JP2014524445A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014524445A5 JP2014524445A5 JP2014526241A JP2014526241A JP2014524445A5 JP 2014524445 A5 JP2014524445 A5 JP 2014524445A5 JP 2014526241 A JP2014526241 A JP 2014526241A JP 2014526241 A JP2014526241 A JP 2014526241A JP 2014524445 A5 JP2014524445 A5 JP 2014524445A5
- Authority
- JP
- Japan
- Prior art keywords
- muc1
- yeast
- composition
- immunotherapy
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 29
- 102100034256 Mucin-1 Human genes 0.000 claims 29
- 238000009169 immunotherapy Methods 0.000 claims 28
- 239000000427 antigen Substances 0.000 claims 16
- 102000036639 antigens Human genes 0.000 claims 16
- 108091007433 antigens Proteins 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 13
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 13
- 108020001507 fusion proteins Proteins 0.000 claims 7
- 102000037865 fusion proteins Human genes 0.000 claims 7
- 239000000556 agonist Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 5
- 230000001024 immunotherapeutic effect Effects 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000001086 cytosolic effect Effects 0.000 claims 2
- 210000005253 yeast cell Anatomy 0.000 claims 2
- 206010027476 Metastases Diseases 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161524407P | 2011-08-17 | 2011-08-17 | |
| US61/524,407 | 2011-08-17 | ||
| PCT/US2012/051299 WO2013025972A1 (en) | 2011-08-17 | 2012-08-17 | Yeast-muc1 immunotherapeutic compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017067243A Division JP6306238B2 (ja) | 2011-08-17 | 2017-03-30 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524445A JP2014524445A (ja) | 2014-09-22 |
| JP2014524445A5 true JP2014524445A5 (https=) | 2015-10-01 |
| JP6122007B2 JP6122007B2 (ja) | 2017-04-26 |
Family
ID=47715495
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014526241A Active JP6122007B2 (ja) | 2011-08-17 | 2012-08-17 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2017067243A Active JP6306238B2 (ja) | 2011-08-17 | 2017-03-30 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2018040308A Active JP6571822B2 (ja) | 2011-08-17 | 2018-03-07 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2019145946A Pending JP2019194261A (ja) | 2011-08-17 | 2019-08-08 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017067243A Active JP6306238B2 (ja) | 2011-08-17 | 2017-03-30 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2018040308A Active JP6571822B2 (ja) | 2011-08-17 | 2018-03-07 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
| JP2019145946A Pending JP2019194261A (ja) | 2011-08-17 | 2019-08-08 | 酵母−ｍｕｃ１免疫療法用組成物およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9533031B2 (https=) |
| EP (1) | EP2744918A4 (https=) |
| JP (4) | JP6122007B2 (https=) |
| KR (1) | KR102049928B1 (https=) |
| CN (3) | CN114617958B (https=) |
| AU (3) | AU2012296425B2 (https=) |
| BR (1) | BR112014003477B1 (https=) |
| CA (1) | CA2844500C (https=) |
| IL (2) | IL230863B (https=) |
| MX (1) | MX352892B (https=) |
| RU (2) | RU2017143985A (https=) |
| SG (1) | SG10201607663YA (https=) |
| WO (1) | WO2013025972A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2170384T3 (en) | 2007-07-02 | 2016-07-25 | Etubics Corp | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination |
| US9254320B2 (en) | 2010-12-17 | 2016-02-09 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| JP5745102B2 (ja) | 2011-02-12 | 2015-07-08 | グローブイミューン，インコーポレイテッド | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
| MX350661B (es) | 2011-03-17 | 2017-09-13 | Us Health | Composiciones inmunoterapeuticas de levadura-brachyuri. |
| CN103732250A (zh) | 2011-06-14 | 2014-04-16 | 全球免疫股份有限公司 | 基于酵母的治疗或预防丁型肝炎病毒感染的组合物和方法 |
| SG10201607663YA (en) | 2011-08-17 | 2016-11-29 | Globeimmune Inc | Yeast-muc1 immunotherapeutic compositions and uses thereof |
| EP2800762B1 (en) | 2012-01-03 | 2018-01-03 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Native and agonist ctl epitopes of the muc1 tumor antigen |
| MX365418B (es) | 2012-06-26 | 2019-06-03 | Biodesix Inc | Metodo por espectros de masa para la seleccion y descarte de pacientes de cancer para el tratamiento con terapias generadoras de respuestas inmunitarias. |
| US9605276B2 (en) | 2012-08-24 | 2017-03-28 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
| AU2014265873B2 (en) | 2013-03-19 | 2019-01-17 | Globeimmune, Inc. | Yeast-based immunotherapy for chordoma |
| TWI626948B (zh) | 2013-03-26 | 2018-06-21 | 環球免疫公司 | 治療或預防人類免疫缺乏病毒感染之組合物及方法 |
| US10226522B2 (en) | 2013-08-30 | 2019-03-12 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of tuberculosis |
| WO2015061416A2 (en) * | 2013-10-23 | 2015-04-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla-a24 agonist epitopes of muc1-c oncoprotein and compositions and methods of use |
| CA2948803A1 (en) | 2014-04-11 | 2015-10-15 | Globeimmune, Inc. | Yeast-based immunotherapy and type i interferon sensitivity |
| WO2016105536A2 (en) | 2014-12-23 | 2016-06-30 | University Of Maryland, Baltimore | Muc1 decoy peptides for treatment and prevention of bacterial infections |
| AU2016205208A1 (en) | 2015-01-09 | 2017-07-06 | Etubics Corporation | Methods and compositions for ebola virus vaccination |
| CN107406857B (zh) * | 2015-01-09 | 2021-06-29 | 埃图比克斯公司 | 用于联合免疫治疗的方法和组合物 |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016170541A1 (en) | 2015-04-21 | 2016-10-27 | Enlivex Therapeutics Ltd. | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| EP3865139B1 (en) | 2015-02-18 | 2023-05-03 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| AU2016303525B2 (en) | 2015-08-03 | 2021-01-21 | Globeimmune, Inc. | Modified yeast-Brachyury immunotherapeutic compositions |
| US11464839B2 (en) * | 2015-12-04 | 2022-10-11 | Mayo Foundation For Medical Education And Research | Methods and vaccines for inducing immune responses to multiple different MHC molecules |
| US20190183870A1 (en) | 2016-01-05 | 2019-06-20 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Combination of histone deacetylase inhibitor and immunotherapy |
| MX2018008797A (es) * | 2016-01-19 | 2018-11-29 | Pfizer | Vacunas contra el cancer. |
| WO2017136342A1 (en) | 2016-02-02 | 2017-08-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fulvestrant for inducing immune-mediated cytotoxic lysis of cancer cells |
| CN109069539A (zh) | 2016-02-18 | 2018-12-21 | 恩立夫克治疗有限责任公司 | 用于癌症治疗的联合免疫疗法和细胞因子控制疗法 |
| KR20180117227A (ko) | 2016-03-24 | 2018-10-26 | 난트셀, 인크. | 네오에피토프 제시를 위한 시퀀스들 및 시퀀스 배열들 |
| US11779637B2 (en) | 2017-04-24 | 2023-10-10 | Nantcell, Inc. | Targeted neoepitope vectors and methods therefor |
| CN119818663A (zh) | 2018-05-15 | 2025-04-15 | 全球免疫公司 | 用于诱导细胞免疫应答的重组酵母裂解物 |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| JP2023522015A (ja) * | 2020-04-17 | 2023-05-26 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | サルコペニアを逆行させる方法、組成物及びその使用 |
| CN113185485B (zh) | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的半合成方法 |
| CN113214210B (zh) | 2021-05-10 | 2022-03-04 | 合肥立方制药股份有限公司 | 一种二氢槲皮素的制备方法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2486400B1 (fr) | 1980-07-09 | 1986-05-30 | Univablot | Medicaments a base de levures ou de leurs extraits insolubles |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| US5310654A (en) | 1985-07-31 | 1994-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining virulence of Yersinia |
| US5234830A (en) | 1988-02-03 | 1993-08-10 | Suntory Limited | DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region |
| IL95019A0 (en) | 1989-08-09 | 1991-06-10 | Mycogen Corp | Process for encapsulation of biologicals |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| US5858378A (en) | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
| CA2282300C (en) | 1997-02-24 | 2011-08-02 | Therion Biologics Corporation | Recombinant pox virus for immunization against muc1 tumor-associated antigen |
| DE19758400A1 (de) | 1997-12-30 | 1999-07-01 | Max Delbrueck Centrum | Tumorvakzine für MUC1-positive Karzinome |
| DK1137792T3 (da) | 1998-12-09 | 2007-09-10 | Us Gov Health & Human Serv | En rekombinant vektor, der udtrykker adskillige costimulatoriske molekyler, og anvendelser deraf |
| DE19906615A1 (de) * | 1999-02-17 | 2000-09-28 | Hanisch Franz Georg | Peptid-Varianten des Tumormarkers MUC1 und ihre Verwendung |
| CA2383737C (en) * | 1999-09-08 | 2011-01-18 | Transgene S.A. | Muc-1 derived peptides |
| DE10006753A1 (de) | 2000-02-15 | 2001-08-16 | Zeiss Carl | Dreh-Schwenkeinrichtung für den Tastkopf eines Koordinatenmeßgerätes |
| US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| AU1951001A (en) | 2000-04-06 | 2001-09-17 | Panacea Pharm Llc | Microbial delivery system |
| AU2002225681A1 (en) | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| KR20050010040A (ko) * | 2002-06-11 | 2005-01-26 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 면역원성 조성물 |
| AU2003251531A1 (en) * | 2002-06-14 | 2003-12-31 | Diadexus, Inc. | Compositions and methods relating to breast specific genes and proteins |
| KR101455222B1 (ko) * | 2002-12-16 | 2014-10-31 | 글로브이뮨 | 면역 요법으로서의 효모계 백신 |
| US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| US7696306B2 (en) | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
| GB0321615D0 (en) * | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| WO2005046622A2 (en) * | 2003-11-12 | 2005-05-26 | Therion Biologics Corporation | Custom vectors for treating and preventing pancreatic cancer |
| US8299229B2 (en) * | 2003-11-24 | 2012-10-30 | Microvax, Llc | Mucin antigen vaccine |
| JP2008504219A (ja) * | 2003-12-11 | 2008-02-14 | シドニー キンメル キャンサー センター | 抗原に対する免疫を生じさせる方法 |
| US8828957B2 (en) * | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
| EP1697399B1 (en) * | 2003-12-12 | 2016-11-23 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as repr. by THE SECR. OF THE DEPT. OF HEALTH AND HUMAN SERVICES AND HIS SUCCESSORS | A human cytotoxic t-lymphocyte epitope and its agonist epitope from the non-variable number of tandem repeat sequence of muc-1 |
| SG163572A1 (en) * | 2005-07-11 | 2010-08-30 | Globeimmune Inc | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
| US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| JP2009544760A (ja) * | 2006-01-23 | 2009-12-17 | レコファーマ アーベー | 酵母におけるオリゴマンノースまたはヒト様グリカンを担持するタンパク質の産生およびその使用 |
| US7736642B2 (en) | 2006-02-02 | 2010-06-15 | Globeimmune, Inc. | Yeast-based vaccine for inducing an immune response |
| BRPI0709340A2 (pt) | 2006-03-27 | 2013-04-16 | Globeimmune, Inc. | mutaÇço ras e composiÇÕes e mÉtodos de uso da mesma |
| WO2008097863A2 (en) | 2007-02-02 | 2008-08-14 | Globeimmune, Inc. | Methods for producing yeast-based vaccines |
| US8501167B2 (en) | 2007-03-19 | 2013-08-06 | Globeimmune, Inc. | Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer |
| CA2704232C (en) | 2007-11-08 | 2017-05-02 | Dana-Farber Cancer Institute, Inc. | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28 |
| WO2010033841A1 (en) | 2008-09-19 | 2010-03-25 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis c virus infection |
| US8524669B2 (en) * | 2008-10-17 | 2013-09-03 | Dana-Farber Cancer Institute, Inc. | MUC-1 cytoplasmic domain peptides as inhibitors of cancer |
| WO2010065626A1 (en) * | 2008-12-02 | 2010-06-10 | Globeimmune, Inc. | Genotyping tools, methods and kits |
| MX2011010977A (es) * | 2009-04-17 | 2012-02-29 | Us Health | Composiciones inmunoterapeuticas combinadas contra cancer y metodos. |
| CA2774326C (en) | 2009-09-14 | 2023-11-07 | Donald Bellgrau | Modulation of yeast-based immunotherapy products and responses |
| EP2547792A4 (en) | 2010-03-14 | 2013-11-27 | Globeimmune Inc | PHARMACOGENOMIC TREATMENT AND ADAPTATION TO THE RESPONSE OF AN INFECTIOUS DISEASE USING YEAST IMMUNOTHERAPY |
| WO2012019127A2 (en) | 2010-08-05 | 2012-02-09 | The Regents Of The University Of Colorado | Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases |
| US9254320B2 (en) | 2010-12-17 | 2016-02-09 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| JP5745102B2 (ja) | 2011-02-12 | 2015-07-08 | グローブイミューン，インコーポレイテッド | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
| MX350661B (es) | 2011-03-17 | 2017-09-13 | Us Health | Composiciones inmunoterapeuticas de levadura-brachyuri. |
| CN103732250A (zh) | 2011-06-14 | 2014-04-16 | 全球免疫股份有限公司 | 基于酵母的治疗或预防丁型肝炎病毒感染的组合物和方法 |
| SG10201607663YA (en) | 2011-08-17 | 2016-11-29 | Globeimmune Inc | Yeast-muc1 immunotherapeutic compositions and uses thereof |
-
2012
- 2012-08-17 SG SG10201607663YA patent/SG10201607663YA/en unknown
- 2012-08-17 BR BR112014003477-0A patent/BR112014003477B1/pt active IP Right Grant
- 2012-08-17 RU RU2017143985A patent/RU2017143985A/ru not_active Application Discontinuation
- 2012-08-17 CN CN202210208007.7A patent/CN114617958B/zh active Active
- 2012-08-17 MX MX2014001717A patent/MX352892B/es active IP Right Grant
- 2012-08-17 JP JP2014526241A patent/JP6122007B2/ja active Active
- 2012-08-17 CA CA2844500A patent/CA2844500C/en active Active
- 2012-08-17 AU AU2012296425A patent/AU2012296425B2/en active Active
- 2012-08-17 KR KR1020147006872A patent/KR102049928B1/ko active Active
- 2012-08-17 CN CN201810735110.0A patent/CN109010809A/zh active Pending
- 2012-08-17 CN CN201280051154.2A patent/CN104024429B/zh active Active
- 2012-08-17 EP EP12824638.6A patent/EP2744918A4/en active Pending
- 2012-08-17 WO PCT/US2012/051299 patent/WO2013025972A1/en not_active Ceased
- 2012-08-17 RU RU2014109741A patent/RU2642300C2/ru active
-
2013
- 2013-03-14 US US13/803,757 patent/US9533031B2/en active Active
-
2014
- 2014-02-06 IL IL230863A patent/IL230863B/en active IP Right Grant
-
2016
- 2016-11-22 US US15/358,797 patent/US10188714B2/en active Active
-
2017
- 2017-03-30 JP JP2017067243A patent/JP6306238B2/ja active Active
- 2017-10-18 AU AU2017248462A patent/AU2017248462B2/en active Active
-
2018
- 2018-02-14 IL IL257533A patent/IL257533B/en active IP Right Grant
- 2018-03-07 JP JP2018040308A patent/JP6571822B2/ja active Active
- 2018-12-06 US US16/211,492 patent/US11065318B2/en active Active
-
2019
- 2019-08-08 JP JP2019145946A patent/JP2019194261A/ja active Pending
-
2020
- 2020-01-08 AU AU2020200137A patent/AU2020200137B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014524445A5 (https=) | ||
| ZA202308846B (en) | Cx3cr1-binding polypeptides | |
| MX2014005546A (es) | Anticuerpos de union de albumina y fragmentos de union de los mismos. | |
| NZ616761A (en) | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same | |
| WO2015051199A3 (en) | Modified pseudomonas exotoxin a | |
| MX354717B (es) | Moleculas de union novedosas con actividad antitumoral. | |
| GB201206559D0 (en) | Polypeptide | |
| WO2014106015A3 (en) | Multivalent binding protein compositions | |
| JP2016185981A5 (https=) | ||
| HK1200468A1 (en) | Anti-erbb3 antibodies and uses thereof | |
| JP2012126742A5 (https=) | ||
| EP4223772A3 (en) | Optimized factor viii gene | |
| MX353813B (es) | Moleculas de union a vegf. | |
| NZ629553A (en) | Anti-big-endothelin-1 (big-et-1) antibodies and uses thereof | |
| SI3191511T1 (en) | Improved TNF binders | |
| JP2014525439A5 (https=) | ||
| WO2015160928A3 (en) | Isolated t cell receptors and methods of use therefor | |
| MY173686A (en) | Fc gamma receptor iib variants | |
| HK1201850A1 (en) | Hydrochloride salt of peptide and its use in combination with other peptides for immunotherapy | |
| MX374403B (es) | Secuencia de endolisina kz144 modificada. | |
| WO2015051379A3 (en) | Dual specific binding proteins directed against immune cell receptors and tlr signaling autoantigens | |
| NZ702285A (en) | Staphylococcal coagulase antigens and methods of their use | |
| WO2014202208A8 (fr) | Polypeptide ayant la capacite de former des branchements d'unites glucosyle en alpha-1,3 sur un accepteur | |
| WO2014152247A8 (en) | Improved tnf binding proteins | |
| WO2014162007A3 (en) | Thymic stromal lymphopoietin fragments and uses thereof |