JP2014532060A - 癌を治療するためのピロロピリミジン化合物 - Google Patents

癌を治療するためのピロロピリミジン化合物 Download PDF

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Publication number
JP2014532060A
JP2014532060A JP2014534626A JP2014534626A JP2014532060A JP 2014532060 A JP2014532060 A JP 2014532060A JP 2014534626 A JP2014534626 A JP 2014534626A JP 2014534626 A JP2014534626 A JP 2014534626A JP 2014532060 A JP2014532060 A JP 2014532060A
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cancer
alkyl
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compound according
compound
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Japanese (ja)
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JP2014532060A5 (pt-PT
Inventor
ワン，シャオドン
リウ，ジン
ジャン，ウェイヒー
フライ，スティーヴン
キレエフ，ディミトリー
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ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル
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Publication of JP2014532060A publication Critical patent/JP2014532060A/ja
Publication of JP2014532060A5 publication Critical patent/JP2014532060A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2014534626A 2011-10-03 2012-10-01 癌を治療するためのピロロピリミジン化合物 Pending JP2014532060A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161542392P 2011-10-03 2011-10-03
US61/542,392 2011-10-03
US201161547183P 2011-10-14 2011-10-14
US61/547,183 2011-10-14
PCT/US2012/058298 WO2013052417A1 (en) 2011-10-03 2012-10-01 Pyrrolopyrimidine compounds for the treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016255095A Division JP6316925B2 (ja) 2011-10-03 2016-12-28 癌を治療するためのピロロピリミジン化合物

Publications (2)

Publication Number Publication Date
JP2014532060A true JP2014532060A (ja) 2014-12-04
JP2014532060A5 JP2014532060A5 (pt-PT) 2016-03-03

Family

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Family Applications (2)

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JP2014534626A Pending JP2014532060A (ja) 2011-10-03 2012-10-01 癌を治療するためのピロロピリミジン化合物
JP2016255095A Active JP6316925B2 (ja) 2011-10-03 2016-12-28 癌を治療するためのピロロピリミジン化合物

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Country Status (14)

Country Link
US (3) US9273056B2 (pt-PT)
EP (1) EP2763988B1 (pt-PT)
JP (2) JP2014532060A (pt-PT)
KR (1) KR102063098B1 (pt-PT)
CN (1) CN103958510B (pt-PT)
AU (1) AU2012318896B2 (pt-PT)
BR (1) BR112014007788A2 (pt-PT)
CA (1) CA2850617A1 (pt-PT)
ES (1) ES2650630T3 (pt-PT)
HK (1) HK1201256A1 (pt-PT)
IL (1) IL231835A0 (pt-PT)
MX (1) MX2014004086A (pt-PT)
RU (1) RU2631655C2 (pt-PT)
WO (1) WO2013052417A1 (pt-PT)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018514559A (ja) * 2015-04-29 2018-06-07 シアメン ユニヴァーシティー ピリミドピロール類化合物、その調製方法、医薬用組成物及びその応用
KR20190111008A (ko) * 2016-09-16 2019-10-01 비타이 파마슈티컬즈, 엘엘씨 메닌-ｍｌｌ 상호작용의 억제제

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WO2011146313A1 (en) 2010-05-19 2011-11-24 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
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WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
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WO2017062797A1 (en) * 2015-10-07 2017-04-13 The University Of North Carolina At Chapel Hill The methods for treatment of tumors
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WO2018094227A1 (en) 2016-11-17 2018-05-24 The University Of North Carolina At Chapel Hill Alkyl pyrrolopyrimidine analogs and methods of making and using same
KR20200088308A (ko) 2017-09-27 2020-07-22 인사이트 코포레이션 Tam 억제제로서 유용한 피롤로트리아진 유도체의 염
WO2019113190A1 (en) 2017-12-07 2019-06-13 Array Biopharma Inc. Bicyclic fused pyridine compounds as inhibitors of tam kinases
KR20200104336A (ko) * 2017-12-28 2020-09-03 재단법인 생물기술개발중심 수용체 티로신 키나제 억제제의 Tyro3, Axl 및 Mertk (TAM) 패밀리로서의 헤테로고리 화합물
AR117600A1 (es) 2018-06-29 2021-08-18 Incyte Corp Formulaciones de un inhibidor de axl / mer
KR102163494B1 (ko) * 2018-10-26 2020-10-08 한국과학기술연구원 단백질 키나아제 저해제인 헤테로방향족 매크로시클릭 유도체
CN114127071B (zh) * 2019-04-02 2024-03-22 梅里克斯股份有限公司 激酶抑制剂的多晶型、含有该化合物的药物组合物、制备方法、及应用
CN112043710A (zh) * 2020-09-28 2020-12-08 广州智睿医药科技有限公司 一种治疗或预防与lrrk2激酶或异常lrrk2突变激酶活性相关疾病的药物
CN115073469B (zh) * 2021-03-15 2023-12-22 药雅科技(上海)有限公司 吡咯并嘧啶类化合物作为激酶抑制剂的制备及其应用

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Cited By (5)

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JP2018514559A (ja) * 2015-04-29 2018-06-07 シアメン ユニヴァーシティー ピリミドピロール類化合物、その調製方法、医薬用組成物及びその応用
KR20190111008A (ko) * 2016-09-16 2019-10-01 비타이 파마슈티컬즈, 엘엘씨 메닌-ｍｌｌ 상호작용의 억제제
JP2019529421A (ja) * 2016-09-16 2019-10-17 ヴァイティー ファーマシューティカルズ，エルエルシー ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤
JP2022189853A (ja) * 2016-09-16 2022-12-22 ヴァイティー ファーマシューティカルズ，エルエルシー ｍｅｎｉｎ－ＭＬＬ相互作用の阻害剤
KR102536029B1 (ko) 2016-09-16 2023-05-23 비타이 파마슈티컬즈, 엘엘씨 메닌-ｍｌｌ 상호작용의 억제제

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WO2013052417A1 (en) 2013-04-11
KR102063098B1 (ko) 2020-01-08
JP2017101043A (ja) 2017-06-08
IL231835A0 (en) 2014-05-28
MX2014004086A (es) 2014-09-22
RU2631655C2 (ru) 2017-09-26
CN103958510B (zh) 2016-10-19
US9795606B2 (en) 2017-10-24
CN103958510A (zh) 2014-07-30
CA2850617A1 (en) 2013-04-11
HK1201256A1 (en) 2015-08-28
US20140243315A1 (en) 2014-08-28
BR112014007788A2 (pt) 2017-04-18
RU2014115847A (ru) 2015-11-10
JP6316925B2 (ja) 2018-04-25
EP2763988A1 (en) 2014-08-13
US20180104247A1 (en) 2018-04-19
EP2763988B1 (en) 2017-09-20
ES2650630T3 (es) 2018-01-19
AU2012318896A1 (en) 2014-05-22
US20160151372A1 (en) 2016-06-02
KR20140095471A (ko) 2014-08-01
US10179133B2 (en) 2019-01-15
EP2763988A4 (en) 2015-06-03
AU2012318896B2 (en) 2017-03-02
US9273056B2 (en) 2016-03-01

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