JP2014519487A5 - - Google Patents
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- JP2014519487A5 JP2014519487A5 JP2014508569A JP2014508569A JP2014519487A5 JP 2014519487 A5 JP2014519487 A5 JP 2014519487A5 JP 2014508569 A JP2014508569 A JP 2014508569A JP 2014508569 A JP2014508569 A JP 2014508569A JP 2014519487 A5 JP2014519487 A5 JP 2014519487A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- interferon
- expression level
- ism
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 102000014150 Interferons Human genes 0.000 claims 13
- 108010050904 Interferons Proteins 0.000 claims 13
- 229940079322 interferon Drugs 0.000 claims 13
- 239000003112 inhibitor Substances 0.000 claims 11
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- 230000001363 autoimmune Effects 0.000 claims 7
- 108020004999 messenger RNA Proteins 0.000 claims 7
- 206010025135 lupus erythematosus Diseases 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 102100039922 E3 ISG15-protein ligase HERC5 Human genes 0.000 claims 4
- 102100039621 Epithelial-stromal interaction protein 1 Human genes 0.000 claims 4
- 101001035145 Homo sapiens E3 ISG15-protein ligase HERC5 Proteins 0.000 claims 4
- 101000814134 Homo sapiens Epithelial-stromal interaction protein 1 Proteins 0.000 claims 4
- 101100440233 Mus musculus Cmpk2 gene Proteins 0.000 claims 4
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 3
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 claims 3
- 102100035389 2'-5'-oligoadenylate synthase 3 Human genes 0.000 claims 3
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 3
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 3
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 claims 3
- 101000597332 Homo sapiens 2'-5'-oligoadenylate synthase 3 Proteins 0.000 claims 3
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 3
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 3
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 3
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 3
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 3
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 claims 2
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 claims 2
- 101100519283 Arabidopsis thaliana PDX13 gene Proteins 0.000 claims 2
- 102100026343 Charged multivesicular body protein 5 Human genes 0.000 claims 2
- 101150099040 GIP2 gene Proteins 0.000 claims 2
- 101100218339 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) aurR1 gene Proteins 0.000 claims 2
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 claims 2
- 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 claims 2
- 101000913952 Homo sapiens Charged multivesicular body protein 5 Proteins 0.000 claims 2
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 2
- 101001032342 Homo sapiens Interferon regulatory factor 7 Proteins 0.000 claims 2
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 2
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims 2
- 101001082063 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 5 Proteins 0.000 claims 2
- 101100182720 Homo sapiens LY6E gene Proteins 0.000 claims 2
- 101000595918 Homo sapiens Phospholipase A and acyltransferase 4 Proteins 0.000 claims 2
- 101000735459 Homo sapiens Protein mono-ADP-ribosyltransferase PARP9 Proteins 0.000 claims 2
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 2
- 101000701625 Homo sapiens Sp110 nuclear body protein Proteins 0.000 claims 2
- 101000822540 Homo sapiens Sterile alpha motif domain-containing protein 9-like Proteins 0.000 claims 2
- 101000942626 Homo sapiens UMP-CMP kinase 2, mitochondrial Proteins 0.000 claims 2
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 2
- 102100038070 Interferon regulatory factor 7 Human genes 0.000 claims 2
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 2
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims 2
- 102100027356 Interferon-induced protein with tetratricopeptide repeats 5 Human genes 0.000 claims 2
- 208000005777 Lupus Nephritis Diseases 0.000 claims 2
- 102100032131 Lymphocyte antigen 6E Human genes 0.000 claims 2
- 102100034930 Protein mono-ADP-ribosyltransferase PARP9 Human genes 0.000 claims 2
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 2
- 102100030435 Sp110 nuclear body protein Human genes 0.000 claims 2
- 102100022459 Sterile alpha motif domain-containing protein 9-like Human genes 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 102100032947 UMP-CMP kinase 2, mitochondrial Human genes 0.000 claims 2
- 230000001064 anti-interferon Effects 0.000 claims 2
- 239000008280 blood Substances 0.000 claims 2
- 210000004369 blood Anatomy 0.000 claims 2
- 230000010468 interferon response Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 201000006417 multiple sclerosis Diseases 0.000 claims 2
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
- 101000828739 Homo sapiens SPATS2-like protein Proteins 0.000 claims 1
- 101000868472 Homo sapiens Sialoadhesin Proteins 0.000 claims 1
- 101000644847 Homo sapiens Ubl carboxyl-terminal hydrolase 18 Proteins 0.000 claims 1
- 101000814514 Homo sapiens XIAP-associated factor 1 Proteins 0.000 claims 1
- 101000964436 Homo sapiens Z-DNA-binding protein 1 Proteins 0.000 claims 1
- -1 IF16 Proteins 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 101000599776 Rattus norvegicus Insulin-like growth factor 2 mRNA-binding protein 1 Proteins 0.000 claims 1
- 102100023521 SPATS2-like protein Human genes 0.000 claims 1
- 102100032855 Sialoadhesin Human genes 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 102100020726 Ubl carboxyl-terminal hydrolase 18 Human genes 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 102100039488 XIAP-associated factor 1 Human genes 0.000 claims 1
- 102100040310 Z-DNA-binding protein 1 Human genes 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 201000001981 dermatomyositis Diseases 0.000 claims 1
- 108010045648 interferon omega 1 Proteins 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 229950010316 rontalizumab Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161479314P | 2011-04-26 | 2011-04-26 | |
| US61/479,314 | 2011-04-26 | ||
| US201161582179P | 2011-12-30 | 2011-12-30 | |
| US61/582,179 | 2011-12-30 | ||
| PCT/US2012/035313 WO2012149228A1 (en) | 2011-04-26 | 2012-04-26 | Compositions and method for treating autoimmune diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014519487A JP2014519487A (ja) | 2014-08-14 |
| JP2014519487A5 true JP2014519487A5 (OSRAM) | 2015-06-18 |
| JP6211513B2 JP6211513B2 (ja) | 2017-10-11 |
Family
ID=47072761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014508569A Expired - Fee Related JP6211513B2 (ja) | 2011-04-26 | 2012-04-26 | 自己免疫疾患の治療のための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20140056889A1 (OSRAM) |
| EP (1) | EP2701742A4 (OSRAM) |
| JP (1) | JP6211513B2 (OSRAM) |
| KR (1) | KR20140048877A (OSRAM) |
| AR (1) | AR086074A1 (OSRAM) |
| AU (1) | AU2012249601A1 (OSRAM) |
| CA (1) | CA2834203A1 (OSRAM) |
| WO (1) | WO2012149228A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2044213A2 (en) | 2006-04-24 | 2009-04-08 | Genentech, Inc. | Methods and compositions for detecting autoimmune disorders |
| CA2836926A1 (en) * | 2011-05-25 | 2012-11-29 | Medimmune, Llc | Methods of treating systemic lupus erythematosus, scleroderma, and myositis with an antibody against interferon-alpha |
| WO2013101771A2 (en) * | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| EP2844227B1 (en) | 2012-05-03 | 2020-11-18 | Kala Pharmaceuticals, Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| US9056057B2 (en) | 2012-05-03 | 2015-06-16 | Kala Pharmaceuticals, Inc. | Nanocrystals, compositions, and methods that aid particle transport in mucus |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| EP2956138B1 (en) | 2013-02-15 | 2022-06-22 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| ES2831625T3 (es) | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN108530458A (zh) | 2013-11-01 | 2018-09-14 | 卡拉制药公司 | 治疗化合物的结晶形式及其用途 |
| GB201501613D0 (en) | 2015-01-30 | 2015-03-18 | Ucb Biopharma Sprl | Treatment of autoimmune disorders with CD154 antibodies |
| EP3426298A4 (en) | 2016-03-10 | 2019-11-27 | Viela Bio, Inc. | ILT7-BINDING MOLECULES AND METHOD OF USE THEREOF |
| US10253036B2 (en) | 2016-09-08 | 2019-04-09 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| EP3509423A4 (en) | 2016-09-08 | 2020-05-13 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| EP3509421A4 (en) | 2016-09-08 | 2020-05-20 | Kala Pharmaceuticals, Inc. | CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF |
| WO2018136625A2 (en) * | 2017-01-20 | 2018-07-26 | Children's Medical Center Corporation | Compositions and methods for treating diseases characterized by reactive microglia mediated synapse loss |
| US12486320B1 (en) * | 2018-01-15 | 2025-12-02 | Washington University | Compositions and methods for treatment of central nervous system (CNS) autoimmune associated diseases or disorders |
| US11769592B1 (en) | 2018-10-07 | 2023-09-26 | Cerner Innovation, Inc. | Classifier apparatus with decision support tool |
| US11749404B1 (en) * | 2018-10-08 | 2023-09-05 | Cerner Innovation, Inc. | Decision support tool for venous thromboembolism (VTE) |
| EA202191133A1 (ru) * | 2018-10-26 | 2021-07-12 | Янссен Байотек, Инк. | Сигнатуры интерферона типа i и способы их применения |
| KR102308865B1 (ko) * | 2019-02-08 | 2021-10-05 | 서울대학교산학협력단 | 전신 홍반 루푸스 산모의 임신 위험도를 평가하는 방법 |
| JP7494416B2 (ja) * | 2019-10-31 | 2024-06-04 | 義知 本田 | 血管老化予測方法、疾患リスク予測方法、血管老化予測用バイオマーカー、疾患用バイオマーカー、測定キット、及び、診断装置 |
| EP4069288A4 (en) * | 2019-12-06 | 2024-01-17 | Viela Bio, Inc. | TREATMENT METHODS USING ILT7 BINDING PROTEINS |
| CN114836534A (zh) * | 2021-06-08 | 2022-08-02 | 中国医学科学院北京协和医院 | Samd9l基因突变作为i型干扰素病诊断的标志物及其应用 |
| AU2024266667A1 (en) * | 2023-05-02 | 2025-10-30 | 4E Therapeutics, Inc. | Composition, methods and uses |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US7087726B2 (en) * | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| BRPI0607490A2 (pt) * | 2005-02-10 | 2009-09-08 | Baylor Res Inst | anticorpos monoclonais antiinterferon alfa e métodos para uso |
| US9168286B2 (en) * | 2005-10-13 | 2015-10-27 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
| EP2044213A2 (en) * | 2006-04-24 | 2009-04-08 | Genentech, Inc. | Methods and compositions for detecting autoimmune disorders |
| RU2527068C2 (ru) * | 2006-12-06 | 2014-08-27 | Медиммун, Ллк | Фармакодинамические маркеры, индуцированные интерфероном альфа |
| JP2010526107A (ja) * | 2007-05-03 | 2010-07-29 | メディミューン，エルエルシー | 自己免疫疾患の自己抗体マーカー |
| SG174258A1 (en) * | 2009-03-06 | 2011-10-28 | Genentech Inc | Antibody formulation |
| PT2473636T (pt) * | 2009-09-03 | 2017-02-06 | Medimmune Llc | Diagnóstico de interferão de tipo-1 |
| WO2013101771A2 (en) * | 2011-12-30 | 2013-07-04 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
-
2012
- 2012-04-26 WO PCT/US2012/035313 patent/WO2012149228A1/en not_active Ceased
- 2012-04-26 JP JP2014508569A patent/JP6211513B2/ja not_active Expired - Fee Related
- 2012-04-26 EP EP12777107.9A patent/EP2701742A4/en not_active Withdrawn
- 2012-04-26 AR ARP120101446A patent/AR086074A1/es unknown
- 2012-04-26 KR KR1020137031178A patent/KR20140048877A/ko not_active Withdrawn
- 2012-04-26 AU AU2012249601A patent/AU2012249601A1/en not_active Abandoned
- 2012-04-26 CA CA2834203A patent/CA2834203A1/en not_active Abandoned
- 2012-04-26 US US14/113,575 patent/US20140056889A1/en not_active Abandoned
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