JP2014515258A5 - - Google Patents
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- Publication number
- JP2014515258A5 JP2014515258A5 JP2014510832A JP2014510832A JP2014515258A5 JP 2014515258 A5 JP2014515258 A5 JP 2014515258A5 JP 2014510832 A JP2014510832 A JP 2014510832A JP 2014510832 A JP2014510832 A JP 2014510832A JP 2014515258 A5 JP2014515258 A5 JP 2014515258A5
- Authority
- JP
- Japan
- Prior art keywords
- cell population
- multiple sclerosis
- protein
- cell
- myelin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004027 cell Anatomy 0.000 claims 21
- 238000000034 method Methods 0.000 claims 12
- 201000006417 multiple sclerosis Diseases 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000006386 Myelin Proteins Human genes 0.000 claims 3
- 108010083674 Myelin Proteins Proteins 0.000 claims 3
- 230000004957 immunoregulator effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 3
- 210000005012 myelin Anatomy 0.000 claims 3
- 210000004248 oligodendroglia Anatomy 0.000 claims 3
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 claims 2
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 2
- 102100027581 Forkhead box protein P3 Human genes 0.000 claims 2
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 2
- 101000861452 Homo sapiens Forkhead box protein P3 Proteins 0.000 claims 2
- 102000047918 Myelin Basic Human genes 0.000 claims 2
- 101710107068 Myelin basic protein Proteins 0.000 claims 2
- 102000002233 Myelin-Oligodendrocyte Glycoprotein Human genes 0.000 claims 2
- 108010000123 Myelin-Oligodendrocyte Glycoprotein Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 210000003289 regulatory T cell Anatomy 0.000 claims 2
- 102100028682 Claudin-11 Human genes 0.000 claims 1
- 108050007280 Claudin-11 Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims 1
- 102000055324 Myelin Proteolipid Human genes 0.000 claims 1
- 101710094913 Myelin proteolipid protein Proteins 0.000 claims 1
- 108010077641 Nogo Proteins Proteins 0.000 claims 1
- 102100035917 Peripheral myelin protein 22 Human genes 0.000 claims 1
- 101710199257 Peripheral myelin protein 22 Proteins 0.000 claims 1
- 101710093543 Probable non-specific lipid-transfer protein Proteins 0.000 claims 1
- 108010010974 Proteolipids Proteins 0.000 claims 1
- 102000016202 Proteolipids Human genes 0.000 claims 1
- 102100029831 Reticulon-4 Human genes 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- -1 expressing CD62-L Proteins 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166808 | 2011-05-19 | ||
| EP11166808.3 | 2011-05-19 | ||
| PCT/EP2012/059313 WO2012156522A1 (en) | 2011-05-19 | 2012-05-18 | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072015A Division JP6592551B2 (ja) | 2011-05-19 | 2018-04-04 | 免疫調節活性を有する細胞集団、その調製方法、及び、その使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014515258A JP2014515258A (ja) | 2014-06-30 |
| JP2014515258A5 true JP2014515258A5 (cg-RX-API-DMAC7.html) | 2015-07-02 |
Family
ID=46149436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510832A Pending JP2014515258A (ja) | 2011-05-19 | 2012-05-18 | 免疫調節活性を有する細胞集団、その調製方法、及び、その使用 |
| JP2018072015A Active JP6592551B2 (ja) | 2011-05-19 | 2018-04-04 | 免疫調節活性を有する細胞集団、その調製方法、及び、その使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018072015A Active JP6592551B2 (ja) | 2011-05-19 | 2018-04-04 | 免疫調節活性を有する細胞集団、その調製方法、及び、その使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140348808A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2710122B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2014515258A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20140071277A (cg-RX-API-DMAC7.html) |
| ES (1) | ES2487465T1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012156522A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9290736B2 (en) * | 2009-11-04 | 2016-03-22 | Case Western Reserve University | Compositions and methods of treating T cell mediated disorder |
| FR2976580B1 (fr) * | 2011-06-14 | 2013-05-31 | Coatex Sas | Epaississants non ioniques associatifs contenant des alkyls cyclohexylols, formulations les contenant et leurs utilisations. |
| WO2018106885A1 (en) | 2016-12-07 | 2018-06-14 | East Carolina University | Compositions and methods for in vitro cultivation and/or expansion of regulatory t cells |
| US12173030B2 (en) | 2018-03-27 | 2024-12-24 | Aztherapies, Inc. | CAR-Treg-based therapies for treating neurodegenerative diseases |
| CN109913415B (zh) * | 2019-03-26 | 2020-05-22 | 广东先康达生物科技有限公司 | Treg细胞的培养液及其培养方法与应用 |
| IL311185A (en) * | 2021-09-03 | 2024-04-01 | Sangamo Therapeutics Inc | MOG-binding proteins and uses thereof |
| TW202417616A (zh) * | 2022-09-02 | 2024-05-01 | 財團法人醫藥工業技術發展中心 | 包含間質幹細胞的組成物在緩解骨髓纖維化上的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030147865A1 (en) * | 2002-02-07 | 2003-08-07 | Benoit Salomon | Cell therapy using immunoregulatory T-cells |
| US20050186207A1 (en) * | 2004-01-08 | 2005-08-25 | The Regents Of The University Of California | Regulatory T cells suppress autoimmunity |
| ES2563955T3 (es) * | 2005-08-02 | 2016-03-16 | Centenary Institute Of Cancer Medicine & Cell Biology | Método para identificar linfocitos T reguladores |
| ES2589311T5 (es) | 2005-09-23 | 2020-02-14 | Tigenix S A U | Poblaciones de células que tienen actividad inmunorreguladora, método de aislamiento y usos |
| EP2050814A1 (en) * | 2007-10-17 | 2009-04-22 | Txcell | Compositions for treating multiple sclerosis |
| US20100291117A1 (en) * | 2009-05-18 | 2010-11-18 | Tinghua Cao | Method for ex-vivo expansion of regulatory t cells with enhanced suppressive function for clinical application in immune mediated diseases |
| GB0918615D0 (en) | 2009-10-23 | 2009-12-09 | Cellerix Sa | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
-
2012
- 2012-05-18 EP EP12723442.5A patent/EP2710122B1/en active Active
- 2012-05-18 WO PCT/EP2012/059313 patent/WO2012156522A1/en not_active Ceased
- 2012-05-18 ES ES12723442.5T patent/ES2487465T1/es active Pending
- 2012-05-18 US US14/118,741 patent/US20140348808A1/en not_active Abandoned
- 2012-05-18 JP JP2014510832A patent/JP2014515258A/ja active Pending
- 2012-05-18 KR KR1020137030844A patent/KR20140071277A/ko not_active Ceased
-
2018
- 2018-04-04 JP JP2018072015A patent/JP6592551B2/ja active Active
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