JP2014515742A5 - - Google Patents
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- Publication number
- JP2014515742A5 JP2014515742A5 JP2014502868A JP2014502868A JP2014515742A5 JP 2014515742 A5 JP2014515742 A5 JP 2014515742A5 JP 2014502868 A JP2014502868 A JP 2014502868A JP 2014502868 A JP2014502868 A JP 2014502868A JP 2014515742 A5 JP2014515742 A5 JP 2014515742A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- polypeptide
- nos
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161470863P | 2011-04-01 | 2011-04-01 | |
| US61/470,863 | 2011-04-01 | ||
| PCT/US2012/031648 WO2012135740A2 (en) | 2011-04-01 | 2012-03-30 | Cd37-binding molecules and immunoconjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016095431A Division JP2016145254A (ja) | 2011-04-01 | 2016-05-11 | Cd37結合性分子及びその免疫複合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014515742A JP2014515742A (ja) | 2014-07-03 |
| JP2014515742A5 true JP2014515742A5 (enExample) | 2015-05-14 |
| JP6018622B2 JP6018622B2 (ja) | 2016-11-02 |
Family
ID=46932414
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014502868A Expired - Fee Related JP6018622B2 (ja) | 2011-04-01 | 2012-03-30 | Cd37結合性分子及びその免疫複合体 |
| JP2016095431A Pending JP2016145254A (ja) | 2011-04-01 | 2016-05-11 | Cd37結合性分子及びその免疫複合体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016095431A Pending JP2016145254A (ja) | 2011-04-01 | 2016-05-11 | Cd37結合性分子及びその免疫複合体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9447189B2 (enExample) |
| EP (1) | EP2694105A4 (enExample) |
| JP (2) | JP6018622B2 (enExample) |
| KR (1) | KR20140031883A (enExample) |
| CN (2) | CN105999293B (enExample) |
| AU (2) | AU2012236210B2 (enExample) |
| BR (1) | BR112013025208A2 (enExample) |
| CA (1) | CA2831111A1 (enExample) |
| EA (1) | EA201391342A1 (enExample) |
| IL (1) | IL228537A0 (enExample) |
| MX (1) | MX2013011385A (enExample) |
| SG (1) | SG193447A1 (enExample) |
| WO (1) | WO2012135740A2 (enExample) |
| ZA (1) | ZA201307302B (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2544719T (lt) | 2010-03-12 | 2019-10-25 | Debiopharm Int Sa | Cd37 surišančios molekulės, ir jų imunokonjugatai |
| AU2012236210B2 (en) | 2011-04-01 | 2016-02-04 | Immunogen, Inc. | CD37-binding molecules and immunoconjugates thereof |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| MA40539A (fr) * | 2014-09-02 | 2016-03-10 | Immunogen Inc | Procédés de formulation de compositions de conjugués anticorps-médicaments |
| BR112017026027A2 (pt) | 2015-06-08 | 2018-08-14 | Debiopharm Int Sa | combinações de imunoconjugado anti-cd37 e anticorpo anti-cd20 |
| JP6890581B2 (ja) | 2015-08-28 | 2021-06-18 | デビオファーム インターナショナル, エス. アー. | Cd37の検出のための抗体およびアッセイ |
| WO2017122203A1 (en) * | 2016-01-11 | 2017-07-20 | Technion Research & Development Foundation Limited | Methods of determining prognosis of sepsis and treating same |
| US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
| US11278629B2 (en) | 2016-11-02 | 2022-03-22 | Debiopharm International, S.A. | Methods for improving anti-CD37 immunoconjugate therapy |
| KR102020706B1 (ko) | 2017-01-20 | 2019-09-11 | 주식회사 엘지화학 | 이차전지 분리막 내 수분함량 측정방법 |
| CN119285787A (zh) | 2017-03-31 | 2025-01-10 | 健玛保控股有限公司 | 双特异性抗cd37抗体、单克隆抗cd37抗体及其使用方法 |
| US11932650B2 (en) | 2017-05-11 | 2024-03-19 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| CN110075315B (zh) * | 2018-01-26 | 2023-08-11 | 上海复旦张江生物医药股份有限公司 | 一种抗体偶联物及其制备方法和应用 |
| AU2019277836A1 (en) | 2018-05-30 | 2021-01-21 | Debiopharm International, S.A. | Anti-CD37 immunoconjugate dosing regimens |
| JP7513530B2 (ja) | 2018-06-22 | 2024-07-09 | ジェンマブ ホールディング ビー.ブイ. | 抗cd37抗体および抗cd20抗体、組成物、ならびにそれらの使用方法 |
| AU2019354105A1 (en) | 2018-10-04 | 2021-04-29 | Genmab Holding B.V. | Pharmaceutical compositions comprising bispecific anti-CD37 antibodies |
| WO2020087065A1 (en) * | 2018-10-26 | 2020-04-30 | Teneobio, Inc. | Heavy chain antibodies binding to cd38 |
| CN111320690B (zh) * | 2018-12-17 | 2022-04-05 | 程联胜 | 一种抗人Tim3单克隆抗体及其应用 |
| US20220226334A1 (en) * | 2019-05-21 | 2022-07-21 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody conjugate and application of pharmaceutical composition thereof |
| WO2020247054A1 (en) | 2019-06-05 | 2020-12-10 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| BR112022011824A2 (pt) * | 2019-12-18 | 2022-08-30 | Teneofour Inc | Anticorpos de cadeia pesada que se ligam a cd38 |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
| CN118339188A (zh) | 2021-09-21 | 2024-07-12 | 齐鲁普吉湾生物治疗公司 | 用于制备融合蛋白和双特异性抗体的异二聚体Fc |
| EP4420683A1 (en) * | 2021-10-18 | 2024-08-28 | Daiichi Sankyo Company, Limited | Anti-cd37 antibody-drug conjugate |
| CN119255824A (zh) | 2022-04-14 | 2025-01-03 | 德比欧药物研究有限公司 | 具有改善的药代动力学和药物释放特性的配体-药物缀合物 |
| CN116286631A (zh) * | 2023-02-15 | 2023-06-23 | 上海长征医院 | 一种利用CD79b单克隆抗体诱导构建B细胞免疫无能模型及其构建方法 |
| CN120209126B (zh) * | 2025-05-28 | 2025-09-16 | 中国医学科学院医学生物学研究所 | 人偏肺病毒单克隆抗体及其应用 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89220A (en) | 1988-02-11 | 1994-02-27 | Bristol Myers Squibb Co | Anthracycline immunoconjugates, their production and pharmaceutical compositions containing them |
| US5977316A (en) * | 1995-01-17 | 1999-11-02 | The Board Of Trustees Of The University Of Kentucky | Monoclonal antibody 1A7 and related polypeptides |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| JP4776843B2 (ja) | 1999-10-01 | 2011-09-21 | イムノゲン インコーポレーティッド | 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法 |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030103971A1 (en) | 2001-11-09 | 2003-06-05 | Kandasamy Hariharan | Immunoregulatory antibodies and uses thereof |
| CA2436180C (en) | 2001-01-31 | 2011-11-08 | Idec Pharmaceutical Corporation | Immunoregulatory antibodies and uses thereof |
| IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
| AU2002349727B2 (en) * | 2001-11-08 | 2008-10-16 | Beijing Wantai Biological Pharmacy Enterprise Co., Ltd | Hepatitis E virus monoclonal antibodies or the binding fragments of it and the use thereof |
| AU2003283599C1 (en) | 2002-11-15 | 2009-06-25 | Immunomedics, Inc. | Use of multi-specific, non-covalent complexes for targeted delivery of therapeutics |
| CA2508831C (en) | 2002-12-13 | 2012-05-01 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| KR101351122B1 (ko) * | 2003-05-09 | 2014-01-14 | 듀크 유니버시티 | Cd20-특이적 항체 및 이를 이용한 방법 |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| CN1835972A (zh) * | 2003-06-05 | 2006-09-20 | 健泰科生物技术公司 | B细胞疾病的联合治疗 |
| US7754209B2 (en) | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| US7241598B2 (en) | 2004-06-29 | 2007-07-10 | The Chinese University Of Hong Kong | Frame-shifting PCR for germline immunoglobulin genes retrieval and antibody engineering |
| US7371825B2 (en) | 2004-06-30 | 2008-05-13 | Centocor, Inc. | Anti-MCP-1 antibodies, compositions, methods and uses |
| CA2593212A1 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Cripto binding molecules |
| FR2880696B1 (fr) * | 2005-01-07 | 2007-08-24 | Ioltechnologie Production Sarl | Lentille intraoculaire photochromique |
| EP1851248B1 (en) | 2005-02-10 | 2016-08-10 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| US8318906B2 (en) | 2005-04-15 | 2012-11-27 | The Regents Of The University Of California | EMP2 antibodies and their therapeutic uses |
| WO2006117910A1 (ja) | 2005-04-28 | 2006-11-09 | Mochida Pharmaceutical Co., Ltd. | 抗血小板膜糖蛋白質ⅵモノクローナル抗体 |
| US7601335B2 (en) * | 2005-05-20 | 2009-10-13 | Genentech, Inc. | Pretreatment of a biological sample from an autoimmune disease subject |
| EP1904101A4 (en) | 2005-06-08 | 2011-06-15 | Univ Duke | ANTI-CD19 ANTIBODY THERAPY FOR TRANSPLANTATION |
| AU2006272555B2 (en) | 2005-07-25 | 2012-03-08 | Aptevo Research And Development Llc | B-cell reduction using CD37-specific and CD20-specific binding molecules |
| US20080279850A1 (en) | 2005-07-25 | 2008-11-13 | Trubion Pharmaceuticals, Inc. | B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules |
| PT2032606E (pt) * | 2006-05-30 | 2014-02-05 | Genentech Inc | Anticorpos e imunoconjugados e respetivas utilizações |
| CN105837690A (zh) | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| WO2008019061A2 (en) * | 2006-08-03 | 2008-02-14 | Vaccinex, Inc. | Anti-il-6 monoclonal antibodies and uses thereof |
| US7846434B2 (en) | 2006-10-24 | 2010-12-07 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
| CA2663536A1 (en) | 2006-10-24 | 2008-05-02 | Trubion Pharmaceuticals, Inc. | Materials and methods for improved immunoglycoproteins |
| WO2008119567A2 (en) | 2007-04-03 | 2008-10-09 | Micromet Ag | Cross-species-specific cd3-epsilon binding domain |
| WO2009023386A2 (en) | 2007-07-06 | 2009-02-19 | Trubion Pharmaceuticals, Inc. | Binding peptides having a c-terminally disposed specific binding domain |
| PE20090499A1 (es) * | 2007-08-09 | 2009-05-18 | Boehringer Ingelheim Int | Anticuerpos anti-cd37 |
| GB2454915B (en) | 2007-11-23 | 2012-02-15 | Schlumberger Holdings | Spooling apparatus for well intervention system |
| WO2009085576A2 (en) | 2007-12-28 | 2009-07-09 | Spring Bioscience Corporation | Positive control cell pellets for immunohistochemistry and methods of use thereof |
| NZ603059A (en) | 2008-04-11 | 2014-07-25 | Emergent Product Dev Seattle | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| US7740844B2 (en) | 2008-04-29 | 2010-06-22 | Taiwan Liposome Co. Ltd | Anti-VEGF monoclonal antibody |
| NZ588884A (en) | 2008-04-30 | 2013-05-31 | Immunogen Inc | Cross-linkers and their uses |
| KR20110028450A (ko) | 2008-06-16 | 2011-03-18 | 이뮤노젠 아이엔씨 | 새로운 상승 효과 |
| AU2009270988A1 (en) | 2008-07-15 | 2010-01-21 | Genentech, Inc. | Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds |
| AU2009313877A1 (en) | 2008-11-13 | 2011-06-30 | Emergent Product Development Seattle, Llc | CD37 immunotherapeutic combination therapies and uses thereof |
| CN102596922A (zh) | 2009-10-06 | 2012-07-18 | 免疫基因公司 | 有效的缀合物和亲水性连接体 |
| US20130089554A1 (en) | 2009-12-29 | 2013-04-11 | Emergent Product Development Seattle, Llc | RON Binding Constructs and Methods of Use Thereof |
| WO2011100398A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc. | Cd20 antibodies and uses thereof |
| LT2544719T (lt) * | 2010-03-12 | 2019-10-25 | Debiopharm Int Sa | Cd37 surišančios molekulės, ir jų imunokonjugatai |
| KR20130108069A (ko) | 2010-04-15 | 2013-10-02 | 알퍼 바이오테크, 엘엘씨 | Her2 항원에 대한 모노클로날 항체 및 그를 위한 용도 |
| AU2012236210B2 (en) | 2011-04-01 | 2016-02-04 | Immunogen, Inc. | CD37-binding molecules and immunoconjugates thereof |
| US20130058947A1 (en) | 2011-09-02 | 2013-03-07 | Stem Centrx, Inc | Novel Modulators and Methods of Use |
| RU2014140119A (ru) | 2012-03-30 | 2016-05-27 | Иммьюноджен, Инк. | Способы повышения эффективности терапии на основе cd37 |
| US20140120083A1 (en) | 2012-11-01 | 2014-05-01 | Infinity Pharmaceuticals, Inc. | Treatment of cancers using pi3 kinase isoform modulators |
| WO2014143807A2 (en) | 2013-03-15 | 2014-09-18 | Stromatt Scott | Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders |
| IL312865B2 (en) | 2013-09-11 | 2025-06-01 | Eagle Biologics Inc | Liquid protein formulations containing viscosity-lowering agents |
| WO2015116729A2 (en) | 2014-01-28 | 2015-08-06 | Emergent Product Development Seattle, Llc | Anti-cd37 antibody and anti-cd20 antibody combination therapy for treatment of b-cell malignancies and disorders |
| WO2015175533A2 (en) | 2014-05-13 | 2015-11-19 | Immunogen, Inc. | Anti-cd37 immunoconjugate dosing regimens |
| BR112017026027A2 (pt) | 2015-06-08 | 2018-08-14 | Debiopharm Int Sa | combinações de imunoconjugado anti-cd37 e anticorpo anti-cd20 |
| JP6890581B2 (ja) | 2015-08-28 | 2021-06-18 | デビオファーム インターナショナル, エス. アー. | Cd37の検出のための抗体およびアッセイ |
-
2012
- 2012-03-30 AU AU2012236210A patent/AU2012236210B2/en not_active Ceased
- 2012-03-30 EA EA201391342A patent/EA201391342A1/ru unknown
- 2012-03-30 CN CN201610305409.3A patent/CN105999293B/zh not_active Expired - Fee Related
- 2012-03-30 KR KR1020137028942A patent/KR20140031883A/ko not_active Withdrawn
- 2012-03-30 MX MX2013011385A patent/MX2013011385A/es not_active Application Discontinuation
- 2012-03-30 SG SG2013069026A patent/SG193447A1/en unknown
- 2012-03-30 US US13/436,528 patent/US9447189B2/en not_active Expired - Fee Related
- 2012-03-30 JP JP2014502868A patent/JP6018622B2/ja not_active Expired - Fee Related
- 2012-03-30 CA CA2831111A patent/CA2831111A1/en not_active Abandoned
- 2012-03-30 EP EP12763324.6A patent/EP2694105A4/en not_active Withdrawn
- 2012-03-30 BR BR112013025208A patent/BR112013025208A2/pt not_active Application Discontinuation
- 2012-03-30 WO PCT/US2012/031648 patent/WO2012135740A2/en not_active Ceased
- 2012-03-30 CN CN201280014646.4A patent/CN103596590A/zh active Pending
-
2013
- 2013-09-29 IL IL228537A patent/IL228537A0/en unknown
- 2013-09-30 ZA ZA2013/07302A patent/ZA201307302B/en unknown
-
2016
- 2016-01-12 AU AU2016200175A patent/AU2016200175A1/en not_active Abandoned
- 2016-05-11 JP JP2016095431A patent/JP2016145254A/ja active Pending
- 2016-08-10 US US15/233,423 patent/US10556958B2/en not_active Expired - Fee Related
-
2020
- 2020-02-10 US US16/785,703 patent/US20200270361A1/en not_active Abandoned
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