JP2014528900A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014528900A5 JP2014528900A5 JP2013551268A JP2013551268A JP2014528900A5 JP 2014528900 A5 JP2014528900 A5 JP 2014528900A5 JP 2013551268 A JP2013551268 A JP 2013551268A JP 2013551268 A JP2013551268 A JP 2013551268A JP 2014528900 A5 JP2014528900 A5 JP 2014528900A5
- Authority
- JP
- Japan
- Prior art keywords
- topical formulation
- item
- facial
- lotion
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 46
- 239000002105 nanoparticle Substances 0.000 claims description 43
- 239000006210 lotion Substances 0.000 claims description 36
- 210000003491 skin Anatomy 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 15
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 14
- 239000013543 active substance Substances 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 12
- 229940124597 therapeutic agent Drugs 0.000 claims description 12
- 108030001720 Bontoxilysin Proteins 0.000 claims description 11
- 229940053031 botulinum toxin Drugs 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 208000035475 disorder Diseases 0.000 claims description 10
- 230000037303 wrinkles Effects 0.000 claims description 10
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 9
- 239000008387 emulsifying waxe Substances 0.000 claims description 9
- 230000001815 facial effect Effects 0.000 claims description 9
- 239000002480 mineral oil Substances 0.000 claims description 9
- 235000010446 mineral oil Nutrition 0.000 claims description 9
- 235000019271 petrolatum Nutrition 0.000 claims description 9
- 239000003871 white petrolatum Substances 0.000 claims description 9
- 208000008454 Hyperhidrosis Diseases 0.000 claims description 8
- 208000005392 Spasm Diseases 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 206010019233 Headaches Diseases 0.000 claims description 7
- 231100000869 headache Toxicity 0.000 claims description 7
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 7
- 229960002216 methylparaben Drugs 0.000 claims description 7
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 7
- 229960003415 propylparaben Drugs 0.000 claims description 7
- 208000008035 Back Pain Diseases 0.000 claims description 6
- 208000008238 Muscle Spasticity Diseases 0.000 claims description 6
- 230000002500 effect on skin Effects 0.000 claims description 6
- 208000014094 Dystonic disease Diseases 0.000 claims description 5
- 239000002609 medium Substances 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 5
- 229940068968 polysorbate 80 Drugs 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 208000018198 spasticity Diseases 0.000 claims description 5
- 230000035900 sweating Effects 0.000 claims description 5
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 5
- 201000004624 Dermatitis Diseases 0.000 claims description 4
- 206010063006 Facial spasm Diseases 0.000 claims description 4
- 208000004095 Hemifacial Spasm Diseases 0.000 claims description 4
- 208000010118 dystonia Diseases 0.000 claims description 4
- 208000004296 neuralgia Diseases 0.000 claims description 4
- 229920000136 polysorbate Polymers 0.000 claims description 4
- 229950008882 polysorbate Drugs 0.000 claims description 4
- 210000002307 prostate Anatomy 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 208000008742 seborrheic dermatitis Diseases 0.000 claims description 4
- 210000005070 sphincter Anatomy 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims description 3
- 208000035985 Body Odor Diseases 0.000 claims description 3
- 208000007101 Muscle Cramp Diseases 0.000 claims description 3
- 208000002193 Pain Diseases 0.000 claims description 3
- 206010040904 Skin odour abnormal Diseases 0.000 claims description 3
- 206010000496 acne Diseases 0.000 claims description 3
- 239000002612 dispersion medium Substances 0.000 claims description 3
- 230000037315 hyperhidrosis Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000003961 penetration enhancing agent Substances 0.000 claims description 3
- 201000004384 Alopecia Diseases 0.000 claims description 2
- 206010002153 Anal fissure Diseases 0.000 claims description 2
- 208000016583 Anus disease Diseases 0.000 claims description 2
- 206010003591 Ataxia Diseases 0.000 claims description 2
- 208000035143 Bacterial infection Diseases 0.000 claims description 2
- 206010069632 Bladder dysfunction Diseases 0.000 claims description 2
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 2
- 208000005872 Diffuse Esophageal Spasm Diseases 0.000 claims description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 2
- 206010013774 Dry eye Diseases 0.000 claims description 2
- 201000011275 Epicondylitis Diseases 0.000 claims description 2
- 208000000289 Esophageal Achalasia Diseases 0.000 claims description 2
- 208000004929 Facial Paralysis Diseases 0.000 claims description 2
- 206010016228 Fasciitis Diseases 0.000 claims description 2
- 208000009531 Fissure in Ano Diseases 0.000 claims description 2
- 206010017533 Fungal infection Diseases 0.000 claims description 2
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims description 2
- 208000021710 Hyperpigmentation disease Diseases 0.000 claims description 2
- 206010020853 Hypertonic bladder Diseases 0.000 claims description 2
- 208000026748 Hypopigmentation disease Diseases 0.000 claims description 2
- 208000003351 Melanosis Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000031888 Mycoses Diseases 0.000 claims description 2
- 206010028836 Neck pain Diseases 0.000 claims description 2
- 206010030136 Oesophageal achalasia Diseases 0.000 claims description 2
- 206010030184 Oesophageal spasm Diseases 0.000 claims description 2
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000036496 Pelvic floor dyssynergia Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 208000012322 Raynaud phenomenon Diseases 0.000 claims description 2
- 208000005793 Restless legs syndrome Diseases 0.000 claims description 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims description 2
- 241001303601 Rosacea Species 0.000 claims description 2
- 206010039792 Seborrhoea Diseases 0.000 claims description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 206010067672 Spasmodic dysphonia Diseases 0.000 claims description 2
- 208000004350 Strabismus Diseases 0.000 claims description 2
- 208000002240 Tennis Elbow Diseases 0.000 claims description 2
- 206010043269 Tension headache Diseases 0.000 claims description 2
- 208000008548 Tension-Type Headache Diseases 0.000 claims description 2
- 206010044074 Torticollis Diseases 0.000 claims description 2
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 2
- 208000016620 Tourette disease Diseases 0.000 claims description 2
- 206010044565 Tremor Diseases 0.000 claims description 2
- 208000036826 VIIth nerve paralysis Diseases 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 206010047642 Vitiligo Diseases 0.000 claims description 2
- 201000000621 achalasia Diseases 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 208000009621 actinic keratosis Diseases 0.000 claims description 2
- 201000010105 allergic rhinitis Diseases 0.000 claims description 2
- 201000002898 anismus Diseases 0.000 claims description 2
- 230000001166 anti-perspirative effect Effects 0.000 claims description 2
- 239000003213 antiperspirant Substances 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 201000008937 atopic dermatitis Diseases 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 2
- 206010006514 bruxism Diseases 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 206010008129 cerebral palsy Diseases 0.000 claims description 2
- 201000002866 cervical dystonia Diseases 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- 201000006517 essential tremor Diseases 0.000 claims description 2
- 210000004709 eyebrow Anatomy 0.000 claims description 2
- 230000008921 facial expression Effects 0.000 claims description 2
- 208000014337 facial nerve disease Diseases 0.000 claims description 2
- 210000001061 forehead Anatomy 0.000 claims description 2
- 230000002496 gastric effect Effects 0.000 claims description 2
- 210000004907 gland Anatomy 0.000 claims description 2
- 210000003780 hair follicle Anatomy 0.000 claims description 2
- 208000024963 hair loss Diseases 0.000 claims description 2
- 230000003676 hair loss Effects 0.000 claims description 2
- 206010020718 hyperplasia Diseases 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 210000001352 masseter muscle Anatomy 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 210000003205 muscle Anatomy 0.000 claims description 2
- 208000018360 neuromuscular disease Diseases 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 208000020629 overactive bladder Diseases 0.000 claims description 2
- 239000011148 porous material Substances 0.000 claims description 2
- 208000017497 prostate disease Diseases 0.000 claims description 2
- 206010039083 rhinitis Diseases 0.000 claims description 2
- 201000004700 rosacea Diseases 0.000 claims description 2
- 210000001732 sebaceous gland Anatomy 0.000 claims description 2
- 210000002374 sebum Anatomy 0.000 claims description 2
- 208000020352 skin basal cell carcinoma Diseases 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000010106 skin squamous cell carcinoma Diseases 0.000 claims description 2
- 201000002849 spasmodic dystonia Diseases 0.000 claims description 2
- 210000000434 stratum corneum Anatomy 0.000 claims description 2
- 210000000106 sweat gland Anatomy 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 210000001738 temporomandibular joint Anatomy 0.000 claims description 2
- 206010044652 trigeminal neuralgia Diseases 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 239000012049 topical pharmaceutical composition Substances 0.000 claims 21
- 239000006071 cream Substances 0.000 claims 6
- 230000000699 topical effect Effects 0.000 claims 5
- 108010010803 Gelatin Proteins 0.000 claims 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 239000000839 emulsion Substances 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 239000002453 shampoo Substances 0.000 claims 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 208000037845 Cutaneous squamous cell carcinoma Diseases 0.000 claims 1
- 206010013642 Drooling Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 208000008630 Sialorrhea Diseases 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 208000013142 Writer cramp Diseases 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 210000002615 epidermis Anatomy 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 201000002865 focal hand dystonia Diseases 0.000 claims 1
- 230000007160 gastrointestinal dysfunction Effects 0.000 claims 1
- 229940014259 gelatin Drugs 0.000 claims 1
- 210000004209 hair Anatomy 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 229940040145 liniment Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 208000021090 palsy Diseases 0.000 claims 1
- -1 patch Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 201000004240 prostatic hypertrophy Diseases 0.000 claims 1
- 239000000344 soap Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000000475 sunscreen effect Effects 0.000 claims 1
- 239000000516 sunscreening agent Substances 0.000 claims 1
- 235000015961 tonic Nutrition 0.000 claims 1
- 230000001256 tonic effect Effects 0.000 claims 1
- 229960000716 tonics Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 description 22
- 206010040954 Skin wrinkling Diseases 0.000 description 5
- 230000000149 penetrating effect Effects 0.000 description 3
- 230000037371 chromhidrosis Effects 0.000 description 2
- 208000015318 chromhidrosis Diseases 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 206010028311 Muscle hypertrophy Diseases 0.000 description 1
- 206010051482 Prostatomegaly Diseases 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010005159 blepharospasm Diseases 0.000 description 1
- 230000000744 blepharospasm Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 230000012042 muscle hypertrophy Effects 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161435780P | 2011-01-24 | 2011-01-24 | |
| US61/435,780 | 2011-01-24 | ||
| PCT/US2012/022276 WO2012103035A1 (en) | 2011-01-24 | 2012-01-23 | Nanoparticle compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016032817A Division JP2016121175A (ja) | 2011-01-24 | 2016-02-24 | ナノ粒子組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014528900A JP2014528900A (ja) | 2014-10-30 |
| JP2014528900A5 true JP2014528900A5 (enExample) | 2015-03-12 |
| JP5938838B2 JP5938838B2 (ja) | 2016-06-22 |
Family
ID=45563579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551268A Active JP5938838B2 (ja) | 2011-01-24 | 2012-01-23 | ナノ粒子組成物 |
| JP2016032817A Pending JP2016121175A (ja) | 2011-01-24 | 2016-02-24 | ナノ粒子組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016032817A Pending JP2016121175A (ja) | 2011-01-24 | 2016-02-24 | ナノ粒子組成物 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20120328702A1 (enExample) |
| EP (2) | EP2667854B1 (enExample) |
| JP (2) | JP5938838B2 (enExample) |
| KR (1) | KR20140003572A (enExample) |
| CN (3) | CN107714645A (enExample) |
| AU (2) | AU2012209339B2 (enExample) |
| BR (1) | BR112013018918A2 (enExample) |
| DK (1) | DK2667854T3 (enExample) |
| ES (1) | ES2720648T3 (enExample) |
| IL (1) | IL227623B (enExample) |
| SG (1) | SG193970A1 (enExample) |
| TR (1) | TR201905477T4 (enExample) |
| WO (1) | WO2012103035A1 (enExample) |
| ZA (1) | ZA201306391B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9486408B2 (en) * | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| EP2494958A1 (en) | 2006-12-01 | 2012-09-05 | Anterios, Inc. | Amphiphilic Entity Nanoparticles |
| CA2696570C (en) | 2007-08-17 | 2020-12-29 | Novartis Ag | Cyclic depsipeptides |
| AR086168A1 (es) | 2011-04-20 | 2013-11-27 | Novartis Ag | Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US20140051637A1 (en) * | 2011-04-28 | 2014-02-20 | National University Corporation Nagoya University | Brain-targeting functional nucleic acid and use thereof |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US8987413B2 (en) | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| EP3068422A1 (en) * | 2013-11-12 | 2016-09-21 | Colgate-Palmolive Company | Screening methods for antiperspirants |
| AU2015252947B2 (en) * | 2014-05-01 | 2020-07-09 | Anterios, Inc. | Demonstrable efficacy across or within patient populations |
| US10512658B2 (en) | 2015-09-16 | 2019-12-24 | Clutch, Inc. | Compositions for the treatment of sweating and methods for making same |
| US10149805B2 (en) | 2015-09-16 | 2018-12-11 | Clutch, Inc. | Compositions for the treatment of sweating and methods for making same |
| CN105249559A (zh) * | 2015-10-27 | 2016-01-20 | 浙江华尔纺织科技有限公司 | 一种美肤护跟套 |
| JP6873598B2 (ja) * | 2015-12-22 | 2021-05-19 | ロレアル | 活性成分のための改善された局所送達系 |
| KR101679992B1 (ko) * | 2015-12-31 | 2016-11-28 | 주식회사 유유제약 | 프로필렌글리콜 모노라우레이트를 포함하는 두타스테리드의 약학적 조성물 및 이의 제조 방법 |
| KR20190123256A (ko) * | 2016-07-29 | 2019-10-31 | 로저 엘. 카스파 | 액취증 치료 방법 |
| US11311496B2 (en) * | 2016-11-21 | 2022-04-26 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
| FR3061434B1 (fr) * | 2017-01-04 | 2019-07-12 | Pierre Fabre Dermo-Cosmetique | Composition cosmetique comprenant une association d'huile de pongamia et de pentylene glycol 4-t-butylcyclohexanol pour lutter contre la rosacee |
| DK3431072T3 (da) | 2017-07-17 | 2020-02-17 | Dr August Wolff Gmbh & Co Kg Arzneimittel | Olie-i-vand-emulsion |
| US12280114B2 (en) * | 2018-03-29 | 2025-04-22 | Institute Of Basic Medical Sciences | Extraction of plant source “medicinal soup” and manual preparation of “herbal medicine” and related products |
| WO2020056191A1 (en) | 2018-09-13 | 2020-03-19 | Eirion Therapeutics, Inc. | Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors |
| EP3849539A1 (en) | 2018-09-13 | 2021-07-21 | Eirion Therapeutics, Inc. | Plasminogen activator inhibitor 1 (pai-1) inhibitors and uses therefor |
| AU2019391791A1 (en) | 2018-12-03 | 2021-06-03 | Eirion Therapeutics, Inc. | Improved delivery of large agents |
| WO2020152350A1 (en) * | 2019-01-25 | 2020-07-30 | Nogra Pharma Limited | Compositions for use in preventing acne |
| WO2020185685A1 (en) * | 2019-03-08 | 2020-09-17 | The Regents Of The University Of California | Compositions and methods for treating acne |
| US20220273765A1 (en) * | 2019-04-24 | 2022-09-01 | Follicum Ab | Topical formulation |
| JP2022533113A (ja) | 2019-05-14 | 2022-07-21 | エイリオン セラピューティクス， インコーポレイテッド | ピーク効果の遅延および／または応答持続時間の延長 |
| US12280096B2 (en) | 2021-07-12 | 2025-04-22 | Penland Foundation | Treatments of cancer using nitrous oxide and botulinum toxin |
| JP2023527162A (ja) * | 2020-05-18 | 2023-06-27 | マックス バイオロジー カンパニー リミテッド | 脂質ポリマー組成物及び使用方法 |
| CN113081905B (zh) * | 2021-04-28 | 2022-11-18 | 媞颂日化用品(广州)有限公司 | 一种仿生皮脂膜组合物及其制备方法和应用 |
| US20240245611A1 (en) | 2021-05-25 | 2024-07-25 | Evonik Operations Gmbh | Hard-shell capsule with influx prevention of gastric fluids |
| EP4346779A1 (en) | 2021-05-25 | 2024-04-10 | Evonik Operations GmbH | Hard shell capsules with modified release coating |
| MX2024000408A (es) | 2021-07-09 | 2024-01-29 | Evonik Operations Gmbh | Capsulas de cubierta dura que tienen liberacion en el colon mejorada. |
| IL315022A (en) | 2022-02-22 | 2024-10-01 | Evonik Operations Gmbh | Hard shell capsule with at least one coating layer with low oxygen permeability |
| KR20240158254A (ko) | 2022-03-15 | 2024-11-04 | 에보닉 오퍼레이션스 게엠베하 | pH 값 5 내지 5.5 에서 약물 방출이 가속화되는 사전 기능화된 경질 쉘 캡슐 |
| WO2023214016A1 (en) | 2022-05-06 | 2023-11-09 | Evonik Operations Gmbh | Dosage form with drug release at ph 3 to 6 using double coating system with at least one release acceleration agent |
| CN115382476B (zh) * | 2022-07-26 | 2024-10-22 | 华东师范大学 | 一种超小粒径聚合物纳米颗粒的制备方法 |
| WO2024150216A1 (en) * | 2023-01-09 | 2024-07-18 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Topical compositions and methods for treating alopecia |
| WO2025064449A1 (en) | 2023-09-18 | 2025-03-27 | Eirion Therapeutics, Inc. | Topical compositions and uses of pai-1 inhibitors |
| WO2025092792A1 (zh) * | 2023-10-31 | 2025-05-08 | 妍诗美社(海南)医美健康科技有限公司 | 一种大分子透皮微乳系统及其应用 |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US296006A (en) | 1884-04-01 | John hoefleb | ||
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4908154A (en) | 1981-04-17 | 1990-03-13 | Biotechnology Development Corporation | Method of forming a microemulsion |
| US4533254A (en) | 1981-04-17 | 1985-08-06 | Biotechnology Development Corporation | Apparatus for forming emulsions |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| AU98530S (en) | 1985-06-20 | 1987-11-05 | Novartis Ag | Subdivided membrane controlled transdermal device |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4886499A (en) | 1986-12-18 | 1989-12-12 | Hoffmann-La Roche Inc. | Portable injection appliance |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5008110A (en) | 1988-11-10 | 1991-04-16 | The Procter & Gamble Company | Storage-stable transdermal patch |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US6005087A (en) | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US6399754B1 (en) | 1991-12-24 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US6165500A (en) | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
| JPH04198122A (ja) * | 1990-11-28 | 1992-07-17 | Procter & Gamble Co:The | チオールヘテロ環脱臭組成物及び脱臭方法 |
| JPH04198123A (ja) * | 1990-11-28 | 1992-07-17 | Procter & Gamble Co:The | アミン脱臭組成物及び脱臭方法 |
| JPH04202122A (ja) * | 1990-11-28 | 1992-07-22 | Procter & Gamble Co:The | ジケトン脱臭組成物及び脱臭方法 |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US7384918B2 (en) | 1991-09-24 | 2008-06-10 | Allergan, Inc. | Botulinum toxin for treating muscle contracture |
| US6939852B2 (en) | 1991-09-24 | 2005-09-06 | Allergan, Inc. | Methods and compositions for the treatment of cerebral palsy |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US6010715A (en) | 1992-04-01 | 2000-01-04 | Bertek, Inc. | Transdermal patch incorporating a polymer film incorporated with an active agent |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1261849B (it) | 1993-09-02 | 1996-06-03 | Avantgarde Spa | Dispositivo medico per la somministrazione di principi attivi o farmaci a bassissimo dosaggio, in particolare di farmaci omeopatici. |
| US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5596091A (en) | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5922695A (en) | 1996-07-26 | 1999-07-13 | Gilead Sciences, Inc. | Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability |
| US6127533A (en) | 1997-02-14 | 2000-10-03 | Isis Pharmaceuticals, Inc. | 2'-O-aminooxy-modified oligonucleotides |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| US5965154A (en) | 1998-03-17 | 1999-10-12 | Plc Holding, L.L.C. | Adhesive matrix type transdermal patch and method of manufacturing same |
| US6403779B1 (en) | 1999-01-08 | 2002-06-11 | Isis Pharmaceuticals, Inc. | Regioselective synthesis of 2′-O-modified nucleosides |
| US7780967B2 (en) * | 2000-02-08 | 2010-08-24 | Allergan, Inc. | Reduced toxicity Clostridial toxin pharmaceutical compositions |
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US20050032733A1 (en) | 2001-05-18 | 2005-02-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
| US20050020525A1 (en) | 2002-02-20 | 2005-01-27 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| US20030072841A1 (en) * | 2001-03-19 | 2003-04-17 | The Procter & Gamble Campany | Polybutene containing chewing gum and confection |
| US20030175950A1 (en) | 2001-05-29 | 2003-09-18 | Mcswiggen James A. | RNA interference mediated inhibition of HIV gene expression using short interfering RNA |
| EP2390328A1 (en) | 2001-09-28 | 2011-11-30 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | MicroRNA molecules |
| US7763663B2 (en) | 2001-12-19 | 2010-07-27 | University Of Massachusetts | Polysaccharide-containing block copolymer particles and uses thereof |
| WO2003105780A2 (en) | 2002-06-18 | 2003-12-24 | Epigenesis Pharmaceuticals, Inc. | A dry powder oligonucleotide formulation, preparation and its uses |
| US20040009180A1 (en) | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
| US7824693B2 (en) * | 2002-08-19 | 2010-11-02 | Ira Sanders | Treatment of fine wrinkles with clostridia neurotoxins |
| PT1729821E (pt) * | 2004-03-03 | 2013-10-23 | Revance Therapeutics Inc | Composições e métodos para aplicação tópica e administração transdérmica de toxinas botulínicas |
| CN103315954A (zh) | 2005-07-18 | 2013-09-25 | 麻萨诸塞州洛厄尔大学 | 制备与使用纳米乳剂的组合物和方法 |
| TR201901443T4 (tr) * | 2005-12-01 | 2019-02-21 | Univ Massachusetts Lowell | Botulinum nanoemülsiyonları. |
| US20080206155A1 (en) * | 2006-11-14 | 2008-08-28 | Foamix Ltd. | Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses |
| CA2671133C (en) | 2006-12-01 | 2015-11-24 | Anterios, Inc. | Peptide nanoparticles and uses therefor |
| EP2494958A1 (en) * | 2006-12-01 | 2012-09-05 | Anterios, Inc. | Amphiphilic Entity Nanoparticles |
| EP1938801A1 (en) * | 2006-12-22 | 2008-07-02 | Biofrontera Bioscience GmbH | Nanoemulsion |
| US10016451B2 (en) * | 2007-05-31 | 2018-07-10 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
| US9511016B2 (en) * | 2007-06-12 | 2016-12-06 | Epicentrx, Inc. | Topical composition for treating pain |
| BRPI0817664A2 (pt) * | 2007-10-12 | 2015-03-24 | Massachusetts Inst Technology | Nanopartículas, método para preparar nanopartículas e método para tratar terapeuticamente ou profilaticamente um indivíduo |
| KR20160130519A (ko) * | 2008-06-26 | 2016-11-11 | 안테리오스, 인코퍼레이티드 | 경피 운반 |
| EP2667860A1 (en) * | 2011-01-24 | 2013-12-04 | Anterios, Inc. | Compositions of empty nanoparticles and their use for treating dermatological conditions |
| WO2012103038A2 (en) * | 2011-01-24 | 2012-08-02 | Anterios, Inc. | Nanoparticle compositions, formulations thereof, and uses therefor |
| US20120328549A1 (en) * | 2011-01-24 | 2012-12-27 | Anterios, Inc. | Oil compositions |
-
2012
- 2012-01-23 WO PCT/US2012/022276 patent/WO2012103035A1/en not_active Ceased
- 2012-01-23 JP JP2013551268A patent/JP5938838B2/ja active Active
- 2012-01-23 US US13/356,621 patent/US20120328702A1/en not_active Abandoned
- 2012-01-23 CN CN201710933664.7A patent/CN107714645A/zh active Pending
- 2012-01-23 DK DK12702700.1T patent/DK2667854T3/en active
- 2012-01-23 ES ES12702700T patent/ES2720648T3/es active Active
- 2012-01-23 BR BR112013018918A patent/BR112013018918A2/pt not_active IP Right Cessation
- 2012-01-23 EP EP12702700.1A patent/EP2667854B1/en active Active
- 2012-01-23 KR KR1020137022334A patent/KR20140003572A/ko not_active Ceased
- 2012-01-23 CN CN201811111999.1A patent/CN109464393A/zh active Pending
- 2012-01-23 EP EP19151722.6A patent/EP3572072A1/en active Pending
- 2012-01-23 CN CN201280014473.6A patent/CN103747782A/zh active Pending
- 2012-01-23 AU AU2012209339A patent/AU2012209339B2/en active Active
- 2012-01-23 SG SG2013072517A patent/SG193970A1/en unknown
- 2012-01-23 TR TR2019/05477T patent/TR201905477T4/tr unknown
-
2013
- 2013-07-24 IL IL227623A patent/IL227623B/en active IP Right Grant
- 2013-08-23 ZA ZA2013/06391A patent/ZA201306391B/en unknown
-
2015
- 2015-01-16 US US14/598,764 patent/US20150196490A1/en not_active Abandoned
-
2016
- 2016-02-24 JP JP2016032817A patent/JP2016121175A/ja active Pending
-
2017
- 2017-04-12 AU AU2017202420A patent/AU2017202420A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014528900A5 (enExample) | ||
| JP2014510041A5 (enExample) | ||
| JP2016117765A5 (enExample) | ||
| JP2014503585A5 (enExample) | ||
| JP6131194B2 (ja) | 皮膚科学的症状を処置するためのエンプティナノ粒子組成物およびその使用 | |
| US20220257482A1 (en) | Anti-aging and skin tone lightening compositions and methods for same | |
| BRPI0619134A2 (pt) | nanoemulsão, composição farmacêutica, e, métodos de administração da toxina botulìnica transdermicamente a um indivìduo, de tratamento de, e de retardar o inìcio das, rugas, linhas faciais e/ou linhas do pescoço, e de fabricação de uma nanoemulsão | |
| JP2022164750A5 (enExample) | ||
| JP2014503587A (ja) | 界面活性剤組成物 | |
| KR102006952B1 (ko) | 주름 예방 및 개선용 화장료 조성물 | |
| US20090047316A1 (en) | Porous particles loaded with cosmetically or pharmaceutically active compounds | |
| JP2014507420A (ja) | パラベン組成物 | |
| KR20150066807A (ko) | 피부 미백용 화장료 조성물 | |
| KR20140147950A (ko) | 필러와 보틀리눔 독소를 포함하는 피부 주름, 노화 개선 또는 신경근육 관련 질환 치료용 조성물 | |
| JP5669437B2 (ja) | 組成物 | |
| KR101626473B1 (ko) | 시클로헥산 디카르복실산 유도체를 함유하는 피부 외용제 조성물 | |
| KR100875042B1 (ko) | 화장용 조성물 및 감각기관의 청량감 발생 방법 | |
| Aziz et al. | Survey of nanotechnology in beauty products development | |
| KR102491996B1 (ko) | 주름 예방 및 개선용 화장료 조성물 | |
| CN106309153B (zh) | 包含脂肪酸和中和剂的多层神经酰胺片状结构体 | |
| KR102502511B1 (ko) | 주름 예방 및 개선용 화장료 조성물 | |
| KR102132713B1 (ko) | 모발 또는 두피 상태 개선용 조성물 | |
| KR102006951B1 (ko) | 비듬 또는 가려움 예방 및 개선용 화장료 조성물 | |
| JP2005053835A (ja) | 乳化型皮膚外用剤 | |
| JP2023553119A (ja) | 構造水培地からの発酵体及びそれを含む化粧品組成物 |