JP2014524936A - システインプロドラッグ - Google Patents
システインプロドラッグ Download PDFInfo
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- JP2014524936A JP2014524936A JP2014523106A JP2014523106A JP2014524936A JP 2014524936 A JP2014524936 A JP 2014524936A JP 2014523106 A JP2014523106 A JP 2014523106A JP 2014523106 A JP2014523106 A JP 2014523106A JP 2014524936 A JP2014524936 A JP 2014524936A
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
- C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
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- C—CHEMISTRY; METALLURGY
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- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
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- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
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- Molecular Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161512751P | 2011-07-28 | 2011-07-28 | |
| US61/512,751 | 2011-07-28 | ||
| PCT/US2012/048820 WO2013016727A1 (en) | 2011-07-28 | 2012-07-30 | Cysteine prodrugs |
Publications (2)
| Publication Number | Publication Date |
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| JP2014524936A true JP2014524936A (ja) | 2014-09-25 |
| JP2014524936A5 JP2014524936A5 (enExample) | 2015-09-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| JP2014523106A Pending JP2014524936A (ja) | 2011-07-28 | 2012-07-30 | システインプロドラッグ |
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| Country | Link |
|---|---|
| US (2) | US9457014B2 (enExample) |
| EP (1) | EP2736890A4 (enExample) |
| JP (1) | JP2014524936A (enExample) |
| CA (1) | CA2842106A1 (enExample) |
| WO (1) | WO2013016727A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2736890A4 (en) * | 2011-07-28 | 2015-07-15 | Promentis Pharm Inc | Cysteine PRODRUGS |
| US20130338165A1 (en) * | 2012-06-15 | 2013-12-19 | Promentis Pharmaceuticals, Inc. | Use of Compounds Elevating Glutathione Levels for the Treatment of Parkinson's Disease |
| US20150045312A1 (en) * | 2013-08-12 | 2015-02-12 | Promentis Pharmaceuticals, Inc. | Use of Compounds Elevating Glutathione Levels for the Treatment of Autism, Autistic Spectrum Disorders and Fragile X Syndrome |
| EP3066089B1 (en) | 2013-11-08 | 2019-11-06 | Promentis Pharmaceuticals, Inc. | Substituted n-acetyl-l-cysteine derivatives and related compounds |
| AU2015317877A1 (en) * | 2014-09-15 | 2017-05-04 | Sound Pharmaceuticals Incorporated | Methods and compositions for treating psychotic disorders |
| SMT202400469T1 (it) | 2016-05-18 | 2025-01-14 | Sound Pharmaceuticals Incorporated | Ebselen per l'uso nel trattamento della malattia di ménière |
| PL3338768T3 (pl) | 2016-12-20 | 2020-05-18 | Lts Lohmann Therapie-Systeme Ag | Transdermalny system terapeutyczny zawierający asenapinę |
| CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
| JP2020525545A (ja) | 2017-06-26 | 2020-08-27 | エルテーエス ローマン テラピー−ジステーメ アーゲー | アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム |
| CN112236138B (zh) | 2017-12-05 | 2024-05-31 | 赛诺维信制药公司 | 晶体形式及其制备方法 |
| AU2018379992B2 (en) | 2017-12-05 | 2022-07-21 | Sunovion Pharmaceuticals Inc. | Nonracemic mixtures and uses thereof |
| CN118806732A (zh) | 2018-06-20 | 2024-10-22 | 罗曼治疗系统股份公司 | 含有阿塞那平的透皮治疗系统 |
| BR112020026099A2 (pt) | 2018-06-20 | 2021-03-23 | Lts Lohmann Therapie-Systeme Ag | sistema terapêutico transdérmico que contém asenapina |
| CA3124825A1 (en) * | 2018-12-31 | 2020-07-09 | Zymergen Inc. | Polymer compositions comprising compounds derived from biology |
| CA3142355A1 (en) | 2019-06-04 | 2020-12-10 | Sunovion Pharmaceuticals Inc. | Modified release formulations and uses thereof |
| CN113024473B (zh) * | 2021-04-13 | 2022-08-23 | 陕西慧康生物科技有限责任公司 | 一种含有半胱氨酸的环二肽的合成方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05213910A (ja) * | 1991-03-27 | 1993-08-24 | Sankyo Co Ltd | チアまたはオキサゾリジノン誘導体 |
| JP2011514324A (ja) * | 2008-02-07 | 2011-05-06 | マーケット ユニバーシティー | 統合失調症を治療するため及び薬物渇望を低減するためのシステイン及びシスチンプロドラッグ |
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| IT995110B (it) * | 1973-08-01 | 1975-11-10 | Snam Progetti | Procedimento per la produzione di composti eterociclici e prodotti ottenuti |
| JPS6016989A (ja) | 1983-07-06 | 1985-01-28 | Shionogi & Co Ltd | オキソ飽和異項環カルボンアミドセフエム化合物 |
| AU682894B2 (en) | 1993-10-28 | 1997-10-23 | Institut National De La Recherche Agronomique | Composition based on amino acids intended for the treatment of sepsis or of an attack bringing about an inflammatory reaction, in animals and man |
| CA2419845A1 (en) * | 1999-08-17 | 2002-02-22 | Phyllis G. Paterson | Improved treatment for acute physical insult to the central nervous system |
| US7829709B1 (en) * | 2007-08-10 | 2010-11-09 | Marquette University | Cysteine prodrugs to treat schizophrenia and drug addiction |
| EP2736890A4 (en) * | 2011-07-28 | 2015-07-15 | Promentis Pharm Inc | Cysteine PRODRUGS |
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2012
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-
2016
- 2016-06-06 US US15/174,410 patent/US20160287563A1/en not_active Abandoned
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|---|---|---|---|---|
| JPH05213910A (ja) * | 1991-03-27 | 1993-08-24 | Sankyo Co Ltd | チアまたはオキサゾリジノン誘導体 |
| JP2011514324A (ja) * | 2008-02-07 | 2011-05-06 | マーケット ユニバーシティー | 統合失調症を治療するため及び薬物渇望を低減するためのシステイン及びシスチンプロドラッグ |
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| Title |
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| CACCIATORE I. ET AL.: "Prodrug approach for increasing cellular glutathione levels", MOLECULES, vol. 15, JPN6016007578, 2010, pages 1242 - 1264, XP055271483, ISSN: 0003266299, DOI: 10.3390/molecules15031242 * |
| STN ON THE WEB, FILE:REGISTRY, JPN7016000468, 11 April 2010 (2010-04-11), ISSN: 0003266298 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US9457014B2 (en) | 2016-10-04 |
| EP2736890A4 (en) | 2015-07-15 |
| EP2736890A1 (en) | 2014-06-04 |
| CA2842106A1 (en) | 2013-01-31 |
| US20160287563A1 (en) | 2016-10-06 |
| US20160081987A1 (en) | 2016-03-24 |
| WO2013016727A1 (en) | 2013-01-31 |
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