JP5411129B2 - インターフェロンα誘導性薬力学的マーカー - Google Patents

インターフェロンα誘導性薬力学的マーカー Download PDF

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JP5411129B2
JP5411129B2 JP2010506715A JP2010506715A JP5411129B2 JP 5411129 B2 JP5411129 B2 JP 5411129B2 JP 2010506715 A JP2010506715 A JP 2010506715A JP 2010506715 A JP2010506715 A JP 2010506715A JP 5411129 B2 JP5411129 B2 JP 5411129B2
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ifnα
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JP2010527917A5 (OSRAM
JP2010527917A (ja
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ヤオ,イーホン
ジャラル,バヒジャ
シボッティ,リカルド
コイル,アンソニー
キーナー,ピーター
ホワイト,バーバラ
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メディミューン,エルエルシー
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    • C07ORGANIC CHEMISTRY
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/564Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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JP2010506715A 2007-05-03 2008-05-05 インターフェロンα誘導性薬力学的マーカー Expired - Fee Related JP5411129B2 (ja)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US92421907P 2007-05-03 2007-05-03
US92422007P 2007-05-03 2007-05-03
US60/924,219 2007-05-03
US60/924,220 2007-05-03
US92458407P 2007-05-21 2007-05-21
US60/924,584 2007-05-21
US96018707P 2007-09-19 2007-09-19
US60/960,187 2007-09-19
US99617407P 2007-11-05 2007-11-05
US99617607P 2007-11-05 2007-11-05
US60/996,174 2007-11-05
US60/996,176 2007-11-05
US99621907P 2007-11-06 2007-11-06
US60/996,219 2007-11-06
US99682007P 2007-12-06 2007-12-06
USPCT/US2007/024941 2007-12-06
PCT/US2007/024947 WO2008070137A2 (en) 2006-12-06 2007-12-06 Interferon alpha-induced pharmacodynamic markers
PCT/US2007/024941 WO2008070135A2 (en) 2006-12-06 2007-12-06 Methods of treating systemic lupus erythematosus
US60/996,820 2007-12-06
USPCT/US2007/024947 2007-12-06
US696308P 2008-02-08 2008-02-08
US61/006,963 2008-02-08
PCT/US2008/062646 WO2008137838A2 (en) 2007-05-03 2008-05-05 Interferon alpha-induced pharmacodynamic markers

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JP2013230753A Division JP2014064577A (ja) 2007-05-03 2013-11-07 インターフェロンα誘導性薬力学的マーカー

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JP2010527917A JP2010527917A (ja) 2010-08-19
JP2010527917A5 JP2010527917A5 (OSRAM) 2011-06-16
JP5411129B2 true JP5411129B2 (ja) 2014-02-12

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JP2010506715A Expired - Fee Related JP5411129B2 (ja) 2007-05-03 2008-05-05 インターフェロンα誘導性薬力学的マーカー
JP2010506714A Withdrawn JP2010526107A (ja) 2007-05-03 2008-05-05 自己免疫疾患の自己抗体マーカー
JP2013230753A Pending JP2014064577A (ja) 2007-05-03 2013-11-07 インターフェロンα誘導性薬力学的マーカー

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JP2010506714A Withdrawn JP2010526107A (ja) 2007-05-03 2008-05-05 自己免疫疾患の自己抗体マーカー
JP2013230753A Pending JP2014064577A (ja) 2007-05-03 2013-11-07 インターフェロンα誘導性薬力学的マーカー

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US (2) US9181345B2 (OSRAM)
EP (2) EP2068924A4 (OSRAM)
JP (3) JP5411129B2 (OSRAM)
AU (2) AU2008247395A1 (OSRAM)
CA (2) CA2685147A1 (OSRAM)
WO (2) WO2008137835A2 (OSRAM)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2712303C (en) 2008-01-18 2015-03-31 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
PL2473636T3 (pl) * 2009-09-03 2017-05-31 Medimmune, Llc Diagnostyka interferonu typu 1
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
WO2011127219A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings Circulating biomarkers for disease
WO2012012694A2 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
EP2596134B1 (en) 2010-07-23 2020-04-08 President and Fellows of Harvard College Methods of detecting diseases or conditions using phagocytic cells
US20130203624A1 (en) 2010-07-23 2013-08-08 President And Fellows Of Harvard College Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions
BR112013001754A2 (pt) 2010-07-23 2016-05-31 Harvard College método para detectar marcas de doença ou condições em fluídos corpóreos
EP2620770B1 (en) * 2010-09-22 2017-04-26 National University Corporation Chiba University Novel testing method for angiitis
GB201017520D0 (en) * 2010-10-15 2010-12-01 Sense Proteomic Ltd Biomarkers
CA2834203A1 (en) * 2011-04-26 2012-11-01 Genentech, Inc. Compositions and method for treating autoimmune diseases
AU2013204880B2 (en) * 2011-04-26 2016-11-24 Genentech, Inc. Compositions and method for treating autoimmune diseases
EP2923205B1 (en) * 2012-11-23 2019-05-15 Baerlecken, Niklas Analysis for adult-onset still's disease
JP2016509471A (ja) * 2012-12-14 2016-03-31 マインデラ コーポレイション バイオマーカーの検出および収集のための方法およびデバイス
EP4513187A3 (en) 2013-03-09 2025-05-21 Immunis.AI, Inc. Methods of detecting prostate cancer
WO2014164366A1 (en) 2013-03-09 2014-10-09 Harry Stylli Methods of detecting cancer
AU2014360328B2 (en) * 2013-12-06 2021-04-01 Celgene Corporation Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers
EP4075139B1 (en) 2014-09-11 2024-05-22 Immunis.AI, Inc. Methods of detecting prostate cancer
CA3029627A1 (en) 2016-07-01 2018-01-04 Resolve Therapeutics, Llc Optimized binuclease fusions and methods
JP7374091B2 (ja) 2017-08-22 2023-11-06 サナバイオ, エルエルシー 可溶性インターフェロン受容体およびその使用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
CN113692287A (zh) * 2018-10-26 2021-11-23 詹森生物科技公司 I型干扰素标记及使用方法
CN110747190B (zh) * 2019-11-27 2021-03-09 浙江华睿生物技术有限公司 一种马来酸水合酶突变体及其应用
WO2025062016A2 (en) * 2023-09-22 2025-03-27 Merck Patent Gmbh Biomarkers for tlr inhibitor treatment

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984003106A1 (en) 1983-02-04 1984-08-16 Wadley Inst Of Molecular Medic Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins
GB8303165D0 (en) 1983-02-04 1983-03-09 Secher D S Monoclonal antibody
DE3306060A1 (de) 1983-02-22 1984-08-23 Boehringer Ingelheim International GmbH, 6507 Ingelheim Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung
ATE78262T1 (de) 1985-06-11 1992-08-15 Ciba Geigy Ag Hybrid-interferone.
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
FR2692168B1 (fr) 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
US5888511A (en) 1993-02-26 1999-03-30 Advanced Biotherapy Concepts, Inc. Treatment of autoimmune diseases, including AIDS
US5972901A (en) 1994-03-23 1999-10-26 Case Western Reserve University Serpin enzyme complex receptor--mediated gene transfer
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
JP4285766B2 (ja) 1994-03-23 2009-06-24 オハイオ ユニバーシティ 緻密にした核酸および細胞へのデリバリ
AU749032B2 (en) 1997-06-13 2002-06-20 Johns Hopkins University, The Therapeutic nanospheres
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20040265874A1 (en) * 2000-10-17 2004-12-30 Bio-Rad Laboratories, Inc. Pattern recognition method for diagnosis of systemic autoimmune diseases
CA2433806C (en) * 2001-01-09 2011-03-15 Baylor Research Institute Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays
US7087726B2 (en) * 2001-02-22 2006-08-08 Genentech, Inc. Anti-interferon-α antibodies
WO2003046008A1 (en) * 2001-11-30 2003-06-05 Innogenetics N.V. Therapeutic use of antibodies and fragments thereof binding primate ifn-gamma
DE60333786D1 (de) * 2002-11-21 2010-09-23 Univ R Verfahren und immunmodulierende nukleinsäurezusammensetzungen zur vorbeugung und behandlungvon erkrankungen
EP1670931A2 (en) * 2003-09-05 2006-06-21 GTC Biotherapeutics, Inc. Method for the production of fusion proteins in transgenic mammal milk
NZ547157A (en) * 2003-12-10 2009-07-31 Medarex Inc Interferon Alpha Antibodies and their uses
MX2007009466A (es) * 2005-02-10 2007-12-07 Baylor Res Inst Anticuerpos monoclonales de anti-interferon alfa y metodos para su uso.
US20070117105A1 (en) * 2005-05-12 2007-05-24 Crow Mary K Interferon assay
US20070065844A1 (en) * 2005-06-08 2007-03-22 Massachusetts Institute Of Technology Solution-based methods for RNA expression profiling
EP2327792B9 (en) * 2005-08-05 2013-12-18 Genentech, Inc. Methods and compositions for detecting auto-immune disorders
US7608395B2 (en) * 2005-09-15 2009-10-27 Baylor Research Institute Systemic lupus erythematosus diagnostic assay
EP1933873A4 (en) * 2005-10-13 2009-12-02 Human Genome Sciences Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF PATIENTS WITH POSITIVE DISEASES FOR SELF-ANTIBODIES
RU2527068C2 (ru) * 2006-12-06 2014-08-27 Медиммун, Ллк Фармакодинамические маркеры, индуцированные интерфероном альфа
US20110287022A1 (en) * 2008-06-20 2011-11-24 Medlmmune, Llc Interferon alpha-induced pharmacodynamic markers
PL2473636T3 (pl) * 2009-09-03 2017-05-31 Medimmune, Llc Diagnostyka interferonu typu 1

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EP2068924A2 (en) 2009-06-17
EP2076590A4 (en) 2011-06-01
EP2076590A2 (en) 2009-07-08
AU2008247395A1 (en) 2008-11-13
AU2008247398A1 (en) 2008-11-13
CA2685147A1 (en) 2008-11-13
US9181345B2 (en) 2015-11-10
AU2008247398B2 (en) 2013-10-10
EP2068924A4 (en) 2011-07-20
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US20120219555A1 (en) 2012-08-30
CA2686861A1 (en) 2008-11-13

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