CA2840901C - A system for extended storage of red blood cells and methods of use - Google Patents

A system for extended storage of red blood cells and methods of use Download PDF

Info

Publication number
CA2840901C
CA2840901C CA2840901A CA2840901A CA2840901C CA 2840901 C CA2840901 C CA 2840901C CA 2840901 A CA2840901 A CA 2840901A CA 2840901 A CA2840901 A CA 2840901A CA 2840901 C CA2840901 C CA 2840901C
Authority
CA
Canada
Prior art keywords
blood cells
red blood
oxygen
carbon dioxide
depleted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2840901A
Other languages
English (en)
French (fr)
Other versions
CA2840901A1 (en
Inventor
Tatsuro Yoshida
Paul Vernucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemanext Inc
Original Assignee
Hemanext Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hemanext Inc filed Critical Hemanext Inc
Publication of CA2840901A1 publication Critical patent/CA2840901A1/en
Application granted granted Critical
Publication of CA2840901C publication Critical patent/CA2840901C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0209—Multiple bag systems for separating or storing blood components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2840901A 2011-07-05 2012-07-03 A system for extended storage of red blood cells and methods of use Active CA2840901C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161504644P 2011-07-05 2011-07-05
US201161504640P 2011-07-05 2011-07-05
US61/504,640 2011-07-05
US61/504,644 2011-07-05
PCT/US2012/045426 WO2013006631A1 (en) 2011-07-05 2012-07-03 A system for extended storage of red blood cells and methods of use

Publications (2)

Publication Number Publication Date
CA2840901A1 CA2840901A1 (en) 2013-01-10
CA2840901C true CA2840901C (en) 2020-12-15

Family

ID=47437415

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2840901A Active CA2840901C (en) 2011-07-05 2012-07-03 A system for extended storage of red blood cells and methods of use

Country Status (8)

Country Link
EP (2) EP2729000B1 (https=)
JP (4) JP2014518283A (https=)
CN (1) CN103732056B (https=)
AU (1) AU2012279043B2 (https=)
CA (1) CA2840901C (https=)
ES (1) ES2941907T3 (https=)
PT (1) PT2729000T (https=)
WO (1) WO2013006631A1 (https=)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
ES2959120T3 (es) 2010-08-25 2024-02-20 Hemanext Inc Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento
PT2635114T (pt) 2010-11-05 2020-06-16 New Health Sciences Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
AU2012279043B2 (en) * 2011-07-05 2016-07-07 Hemanext Inc. A system for extended storage of red blood cells and methods of use
AU2012294269B2 (en) 2011-08-10 2016-11-24 Hemanext Inc. Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device
EP2961269B1 (en) 2013-02-28 2021-09-15 Hemanext Inc. Gas depletion device for blood products
WO2014183134A1 (en) * 2013-05-10 2014-11-13 President And Fellows Of Harvard College Solutions for red blood cells
WO2015106240A1 (en) 2014-01-13 2015-07-16 The General Hospital Corporation Heteroaryl disulfide compounds as allosteric effectors for increasing the oxygen-binding affinity of hemoglobin
US20160331783A1 (en) * 2014-01-13 2016-11-17 The General Hospital Corporation Bisamide compounds as allosteric effectors for reducing the oxygen-binding affinity of hemoglobin
KR102554521B1 (ko) 2014-02-20 2023-07-11 프레제니우스 카비 도이치란트 게엠베하 적혈구 제품, 혈장 및 혈소판의 보관을 위한 비-ｄｅｈｐ 가소제를 갖는 의료용 컨테이너 및 시스템 구성요소
US20170105407A1 (en) * 2014-05-21 2017-04-20 Albert Einstein College Of Medicine, Inc. Compositions and methods for enhancing red blood cell storage time and survivability using nitric oxide releasing hybrid hydrogel nanoparticles
CN104406831B (zh) * 2014-11-21 2017-08-25 广东万事泰集团有限公司 血液分离装置、血液分离检测装置及分离检测方法
KR102701691B1 (ko) 2015-03-10 2024-08-30 헤마넥스트 인코포레이티드 산소 감소 1회용 키트, 장치 및 이의 사용 방법
KR20250126858A (ko) 2015-04-23 2025-08-25 헤마넥스트 인코포레이티드 혐기성 혈액 저장 용기
IL289099B2 (en) * 2015-05-18 2024-04-01 Hemanext Inc Methods for the storage of whole blood, and compositions thereof
MX393877B (es) * 2016-05-27 2025-03-24 Hemanext Inc Almacenamiento anaerobico de sangre y metodo de inactivacion de patogenos
IL305115A (en) * 2016-06-23 2023-10-01 Hemanext Inc Methods for treating side effects in patient populations requiring transfusions
WO2017223318A1 (en) * 2016-06-24 2017-12-28 Dominique Uhlmann System and Method for Continuous Flow Red Blood Cell Washing
CN106421949B (zh) * 2016-08-29 2018-10-02 安徽通灵仿生科技有限公司 一种氧合引流管、氧合装置及氧合方法
JP7837502B2 (ja) * 2017-05-19 2026-03-31 ヘマネクスト インコーポレイテッド 外傷の方法および治療
CN120189436A (zh) * 2018-11-16 2025-06-24 希玛奈克斯特股份有限公司 用于控制炎症患者中不良事件的方法
JPWO2023167248A1 (https=) * 2022-03-01 2023-09-07

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6447987B1 (en) 1978-09-09 2002-09-10 The United States Of America As Represented By The Secretary Of The Army Prolonged storage of red blood cells
DE3582523D1 (de) 1984-07-16 1991-05-23 Sumitomo Bakelite Co Behaelter und verfahren zur aufbewahrung von blut.
US4769318A (en) 1986-06-03 1988-09-06 Ube Industries, Ltd. Additive solution for blood preservation and activation
US4880786A (en) 1987-01-14 1989-11-14 Ube Industries, Ltd. Additive solution for blood preservation and activation
US4925572A (en) 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US4880548A (en) 1988-02-17 1989-11-14 Pall Corporation Device and method for separating leucocytes from platelet concentrate
US5152905A (en) 1989-09-12 1992-10-06 Pall Corporation Method for processing blood for human transfusion
US5037419A (en) * 1989-09-21 1991-08-06 Eastman Kodak Company Blood bag system containing vitamin E
ES2110002T3 (es) * 1991-06-21 1998-02-01 Baxter Int Procedimiento de inactivacion de agentes patogenos en fluidos corporales.
US5443743A (en) 1991-09-11 1995-08-22 Pall Corporation Gas plasma treated porous medium and method of separation using same
US5529821A (en) 1992-06-29 1996-06-25 Terumo Kabushiki Kaisha Container for storing blood or blood component
US5476764A (en) 1994-09-16 1995-12-19 The Regents Of The University Of California Method using CO for extending the useful shelf-life of refrigerated red blood cells
US5624794A (en) * 1995-06-05 1997-04-29 The Regents Of The University Of California Method for extending the useful shelf-life of refrigerated red blood cells by flushing with inert gas
CA2258211C (en) 1996-07-09 2003-05-13 Pall Corporation Multiple element filter
US6358678B1 (en) * 1998-02-11 2002-03-19 The United States Of America As Represented By The Secretary Of The Navy Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes
US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US6162396A (en) * 1997-04-26 2000-12-19 The Regents Of The University Of California Blood storage device and method for oxygen removal
US5789151A (en) * 1997-05-15 1998-08-04 The Regents Of The University Of California Prolonged cold storage of red blood cells by oxygen removal and additive usage
DE69912457T2 (de) * 1998-08-31 2004-08-19 Walter Reed Army Institute Of Research Verlängerte lagerung roter blutzellen
US6413713B1 (en) 1998-10-30 2002-07-02 Hyperbaric Systems Method for preserving blood platelets
US6945411B1 (en) 1999-03-16 2005-09-20 Pall Corporation Biological fluid filter and system
US6548241B1 (en) * 2000-11-28 2003-04-15 Gambro, Inc. Storage solution containing photosensitizer for inactivation of biological contaminants
WO2002096471A2 (en) * 2001-05-30 2002-12-05 Gambro, Inc. Viral inactivation process using antioxidant
US20030124504A1 (en) * 2001-11-16 2003-07-03 Bitensky Mark W. Additive solution for blood preservation
EP2208502B1 (en) * 2001-12-10 2019-05-08 Terumo BCT, Inc. Disposable assembly for an apheresis system
US20040126880A1 (en) * 2002-06-07 2004-07-01 Manders Ernest K. Sterilization, stabilization and preservation of functional biologics
US20080160107A1 (en) * 2002-09-10 2008-07-03 Nitric Biotherapeutics, Inc. Use of nitric oxide gas to treat blood and blood products
US20080299538A1 (en) * 2003-02-28 2008-12-04 Caridianbct Biotechnologies, Llc Pathogen Inactivation of Whole Blood
US7517453B2 (en) * 2003-03-01 2009-04-14 The Trustees Of Boston University Microvascular network device
US7575856B2 (en) * 2005-10-28 2009-08-18 The United States Of America As Represented By The Department Of Veterans Affairs Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
WO2008063868A2 (en) * 2006-11-07 2008-05-29 The General Hospital Corporation Attenuation of vasoactive oxygen carrier-induced vasoconstriction
JP6199557B2 (ja) * 2009-10-12 2017-09-20 ニュー ヘルス サイエンシーズ、インク．Ｎｅｗ Ｈｅａｌｔｈ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 酸素及び二酸化炭素の減損能力をもつ血液保存袋システム及び減損装置
ES2959120T3 (es) 2010-08-25 2024-02-20 Hemanext Inc Método para potenciar la calidad y la supervivencia de glóbulos rojos durante el almacenamiento
PT2635114T (pt) * 2010-11-05 2020-06-16 New Health Sciences Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
AU2012279043B2 (en) * 2011-07-05 2016-07-07 Hemanext Inc. A system for extended storage of red blood cells and methods of use

Also Published As

Publication number Publication date
EP2729000A1 (en) 2014-05-14
ES2941907T3 (es) 2023-05-26
EP2729000B1 (en) 2022-12-14
EP4190154A1 (en) 2023-06-07
JP2019038852A (ja) 2019-03-14
JP6857291B2 (ja) 2021-04-14
CN103732056B (zh) 2016-08-17
WO2013006631A8 (en) 2014-01-30
CA2840901A1 (en) 2013-01-10
EP2729000A4 (en) 2014-12-03
JP2014518283A (ja) 2014-07-28
PT2729000T (pt) 2023-04-10
WO2013006631A1 (en) 2013-01-10
AU2012279043B2 (en) 2016-07-07
JP2017122118A (ja) 2017-07-13
JP2021011497A (ja) 2021-02-04
CN103732056A (zh) 2014-04-16
AU2012279043A1 (en) 2014-01-23

Similar Documents

Publication Publication Date Title
US12502462B2 (en) System for extended storage of red blood cells and methods of use
CA2840901C (en) A system for extended storage of red blood cells and methods of use
JP7629891B2 (ja) 嫌気性血液貯蔵および病原体不活性化方法
EP3539381B1 (en) Irradiation of red blood cells and anaerobic storage
US9296990B2 (en) Oxygen depletion devices and methods for removing oxygen from red blood cells
CN114748503A (zh) 储存全血的方法及其组合物
US11284616B2 (en) Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) Irradiation of red blood cells and anaerobic storage

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170704

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD

Year of fee payment: 13

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250520

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250520