JP2010526107A5 - - Google Patents
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- JP2010526107A5 JP2010526107A5 JP2010506714A JP2010506714A JP2010526107A5 JP 2010526107 A5 JP2010526107 A5 JP 2010526107A5 JP 2010506714 A JP2010506714 A JP 2010506714A JP 2010506714 A JP2010506714 A JP 2010506714A JP 2010526107 A5 JP2010526107 A5 JP 2010526107A5
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- 239000003795 chemical substances by application Substances 0.000 claims 16
- 208000023275 Autoimmune disease Diseases 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 7
- 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 claims 4
- 101000583692 Homo sapiens Pleckstrin homology-like domain family A member 1 Proteins 0.000 claims 4
- 102100030887 Pleckstrin homology-like domain family A member 1 Human genes 0.000 claims 4
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 108010036781 Fumarate Hydratase Proteins 0.000 claims 3
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 claims 3
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 3
- 206010025135 lupus erythematosus Diseases 0.000 claims 3
- 108091008726 retinoic acid receptors α Proteins 0.000 claims 3
- 102100033756 39S ribosomal protein L45, mitochondrial Human genes 0.000 claims 2
- 102100033416 60S acidic ribosomal protein P1 Human genes 0.000 claims 2
- 241000351920 Aspergillus nidulans Species 0.000 claims 2
- 208000031713 Autosomal recessive spastic paraplegia type 20 Diseases 0.000 claims 2
- 108010059013 Chaperonin 10 Proteins 0.000 claims 2
- 102100028843 DNA mismatch repair protein Mlh1 Human genes 0.000 claims 2
- 102000008013 Electron Transport Complex I Human genes 0.000 claims 2
- 108010089760 Electron Transport Complex I Proteins 0.000 claims 2
- 101000980303 Homo sapiens 10 kDa heat shock protein, mitochondrial Proteins 0.000 claims 2
- 101000733888 Homo sapiens 39S ribosomal protein L45, mitochondrial Proteins 0.000 claims 2
- 101000712357 Homo sapiens 60S acidic ribosomal protein P1 Proteins 0.000 claims 2
- 101000577853 Homo sapiens DNA mismatch repair protein Mlh1 Proteins 0.000 claims 2
- 101001068011 Homo sapiens Hydroxyacylglutathione hydrolase-like protein Proteins 0.000 claims 2
- 101000582846 Homo sapiens Mediator of RNA polymerase II transcription subunit 22 Proteins 0.000 claims 2
- 101000992387 Homo sapiens Oxysterol-binding protein-related protein 9 Proteins 0.000 claims 2
- 101000705766 Homo sapiens Proteasome activator complex subunit 3 Proteins 0.000 claims 2
- 101000893493 Homo sapiens Protein flightless-1 homolog Proteins 0.000 claims 2
- 102100034468 Hydroxyacylglutathione hydrolase-like protein Human genes 0.000 claims 2
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 2
- 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 claims 2
- 108010006444 Leucine-Rich Repeat Proteins Proteins 0.000 claims 2
- 102100030223 Mediator of RNA polymerase II transcription subunit 22 Human genes 0.000 claims 2
- 102100027869 Moesin Human genes 0.000 claims 2
- 201000002481 Myositis Diseases 0.000 claims 2
- 102100032162 Oxysterol-binding protein-related protein 9 Human genes 0.000 claims 2
- 206010033892 Paraplegia Diseases 0.000 claims 2
- 102100031298 Proteasome activator complex subunit 3 Human genes 0.000 claims 2
- 102100040923 Protein flightless-1 homolog Human genes 0.000 claims 2
- 102100039407 Pyrroline-5-carboxylate reductase 1, mitochondrial Human genes 0.000 claims 2
- 102100022122 Ras-related C3 botulinum toxin substrate 1 Human genes 0.000 claims 2
- 102000004389 Ribonucleoproteins Human genes 0.000 claims 2
- 108010081734 Ribonucleoproteins Proteins 0.000 claims 2
- 102100030537 Spartin Human genes 0.000 claims 2
- 101710015530 Spartin Proteins 0.000 claims 2
- 208000032930 Spastic paraplegia Diseases 0.000 claims 2
- 102100033632 Tropomyosin alpha-1 chain Human genes 0.000 claims 2
- 101710128188 Tropomyosin alpha-1 chain Proteins 0.000 claims 2
- 102100033080 Tropomyosin alpha-3 chain Human genes 0.000 claims 2
- 101710091952 Tropomyosin alpha-3 chain Proteins 0.000 claims 2
- 201000003397 Troyer syndrome Diseases 0.000 claims 2
- 206010047115 Vasculitis Diseases 0.000 claims 2
- 208000033017 acquired idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 210000004292 cytoskeleton Anatomy 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 208000013643 idiopathic inflammatory myopathy Diseases 0.000 claims 2
- 108010087599 lactate dehydrogenase 1 Proteins 0.000 claims 2
- 210000004901 leucine-rich repeat Anatomy 0.000 claims 2
- 108010071525 moesin Proteins 0.000 claims 2
- 108010062302 rac1 GTP Binding Protein Proteins 0.000 claims 2
- 201000000306 sarcoidosis Diseases 0.000 claims 2
- 238000000638 solvent extraction Methods 0.000 claims 2
- FCEHFCFHANDXMB-UMEYXWOPSA-N tocosimplex Chemical compound OS(O)(=O)=O.C1N2CCCC[C@@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 FCEHFCFHANDXMB-UMEYXWOPSA-N 0.000 claims 2
- 241000712461 unidentified influenza virus Species 0.000 claims 2
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 1
- 102100035473 2'-5'-oligoadenylate synthase-like protein Human genes 0.000 claims 1
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 1
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims 1
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 1
- 101000597360 Homo sapiens 2'-5'-oligoadenylate synthase-like protein Proteins 0.000 claims 1
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 claims 1
- 101001078626 Homo sapiens Heat shock protein HSP 90-alpha A2 Proteins 0.000 claims 1
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 1
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 1
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 1
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 1
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 1
- 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 claims 1
- 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 1
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 1
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 1
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 1
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 1
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 1
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 1
- 102100032131 Lymphocyte antigen 6E Human genes 0.000 claims 1
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
- 101710142338 Pyrroline-5-carboxylate reductase 1 Proteins 0.000 claims 1
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 1
- 102000034527 Retinoid X Receptors Human genes 0.000 claims 1
- 108010038912 Retinoid X Receptors Proteins 0.000 claims 1
- 102000042463 Rho family Human genes 0.000 claims 1
- 108091078243 Rho family Proteins 0.000 claims 1
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 229930002330 retinoic acid Natural products 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 229960001727 tretinoin Drugs 0.000 claims 1
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92421907P | 2007-05-03 | 2007-05-03 | |
| US92422007P | 2007-05-03 | 2007-05-03 | |
| US92458407P | 2007-05-21 | 2007-05-21 | |
| US96018707P | 2007-09-19 | 2007-09-19 | |
| US99617607P | 2007-11-05 | 2007-11-05 | |
| US99617407P | 2007-11-05 | 2007-11-05 | |
| US99621907P | 2007-11-06 | 2007-11-06 | |
| US99682007P | 2007-12-06 | 2007-12-06 | |
| PCT/US2007/024947 WO2008070137A2 (en) | 2006-12-06 | 2007-12-06 | Interferon alpha-induced pharmacodynamic markers |
| PCT/US2007/024941 WO2008070135A2 (en) | 2006-12-06 | 2007-12-06 | Methods of treating systemic lupus erythematosus |
| US696308P | 2008-02-08 | 2008-02-08 | |
| PCT/US2008/062639 WO2008137835A2 (en) | 2007-05-03 | 2008-05-05 | Auto-antibody markers of autoimmune disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010526107A JP2010526107A (ja) | 2010-07-29 |
| JP2010526107A5 true JP2010526107A5 (OSRAM) | 2011-06-16 |
Family
ID=39944226
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506715A Expired - Fee Related JP5411129B2 (ja) | 2007-05-03 | 2008-05-05 | インターフェロンα誘導性薬力学的マーカー |
| JP2010506714A Withdrawn JP2010526107A (ja) | 2007-05-03 | 2008-05-05 | 自己免疫疾患の自己抗体マーカー |
| JP2013230753A Pending JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506715A Expired - Fee Related JP5411129B2 (ja) | 2007-05-03 | 2008-05-05 | インターフェロンα誘導性薬力学的マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013230753A Pending JP2014064577A (ja) | 2007-05-03 | 2013-11-07 | インターフェロンα誘導性薬力学的マーカー |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9181345B2 (OSRAM) |
| EP (2) | EP2068924A4 (OSRAM) |
| JP (3) | JP5411129B2 (OSRAM) |
| AU (2) | AU2008247395A1 (OSRAM) |
| CA (2) | CA2685147A1 (OSRAM) |
| WO (2) | WO2008137835A2 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2712303C (en) | 2008-01-18 | 2015-03-31 | President And Fellows Of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| PL2473636T3 (pl) * | 2009-09-03 | 2017-05-31 | Medimmune, Llc | Diagnostyka interferonu typu 1 |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| WO2011127219A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings | Circulating biomarkers for disease |
| WO2012012694A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| EP2596134B1 (en) | 2010-07-23 | 2020-04-08 | President and Fellows of Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| BR112013001754A2 (pt) | 2010-07-23 | 2016-05-31 | Harvard College | método para detectar marcas de doença ou condições em fluídos corpóreos |
| EP2620770B1 (en) * | 2010-09-22 | 2017-04-26 | National University Corporation Chiba University | Novel testing method for angiitis |
| GB201017520D0 (en) * | 2010-10-15 | 2010-12-01 | Sense Proteomic Ltd | Biomarkers |
| CA2834203A1 (en) * | 2011-04-26 | 2012-11-01 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| AU2013204880B2 (en) * | 2011-04-26 | 2016-11-24 | Genentech, Inc. | Compositions and method for treating autoimmune diseases |
| EP2923205B1 (en) * | 2012-11-23 | 2019-05-15 | Baerlecken, Niklas | Analysis for adult-onset still's disease |
| JP2016509471A (ja) * | 2012-12-14 | 2016-03-31 | マインデラ コーポレイション | バイオマーカーの検出および収集のための方法およびデバイス |
| EP4513187A3 (en) | 2013-03-09 | 2025-05-21 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| WO2014164366A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting cancer |
| AU2014360328B2 (en) * | 2013-12-06 | 2021-04-01 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers |
| EP4075139B1 (en) | 2014-09-11 | 2024-05-22 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| CA3029627A1 (en) | 2016-07-01 | 2018-01-04 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| JP7374091B2 (ja) | 2017-08-22 | 2023-11-06 | サナバイオ， エルエルシー | 可溶性インターフェロン受容体およびその使用 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN113692287A (zh) * | 2018-10-26 | 2021-11-23 | 詹森生物科技公司 | I型干扰素标记及使用方法 |
| CN110747190B (zh) * | 2019-11-27 | 2021-03-09 | 浙江华睿生物技术有限公司 | 一种马来酸水合酶突变体及其应用 |
| WO2025062016A2 (en) * | 2023-09-22 | 2025-03-27 | Merck Patent Gmbh | Biomarkers for tlr inhibitor treatment |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984003106A1 (en) | 1983-02-04 | 1984-08-16 | Wadley Inst Of Molecular Medic | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| ATE78262T1 (de) | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| FR2692168B1 (fr) | 1992-06-16 | 1995-03-24 | Centre Nat Rech Scient | Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères. |
| US5888511A (en) | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| US5972901A (en) | 1994-03-23 | 1999-10-26 | Case Western Reserve University | Serpin enzyme complex receptor--mediated gene transfer |
| US6077835A (en) | 1994-03-23 | 2000-06-20 | Case Western Reserve University | Delivery of compacted nucleic acid to cells |
| JP4285766B2 (ja) | 1994-03-23 | 2009-06-24 | オハイオ ユニバーシティ | 緻密にした核酸および細胞へのデリバリ |
| AU749032B2 (en) | 1997-06-13 | 2002-06-20 | Johns Hopkins University, The | Therapeutic nanospheres |
| US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
| US20040265874A1 (en) * | 2000-10-17 | 2004-12-30 | Bio-Rad Laboratories, Inc. | Pattern recognition method for diagnosis of systemic autoimmune diseases |
| CA2433806C (en) * | 2001-01-09 | 2011-03-15 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
| US7087726B2 (en) * | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| WO2003046008A1 (en) * | 2001-11-30 | 2003-06-05 | Innogenetics N.V. | Therapeutic use of antibodies and fragments thereof binding primate ifn-gamma |
| DE60333786D1 (de) * | 2002-11-21 | 2010-09-23 | Univ R | Verfahren und immunmodulierende nukleinsäurezusammensetzungen zur vorbeugung und behandlungvon erkrankungen |
| EP1670931A2 (en) * | 2003-09-05 | 2006-06-21 | GTC Biotherapeutics, Inc. | Method for the production of fusion proteins in transgenic mammal milk |
| NZ547157A (en) * | 2003-12-10 | 2009-07-31 | Medarex Inc | Interferon Alpha Antibodies and their uses |
| MX2007009466A (es) * | 2005-02-10 | 2007-12-07 | Baylor Res Inst | Anticuerpos monoclonales de anti-interferon alfa y metodos para su uso. |
| US20070117105A1 (en) * | 2005-05-12 | 2007-05-24 | Crow Mary K | Interferon assay |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| EP2327792B9 (en) * | 2005-08-05 | 2013-12-18 | Genentech, Inc. | Methods and compositions for detecting auto-immune disorders |
| US7608395B2 (en) * | 2005-09-15 | 2009-10-27 | Baylor Research Institute | Systemic lupus erythematosus diagnostic assay |
| EP1933873A4 (en) * | 2005-10-13 | 2009-12-02 | Human Genome Sciences Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF PATIENTS WITH POSITIVE DISEASES FOR SELF-ANTIBODIES |
| RU2527068C2 (ru) * | 2006-12-06 | 2014-08-27 | Медиммун, Ллк | Фармакодинамические маркеры, индуцированные интерфероном альфа |
| US20110287022A1 (en) * | 2008-06-20 | 2011-11-24 | Medlmmune, Llc | Interferon alpha-induced pharmacodynamic markers |
| PL2473636T3 (pl) * | 2009-09-03 | 2017-05-31 | Medimmune, Llc | Diagnostyka interferonu typu 1 |
-
2008
- 2008-05-05 EP EP08747639A patent/EP2068924A4/en not_active Withdrawn
- 2008-05-05 JP JP2010506715A patent/JP5411129B2/ja not_active Expired - Fee Related
- 2008-05-05 JP JP2010506714A patent/JP2010526107A/ja not_active Withdrawn
- 2008-05-05 AU AU2008247395A patent/AU2008247395A1/en not_active Abandoned
- 2008-05-05 WO PCT/US2008/062639 patent/WO2008137835A2/en not_active Ceased
- 2008-05-05 AU AU2008247398A patent/AU2008247398B2/en not_active Ceased
- 2008-05-05 WO PCT/US2008/062646 patent/WO2008137838A2/en not_active Ceased
- 2008-05-05 CA CA002685147A patent/CA2685147A1/en not_active Abandoned
- 2008-05-05 CA CA002686861A patent/CA2686861A1/en not_active Abandoned
- 2008-05-05 EP EP08769294A patent/EP2076590A4/en not_active Withdrawn
-
2011
- 2011-11-07 US US13/290,850 patent/US9181345B2/en active Active
-
2013
- 2013-11-07 JP JP2013230753A patent/JP2014064577A/ja active Pending
-
2014
- 2014-09-23 US US14/494,439 patent/US20150132313A1/en not_active Abandoned
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