JP2017536826A5 - - Google Patents
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- Publication number
- JP2017536826A5 JP2017536826A5 JP2017527898A JP2017527898A JP2017536826A5 JP 2017536826 A5 JP2017536826 A5 JP 2017536826A5 JP 2017527898 A JP2017527898 A JP 2017527898A JP 2017527898 A JP2017527898 A JP 2017527898A JP 2017536826 A5 JP2017536826 A5 JP 2017536826A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- cells
- sh2b3
- stem cells
- rbc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000130 stem cell Anatomy 0.000 claims description 84
- 210000003743 erythrocyte Anatomy 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 39
- 101000616523 Homo sapiens SH2B adapter protein 3 Proteins 0.000 claims description 38
- 102100021778 SH2B adapter protein 3 Human genes 0.000 claims description 33
- 239000005557 antagonist Substances 0.000 claims description 14
- 230000002401 inhibitory effect Effects 0.000 claims description 8
- 238000010362 genome editing Methods 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 5
- 108020004999 messenger RNA Proteins 0.000 claims description 5
- 102000014400 SH2 domains Human genes 0.000 claims description 4
- 108050003452 SH2 domains Proteins 0.000 claims description 4
- 238000010459 TALEN Methods 0.000 claims description 4
- 108010017070 Zinc Finger Nucleases Proteins 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 230000004069 differentiation Effects 0.000 claims description 4
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 108091030071 RNAI Proteins 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 239000008280 blood Substances 0.000 claims description 3
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000006143 cell culture medium Substances 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 210000004700 fetal blood Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 239000000816 peptidomimetic Substances 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 2
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 230000004952 protein activity Effects 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 238000003860 storage Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 210000003954 umbilical cord Anatomy 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 230000009368 gene silencing by RNA Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 108091027967 Small hairpin RNA Proteins 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002924 silencing RNA Substances 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462083439P | 2014-11-24 | 2014-11-24 | |
| US62/083,439 | 2014-11-24 | ||
| PCT/US2015/062333 WO2016085934A1 (en) | 2014-11-24 | 2015-11-24 | Modulation of sh2b3 to improve red blood cell production from stem cells and/or progenitor cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017536826A JP2017536826A (ja) | 2017-12-14 |
| JP2017536826A5 true JP2017536826A5 (cg-RX-API-DMAC7.html) | 2019-01-10 |
Family
ID=56074950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527898A Pending JP2017536826A (ja) | 2014-11-24 | 2015-11-24 | 幹細胞および／または前駆細胞からの赤血球産生を改善するためのｓｈ２ｂ３の調節 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20170355958A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3224350A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017536826A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107429231A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016085934A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107663515B (zh) * | 2016-07-28 | 2020-12-15 | 苏州方舟生物医药有限公司 | 一种定向制备人红细胞的方法及制剂 |
| DE102017107661A1 (de) | 2017-04-10 | 2018-10-11 | Universität Rostock | SH2B-Adapterprotein-3 für die Vorhersage einer Knochenmarkantwort und Immunantwort |
| US11708559B2 (en) | 2017-10-27 | 2023-07-25 | The Children's Hospital Of Philadelphia | Engineered red blood cells having rare antigen phenotypes |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| DE102018125324A1 (de) * | 2018-10-12 | 2020-04-16 | Universität Rostock | Verfahren zur Vorhersage einer Antwort auf die Therapie von Krankheiten |
| WO2020174472A1 (en) * | 2019-02-26 | 2020-09-03 | Rambam Med-Tech Ltd. | Cells and methods for improved immunotherapy |
| US20230212513A1 (en) * | 2020-06-19 | 2023-07-06 | The Children's Medical Center Corporation | Compositions and methods for red blood cell differentiation |
| CN112143697B (zh) * | 2020-10-08 | 2021-08-06 | 宁波希诺赛生物科技有限公司 | 一种促进胚胎干细胞增殖和分化的方法 |
| CN113025579A (zh) * | 2021-04-22 | 2021-06-25 | 河南农业大学 | 一种稳定敲低猪abhd16a基因的ST-KDABHD16A细胞系及其构建方法 |
| CN116640728B (zh) * | 2023-07-24 | 2023-10-20 | 呈诺再生医学科技(北京)有限公司 | RO8191和AS2863619在诱导产生表达成人型β珠蛋白的脱核红细胞中的应用 |
| CN119535779B (zh) * | 2025-01-23 | 2025-05-06 | 浙江农林大学 | 空间频域成像中结构光漫反射图案仿真模型的构建方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5896457B2 (ja) * | 2009-12-08 | 2016-03-30 | 国立大学法人 東京大学 | 多能性幹細胞から分化誘導された細胞の生産方法 |
| US20140328811A1 (en) * | 2011-08-01 | 2014-11-06 | Alnylam Pharmaceuticals, Inc. | Method for improving the success rate of hematopoietic stem cell transplants |
| SG11201500852WA (en) * | 2012-08-29 | 2015-04-29 | Sangamo Biosciences Inc | Methods and compositions for treatment of a genetic condition |
-
2015
- 2015-11-24 US US15/529,220 patent/US20170355958A1/en not_active Abandoned
- 2015-11-24 EP EP15863890.8A patent/EP3224350A4/en not_active Withdrawn
- 2015-11-24 WO PCT/US2015/062333 patent/WO2016085934A1/en not_active Ceased
- 2015-11-24 CN CN201580074325.7A patent/CN107429231A/zh not_active Withdrawn
- 2015-11-24 JP JP2017527898A patent/JP2017536826A/ja active Pending
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