JP2014525429A - Staphylococcusaureus抗原のアジュバント添加処方物 - Google Patents
Staphylococcusaureus抗原のアジュバント添加処方物 Download PDFInfo
- Publication number
- JP2014525429A JP2014525429A JP2014527686A JP2014527686A JP2014525429A JP 2014525429 A JP2014525429 A JP 2014525429A JP 2014527686 A JP2014527686 A JP 2014527686A JP 2014527686 A JP2014527686 A JP 2014527686A JP 2014525429 A JP2014525429 A JP 2014525429A
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antigen
- tlr agonist
- aureus
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530162P | 2011-09-01 | 2011-09-01 | |
| US61/530,162 | 2011-09-01 | ||
| US201261607999P | 2012-03-07 | 2012-03-07 | |
| US61/607,999 | 2012-03-07 | ||
| PCT/EP2012/067032 WO2013030378A1 (en) | 2011-09-01 | 2012-08-31 | Adjuvanted formulations of staphylococcus aureus antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014525429A true JP2014525429A (ja) | 2014-09-29 |
| JP2014525429A5 JP2014525429A5 (https=) | 2015-10-01 |
Family
ID=46763095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014527686A Pending JP2014525429A (ja) | 2011-09-01 | 2012-08-31 | Staphylococcusaureus抗原のアジュバント添加処方物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20140363461A1 (https=) |
| EP (1) | EP2763695A1 (https=) |
| JP (1) | JP2014525429A (https=) |
| KR (1) | KR20140066212A (https=) |
| CN (1) | CN104093418A (https=) |
| AU (1) | AU2012300765A1 (https=) |
| BR (1) | BR112014004782A2 (https=) |
| CA (1) | CA2847204A1 (https=) |
| IL (1) | IL231104A0 (https=) |
| IN (1) | IN2014CN02152A (https=) |
| MX (1) | MX2014002363A (https=) |
| RU (1) | RU2014112343A (https=) |
| SG (1) | SG11201400210RA (https=) |
| WO (1) | WO2013030378A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2011144566A (ru) * | 2009-04-03 | 2013-05-10 | Момента Фармасьютикалз, Инк. | Контроль сополимерных композиций |
| WO2011027222A2 (en) | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| AU2011295853A1 (en) | 2010-09-01 | 2013-04-04 | Irm Llc | Adsorption of immunopotentiators to insoluble metal salts |
| AU2012214677B2 (en) * | 2011-02-08 | 2016-11-10 | Abvacc, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| WO2012117377A1 (en) | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| RU2014112343A (ru) * | 2011-09-01 | 2015-10-10 | Новартис Аг | Оставы антигенов staphylococcus aureus, содержащие адъюванты |
| SI2822947T1 (sl) * | 2012-03-07 | 2016-10-28 | Glaxosmithkline Biologicals S.A. | Argininske soli TLR7 agonista |
| MX372965B (es) | 2012-03-08 | 2020-04-01 | Glaxosmithkline Biologicals Sa | Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo. |
| US20150202277A1 (en) * | 2012-08-31 | 2015-07-23 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| HUE044211T2 (hu) * | 2012-08-31 | 2019-10-28 | Glaxosmithkline Biologicals Sa | Staphylococcus aureus elleni immunizálásra szolgáló, stabilizált fehérjék |
| US20150191513A1 (en) * | 2012-08-31 | 2015-07-09 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| BE1022359B1 (fr) * | 2014-03-17 | 2016-03-25 | Glaxosmithkline Biologicals Sa | Immunisation contre des infections staphylococciques des os et des articulations |
| BE1022875B1 (fr) * | 2014-03-26 | 2016-09-30 | Glaxosmithkline Biologicals S.A. | Compositions pour une immunisation contre staphylococcus aureus |
| CN106103469B (zh) * | 2014-03-26 | 2020-11-27 | 葛兰素史密丝克莱恩生物有限公司 | 突变型葡萄球菌抗原 |
| CN105646681B (zh) * | 2016-01-21 | 2021-07-16 | 浙江海隆生物科技有限公司 | 一种奶牛金黄色葡萄球菌α-溶血素亚单位疫苗的制备方法及应用 |
| CN109843327B (zh) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| AR111760A1 (es) | 2017-05-19 | 2019-08-14 | Novartis Ag | Compuestos y composiciones para el tratamiento de tumores sólidos mediante administración intratumoral |
| WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010119343A2 (en) * | 2009-04-14 | 2010-10-21 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| WO2011027222A2 (en) * | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| JP2013503884A (ja) * | 2009-09-02 | 2013-02-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Tlr活性モジュレーターとしての化合物および組成物 |
| JP2013538217A (ja) * | 2010-09-01 | 2013-10-10 | ノバルティス アーゲー | 不溶性金属塩への免疫増強物質の吸着 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0114787B1 (de) | 1983-01-25 | 1991-09-25 | Ciba-Geigy Ag | Neue Peptidderivate |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5776468A (en) | 1993-03-23 | 1998-07-07 | Smithkline Beecham Biologicals (S.A.) | Vaccine compositions containing 3-0 deacylated monophosphoryl lipid A |
| WO2005009378A2 (en) | 2003-07-24 | 2005-02-03 | Merck & Co., Inc. | Polypeptides for inducing a protective immune response against staphylococcus aureus |
| KR20060065643A (ko) | 2003-07-24 | 2006-06-14 | 머크 앤드 캄파니 인코포레이티드 | 스타필로코쿠스 아우레우스에 대한 방어 면역 반응을유도하는 폴리펩타이드 |
| US20070134263A1 (en) | 2004-02-18 | 2007-06-14 | Anderson Annaliesa S | Polypeptides for inducing a protective immune response against staphyloococcus aureus |
| TWI382019B (zh) | 2005-08-19 | 2013-01-11 | Array Biopharma Inc | 作為類鐸受體(toll-like receptor)調節劑之胺基二氮雜呯 |
| TW200801003A (en) | 2005-09-16 | 2008-01-01 | Astrazeneca Ab | Novel compounds |
| US20090105212A1 (en) | 2005-09-22 | 2009-04-23 | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan | Novel adenine compound |
| JPWO2007034817A1 (ja) | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
| JPWO2007034881A1 (ja) | 2005-09-22 | 2009-03-26 | 大日本住友製薬株式会社 | 新規アデニン化合物 |
| TW200745114A (en) | 2005-09-22 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| EP1939200A4 (en) | 2005-09-22 | 2010-06-16 | Dainippon Sumitomo Pharma Co | NEW ADENINE CONNECTION |
| JP2009528989A (ja) | 2006-02-17 | 2009-08-13 | ファイザー・リミテッド | Tlr7変調剤としての3−デアザプリン誘導体 |
| US20080131457A1 (en) | 2006-06-12 | 2008-06-05 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
| US8138172B2 (en) | 2006-07-05 | 2012-03-20 | Astrazeneca Ab | 8-oxoadenine derivatives acting as modulators of TLR7 |
| US20080008682A1 (en) | 2006-07-07 | 2008-01-10 | Chong Lee S | Modulators of toll-like receptor 7 |
| CA2667788A1 (en) | 2006-10-30 | 2008-12-18 | The University Of Western Ontario | Staphylococcus aureus specific anti-infectives |
| AR065372A1 (es) | 2007-02-19 | 2009-06-03 | Smithkline Beecham Corp | Derivados de purina |
| AR065784A1 (es) | 2007-03-20 | 2009-07-01 | Dainippon Sumitomo Pharma Co | Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. |
| HRP20120895T1 (hr) | 2007-05-08 | 2012-11-30 | Astrazeneca Ab | Imidazokinolini sa imuno-modulacijskim svojstvima |
| ES2359123T3 (es) | 2007-08-03 | 2011-05-18 | Pfizer Limited | Imidazopiridinonas. |
| JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
| PE20091236A1 (es) | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| CN102015651B (zh) | 2008-03-03 | 2014-12-31 | Irm责任有限公司 | 作为tlr活性调节剂的化合物和组合物 |
| DK2276486T3 (da) | 2008-03-24 | 2013-11-25 | 4Sc Discovery Gmbh | Nye substituerede imidazo-quinoliner |
| WO2010014913A1 (en) | 2008-08-01 | 2010-02-04 | Ventirx Pharmaceuticals, Inc. | Toll-like receptor agonist formulations and their use |
| RS53347B (sr) | 2008-12-09 | 2014-10-31 | Gilead Sciences, Inc. | Modulatori toll-sličnih receptora |
| SA110310528B1 (ar) * | 2009-06-22 | 2014-07-02 | Wyeth Llc | التركيبات المولدة للمناعة لأنتيجينات ستافيلوكوكس أوريس |
| CA2768485C (en) | 2009-07-16 | 2018-12-04 | Timothy Foster | Treatment of staphylococci infections using recombinant fibrinogen binding protein clumping factor a |
| GB0913681D0 (en) * | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EA031379B1 (ru) | 2010-03-23 | 2018-12-28 | Новартис Аг | Соединения (липопептиды на основе цистеина) и композиции в качестве агонистов tlr2, применяемые для лечения инфекционных, воспалительных, респираторных и других заболеваний |
| WO2012117377A1 (en) * | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| RU2014112343A (ru) * | 2011-09-01 | 2015-10-10 | Новартис Аг | Оставы антигенов staphylococcus aureus, содержащие адъюванты |
| JP2015510872A (ja) * | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Streptococcuspneumoniae抗原の増強された製剤 |
| MX372965B (es) * | 2012-03-08 | 2020-04-01 | Glaxosmithkline Biologicals Sa | Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo. |
| EP2822584A1 (en) * | 2012-03-08 | 2015-01-14 | Novartis AG | Combination vaccines with tlr4 agonists |
| US20150191513A1 (en) * | 2012-08-31 | 2015-07-09 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| US20150203543A1 (en) * | 2012-08-31 | 2015-07-23 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| HUE044211T2 (hu) * | 2012-08-31 | 2019-10-28 | Glaxosmithkline Biologicals Sa | Staphylococcus aureus elleni immunizálásra szolgáló, stabilizált fehérjék |
| US20150202277A1 (en) * | 2012-08-31 | 2015-07-23 | Novartis Ag | Stabilised proteins for immunising against staphylococcus aureus |
| JP6324961B2 (ja) * | 2012-09-06 | 2018-05-16 | ノバルティス アーゲー | 血清群b髄膜炎菌とd/t/pとの組み合わせワクチン |
| GB201219420D0 (en) * | 2012-10-29 | 2012-12-12 | Novartis Ag | Staphyloccal immunogens |
| BR112015018014A2 (pt) * | 2013-02-01 | 2017-07-11 | Glaxosmithkline Biologicals Sa | liberação intradérmica de composições imunológicas compreendendo agonistas do receptor do tipo toll |
| BE1022359B1 (fr) * | 2014-03-17 | 2016-03-25 | Glaxosmithkline Biologicals Sa | Immunisation contre des infections staphylococciques des os et des articulations |
| BE1022875B1 (fr) * | 2014-03-26 | 2016-09-30 | Glaxosmithkline Biologicals S.A. | Compositions pour une immunisation contre staphylococcus aureus |
| CN106103469B (zh) * | 2014-03-26 | 2020-11-27 | 葛兰素史密丝克莱恩生物有限公司 | 突变型葡萄球菌抗原 |
-
2012
- 2012-08-31 RU RU2014112343/10A patent/RU2014112343A/ru not_active Application Discontinuation
- 2012-08-31 CA CA2847204A patent/CA2847204A1/en not_active Abandoned
- 2012-08-31 CN CN201280053918.1A patent/CN104093418A/zh active Pending
- 2012-08-31 MX MX2014002363A patent/MX2014002363A/es unknown
- 2012-08-31 KR KR1020147008622A patent/KR20140066212A/ko not_active Withdrawn
- 2012-08-31 WO PCT/EP2012/067032 patent/WO2013030378A1/en not_active Ceased
- 2012-08-31 IN IN2152CHN2014 patent/IN2014CN02152A/en unknown
- 2012-08-31 BR BR112014004782A patent/BR112014004782A2/pt not_active IP Right Cessation
- 2012-08-31 JP JP2014527686A patent/JP2014525429A/ja active Pending
- 2012-08-31 AU AU2012300765A patent/AU2012300765A1/en not_active Abandoned
- 2012-08-31 EP EP12753488.1A patent/EP2763695A1/en not_active Withdrawn
- 2012-08-31 SG SG11201400210RA patent/SG11201400210RA/en unknown
- 2012-08-31 US US14/240,616 patent/US20140363461A1/en not_active Abandoned
-
2014
- 2014-02-24 IL IL231104A patent/IL231104A0/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010119343A2 (en) * | 2009-04-14 | 2010-10-21 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
| WO2011027222A2 (en) * | 2009-09-02 | 2011-03-10 | Novartis Ag | Immunogenic compositions including tlr activity modulators |
| JP2013503884A (ja) * | 2009-09-02 | 2013-02-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Tlr活性モジュレーターとしての化合物および組成物 |
| JP2013538217A (ja) * | 2010-09-01 | 2013-10-10 | ノバルティス アーゲー | 不溶性金属塩への免疫増強物質の吸着 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140066212A (ko) | 2014-05-30 |
| CA2847204A1 (en) | 2013-03-07 |
| BR112014004782A2 (pt) | 2017-03-21 |
| MX2014002363A (es) | 2014-04-14 |
| EP2763695A1 (en) | 2014-08-13 |
| US20140363461A1 (en) | 2014-12-11 |
| AU2012300765A1 (en) | 2014-03-13 |
| CN104093418A (zh) | 2014-10-08 |
| SG11201400210RA (en) | 2014-03-28 |
| RU2014112343A (ru) | 2015-10-10 |
| IL231104A0 (en) | 2014-04-30 |
| WO2013030378A1 (en) | 2013-03-07 |
| IN2014CN02152A (https=) | 2015-09-04 |
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