01-05 | 窒素捕集薬の治療監視の方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017000550A Active JP6425746B2 (ja) | 2011-09-30 | 2017-01-05 | 窒素捕集薬の治療監視の方法 |
Country Status (25)
| Country | Link |
|---|---|
| US (21) | US8404215B1 (https=) |
| EP (2) | EP2760479B1 (https=) |
| JP (2) | JP6073898B2 (https=) |
| KR (2) | KR102019000B1 (https=) |
| CN (2) | CN107271696A (https=) |
| AU (2) | AU2012316750B2 (https=) |
| BR (1) | BR112014007357B1 (https=) |
| CA (1) | CA2850391A1 (https=) |
| CL (1) | CL2014000783A1 (https=) |
| CY (1) | CY1119028T1 (https=) |
| DK (1) | DK2760479T3 (https=) |
| ES (1) | ES2629859T3 (https=) |
| HR (1) | HRP20171063T1 (https=) |
| HU (1) | HUE035220T2 (https=) |
| IL (2) | IL231732A (https=) |
| LT (1) | LT2760479T (https=) |
| MX (2) | MX366197B (https=) |
| PL (1) | PL2760479T3 (https=) |
| PT (1) | PT2760479T (https=) |
| RS (1) | RS56196B1 (https=) |
| SG (1) | SG11201400781TA (https=) |
| SI (1) | SI2760479T1 (https=) |
| SM (1) | SMT201700321T1 (https=) |
| WO (1) | WO2013048558A2 (https=) |
| ZA (1) | ZA201401851B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2760479T3 (en) | 2011-09-30 | 2017-07-17 | Horizon Therapeutics Llc | Nitrogen-removing drug for use in a method of treating a nitrogen retention disorder |
| ES2623470T3 (es) * | 2012-04-20 | 2017-07-11 | Horizon Therapeutics, Llc | HPN-100 para uso en el tratamiento de trastornos de retención de nitrógeno |
| EP2922576B1 (en) * | 2012-11-21 | 2017-11-08 | Horizon Therapeutics, LLC | Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy |
| EP3019074B1 (en) * | 2013-09-30 | 2018-08-29 | Horizon Therapeutics, LLC | Diagnosing, grading, monitoring, and treating hepatic encephalopathy |
| EP2986325B1 (en) | 2013-10-14 | 2019-06-26 | Immedica Pharma AB | Methods of treating urea cycle disorders |
| TWI640327B (zh) | 2013-11-14 | 2018-11-11 | 美商奧崔基尼克斯製藥公司 | 三酸甘油酯之固體組合物及其用途 |
| CA2946422C (en) | 2014-04-30 | 2019-03-05 | The Johns Hopkins University | Dendrimer compositions and their use in treatment of diseases of the eye |
| US20170087113A1 (en) * | 2014-06-04 | 2017-03-30 | Horizon Therapeutics, Llc | Methods for treating urea cycle disorders to prevent hyperammonemic crises by controlling blood ammonia levels |
| CA2957721C (en) | 2014-08-13 | 2021-04-13 | The Johns Hopkins University | Selective dendrimer delivery to brain tumors |
| CA3003589C (en) | 2015-10-29 | 2021-12-07 | The Johns Hopkins University | Dendrimer compositions and methods for treatment of peroxisomal disorders and leukodystrophies |
| WO2017147193A1 (en) * | 2016-02-22 | 2017-08-31 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
| US9914692B2 (en) * | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
| JP6752748B2 (ja) | 2017-03-30 | 2020-09-09 | 住友重機械工業株式会社 | 減速装置 |
| JP7454945B2 (ja) * | 2017-07-03 | 2024-03-25 | アボット・ラボラトリーズ | 血液中のユビキチンカルボキシ末端ヒドロラーゼｌ１レベルを測定するための、改善された方法 |
| CA3071387A1 (en) * | 2017-08-22 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
| US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
| JP7759322B2 (ja) | 2019-12-04 | 2025-10-23 | アシュバッタ セラピューティクス， インコーポレイテッド | 眼に薬物送達するためのデンドリマー組成物および方法 |
| CA3184989A1 (en) * | 2020-07-07 | 2022-01-13 | Christopher D. Schelling | Methods of administering taste masked phenylbutyrate and compositions therefor |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1004595A (en) | 1911-05-25 | 1911-10-03 | Sargents Sons Corp C G | Carrier for washing-bowls. |
| US1018300A (en) | 1911-06-12 | 1912-02-20 | John Davidson | Condensing steam-engine. |
| US3686238A (en) | 1970-01-19 | 1972-08-22 | Syntex Corp | Glycerol esterified with 2-naphthyl-acetic acids and fatty acids |
| US4284647A (en) | 1980-03-31 | 1981-08-18 | The Johns Hopkins University | Process for waste nitrogen removal |
| US4457942A (en) | 1982-08-20 | 1984-07-03 | Brusilow Saul W | Process for waste nitrogen removal |
| US5635532A (en) | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
| US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| ES2157422T3 (es) | 1995-02-07 | 2001-08-16 | Brusilow Entpr Llc | Trigliceridos y esteres etilicos de acido fenilalcanoico y acido fenilalquenoico utiles en el tratamiento de diversos trastornos. |
| DE19805854C1 (de) | 1998-02-13 | 1999-05-12 | Claas Usines France | Schalteinrichtung für Schneidmesser |
| US6219567B1 (en) * | 1999-06-21 | 2001-04-17 | Cardiox Corporation | Monitoring of total ammoniacal concentration in blood |
| IT1317073B1 (it) | 2000-12-12 | 2003-05-26 | Mini Ricerca Scient Tecnolog | Esteri dell'acido fenilbutirrico, procedimenti per la loro produzionee loro impiego terapeutico. |
| US20040229948A1 (en) | 2002-04-12 | 2004-11-18 | Summar Marshall L. | Method for preventing hepatic encephalopathic episodes |
| US20030195255A1 (en) | 2002-04-12 | 2003-10-16 | Summar Marshall L. | Method for treating hepatic encephalopathies |
| US6825384B1 (en) | 2004-01-29 | 2004-11-30 | The Nutrasweet Company | Bromine free TEMPO based catalyst system for oxidation of primary and secondary alcohols using NaOCl as an oxidant |
| US20050273359A1 (en) | 2004-06-03 | 2005-12-08 | Young David E | System and method of evaluating preoperative medical care and determining recommended tests based on patient health history and medical condition and nature of surgical procedure |
| CN1778963A (zh) * | 2004-11-23 | 2006-05-31 | 苏州艾杰生物科技有限公司 | 血氨含量测定方法及血氨诊断试剂盒 |
| SG158073A1 (en) | 2004-11-26 | 2010-01-29 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| US20060135612A1 (en) | 2004-12-17 | 2006-06-22 | U.S. Department Of Veterans Affairs | Method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as amyotrophic lateral sclerosis (ALS), by using a HDAC inhibiting agent |
| US20070004805A1 (en) | 2005-07-01 | 2007-01-04 | Navinta Llc | Process for preparation of liquid dosage form containing sodium 4-phenylbutyrate |
| WO2007059031A2 (en) | 2005-11-10 | 2007-05-24 | Massachusetts Institute Of Technology | Methods and compositions for raising levels and release of gamma aminobutyric acid |
| US8094521B2 (en) | 2007-02-28 | 2012-01-10 | Nightingale Products LLC | Caregiver personal alert device |
| CN101959429B (zh) | 2008-01-08 | 2014-09-10 | 阿克塞利亚制药公司 | 抗微生物肽系统的激动剂 |
| PL3133396T3 (pl) | 2008-04-29 | 2019-03-29 | Horizon Therapeutics, Llc | Sposób leczenia z zastosowaniem leków wychwytujących amoniak |
| WO2009145323A1 (ja) | 2008-05-30 | 2009-12-03 | 日産化学工業株式会社 | 多環式化合物を用いるアルコールの酸化方法 |
| US20120022157A1 (en) | 2008-08-29 | 2012-01-26 | Ucyclyd Pharma, Inc | Dosing and monitoring patients on nitrogen-scavenging drugs |
| PT3133396T (pt) | 2008-08-29 | 2018-12-07 | Immedica Pharma Ab | Métodos de tratamento utilizando fármacos eliminadores de amoníaco |
| EP2954780A1 (en) | 2009-07-24 | 2015-12-16 | Baylor College Of Medicine | Methods of modulation of branched chain acids and uses thereof |
| JP5763638B2 (ja) | 2010-07-16 | 2015-08-12 | 第一三共株式会社 | アルコール類の酸化方法 |
| US20130224277A1 (en) | 2010-08-31 | 2013-08-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Porous polysaccharide scaffold comprising nano-hydroxyapatite and use for bone formation |
| DK2760479T3 (en) | 2011-09-30 | 2017-07-17 | Horizon Therapeutics Llc | Nitrogen-removing drug for use in a method of treating a nitrogen retention disorder |
| EP2607366A1 (en) | 2011-12-21 | 2013-06-26 | Lunamed AG | Glycerol phenyl butyrate esters |
| ES2623470T3 (es) | 2012-04-20 | 2017-07-11 | Horizon Therapeutics, Llc | HPN-100 para uso en el tratamiento de trastornos de retención de nitrógeno |
| EP2922576B1 (en) | 2012-11-21 | 2017-11-08 | Horizon Therapeutics, LLC | Methods of administering and evaluating nitrogen scavenging drugs for the treatment of hepatic encephalopathy |
| CN103304402B (zh) | 2013-05-24 | 2015-04-22 | 苏州诚和医药化学有限公司 | 一种制备4-苯-1-丁酸的方法 |
| EP3019074B1 (en) | 2013-09-30 | 2018-08-29 | Horizon Therapeutics, LLC | Diagnosing, grading, monitoring, and treating hepatic encephalopathy |
| EP2986325B1 (en) | 2013-10-14 | 2019-06-26 | Immedica Pharma AB | Methods of treating urea cycle disorders |
| IN2013MU03442A (https=) | 2013-10-30 | 2015-07-17 | Lupin Ltd | |
| US20170087113A1 (en) | 2014-06-04 | 2017-03-30 | Horizon Therapeutics, Llc | Methods for treating urea cycle disorders to prevent hyperammonemic crises by controlling blood ammonia levels |
| WO2017147193A1 (en) | 2016-02-22 | 2017-08-31 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
| US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
| US20190076383A1 (en) | 2017-09-08 | 2019-03-14 | Horizon Therapeutics, Llc | Methods for treating urea cycle disorders |
| US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
-
2012
- 2012-03-09 DK DK12835407.3T patent/DK2760479T3/en active
- 2012-03-09 CN CN201710239760.1A patent/CN107271696A/zh active Pending
- 2012-03-09 US US13/417,137 patent/US8404215B1/en active Active
- 2012-03-09 PL PL12835407T patent/PL2760479T3/pl unknown
- 2012-03-09 AU AU2012316750A patent/AU2012316750B2/en active Active
- 2012-03-09 KR KR1020187020761A patent/KR102019000B1/ko active Active
- 2012-03-09 WO PCT/US2012/028620 patent/WO2013048558A2/en not_active Ceased
- 2012-03-09 BR BR112014007357-0A patent/BR112014007357B1/pt active IP Right Grant
- 2012-03-09 HR HRP20171063TT patent/HRP20171063T1/hr unknown
- 2012-03-09 SM SM20170321T patent/SMT201700321T1/it unknown
- 2012-03-09 CN CN201280048373.5A patent/CN104039358A/zh active Pending
- 2012-03-09 KR KR1020147011146A patent/KR20140094517A/ko not_active Ceased
- 2012-03-09 LT LTEP12835407.3T patent/LT2760479T/lt unknown
- 2012-03-09 HU HUE12835407A patent/HUE035220T2/hu unknown
- 2012-03-09 EP EP12835407.3A patent/EP2760479B1/en active Active
- 2012-03-09 ES ES12835407.3T patent/ES2629859T3/es active Active
- 2012-03-09 MX MX2014003854A patent/MX366197B/es active IP Right Grant
- 2012-03-09 SG SG11201400781TA patent/SG11201400781TA/en unknown
- 2012-03-09 PT PT128354073T patent/PT2760479T/pt unknown
- 2012-03-09 CA CA2850391A patent/CA2850391A1/en not_active Withdrawn
- 2012-03-09 JP JP2014533519A patent/JP6073898B2/ja active Active
- 2012-03-09 SI SI201230985A patent/SI2760479T1/sl unknown
- 2012-03-09 EP EP17168773.4A patent/EP3263102A1/en not_active Withdrawn
- 2012-03-09 RS RS20170682A patent/RS56196B1/sr unknown
-
2013
- 2013-02-22 US US13/775,000 patent/US9095559B2/en active Active
-
2014
- 2014-03-12 ZA ZA2014/01851A patent/ZA201401851B/en unknown
- 2014-03-27 IL IL231732A patent/IL231732A/en active IP Right Grant
- 2014-03-28 CL CL2014000783A patent/CL2014000783A1/es unknown
- 2014-03-28 MX MX2019006900A patent/MX2019006900A/es unknown
-
2015
- 2015-08-03 US US14/816,674 patent/US9254278B2/en active Active
- 2015-12-03 US US14/958,259 patent/US9326966B2/en active Active
-
2016
- 2016-03-18 US US15/074,625 patent/US20160199332A1/en not_active Abandoned
- 2016-03-18 US US15/074,666 patent/US20160202240A1/en not_active Abandoned
- 2016-03-18 US US15/074,716 patent/US20160199334A1/en not_active Abandoned
- 2016-03-18 US US15/074,691 patent/US20160199333A1/en not_active Abandoned
-
2017
- 2017-01-05 JP JP2017000550A patent/JP6425746B2/ja active Active
- 2017-03-13 US US15/457,643 patent/US9999608B2/en active Active
- 2017-06-28 CY CY20171100688T patent/CY1119028T1/el unknown
- 2017-08-24 IL IL254134A patent/IL254134A0/en unknown
- 2017-08-25 US US15/687,118 patent/US9962358B2/en active Active
- 2017-08-25 US US15/687,132 patent/US9962359B2/en active Active
- 2017-09-08 US US15/699,209 patent/US20180021293A1/en not_active Abandoned
- 2017-10-23 AU AU2017251691A patent/AU2017251691A1/en not_active Abandoned
-
2018
- 2018-04-03 US US15/944,411 patent/US10183002B2/en active Active
- 2018-04-03 US US15/944,398 patent/US10045958B1/en active Active
- 2018-04-03 US US15/944,416 patent/US10045959B1/en active Active
- 2018-04-03 US US15/944,432 patent/US10183005B2/en active Active
- 2018-04-03 US US15/944,422 patent/US10183003B2/en active Active
- 2018-04-03 US US15/944,428 patent/US10183004B2/en active Active
- 2018-05-15 US US15/980,376 patent/US10183006B2/en active Active
- 2018-11-16 US US16/194,061 patent/US10617665B2/en active Active
-
2020
- 2020-03-10 US US16/814,549 patent/US20210000784A1/en not_active Abandoned
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