JP2014530861A5 - - Google Patents
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- Publication number
- JP2014530861A5 JP2014530861A5 JP2014537216A JP2014537216A JP2014530861A5 JP 2014530861 A5 JP2014530861 A5 JP 2014530861A5 JP 2014537216 A JP2014537216 A JP 2014537216A JP 2014537216 A JP2014537216 A JP 2014537216A JP 2014530861 A5 JP2014530861 A5 JP 2014530861A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- kinase inhibitor
- tor kinase
- use according
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549034P | 2011-10-19 | 2011-10-19 | |
| US61/549,034 | 2011-10-19 | ||
| US201261591401P | 2012-01-27 | 2012-01-27 | |
| US61/591,401 | 2012-01-27 | ||
| US201261647233P | 2012-05-15 | 2012-05-15 | |
| US61/647,233 | 2012-05-15 | ||
| US201261653436P | 2012-05-31 | 2012-05-31 | |
| US61/653,436 | 2012-05-31 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016234951A Division JP6360136B2 (ja) | 2011-10-19 | 2016-12-02 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014530861A JP2014530861A (ja) | 2014-11-20 |
| JP2014530861A5 true JP2014530861A5 (https=) | 2015-11-12 |
Family
ID=47116477
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537216A Pending JP2014530861A (ja) | 2011-10-19 | 2012-10-18 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2016234951A Active JP6360136B2 (ja) | 2011-10-19 | 2016-12-02 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2018117932A Pending JP2018162286A (ja) | 2011-10-19 | 2018-06-21 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2020117028A Pending JP2020169203A (ja) | 2011-10-19 | 2020-07-07 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2021078559A Pending JP2021107461A (ja) | 2011-10-19 | 2021-05-06 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016234951A Active JP6360136B2 (ja) | 2011-10-19 | 2016-12-02 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2018117932A Pending JP2018162286A (ja) | 2011-10-19 | 2018-06-21 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2020117028A Pending JP2020169203A (ja) | 2011-10-19 | 2020-07-07 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
| JP2021078559A Pending JP2021107461A (ja) | 2011-10-19 | 2021-05-06 | Ｔｏｒキナーゼ阻害剤を用いたがんの処置 |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US9493466B2 (https=) |
| EP (3) | EP3466423B1 (https=) |
| JP (5) | JP2014530861A (https=) |
| KR (1) | KR101978537B1 (https=) |
| CN (2) | CN103998036B (https=) |
| BR (1) | BR112014009755B1 (https=) |
| CA (1) | CA2852921C (https=) |
| EA (2) | EA030664B1 (https=) |
| ES (2) | ES2894958T3 (https=) |
| IL (3) | IL232128B (https=) |
| IN (1) | IN2014CN02887A (https=) |
| MX (4) | MX348566B (https=) |
| MY (1) | MY183661A (https=) |
| PH (1) | PH12014500869A1 (https=) |
| SG (3) | SG10201912850WA (https=) |
| TW (4) | TWI708605B (https=) |
| UA (1) | UA115319C2 (https=) |
| WO (1) | WO2013059396A2 (https=) |
| ZA (2) | ZA201402771B (https=) |
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| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| EP2945636B1 (en) | 2013-01-16 | 2017-06-28 | Signal Pharmaceuticals, LLC | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith |
| EP2961408A1 (en) * | 2013-02-28 | 2016-01-06 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
| CN105358177B (zh) * | 2013-04-17 | 2018-11-23 | 西格诺药品有限公司 | 包含tor激酶抑制剂和imid化合物的联合疗法用于治疗癌症 |
| BR112015026297B1 (pt) * | 2013-04-17 | 2022-08-23 | Signal Pharmaceuticals, Llc | Uso de um inibidor da quinase tor e quinazolinona 5-substituída, composição farmacêutica que os compreende, e kit |
| US9782427B2 (en) * | 2013-04-17 | 2017-10-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
| BR112015026292B1 (pt) | 2013-04-17 | 2022-04-12 | Signal Pharmaceuticals, Llc | Uso de 1-etil-7-(2-metil-6-(1h-1,2,4-triazol-3-il)piridin-3-il)-3,4-dihidropirazino [2,3-b]pirazin-2(1h)- ona e métodos in vitro |
| TW201527300A (zh) | 2013-04-17 | 2015-07-16 | Signal Pharm Llc | 關於１－乙基－７－（２－甲基－６－（１Ｈ－１，２，４－三唑－３－基）吡啶－３－基）－３，４－二氫吡并［２，３－ｂ］吡－２（１Ｈ）－酮之醫藥調配物、方法、固態型式及使用方法 |
| TW201521725A (zh) * | 2013-04-17 | 2015-06-16 | Signal Pharm Llc | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| AU2014254052B2 (en) | 2013-04-17 | 2019-06-06 | Signal Pharmaceuticals, Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| US9937169B2 (en) * | 2013-04-17 | 2018-04-10 | Signal Pharmaceuticals, Llc | Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy |
| EP3003313A1 (en) * | 2013-05-29 | 2016-04-13 | Signal Pharmaceuticals, LLC | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use |
| WO2015051251A1 (en) * | 2013-10-04 | 2015-04-09 | Signal Pharmaceuticals, Llc | A tor kinase inhibitor in the prevention or treatment of cancer characterized by gene mutations |
| US9512129B2 (en) | 2014-04-16 | 2016-12-06 | Signal Pharmaceuticals, Llc | Solid forms comprising 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one and a coformer |
| EP3131552B1 (en) | 2014-04-16 | 2020-07-15 | Signal Pharmaceuticals, LLC | Methods for treating cancer using tor kinase inhibitor combination therapy |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| US9718824B2 (en) | 2014-04-16 | 2017-08-01 | Signal Pharmaceuticals, Llc | Solid forms comprising 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one, and a coformer, compositions and methods of use thereof |
| NZ629796A (en) | 2014-07-14 | 2015-12-24 | Signal Pharm Llc | Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use |
| EA201790189A1 (ru) | 2014-07-14 | 2017-11-30 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Способы лечения злокачественного новообразования с использованием замещенных пирролопиримидиновых соединений, композиции на их основе |
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| WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
| SMT202100225T1 (it) | 2016-12-20 | 2021-05-07 | Astrazeneca Ab | Composti di ammino-triazolopiridina e loro uso nel trattamento del cancro |
| EP3641772B1 (en) | 2017-06-22 | 2023-08-02 | Celgene Corporation | Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection |
| SG11202003657VA (en) * | 2017-11-01 | 2020-05-28 | Juno Therapeutics Inc | Process for producing a t cell composition |
| MX2020009372A (es) | 2018-03-09 | 2020-10-14 | Recurium Ip Holdings Llc | 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-onas sustituidas. |
| CN110526907B (zh) * | 2018-05-23 | 2021-04-23 | 四川大学 | 苯并噁嗪酮类衍生物及其应用 |
| US12419865B2 (en) | 2018-12-06 | 2025-09-23 | Arisan Therapeutics Inc. | Compounds for the treatment of arenavirus infection |
| WO2021021986A1 (en) | 2019-07-31 | 2021-02-04 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of cd38 |
| AU2020385513A1 (en) * | 2019-11-22 | 2022-07-14 | Medshine Discovery Inc. | Pyrimidopyrrole spiro compounds and derivatives thereof as DNA-PK inhibitors |
| JP7383818B2 (ja) * | 2019-11-25 | 2023-11-20 | ザイ ラボ （シャンハイ） カンパニー、リミテッド． | Ｄｎａ－ｐｋ阻害剤としてのピリミドイミダゾル系化合物 |
| CN117355526A (zh) * | 2021-05-19 | 2024-01-05 | 再鼎医药(上海)有限公司 | 杂环取代的嘌呤酮衍生物的盐型及晶型 |
| WO2025199376A1 (en) * | 2024-03-22 | 2025-09-25 | Padarn Therapeutics, Inc. | Cdk2 inhibitors |
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2012
- 2012-10-18 KR KR1020147012908A patent/KR101978537B1/ko active Active
- 2012-10-18 CN CN201280062920.5A patent/CN103998036B/zh active Active
- 2012-10-18 UA UAA201405225A patent/UA115319C2/uk unknown
- 2012-10-18 WO PCT/US2012/060723 patent/WO2013059396A2/en not_active Ceased
- 2012-10-18 IN IN2887CHN2014 patent/IN2014CN02887A/en unknown
- 2012-10-18 MY MYPI2017000252A patent/MY183661A/en unknown
- 2012-10-18 PH PH1/2014/500869A patent/PH12014500869A1/en unknown
- 2012-10-18 MX MX2014004775A patent/MX348566B/es active IP Right Grant
- 2012-10-18 ES ES18207204T patent/ES2894958T3/es active Active
- 2012-10-18 US US13/654,441 patent/US9493466B2/en active Active
- 2012-10-18 TW TW106118908A patent/TWI708605B/zh active
- 2012-10-18 MX MX2018008536A patent/MX373925B/es unknown
- 2012-10-18 SG SG10201912850WA patent/SG10201912850WA/en unknown
- 2012-10-18 EP EP18207204.1A patent/EP3466423B1/en active Active
- 2012-10-18 MX MX2020004689A patent/MX384385B/es unknown
- 2012-10-18 TW TW101138515A patent/TWI629983B/zh active
- 2012-10-18 JP JP2014537216A patent/JP2014530861A/ja active Pending
- 2012-10-18 TW TW109119519A patent/TWI758746B/zh active
- 2012-10-18 SG SG10201505102WA patent/SG10201505102WA/en unknown
- 2012-10-18 EA EA201490814A patent/EA030664B1/ru not_active IP Right Cessation
- 2012-10-18 EA EA201890768A patent/EA034512B1/ru not_active IP Right Cessation
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