JP2014523421A5 - - Google Patents
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- Publication number
- JP2014523421A5 JP2014523421A5 JP2014516039A JP2014516039A JP2014523421A5 JP 2014523421 A5 JP2014523421 A5 JP 2014523421A5 JP 2014516039 A JP2014516039 A JP 2014516039A JP 2014516039 A JP2014516039 A JP 2014516039A JP 2014523421 A5 JP2014523421 A5 JP 2014523421A5
- Authority
- JP
- Japan
- Prior art keywords
- dll4
- formulation
- ionizing radiation
- cancer
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498200P | 2011-06-17 | 2011-06-17 | |
| US61/498,200 | 2011-06-17 | ||
| PCT/US2012/042695 WO2012174394A1 (en) | 2011-06-17 | 2012-06-15 | Methods of enhancing the response to radiation in tumor therapy using anti-dll4 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014523421A JP2014523421A (ja) | 2014-09-11 |
| JP2014523421A5 true JP2014523421A5 (https=) | 2015-08-06 |
Family
ID=46397640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516039A Ceased JP2014523421A (ja) | 2011-06-17 | 2012-06-15 | 抗ｄｌｌ４抗体を使用して腫瘍治療における放射線に対する反応を増大させる方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8685401B2 (https=) |
| EP (1) | EP2721070A1 (https=) |
| JP (1) | JP2014523421A (https=) |
| AU (1) | AU2012271450A1 (https=) |
| CA (1) | CA2838973A1 (https=) |
| WO (1) | WO2012174394A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE029661T2 (en) | 2009-10-16 | 2017-03-28 | Oncomed Pharm Inc | A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents |
| LT3485903T (lt) | 2011-09-23 | 2023-02-27 | Mereo Biopharma 5, Inc. | Vegf/ dll4 surišantys agentai ir jų panaudojimas |
| ES2808153T3 (es) | 2014-10-31 | 2021-02-25 | Mereo Biopharma 5 Inc | Terapia de combinación para tratamiento de enfermedad |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| US12064436B2 (en) | 2017-06-12 | 2024-08-20 | Servier Pharmaceuticals Llc | Methods of treating brain tumors using combination therapy |
| CA3067035A1 (en) * | 2017-06-12 | 2018-12-20 | Agios Pharmaceuticals, Inc. | Methods of treating brain tumors using combination therapy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| US5916771A (en) | 1996-10-11 | 1999-06-29 | Abgenix, Inc. | Production of a multimeric protein by cell fusion method |
| DK2066694T3 (en) * | 2006-09-29 | 2016-02-08 | Oncomed Pharm Inc | Compositions and Methods for Diagnosing and Treating Cancer |
| AU2009294415B2 (en) * | 2008-09-19 | 2015-09-24 | Medimmune Llc | Antibodies directed to DLL4 and uses thereof |
| US20110059114A1 (en) | 2009-08-05 | 2011-03-10 | Duke University | Compositions and Methods for the Treatment of Radioresistant Glioma Stem Cells |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2012
- 2012-06-15 US US13/524,396 patent/US8685401B2/en not_active Expired - Fee Related
- 2012-06-15 AU AU2012271450A patent/AU2012271450A1/en not_active Abandoned
- 2012-06-15 WO PCT/US2012/042695 patent/WO2012174394A1/en not_active Ceased
- 2012-06-15 JP JP2014516039A patent/JP2014523421A/ja not_active Ceased
- 2012-06-15 CA CA2838973A patent/CA2838973A1/en not_active Abandoned
- 2012-06-15 EP EP12730733.8A patent/EP2721070A1/en not_active Withdrawn
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