JP2014515742A5 - - Google Patents

Download PDF

Info

Publication number
JP2014515742A5
JP2014515742A5 JP2014502868A JP2014502868A JP2014515742A5 JP 2014515742 A5 JP2014515742 A5 JP 2014515742A5 JP 2014502868 A JP2014502868 A JP 2014502868A JP 2014502868 A JP2014502868 A JP 2014502868A JP 2014515742 A5 JP2014515742 A5 JP 2014515742A5
Authority
JP
Japan
Prior art keywords
seq
antibody
polypeptide
nos
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014502868A
Other languages
English (en)
Japanese (ja)
Other versions
JP6018622B2 (ja
JP2014515742A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/031648 external-priority patent/WO2012135740A2/en
Publication of JP2014515742A publication Critical patent/JP2014515742A/ja
Publication of JP2014515742A5 publication Critical patent/JP2014515742A5/ja
Application granted granted Critical
Publication of JP6018622B2 publication Critical patent/JP6018622B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014502868A 2011-04-01 2012-03-30 Ｃｄ３７結合性分子及びその免疫複合体 Expired - Fee Related JP6018622B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161470863P 2011-04-01 2011-04-01
US61/470,863 2011-04-01
PCT/US2012/031648 WO2012135740A2 (en) 2011-04-01 2012-03-30 Cd37-binding molecules and immunoconjugates thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016095431A Division JP2016145254A (ja) 2011-04-01 2016-05-11 Ｃｄ３７結合性分子及びその免疫複合体

Publications (3)

Publication Number Publication Date
JP2014515742A JP2014515742A (ja) 2014-07-03
JP2014515742A5 true JP2014515742A5 (enExample) 2015-05-14
JP6018622B2 JP6018622B2 (ja) 2016-11-02

Family

ID=46932414

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014502868A Expired - Fee Related JP6018622B2 (ja) 2011-04-01 2012-03-30 Ｃｄ３７結合性分子及びその免疫複合体
JP2016095431A Pending JP2016145254A (ja) 2011-04-01 2016-05-11 Ｃｄ３７結合性分子及びその免疫複合体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016095431A Pending JP2016145254A (ja) 2011-04-01 2016-05-11 Ｃｄ３７結合性分子及びその免疫複合体

Country Status (14)

Country Link
US (3) US9447189B2 (enExample)
EP (1) EP2694105A4 (enExample)
JP (2) JP6018622B2 (enExample)
KR (1) KR20140031883A (enExample)
CN (2) CN105999293B (enExample)
AU (2) AU2012236210B2 (enExample)
BR (1) BR112013025208A2 (enExample)
CA (1) CA2831111A1 (enExample)
EA (1) EA201391342A1 (enExample)
IL (1) IL228537A0 (enExample)
MX (1) MX2013011385A (enExample)
SG (1) SG193447A1 (enExample)
WO (1) WO2012135740A2 (enExample)
ZA (1) ZA201307302B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX338932B (es) 2010-03-12 2016-05-06 Immunogen Inc Moleculas de union cd37 y sus inmunoconjugados.
CN105999293B (zh) 2011-04-01 2019-07-23 德彪发姆国际有限公司 Cd37结合分子及其免疫缀合物
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
AU2015311951B2 (en) 2014-09-02 2021-04-08 Immunogen, Inc. Methods for formulating antibody drug conjugate compositions
UA125496C2 (uk) 2015-06-08 2022-04-13 Дебіофарм Інтернаціонал, С.А. Спосіб лікування пацієнта з в-клітинним раком імунокон’югатом, який зв’язується з cd37 разом з антитілом, що зв'язується з cd20
AU2016316758B2 (en) 2015-08-28 2023-02-02 Debiopharm International, S.A. Antibodies and assays for detection of CD37
EP3403091B1 (en) * 2016-01-11 2021-12-22 Technion Research & Development Foundation Limited Methods of determining prognosis of sepsis and treating same
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
WO2018083633A1 (en) 2016-11-02 2018-05-11 Debiopharm International, S.A. Methods for improving anti-cd37 immunoconjugate therapy
KR102020706B1 (ko) 2017-01-20 2019-09-11 주식회사 엘지화학 이차전지 분리막 내 수분함량 측정방법
SG11201908772TA (en) * 2017-03-31 2019-10-30 Genmab Holding B V Bispecific anti-cd37 antibodies, monoclonal anti-cd37 antibodies and methods of use thereof
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
CN110075315B (zh) * 2018-01-26 2023-08-11 上海复旦张江生物医药股份有限公司 一种抗体偶联物及其制备方法和应用
CA3101790A1 (en) 2018-05-30 2019-12-05 Debiopharm International, S.A. Anti-cd37 immunoconjugate dosing regimens
US12275797B2 (en) 2018-06-22 2025-04-15 Genmab Holding B.V. Anti-CD37 antibodies and anti-CD20 antibodies, compositions and methods of use thereof
US20240252635A1 (en) 2018-10-04 2024-08-01 Genmab Holding B.V. Pharmaceutical compositions comprising bispecific anti-cd37 antibodies
CN112955467A (zh) * 2018-10-26 2021-06-11 特尼奥生物股份有限公司 与cd38结合的重链抗体
CN111320690B (zh) * 2018-12-17 2022-04-05 程联胜 一种抗人Tim3单克隆抗体及其应用
WO2020232638A1 (zh) * 2019-05-21 2020-11-26 上海复旦张江生物医药股份有限公司 一种抗体偶联物及其药物组合物的应用
US11535634B2 (en) 2019-06-05 2022-12-27 Massachusetts Institute Of Technology Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
CN115023441A (zh) * 2019-12-18 2022-09-06 特诺福尔股份有限公司 与cd38结合的重链抗体
US12030888B2 (en) 2021-02-24 2024-07-09 Massachusetts Institute Of Technology Himastatin derivatives, and processes of preparation thereof, and uses thereof
WO2023049732A1 (en) 2021-09-21 2023-03-30 Qilu Puget Sound Biotherapeutics Corporation HETERODIMERIC Fc FOR MAKING FUSION PROTEINS AND BISPECIFIC ANTIBODIES
MX2024004048A (es) 2021-10-18 2024-04-25 Daiichi Sankyo Co Ltd Conjugado anticuerpo-farmaco anti-cd37.
CN119255824A (zh) 2022-04-14 2025-01-03 德比欧药物研究有限公司 具有改善的药代动力学和药物释放特性的配体-药物缀合物
CN120209126B (zh) * 2025-05-28 2025-09-16 中国医学科学院医学生物学研究所 人偏肺病毒单克隆抗体及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI102355B1 (fi) * 1988-02-11 1998-11-30 Bristol Myers Squibb Co Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi
US5977316A (en) * 1995-01-17 1999-11-02 The Board Of Trustees Of The University Of Kentucky Monoclonal antibody 1A7 and related polypeptides
US7303749B1 (en) 1999-10-01 2007-12-04 Immunogen Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2385528C (en) 1999-10-01 2013-12-10 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
CN100574803C (zh) 2001-01-31 2009-12-30 拜奥根Idec公司 免疫调节抗体在治疗肿瘤性疾病中的用途
US20030103971A1 (en) 2001-11-09 2003-06-05 Kandasamy Hariharan Immunoregulatory antibodies and uses thereof
CA2450793A1 (en) 2001-06-20 2002-12-27 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
WO2003040187A1 (en) * 2001-11-08 2003-05-15 Yang Sheng Tang Company Limited Hepatitis e virus monoclonal antibodies or the binding fragments of it and the use thereof
CA2505717A1 (en) 2002-11-15 2004-06-03 Immunomedics, Inc. Use of multi-specific, non-covalent complexes for targeted delivery of therapeutics
JP4959136B2 (ja) 2002-12-13 2012-06-20 イミューノメディクス、インコーポレイテッド 細胞内で開裂可能な結合を有する免疫接合体
KR101351122B1 (ko) * 2003-05-09 2014-01-14 듀크 유니버시티 Ｃｄ２０-특이적 항체 및 이를 이용한 방법
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
SI2272868T1 (sl) * 2003-06-05 2015-07-31 Genentech, Inc., Kombinirana terapija za B-celične motnje
US7754209B2 (en) 2003-07-26 2010-07-13 Trubion Pharmaceuticals Binding constructs and methods for use thereof
US7241598B2 (en) 2004-06-29 2007-07-10 The Chinese University Of Hong Kong Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering
US7371825B2 (en) 2004-06-30 2008-05-13 Centocor, Inc. Anti-MCP-1 antibodies, compositions, methods and uses
AU2006203889A1 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. CRIPTO binding molecules
FR2880696B1 (fr) * 2005-01-07 2007-08-24 Ioltechnologie Production Sarl Lentille intraoculaire photochromique
JP5837730B2 (ja) 2005-02-10 2015-12-24 ベイラー リサーチ インスティテュートＢａｙｌｏｒ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 抗インターフェロンアルファモノクローナル抗体及び使用方法
US8318906B2 (en) 2005-04-15 2012-11-27 The Regents Of The University Of California EMP2 antibodies and their therapeutic uses
WO2006117910A1 (ja) 2005-04-28 2006-11-09 Mochida Pharmaceutical Co., Ltd. 抗血小板膜糖蛋白質ⅵモノクローナル抗体
ZA200709956B (en) 2005-05-20 2009-02-25 Genentech Inc Pretreatment of a biological sample from an autoimmune disease subject
WO2006133450A2 (en) 2005-06-08 2006-12-14 Duke University Anti-cd19 antibody therapy for the transplantation
US20080279850A1 (en) 2005-07-25 2008-11-13 Trubion Pharmaceuticals, Inc. B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
EP2295080A3 (en) * 2005-07-25 2011-06-22 Emergent Product Development Seattle, LLC B-cell reduction using CD37-specific and CD20-specific binding molecules
WO2007140371A2 (en) 2006-05-30 2007-12-06 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
AU2007282023B2 (en) * 2006-08-03 2012-09-13 Vaccinex, Inc. Anti-IL-6 monoclonal antibodies and uses thereof
US7846434B2 (en) 2006-10-24 2010-12-07 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
CA2663536A1 (en) 2006-10-24 2008-05-02 Trubion Pharmaceuticals, Inc. Materials and methods for improved immunoglycoproteins
SG10201808730VA (en) 2007-04-03 2018-11-29 Amgen Res Munich Gmbh Cross-species-specific binding domain
CN101990439A (zh) 2007-07-06 2011-03-23 特鲁比昂药品公司 具有置于c末端的特异性结合结构域的结合肽
PE20140196A1 (es) * 2007-08-09 2014-03-19 Boehringer Ingelheim Int Anticuerpos anti-cd37
GB2454915B (en) 2007-11-23 2012-02-15 Schlumberger Holdings Spooling apparatus for well intervention system
WO2009085576A2 (en) 2007-12-28 2009-07-09 Spring Bioscience Corporation Positive control cell pellets for immunohistochemistry and methods of use thereof
PT2132228E (pt) 2008-04-11 2011-10-11 Emergent Product Dev Seattle Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
US7740844B2 (en) 2008-04-29 2010-06-22 Taiwan Liposome Co. Ltd Anti-VEGF monoclonal antibody
EP2281006B1 (en) 2008-04-30 2017-08-02 Immunogen, Inc. Cross-linkers and their uses
JP2011524421A (ja) * 2008-06-16 2011-09-01 イミュノジェン・インコーポレーテッド 新規の相乗効果
WO2010009124A2 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
WO2010057047A1 (en) 2008-11-13 2010-05-20 Trubion Pharmaceutics, Inc. Cd37 immunotherapeutic combination therapies and uses thereof
JP2013506709A (ja) * 2009-10-06 2013-02-28 イミュノジェン・インコーポレーテッド 有効なコンジュゲートおよび親水性リンカー
SI2519543T1 (sl) 2009-12-29 2016-08-31 Emergent Product Development Seattle, Llc Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
AR080155A1 (es) 2010-02-10 2012-03-14 Immunogen Inc Anticuerpos anti-cd20 y su utilizacion
MX338932B (es) 2010-03-12 2016-05-06 Immunogen Inc Moleculas de union cd37 y sus inmunoconjugados.
AU2011239583A1 (en) 2010-04-15 2012-11-29 Alper Biotech, Llc Monoclonal antibodies against HER2 antigens, and uses therefor
CN105999293B (zh) 2011-04-01 2019-07-23 德彪发姆国际有限公司 Cd37结合分子及其免疫缀合物
US20130058947A1 (en) 2011-09-02 2013-03-07 Stem Centrx, Inc Novel Modulators and Methods of Use
RU2014140119A (ru) 2012-03-30 2016-05-27 Иммьюноджен, Инк. Способы повышения эффективности терапии на основе cd37
US20140120083A1 (en) 2012-11-01 2014-05-01 Infinity Pharmaceuticals, Inc. Treatment of cancers using pi3 kinase isoform modulators
WO2014143807A2 (en) 2013-03-15 2014-09-18 Stromatt Scott Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders
IL312865B2 (en) 2013-09-11 2025-06-01 Eagle Biologics Inc Liquid protein formulations containing viscosity-lowering agents
WO2015116729A2 (en) 2014-01-28 2015-08-06 Emergent Product Development Seattle, Llc Anti-cd37 antibody and anti-cd20 antibody combination therapy for treatment of b-cell malignancies and disorders
WO2015175533A2 (en) 2014-05-13 2015-11-19 Immunogen, Inc. Anti-cd37 immunoconjugate dosing regimens
UA125496C2 (uk) 2015-06-08 2022-04-13 Дебіофарм Інтернаціонал, С.А. Спосіб лікування пацієнта з в-клітинним раком імунокон’югатом, який зв’язується з cd37 разом з антитілом, що зв'язується з cd20
AU2016316758B2 (en) 2015-08-28 2023-02-02 Debiopharm International, S.A. Antibodies and assays for detection of CD37

Similar Documents

Publication Publication Date Title
JP5894912B2 (ja) 抗ヒトｃｄ５２免疫グロブリン
CN110461876B (zh) 用于耗尽cd137+细胞的组合物和方法
KR101739620B1 (ko) 특히, 대숙주성 이식편병(gvhd)을 예방하기 위한 항 cd4 항체
AU2012236210B2 (en) CD37-binding molecules and immunoconjugates thereof
KR20200110358A (ko) 항-pd-1 항체 및 치료 방법
US12187797B2 (en) SIRP α, SIRP β 1, and SIRP γ antibodies and uses thereof
RU2012138399A (ru) Антитела против cd20 и их применение
KR20190039085A (ko) 세포의 고갈을 위한 조성물 및 방법
JP2008516970A5 (enExample)
JP2012526558A5 (enExample)
JP2012500020A5 (enExample)
JP2023519099A5 (enExample)
JP2022517441A (ja) Ｂｔｌａ抗体
WO2007102200A1 (ja) 抗ｃｄ２０モノクローナル抗体
JP2016507521A5 (enExample)
JP2018502068A5 (enExample)
US20250262243A1 (en) Bispecific chimeric antigen receptors targeting cd20 and bcma
JP2026021532A (ja) Ｂｔｌａ抗体
JP2024516713A5 (enExample)
JP2022534433A5 (enExample)
JP2013508391A5 (enExample)
JP2015533374A5 (enExample)
CN113692286A (zh) 一种用于免疫抑制的方法
HK40121520A (zh) 抗-tnfr2抗体及其使用方法
WO2026096570A1 (en) Hybrid anti-cd20 car t cell therapy for the treatment of autoimmune diseases