JP2014527042A5 - - Google Patents
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- Publication number
- JP2014527042A5 JP2014527042A5 JP2014522877A JP2014522877A JP2014527042A5 JP 2014527042 A5 JP2014527042 A5 JP 2014527042A5 JP 2014522877 A JP2014522877 A JP 2014522877A JP 2014522877 A JP2014522877 A JP 2014522877A JP 2014527042 A5 JP2014527042 A5 JP 2014527042A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutically acceptable
- acute lymphoblastic
- hydrate
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 4
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 4
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 claims 4
- 208000036566 Erythroleukaemia Diseases 0.000 claims 4
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 4
- 208000005017 glioblastoma Diseases 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 3
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 3
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000000172 Medulloblastoma Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 210000000214 mouth Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161512016P | 2011-07-27 | 2011-07-27 | |
| US61/512,016 | 2011-07-27 | ||
| US201161560486P | 2011-11-16 | 2011-11-16 | |
| US61/560,486 | 2011-11-16 | ||
| PCT/US2012/047100 WO2013016081A1 (en) | 2011-07-27 | 2012-07-18 | Notch pathway signaling inhibitor compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014527042A JP2014527042A (ja) | 2014-10-09 |
| JP2014527042A5 true JP2014527042A5 (OSRAM) | 2015-08-20 |
| JP6027110B2 JP6027110B2 (ja) | 2016-11-16 |
Family
ID=46598983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014522877A Active JP6027110B2 (ja) | 2011-07-27 | 2012-07-18 | ノッチ経路シグナリングインヒビター化合物 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8569286B2 (OSRAM) |
| EP (1) | EP2736920B1 (OSRAM) |
| JP (1) | JP6027110B2 (OSRAM) |
| KR (1) | KR101578309B1 (OSRAM) |
| CN (1) | CN103732612B (OSRAM) |
| AP (1) | AP4080A (OSRAM) |
| AR (1) | AR087107A1 (OSRAM) |
| AU (1) | AU2012287251B2 (OSRAM) |
| BR (1) | BR112014001600B1 (OSRAM) |
| CA (1) | CA2841178C (OSRAM) |
| CL (1) | CL2014000175A1 (OSRAM) |
| CO (1) | CO6862159A2 (OSRAM) |
| CR (1) | CR20140036A (OSRAM) |
| CY (1) | CY1116645T1 (OSRAM) |
| DK (1) | DK2736920T3 (OSRAM) |
| DO (1) | DOP2014000011A (OSRAM) |
| EA (1) | EA023044B1 (OSRAM) |
| EC (1) | ECSP14013179A (OSRAM) |
| ES (1) | ES2544937T3 (OSRAM) |
| GT (1) | GT201400012A (OSRAM) |
| HR (1) | HRP20150771T1 (OSRAM) |
| HU (1) | HUE027534T2 (OSRAM) |
| IL (1) | IL229988A (OSRAM) |
| JO (1) | JO3148B1 (OSRAM) |
| MA (1) | MA35611B1 (OSRAM) |
| ME (1) | ME02171B (OSRAM) |
| MX (1) | MX356536B (OSRAM) |
| MY (1) | MY184303A (OSRAM) |
| PE (1) | PE20141061A1 (OSRAM) |
| PH (1) | PH12014500215B1 (OSRAM) |
| PL (1) | PL2736920T3 (OSRAM) |
| PT (1) | PT2736920E (OSRAM) |
| RS (1) | RS54135B1 (OSRAM) |
| SI (1) | SI2736920T1 (OSRAM) |
| TW (1) | TWI568730B (OSRAM) |
| WO (1) | WO2013016081A1 (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014110506A2 (en) * | 2013-01-14 | 2014-07-17 | The Trustees Of Columbia University In The City Of New York | Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders |
| CN105764502A (zh) | 2013-07-26 | 2016-07-13 | 现代化制药公司 | 改善比生群及其类似物及衍生物的治疗益处的组合方法 |
| TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
| TWI609687B (zh) | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
| AR105080A1 (es) | 2015-07-07 | 2017-09-06 | Lilly Co Eli | Compuestos inhibidores de la señalización de la vía de notch |
| TWI781920B (zh) | 2016-02-05 | 2022-11-01 | 美商戴納立製藥公司 | 化合物、組合物及方法 |
| EA201892075A1 (ru) | 2016-03-15 | 2019-04-30 | Оризон Дженомикс, С.А. | Комбинации ингибиторов lsd1 для применения для лечения солидных опухолей |
| RU2754452C2 (ru) * | 2016-04-12 | 2021-09-02 | Эли Лилли Энд Компани | Комбинированная терапия ингибиторами notch и pi3k/mtor для применения в лечении рака |
| CA3020875A1 (en) * | 2016-04-12 | 2017-10-19 | Eli Lilly And Company | Combination therapy with notch and cdk4/6 inhibitors for the treatment of cancer |
| ES2904880T3 (es) * | 2016-05-20 | 2022-04-06 | Lilly Co Eli | Terapia combinada con inhibidores de Notch y de PD-1 o PD-L1 |
| CN109562114A (zh) * | 2016-08-31 | 2019-04-02 | 伊莱利利公司 | 用于治疗实体瘤的给药方案 |
| WO2018071307A1 (en) | 2016-10-12 | 2018-04-19 | Eli Lilly And Company | Targeted treatment of mature t-cell lymphoma |
| PL3552017T3 (pl) | 2016-12-09 | 2022-08-08 | Denali Therapeutics Inc. | Związki użyteczne jako inhibitory RIPK1 |
| MX2019009552A (es) | 2017-02-17 | 2019-10-02 | Hutchinson Fred Cancer Res | Terapias de combinacion para el tratamiento de canceres relacionados con el antigeno de maduracion de celulas b (bcma) y trastornos autoinmunitarios. |
| PL3703750T3 (pl) | 2017-11-01 | 2025-04-07 | Juno Therapeutics, Inc. | Chimeryczne receptory antygenowe specyficzne dla antygenu dojrzewania komórek b i kodujące polinukleotydy |
| CA3080395A1 (en) * | 2017-11-06 | 2019-05-09 | Juno Therapeutics, Inc. | Combination of a cell therapy and a gamma secretase inhibitor |
| KR20210005714A (ko) * | 2018-05-06 | 2021-01-14 | 아얄라 파마큐티컬즈 아이엔씨. | 비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조합 조성물 및 이의 사용 방법 |
| WO2020072601A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions comprising otic therapeutic agents and related methods |
| CN114340611A (zh) | 2019-04-08 | 2022-04-12 | 频率医疗公司 | 用于治疗听力损失的chir99021和丙戊酸的组合 |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL158355A0 (en) * | 1996-12-23 | 2004-05-12 | Elan Pharm Inc | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS AS beta-AMYLOID PEPTIDE RELEASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| CA2324474A1 (en) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| CA2325389A1 (en) * | 1998-06-22 | 1999-12-29 | James E. Audia | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| MXPA05008172A (es) | 2003-02-04 | 2005-10-05 | Hoffmann La Roche | Derivados de malonamida como inhibidores gamma-secretasa. |
| ES2322652T3 (es) | 2003-09-09 | 2009-06-24 | F. Hoffmann-La Roche Ag | Derivados de malonamida bloqueantes de la actividad gamma-secretasa. |
| MXPA06003870A (es) | 2003-10-06 | 2006-07-03 | Hoffmann La Roche | Derivados de dibenzo-azepina y benzo-diazepina substituidas utiles como inhibidores de gama-secretasa. |
| EP2018368B1 (en) | 2006-03-27 | 2012-12-05 | F. Hoffmann-La Roche AG | Malonamide derivatives as gamma secretase inhibitors |
| AU2008209861B2 (en) * | 2007-02-02 | 2012-08-09 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives |
| KR20140007979A (ko) | 2008-01-11 | 2014-01-20 | 에프. 호프만-라 로슈 아게 | 암 치료를 위한 감마-세크레타제 저해제의 용도 |
| US8637493B2 (en) * | 2009-11-12 | 2014-01-28 | University Of Massachusetts | Methods for treating glioblastoma |
-
2012
- 2012-07-10 AR ARP120102486A patent/AR087107A1/es not_active Application Discontinuation
- 2012-07-10 JO JOP/2012/0190A patent/JO3148B1/ar active
- 2012-07-13 TW TW101125459A patent/TWI568730B/zh active
- 2012-07-18 EA EA201490161A patent/EA023044B1/ru not_active IP Right Cessation
- 2012-07-18 CA CA2841178A patent/CA2841178C/en active Active
- 2012-07-18 BR BR112014001600-3A patent/BR112014001600B1/pt active IP Right Grant
- 2012-07-18 AU AU2012287251A patent/AU2012287251B2/en active Active
- 2012-07-18 PE PE2014000129A patent/PE20141061A1/es active IP Right Grant
- 2012-07-18 KR KR1020147001731A patent/KR101578309B1/ko active Active
- 2012-07-18 MY MYPI2014700183A patent/MY184303A/en unknown
- 2012-07-18 HU HUE12741192A patent/HUE027534T2/en unknown
- 2012-07-18 WO PCT/US2012/047100 patent/WO2013016081A1/en not_active Ceased
- 2012-07-18 CN CN201280037471.9A patent/CN103732612B/zh active Active
- 2012-07-18 PH PH1/2014/500215A patent/PH12014500215B1/en unknown
- 2012-07-18 ES ES12741192.4T patent/ES2544937T3/es active Active
- 2012-07-18 ME MEP-2015-105A patent/ME02171B/me unknown
- 2012-07-18 HR HRP20150771TT patent/HRP20150771T1/hr unknown
- 2012-07-18 AP AP2014007362A patent/AP4080A/en active
- 2012-07-18 MX MX2014001084A patent/MX356536B/es active IP Right Grant
- 2012-07-18 US US13/551,681 patent/US8569286B2/en active Active
- 2012-07-18 SI SI201230246T patent/SI2736920T1/sl unknown
- 2012-07-18 PL PL12741192T patent/PL2736920T3/pl unknown
- 2012-07-18 EP EP12741192.4A patent/EP2736920B1/en active Active
- 2012-07-18 JP JP2014522877A patent/JP6027110B2/ja active Active
- 2012-07-18 RS RS20150496A patent/RS54135B1/sr unknown
- 2012-07-18 DK DK12741192.4T patent/DK2736920T3/en active
- 2012-07-18 PT PT127411924T patent/PT2736920E/pt unknown
-
2013
- 2013-12-17 IL IL229988A patent/IL229988A/en active IP Right Grant
-
2014
- 2014-01-22 MA MA36712A patent/MA35611B1/fr unknown
- 2014-01-22 DO DO2014000011A patent/DOP2014000011A/es unknown
- 2014-01-23 CL CL2014000175A patent/CL2014000175A1/es unknown
- 2014-01-24 GT GT201400012A patent/GT201400012A/es unknown
- 2014-01-24 CO CO14014585A patent/CO6862159A2/es active IP Right Grant
- 2014-01-24 CR CR20140036A patent/CR20140036A/es unknown
- 2014-01-27 EC ECSP14013179 patent/ECSP14013179A/es unknown
-
2015
- 2015-08-25 CY CY20151100742T patent/CY1116645T1/el unknown
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