JP2014518283A5 - - Google Patents
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- Publication number
- JP2014518283A5 JP2014518283A5 JP2014519262A JP2014519262A JP2014518283A5 JP 2014518283 A5 JP2014518283 A5 JP 2014518283A5 JP 2014519262 A JP2014519262 A JP 2014519262A JP 2014519262 A JP2014519262 A JP 2014519262A JP 2014518283 A5 JP2014518283 A5 JP 2014518283A5
- Authority
- JP
- Japan
- Prior art keywords
- rbc
- oxygen
- carbon dioxide
- depleted
- concentrated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 136
- 210000003743 erythrocyte Anatomy 0.000 claims 122
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 74
- 229910052760 oxygen Inorganic materials 0.000 claims 74
- 239000001301 oxygen Substances 0.000 claims 74
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 68
- 239000001569 carbon dioxide Substances 0.000 claims 68
- 239000000725 suspension Substances 0.000 claims 31
- 238000000034 method Methods 0.000 claims 29
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 18
- 239000003463 adsorbent Substances 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 239000000654 additive Substances 0.000 claims 4
- 230000000996 additive effect Effects 0.000 claims 4
- 239000000243 solution Substances 0.000 claims 4
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 claims 3
- 210000000265 leukocyte Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000003078 antioxidant effect Effects 0.000 claims 2
- 235000006708 antioxidants Nutrition 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 230000000779 depleting effect Effects 0.000 claims 2
- 239000007789 gas Substances 0.000 claims 2
- 230000002779 inactivation Effects 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 238000000926 separation method Methods 0.000 claims 2
- 230000035939 shock Effects 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- 102000004316 Oxidoreductases Human genes 0.000 claims 1
- 108090000854 Oxidoreductases Proteins 0.000 claims 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims 1
- 229940087168 alpha tocopherol Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002532 enzyme inhibitor Substances 0.000 claims 1
- 229940125532 enzyme inhibitor Drugs 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000000815 hypotonic solution Substances 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 claims 1
- 229960001285 quercetin Drugs 0.000 claims 1
- 235000005875 quercetin Nutrition 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
- 239000004753 textile Substances 0.000 claims 1
- 229960000984 tocofersolan Drugs 0.000 claims 1
- 235000004835 α-tocopherol Nutrition 0.000 claims 1
- 239000002076 α-tocopherol Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161504640P | 2011-07-05 | 2011-07-05 | |
| US201161504644P | 2011-07-05 | 2011-07-05 | |
| US61/504,644 | 2011-07-05 | ||
| US61/504,640 | 2011-07-05 | ||
| PCT/US2012/045426 WO2013006631A1 (en) | 2011-07-05 | 2012-07-03 | A system for extended storage of red blood cells and methods of use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017054220A Division JP2017122118A (ja) | 2011-07-05 | 2017-03-21 | 赤血球の長期保存システムおよび使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014518283A JP2014518283A (ja) | 2014-07-28 |
| JP2014518283A5 true JP2014518283A5 (https=) | 2015-08-20 |
Family
ID=47437415
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519262A Pending JP2014518283A (ja) | 2011-07-05 | 2012-07-03 | 赤血球の長期保存システムおよび使用方法 |
| JP2017054220A Pending JP2017122118A (ja) | 2011-07-05 | 2017-03-21 | 赤血球の長期保存システムおよび使用方法 |
| JP2018227269A Active JP6857291B2 (ja) | 2011-07-05 | 2018-12-04 | 赤血球の長期保存システムおよび使用方法 |
| JP2020177109A Pending JP2021011497A (ja) | 2011-07-05 | 2020-10-22 | 赤血球の長期保存システムおよび使用方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017054220A Pending JP2017122118A (ja) | 2011-07-05 | 2017-03-21 | 赤血球の長期保存システムおよび使用方法 |
| JP2018227269A Active JP6857291B2 (ja) | 2011-07-05 | 2018-12-04 | 赤血球の長期保存システムおよび使用方法 |
| JP2020177109A Pending JP2021011497A (ja) | 2011-07-05 | 2020-10-22 | 赤血球の長期保存システムおよび使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP2729000B1 (https=) |
| JP (4) | JP2014518283A (https=) |
| CN (1) | CN103732056B (https=) |
| AU (1) | AU2012279043B2 (https=) |
| CA (1) | CA2840901C (https=) |
| ES (1) | ES2941907T3 (https=) |
| PT (1) | PT2729000T (https=) |
| WO (1) | WO2013006631A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9199016B2 (en) | 2009-10-12 | 2015-12-01 | New Health Sciences, Inc. | System for extended storage of red blood cells and methods of use |
| US11284616B2 (en) | 2010-05-05 | 2022-03-29 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US12089589B2 (en) | 2009-10-12 | 2024-09-17 | Hemanext Inc. | Irradiation of red blood cells and anaerobic storage |
| US9339025B2 (en) | 2010-08-25 | 2016-05-17 | New Health Sciences, Inc. | Method for enhancing red blood cell quality and survival during storage |
| PT2635114T (pt) | 2010-11-05 | 2020-06-16 | New Health Sciences Inc | Irradiação de glóbulos vermelhos e armazenamento anaeróbico |
| US9067004B2 (en) | 2011-03-28 | 2015-06-30 | New Health Sciences, Inc. | Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly |
| EP2729000B1 (en) * | 2011-07-05 | 2022-12-14 | Hemanext Inc. | A method for extended storage of red blood cells |
| ES2984863T3 (es) | 2011-08-10 | 2024-10-31 | Hemanext Inc | Dispositivo integrado de filtrado de leucocitos, oxígeno y/o agotamiento de CO2, y separación de plasma |
| ES2900298T3 (es) * | 2013-02-28 | 2022-03-16 | Hemanext Inc | Dispositivo de agotamiento de gas para productos sanguíneos |
| WO2014183134A1 (en) * | 2013-05-10 | 2014-11-13 | President And Fellows Of Harvard College | Solutions for red blood cells |
| US20160331783A1 (en) * | 2014-01-13 | 2016-11-17 | The General Hospital Corporation | Bisamide compounds as allosteric effectors for reducing the oxygen-binding affinity of hemoglobin |
| EP3626707A1 (en) | 2014-01-13 | 2020-03-25 | The General Hospital Corporation | Heteroaryl disulfide compounds as allosteric effectors for increasing the oxygen-binding affinity of hemoglobin |
| KR102554521B1 (ko) | 2014-02-20 | 2023-07-11 | 프레제니우스 카비 도이치란트 게엠베하 | 적혈구 제품, 혈장 및 혈소판의 보관을 위한 비-ｄｅｈｐ 가소제를 갖는 의료용 컨테이너 및 시스템 구성요소 |
| US20170105407A1 (en) * | 2014-05-21 | 2017-04-20 | Albert Einstein College Of Medicine, Inc. | Compositions and methods for enhancing red blood cell storage time and survivability using nitric oxide releasing hybrid hydrogel nanoparticles |
| CN104406831B (zh) * | 2014-11-21 | 2017-08-25 | 广东万事泰集团有限公司 | 血液分离装置、血液分离检测装置及分离检测方法 |
| PT3970731T (pt) | 2015-03-10 | 2026-02-24 | Hemanext Inc | Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos |
| WO2016172645A1 (en) | 2015-04-23 | 2016-10-27 | New Health Sciences, Inc. | Anaerobic blood storage containers |
| CA2985799A1 (en) * | 2015-05-18 | 2016-11-24 | New Health Sciences, Inc. | Methods for the storage of whole blood, and compositions thereof |
| KR20240132129A (ko) | 2016-05-27 | 2024-09-02 | 헤마넥스트 인코포레이티드 | 혐기성 혈액 저장 및 병원체 불활성화 방법 |
| JP7053508B2 (ja) * | 2016-06-23 | 2022-04-12 | ヘマネクスト インコーポレイテッド | 輸血を必要とする患者集団における有害事象を管理するための方法 |
| US11541161B2 (en) | 2016-06-24 | 2023-01-03 | Haemonetics Corporation | System and method for continuous flow red blood cell washing |
| CN106421949B (zh) * | 2016-08-29 | 2018-10-02 | 安徽通灵仿生科技有限公司 | 一种氧合引流管、氧合装置及氧合方法 |
| CA3063445A1 (en) | 2017-05-19 | 2018-11-22 | New Health Sciences, Inc. | Methods and treatment of trauma |
| CN113365642A (zh) | 2018-11-16 | 2021-09-07 | 希玛奈克斯特股份有限公司 | 用于控制炎症患者中不良事件的方法 |
| JPWO2023167248A1 (https=) * | 2022-03-01 | 2023-09-07 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6447987B1 (en) | 1978-09-09 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Prolonged storage of red blood cells |
| EP0168755B1 (en) | 1984-07-16 | 1991-04-17 | Sumitomo Bakelite Company Limited | Container and method for storing blood |
| US4769318A (en) | 1986-06-03 | 1988-09-06 | Ube Industries, Ltd. | Additive solution for blood preservation and activation |
| US4880786A (en) | 1987-01-14 | 1989-11-14 | Ube Industries, Ltd. | Additive solution for blood preservation and activation |
| US4925572A (en) | 1987-10-20 | 1990-05-15 | Pall Corporation | Device and method for depletion of the leukocyte content of blood and blood components |
| US4880548A (en) | 1988-02-17 | 1989-11-14 | Pall Corporation | Device and method for separating leucocytes from platelet concentrate |
| US5152905A (en) | 1989-09-12 | 1992-10-06 | Pall Corporation | Method for processing blood for human transfusion |
| US5037419A (en) * | 1989-09-21 | 1991-08-06 | Eastman Kodak Company | Blood bag system containing vitamin E |
| EP0544895B1 (en) * | 1991-06-21 | 1997-08-27 | Baxter International Inc. | Method for inactivating pathogens in a body fluid |
| US5443743A (en) | 1991-09-11 | 1995-08-22 | Pall Corporation | Gas plasma treated porous medium and method of separation using same |
| US5529821A (en) | 1992-06-29 | 1996-06-25 | Terumo Kabushiki Kaisha | Container for storing blood or blood component |
| US5476764A (en) | 1994-09-16 | 1995-12-19 | The Regents Of The University Of California | Method using CO for extending the useful shelf-life of refrigerated red blood cells |
| US5624794A (en) * | 1995-06-05 | 1997-04-29 | The Regents Of The University Of California | Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas |
| AU725080B2 (en) | 1996-07-09 | 2000-10-05 | Pall Corporation | Multiple element filter |
| US6358678B1 (en) * | 1998-02-11 | 2002-03-19 | The United States Of America As Represented By The Secretary Of The Navy | Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes |
| US6482585B2 (en) * | 1997-04-16 | 2002-11-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Storage and maintenance of blood products including red blood cells and platelets |
| US6162396A (en) * | 1997-04-26 | 2000-12-19 | The Regents Of The University Of California | Blood storage device and method for oxygen removal |
| US5789151A (en) | 1997-05-15 | 1998-08-04 | The Regents Of The University Of California | Prolonged cold storage of red blood cells by oxygen removal and additive usage |
| WO2000011946A2 (en) * | 1998-08-31 | 2000-03-09 | Walter Reed Army Institute Of Research | Prolonged storage of red blood cells |
| US6413713B1 (en) | 1998-10-30 | 2002-07-02 | Hyperbaric Systems | Method for preserving blood platelets |
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| US6548241B1 (en) * | 2000-11-28 | 2003-04-15 | Gambro, Inc. | Storage solution containing photosensitizer for inactivation of biological contaminants |
| EP1404379A2 (en) * | 2001-05-30 | 2004-04-07 | Gambro, Inc. | Viral inactivation process using antioxidant |
| CA2467087A1 (en) * | 2001-11-16 | 2003-05-30 | Hemanext, Llc | Additive solution for blood preservation |
| EP1455860B1 (en) * | 2001-12-10 | 2011-08-31 | CaridianBCT, Inc. | Method for the leukoreduction of red blood cells |
| WO2003103390A1 (en) * | 2002-06-07 | 2003-12-18 | Promethean Lifesciences, Inc. | Sterilization, stabilization and preservation of functional biologics |
| US20080160107A1 (en) * | 2002-09-10 | 2008-07-03 | Nitric Biotherapeutics, Inc. | Use of nitric oxide gas to treat blood and blood products |
| US7517453B2 (en) * | 2003-03-01 | 2009-04-14 | The Trustees Of Boston University | Microvascular network device |
| US7575856B2 (en) * | 2005-10-28 | 2009-08-18 | The United States Of America As Represented By The Department Of Veterans Affairs | Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant |
| EP2514473A1 (en) * | 2006-11-07 | 2012-10-24 | The General Hospital Corporation | Nitric oxide delivery device |
| JP2010535235A (ja) * | 2007-08-01 | 2010-11-18 | カリディアンビーシーティ バイオテクノロジーズ，エルエルシー | 全血の病原性不活性化 |
| CA2781866C (en) * | 2009-10-12 | 2019-12-03 | New Health Sciences, Inc. | Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities |
| US9339025B2 (en) * | 2010-08-25 | 2016-05-17 | New Health Sciences, Inc. | Method for enhancing red blood cell quality and survival during storage |
| PT2635114T (pt) * | 2010-11-05 | 2020-06-16 | New Health Sciences Inc | Irradiação de glóbulos vermelhos e armazenamento anaeróbico |
| EP2729000B1 (en) * | 2011-07-05 | 2022-12-14 | Hemanext Inc. | A method for extended storage of red blood cells |
-
2012
- 2012-07-03 EP EP12807324.4A patent/EP2729000B1/en active Active
- 2012-07-03 PT PT128073244T patent/PT2729000T/pt unknown
- 2012-07-03 JP JP2014519262A patent/JP2014518283A/ja active Pending
- 2012-07-03 WO PCT/US2012/045426 patent/WO2013006631A1/en not_active Ceased
- 2012-07-03 EP EP22212891.0A patent/EP4190154A1/en active Pending
- 2012-07-03 CA CA2840901A patent/CA2840901C/en active Active
- 2012-07-03 AU AU2012279043A patent/AU2012279043B2/en active Active
- 2012-07-03 CN CN201280038814.3A patent/CN103732056B/zh active Active
- 2012-07-03 ES ES12807324T patent/ES2941907T3/es active Active
-
2017
- 2017-03-21 JP JP2017054220A patent/JP2017122118A/ja active Pending
-
2018
- 2018-12-04 JP JP2018227269A patent/JP6857291B2/ja active Active
-
2020
- 2020-10-22 JP JP2020177109A patent/JP2021011497A/ja active Pending
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