JP2014530627A - 抗原提示癌ワクチン - Google Patents

抗原提示癌ワクチン Download PDF

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Publication number
JP2014530627A
JP2014530627A JP2014537358A JP2014537358A JP2014530627A JP 2014530627 A JP2014530627 A JP 2014530627A JP 2014537358 A JP2014537358 A JP 2014537358A JP 2014537358 A JP2014537358 A JP 2014537358A JP 2014530627 A JP2014530627 A JP 2014530627A
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JP
Japan
Prior art keywords
cells
melanoma
ifn
cell
subject
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JP2014537358A
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English (en)
Japanese (ja)
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JP2014530627A5 (enExample
Inventor
コーンフォース、アンドリュー
ディルマン、ロバート
Original Assignee
カリフォルニア ステム セル インコーポレイテッド
カリフォルニア ステム セル インコーポレイテッド
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Application filed by カリフォルニア ステム セル インコーポレイテッド, カリフォルニア ステム セル インコーポレイテッド filed Critical カリフォルニア ステム セル インコーポレイテッド
Publication of JP2014530627A publication Critical patent/JP2014530627A/ja
Publication of JP2014530627A5 publication Critical patent/JP2014530627A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4271—Melanoma antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/876—Skin, melanoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2014537358A 2011-10-20 2012-10-22 抗原提示癌ワクチン Pending JP2014530627A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161549681P 2011-10-20 2011-10-20
US61/549,681 2011-10-20
US201261594304P 2012-02-02 2012-02-02
US61/594,304 2012-02-02

Publications (2)

Publication Number Publication Date
JP2014530627A true JP2014530627A (ja) 2014-11-20
JP2014530627A5 JP2014530627A5 (enExample) 2016-02-25

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014537358A Pending JP2014530627A (ja) 2011-10-20 2012-10-22 抗原提示癌ワクチン
JP2014537355A Pending JP2014533938A (ja) 2011-10-20 2012-10-22 γインターフェロンを用いた抗原提示癌ワクチン

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014537355A Pending JP2014533938A (ja) 2011-10-20 2012-10-22 γインターフェロンを用いた抗原提示癌ワクチン

Country Status (11)

Country Link
US (2) US20140308316A1 (enExample)
EP (2) EP2768519A4 (enExample)
JP (2) JP2014530627A (enExample)
KR (2) KR20150016200A (enExample)
CN (5) CN105861437A (enExample)
AU (2) AU2012325764A1 (enExample)
CA (2) CA2852960A1 (enExample)
HK (2) HK1201175A1 (enExample)
IL (2) IL232172A0 (enExample)
SG (4) SG10201508535RA (enExample)
WO (2) WO2013059778A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014533938A (ja) * 2011-10-20 2014-12-18 カリフォルニア ステム セル インコーポレイテッド γインターフェロンを用いた抗原提示癌ワクチン

Families Citing this family (7)

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FR2865830B1 (fr) 2004-01-30 2006-05-19 Neopost Ind Systeme d'affranchissement de courrier a mode d'impression externe securise
CN103599528B (zh) * 2013-12-04 2015-08-05 深圳市合一康生物科技股份有限公司 人树突状细胞疫苗的制备方法
CN107109365A (zh) * 2014-07-17 2017-08-29 布莱恩·J·赫尔尼奇 多剂量注射用树突状细胞疫苗的制备及用于阻断her2和her3的联合治疗
CA3023265A1 (en) * 2016-05-05 2017-11-09 Nantomics, Llc Checkpoint failure and methods therefor
EP3582793A4 (en) * 2017-02-17 2020-12-16 Aivita Biomedical, Inc. METHODS TO IMPROVE TUMOR IMMUNOGENICITY AND COMPOSITIONS FOR AUTOLOGOUS ANTI-CANCER IMMUNOTHERAPEUTICS USING MODIFIED TUMOR CELLS AND MODIFIED DENDRITIC CELLS
WO2024107624A1 (en) * 2022-11-14 2024-05-23 Shattuck Labs, Inc. Methods of overcoming resistance to checkpoint inhibitor therapies
CN118441033B (zh) * 2024-04-24 2025-06-20 广西医科大学 HLA-DPB1*05:01在抗γ干扰素自身抗体所致获得性免疫缺陷筛查中的应用

Citations (3)

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JP2008517946A (ja) * 2004-10-25 2008-05-29 ベイラー・リサーチ・インスチチユート 熱ショックをかけたメラノーマ細胞体が装填された樹状細胞
JP2009502955A (ja) * 2005-07-29 2009-01-29 プロビデンス ヘルス システム 小胞（ｄｒｉｂｂｌｅ）中の不完全なリボソーム産物、および免疫応答を刺激するための使用方法
JP2014533938A (ja) * 2011-10-20 2014-12-18 カリフォルニア ステム セル インコーポレイテッド γインターフェロンを用いた抗原提示癌ワクチン

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AU669379B2 (en) * 1992-09-07 1996-06-06 Kyowa Hakko Kirin Co., Ltd. Humanized antibodies
US5874560A (en) * 1994-04-22 1999-02-23 The United States Of America As Represented By The Department Of Health And Human Services Melanoma antigens and their use in diagnostic and therapeutic methods
WO1999042564A2 (en) 1998-02-20 1999-08-26 The Rockefeller University Apoptotic cell-mediated antigen presentation to dendritic cells
PT1224264E (pt) 1999-10-15 2010-03-15 Baylor Res Inst Modificação de células imunogénicas
US7015205B1 (en) * 1999-10-18 2006-03-21 St. Vincent's Hospital And Medical Center Of New York Melanoma vaccine and methods of making and using same
JP2005515192A (ja) * 2001-11-29 2005-05-26 ダンドリット バイオテック アクティーゼルスカブ ヒト又は動物において免疫応答を誘導するための医薬組成物
GB0130720D0 (en) * 2001-12-21 2002-02-06 Serono Internat S A Proteins
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JP2009502955A (ja) * 2005-07-29 2009-01-29 プロビデンス ヘルス システム 小胞（ｄｒｉｂｂｌｅ）中の不完全なリボソーム産物、および免疫応答を刺激するための使用方法
JP2014533938A (ja) * 2011-10-20 2014-12-18 カリフォルニア ステム セル インコーポレイテッド γインターフェロンを用いた抗原提示癌ワクチン

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014533938A (ja) * 2011-10-20 2014-12-18 カリフォルニア ステム セル インコーポレイテッド γインターフェロンを用いた抗原提示癌ワクチン
US9555058B2 (en) 2011-10-20 2017-01-31 Neostem Oncology, Llc Antigen presenting cancer vaccine

Also Published As

Publication number Publication date
KR20150004791A (ko) 2015-01-13
SG10201602424RA (en) 2016-05-30
WO2013059778A3 (en) 2013-07-04
HK1201176A1 (en) 2015-08-28
NZ623915A (en) 2016-02-26
CN105999249A (zh) 2016-10-12
CN105861437A (zh) 2016-08-17
JP2014533938A (ja) 2014-12-18
EP2768519A4 (en) 2015-07-01
SG11201401632WA (en) 2014-05-29
EP2768534A4 (en) 2015-04-01
US9555058B2 (en) 2017-01-31
AU2012325764A1 (en) 2014-04-24
AU2012325758A1 (en) 2014-04-24
WO2013059778A2 (en) 2013-04-25
WO2013059784A1 (en) 2013-04-25
HK1201175A1 (en) 2015-08-28
SG10201508535RA (en) 2015-11-27
IL232173A0 (en) 2014-06-30
CA2852960A1 (en) 2013-04-25
CN103917246A (zh) 2014-07-09
EP2768519A2 (en) 2014-08-27
KR20150016200A (ko) 2015-02-11
US20140314814A1 (en) 2014-10-23
CN105288602A (zh) 2016-02-03
CA2852967A1 (en) 2013-04-25
CN103957925A (zh) 2014-07-30
US20140308316A1 (en) 2014-10-16
SG11201401631VA (en) 2014-05-29
NZ623917A (en) 2016-09-30
IL232172A0 (en) 2014-06-30
EP2768534A1 (en) 2014-08-27

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