JP2014520795A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014520795A5 JP2014520795A5 JP2014518058A JP2014518058A JP2014520795A5 JP 2014520795 A5 JP2014520795 A5 JP 2014520795A5 JP 2014518058 A JP2014518058 A JP 2014518058A JP 2014518058 A JP2014518058 A JP 2014518058A JP 2014520795 A5 JP2014520795 A5 JP 2014520795A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halo
- alkoxy
- alkylamino
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*#Cc1ccc(*C(*)N(*)C2CC*C(CIC(O)=O)CCCC2)cc1 Chemical compound C*#Cc1ccc(*C(*)N(*)C2CC*C(CIC(O)=O)CCCC2)cc1 0.000 description 5
- KSPXRTYMEVDHAB-FOQIAJMMSA-N CC[C@H](C[C@@H](C[C@@H]1CC)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(nc2)ncc2-c2c[n](C)nc2)N1C(O[C@H](CC1)CC[C@@H]1C(O)=O)=O Chemical compound CC[C@H](C[C@@H](C[C@@H]1CC)N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c(nc2)ncc2-c2c[n](C)nc2)N1C(O[C@H](CC1)CC[C@@H]1C(O)=O)=O KSPXRTYMEVDHAB-FOQIAJMMSA-N 0.000 description 1
- IHIUGIVXARLYHP-UXNJHFGPSA-N Cc(cc12)cc(C)c1N(CC(CC1)CCC1C(O)=O)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1n[n](C)nn1 Chemical compound Cc(cc12)cc(C)c1N(CC(CC1)CCC1C(O)=O)CCC[C@@H]2N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1n[n](C)nn1 IHIUGIVXARLYHP-UXNJHFGPSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505584P | 2011-07-08 | 2011-07-08 | |
| US61/505,584 | 2011-07-08 | ||
| US201261657061P | 2012-06-08 | 2012-06-08 | |
| US61/657,061 | 2012-06-08 | ||
| PCT/IB2012/053479 WO2013008164A2 (en) | 2011-07-08 | 2012-07-06 | Method of treating atherosclerosis in high triglyceride subjects |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017003519A Division JP6310581B2 (ja) | 2011-07-08 | 2017-01-12 | 高トリグリセリド対象においてアテローム性動脈硬化症を治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014520795A JP2014520795A (ja) | 2014-08-25 |
| JP2014520795A5 true JP2014520795A5 (https=) | 2015-08-20 |
Family
ID=46724554
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014518058A Pending JP2014520795A (ja) | 2011-07-08 | 2012-07-06 | 高トリグリセリド対象においてアテローム性動脈硬化症を治療する方法 |
| JP2017003519A Expired - Fee Related JP6310581B2 (ja) | 2011-07-08 | 2017-01-12 | 高トリグリセリド対象においてアテローム性動脈硬化症を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017003519A Expired - Fee Related JP6310581B2 (ja) | 2011-07-08 | 2017-01-12 | 高トリグリセリド対象においてアテローム性動脈硬化症を治療する方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9867811B2 (https=) |
| EP (1) | EP2729142B1 (https=) |
| JP (2) | JP2014520795A (https=) |
| KR (2) | KR20190025737A (https=) |
| CN (2) | CN103648495A (https=) |
| AU (1) | AU2012282109B2 (https=) |
| BR (1) | BR112014000333A2 (https=) |
| CA (1) | CA2841117A1 (https=) |
| ES (1) | ES2683350T3 (https=) |
| MX (1) | MX2014000342A (https=) |
| PL (1) | PL2729142T3 (https=) |
| PT (1) | PT2729142T (https=) |
| RU (1) | RU2609200C2 (https=) |
| SG (1) | SG10201605304VA (https=) |
| TW (1) | TWI627167B (https=) |
| WO (1) | WO2013008164A2 (https=) |
| ZA (1) | ZA201400176B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201335109A (zh) * | 2011-12-02 | 2013-09-01 | Kowa Co | 光學活性化合物之製造方法 |
| JPWO2014017569A1 (ja) * | 2012-07-26 | 2016-07-11 | 興和株式会社 | 血中ｌｄｌを低下させるための医薬 |
| US20160000799A1 (en) * | 2013-02-21 | 2016-01-07 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions of cetp inhibitors |
| EP3197448B1 (en) | 2014-09-24 | 2019-04-24 | Gilead Sciences, Inc. | Methods of treating liver disease |
| TWI691331B (zh) * | 2014-09-26 | 2020-04-21 | 日商興和股份有限公司 | 脂質異常症治療劑 |
| WO2016084950A1 (ja) * | 2014-11-28 | 2016-06-02 | 興和株式会社 | 医薬組成物 |
| WO2016084949A1 (ja) * | 2014-11-28 | 2016-06-02 | 興和株式会社 | 医薬 |
| WO2018020477A1 (en) * | 2016-07-28 | 2018-02-01 | The Regents Of The University Of California | Methods and compositions for treating hypertriglyceridemia |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889861A (en) | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
| US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| IL152081A0 (en) | 2000-04-12 | 2003-05-29 | Novartis Ag | Novel medical use of aldosterone synthase inhibitors alone or in combination with at1-receptor antagonists |
| ATE316957T1 (de) | 2001-04-30 | 2006-02-15 | Pfizer Prod Inc | Verbindungen verwendbar als zwischenprodukte für 4-aminochinolinderivate |
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| EP1537114B8 (en) | 2002-08-07 | 2007-10-03 | Novartis AG | Organic compounds as agents for the treatment of aldosterone mediated conditions |
| BR0306208A (pt) * | 2002-08-30 | 2004-10-13 | Japan Tobacco Inc | Compostos de dibenzilamina e seu uso farmacêutico |
| WO2004046145A1 (en) | 2002-11-18 | 2004-06-03 | Novartis Ag | Imidazo[1, 5a]pyridine derivatives and methods for treating aldosterone mediated diseases |
| WO2005097805A1 (en) | 2004-03-26 | 2005-10-20 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
| CA2568159A1 (en) | 2004-05-28 | 2005-12-15 | Speedel Experimenta Ag | Tetrahydro-imidazo [1,5-a] pyridin derivatives as aldosterone synthase inhibitors |
| CN1997643A (zh) | 2004-05-28 | 2007-07-11 | 斯皮德尔实验股份公司 | 杂环化合物及其作为醛固酮合酶抑制剂的应用 |
| AR050251A1 (es) | 2004-05-28 | 2006-10-11 | Speedel Experimenta Ag | Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto |
| AU2005267436A1 (en) | 2004-06-24 | 2006-02-02 | Eli Lilly And Company | Compounds and methods for treating dyslipidemia |
| DOP2005000123A (es) | 2004-07-02 | 2011-07-15 | Merck Sharp & Dohme | Inhibidores de cetp |
| TW200611897A (en) | 2004-07-09 | 2006-04-16 | Speedel Experimenta Ag | Organic compounds |
| US20060063803A1 (en) | 2004-09-23 | 2006-03-23 | Pfizer Inc | 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds |
| PE20061124A1 (es) | 2004-11-23 | 2006-10-13 | Pfizer Prod Inc | Compuestos y derivados de dibencil amina |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| TW200716105A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Imidazole compounds |
| TW200716636A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
| TW200716634A (en) | 2005-05-31 | 2007-05-01 | Speedel Experimenta Ag | Heterocyclic spiro-compounds |
| GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
| TW200804378A (en) | 2005-12-09 | 2008-01-16 | Speedel Experimenta Ag | Organic compounds |
| JP2009522224A (ja) | 2005-12-29 | 2009-06-11 | ノバルティス アクチエンゲゼルシャフト | コレステリルエステル輸送タンパク質（ｃｅｔｐ）の阻害剤としてのピリジニルアミン誘導体 |
| EP1973889B1 (en) | 2005-12-30 | 2016-08-24 | Merck Sharp & Dohme Corp. | Cetp inhibitors |
| EP1971595B1 (en) | 2005-12-30 | 2013-10-16 | Merck Sharp & Dohme Corp. | Cetp inhibitors |
| US7915271B2 (en) | 2005-12-30 | 2011-03-29 | Merck Sharp & Dohme Corp. | 1,3-oxazolidin-2-one derivatives useful as CETP inhibitors |
| UY30117A1 (es) | 2006-01-31 | 2007-06-29 | Tanabe Seiyaku Co | Compuesto amina trisustituido |
| PE20071025A1 (es) | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
| JP5773560B2 (ja) * | 2006-02-09 | 2015-09-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｃｅｔｐ阻害剤のポリマー製剤 |
| US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| EP2402320A1 (en) | 2006-03-31 | 2012-01-04 | Novartis AG | Anorectic agents |
| EP2009080A4 (en) | 2006-04-04 | 2010-05-26 | Taiyo Nippon Sanso Corp | METHOD OF REMOVING METHANE, METHANE PARATOR AND METHOD USE SYSTEM |
| TW200808812A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
| TW200808813A (en) | 2006-04-12 | 2008-02-16 | Speedel Experimenta Ag | Imidazo compounds |
| WO2007128568A1 (en) | 2006-05-10 | 2007-11-15 | Novartis Ag | Bicyclic derivatives as cetp inhibitors |
| US7659287B2 (en) | 2006-06-08 | 2010-02-09 | Amgen Inc. | Benzamide derivatives and uses related thereto |
| EP1886695A1 (en) | 2006-06-27 | 2008-02-13 | Speedel Experimenta AG | Pharmaceutical combination of an aldosterone synthase inhibitor and a glucocorticoid receptor antagonist or a cortisol synthesis inhibitor or a corticotropin releasing factor antagonist |
| DE102006034048B4 (de) * | 2006-07-20 | 2016-05-19 | Wanzl Metallwarenfabrik Gmbh | Einkaufswagen |
| CA2657258A1 (en) * | 2006-07-20 | 2008-01-24 | Novartis Ag | Amino-piperidine derivatives as cetp inhibitors |
| JP2010501573A (ja) | 2006-08-25 | 2010-01-21 | ノバルティス アクチエンゲゼルシャフト | アルドステロン合成酵素および／または１１−β−ヒドロキシラーゼおよび／またはアロマターゼが介在する疾患の処置のための縮合イミダゾール誘導体 |
| CN101578272A (zh) | 2006-12-18 | 2009-11-11 | 诺瓦提斯公司 | 1-取代的咪唑衍生物和它们作为醛固酮合酶抑制剂的用途 |
| EP2094680A2 (en) | 2006-12-18 | 2009-09-02 | Novartis AG | Imidazoles as aldosterone synthase inhibitors |
| WO2008076860A1 (en) | 2006-12-18 | 2008-06-26 | Novartis Ag | 4-imidazolyl-1,2,3,4-tetrahydroquinoline derivatives and their use as aldosterone/11-beta-hydroxylase inhibitors |
| EP2120928A2 (en) | 2007-02-15 | 2009-11-25 | Pfizer Limited | Pharmaceutical compositions and methods for ccr5 antagonists |
| PL2134720T3 (pl) | 2007-03-29 | 2011-04-29 | Novartis Ag | Heterocykliczne spiro-związki |
| JP5244095B2 (ja) | 2007-04-13 | 2013-07-24 | 興和株式会社 | 新規なジベンジルアミン構造を有するピリミジン化合物及びこれを含有する医薬 |
| JP4846769B2 (ja) | 2007-07-30 | 2011-12-28 | 田辺三菱製薬株式会社 | 医薬組成物 |
| JP4834699B2 (ja) | 2007-07-30 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
| WO2009027785A2 (en) | 2007-08-30 | 2009-03-05 | Pfizer Products Inc. | 1, 3-oxazole derivatives as cetp inhibitors |
| AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
| EP2463282B1 (en) * | 2007-11-05 | 2013-08-07 | Novartis AG | 4-Benzylamino-1-carboxyacyl-piperidine derivatives as CETP inhibitors useful for the treatment of diseases such as hyperlipidemia or arteriosclerosis |
| MX2010006063A (es) | 2007-12-03 | 2010-07-01 | Novartis Ag | Derivados de 4-bencil-amino-pirrolidina 1,2-disustituida como inhibidores de la proteina de transferencia de colesteril-ester (cetp) utiles para el tratamiento de las enfermedades tales como hiperlipidemia o arterioesclerosis. |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| HRP20140371T1 (hr) | 2009-05-15 | 2014-05-23 | Novartis Ag | Arilpiridini kao inhibitori sinteze aldosterona |
| AR077208A1 (es) * | 2009-06-30 | 2011-08-10 | Lilly Co Eli | Derivados del acido trans-4-[[(5s)-5-[[[3,5-bis(trifluorometil) fenil] metil] (2-metil-2h-tetrazol-5-il) amino) -2,3,4,5-tetrahidro-7,9-dimetil-1h-1-benzazepin-1-il) metil)-ciclohexancarboxilico y sus formas cristalinas, composiciones farmaceuticas que los comprenden, su uso para preparar un medicam |
| WO2011028395A1 (en) | 2009-08-24 | 2011-03-10 | Merck Sharp & Dohme Corp. | Pyridyl oxazolidinone cetp inhibitor |
-
2012
- 2012-07-06 ES ES12750616.0T patent/ES2683350T3/es active Active
- 2012-07-06 US US14/128,877 patent/US9867811B2/en not_active Expired - Fee Related
- 2012-07-06 KR KR1020197005512A patent/KR20190025737A/ko not_active Ceased
- 2012-07-06 BR BR112014000333A patent/BR112014000333A2/pt not_active Application Discontinuation
- 2012-07-06 JP JP2014518058A patent/JP2014520795A/ja active Pending
- 2012-07-06 PT PT12750616T patent/PT2729142T/pt unknown
- 2012-07-06 SG SG10201605304VA patent/SG10201605304VA/en unknown
- 2012-07-06 TW TW101124537A patent/TWI627167B/zh not_active IP Right Cessation
- 2012-07-06 RU RU2014104377A patent/RU2609200C2/ru not_active IP Right Cessation
- 2012-07-06 MX MX2014000342A patent/MX2014000342A/es unknown
- 2012-07-06 PL PL12750616T patent/PL2729142T3/pl unknown
- 2012-07-06 KR KR1020147002988A patent/KR20140056258A/ko not_active Ceased
- 2012-07-06 AU AU2012282109A patent/AU2012282109B2/en not_active Ceased
- 2012-07-06 WO PCT/IB2012/053479 patent/WO2013008164A2/en not_active Ceased
- 2012-07-06 EP EP12750616.0A patent/EP2729142B1/en not_active Not-in-force
- 2012-07-06 CN CN201280034037.5A patent/CN103648495A/zh active Pending
- 2012-07-06 CA CA2841117A patent/CA2841117A1/en not_active Abandoned
- 2012-07-06 CN CN201710928984.3A patent/CN107550914A/zh active Pending
-
2014
- 2014-01-09 ZA ZA2014/00176A patent/ZA201400176B/en unknown
-
2017
- 2017-01-12 JP JP2017003519A patent/JP6310581B2/ja not_active Expired - Fee Related
- 2017-12-05 US US15/831,545 patent/US20180153861A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014520795A5 (https=) | ||
| RU2014104377A (ru) | Способ лечения атеросклероза у субъектов с высоким уровнем триглицеридов | |
| JP2015518004A5 (https=) | ||
| MA35643B1 (fr) | Inhibiteur de cetp d'oxazolidinone bicyclique condensée | |
| AR084001A1 (es) | Monobactamas y su uso en el tratamiento de infecciones bacterianas | |
| CN114430739A (zh) | Egfr抑制剂、组合物及其制备方法 | |
| PE20161218A1 (es) | (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1 | |
| PE20230834A1 (es) | Antagonistas del receptor de lpa y usos de los mismos | |
| JP2019534291A5 (https=) | ||
| JP2015504067A5 (https=) | ||
| JP2011500758A5 (https=) | ||
| MA37712B1 (fr) | Inhibiteurs macrocycliques de virus flaviviridae | |
| RU2014105624A (ru) | Соединения индазола, способ их применения и фармацевтическая композиция | |
| JP2017515844A5 (https=) | ||
| AR087151A1 (es) | Diaminocarboxamida y diaminocarbonitrilo pirimidinas sustituidas, sus composiciones y los metodos de tratamiento | |
| JP2017515893A5 (https=) | ||
| AR074676A1 (es) | Derivados de isooxazol como antagonistas de receptores de acido lisofosfatidico, composicion farmaceutica que los comprende y su uso en el tratamiento de enfermedades mediadas por la actividad fisiologica de lpa. | |
| MY165906A (en) | Phenothiazine diaminium salts and their use | |
| JP2013525286A5 (https=) | ||
| JP2014500265A5 (https=) | ||
| EA201490103A1 (ru) | Гидроксиметиларилзамещенные пирролотриазины в качестве ингибиторов alk1 | |
| JP2014508720A5 (https=) | ||
| JP2016503797A5 (https=) | ||
| PH12012501422B1 (en) | Use of an adrenal hormone-modifying agent | |
| NZ610353A (en) | Imidazole derivatives as pde10a enzyme inhibitors |