JP2014518228A5 - - Google Patents

Info

Publication number

JP2014518228A5

JP2014518228A5 JP2014517574A JP2014517574A JP2014518228A5 JP 2014518228 A5 JP2014518228 A5 JP 2014518228A5 JP 2014517574 A JP2014517574 A JP 2014517574A JP 2014517574 A JP2014517574 A JP 2014517574A JP 2014518228 A5 JP2014518228 A5 JP 2014518228A5

Authority

JP

Japan

Prior art keywords

tomoxyprol

hydroxypropyl

cyclodextrin

complex

amorphous

Prior art date

2012-06-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 13
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
• 229920000858 Cyclodextrin Polymers 0.000 claims description 7
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 6
• 238000000034 method Methods 0.000 claims description 3
• 239000007787 solid Substances 0.000 claims description 3
• 239000000203 mixture Substances 0.000 claims description 2
• 239000000843 powder Substances 0.000 claims description 2
• 238000005406 washing Methods 0.000 claims description 2
• 239000003814 drug Substances 0.000 claims 3
• 238000010521 absorption reaction Methods 0.000 claims 2
• 239000002775 capsule Substances 0.000 claims 2
• 239000002552 dosage form Substances 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 1
• 230000000202 analgesic effect Effects 0.000 claims 1
• 239000000730 antalgic agent Substances 0.000 claims 1
• 239000002260 anti-inflammatory agent Substances 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 230000003110 anti-inflammatory effect Effects 0.000 claims 1
• 229940124346 antiarthritic agent Drugs 0.000 claims 1
• 239000003435 antirheumatic agent Substances 0.000 claims 1
• 239000002131 composite material Substances 0.000 claims 1
• 238000001704 evaporation Methods 0.000 claims 1
• 230000008020 evaporation Effects 0.000 claims 1
• 239000011541 reaction mixture Substances 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000001291 vacuum drying Methods 0.000 claims 1
• XVDXNSRMHBAVAX-UHFFFAOYSA-N 2-(4-methoxyphenyl)-3-propan-2-ylbenzo[e]benzimidazole Chemical compound C1=CC(OC)=CC=C1C(N1C(C)C)=NC2=C1C=CC1=CC=CC=C21 XVDXNSRMHBAVAX-UHFFFAOYSA-N 0.000 description 2
• 239000013078 crystal Substances 0.000 description 2
• 238000004090 dissolution Methods 0.000 description 1
• 230000005284 excitation Effects 0.000 description 1
• 238000002329 infrared spectrum Methods 0.000 description 1
• 238000000634 powder X-ray diffraction Methods 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 239000000126 substance Substances 0.000 description 1
• 238000004448 titration Methods 0.000 description 1