JP2014511885A5 - - Google Patents
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- Publication number
- JP2014511885A5 JP2014511885A5 JP2014505544A JP2014505544A JP2014511885A5 JP 2014511885 A5 JP2014511885 A5 JP 2014511885A5 JP 2014505544 A JP2014505544 A JP 2014505544A JP 2014505544 A JP2014505544 A JP 2014505544A JP 2014511885 A5 JP2014511885 A5 JP 2014511885A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazolo
- pyrimidin
- phenyl
- amine
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PQNUIDJXNXPHGG-UHFFFAOYSA-N Cc(cc1)cnc1N1CCCC1 Chemical compound Cc(cc1)cnc1N1CCCC1 PQNUIDJXNXPHGG-UHFFFAOYSA-N 0.000 description 1
- BZACBBRLMWHCNM-UHFFFAOYSA-N Cc1c[n](cccc2)c2n1 Chemical compound Cc1c[n](cccc2)c2n1 BZACBBRLMWHCNM-UHFFFAOYSA-N 0.000 description 1
- XKVUYEYANWFIJX-UHFFFAOYSA-N Cc1n[nH]cc1 Chemical compound Cc1n[nH]cc1 XKVUYEYANWFIJX-UHFFFAOYSA-N 0.000 description 1
- LDZYRENCLPUXAX-UHFFFAOYSA-N Cc1nc(cccc2)c2[nH]1 Chemical compound Cc1nc(cccc2)c2[nH]1 LDZYRENCLPUXAX-UHFFFAOYSA-N 0.000 description 1
- PJQIBTFOXWGAEN-UHFFFAOYSA-N Cc1nc(cccc2)c2[n]1C Chemical compound Cc1nc(cccc2)c2[n]1C PJQIBTFOXWGAEN-UHFFFAOYSA-N 0.000 description 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161517582P | 2011-04-21 | 2011-04-21 | |
| US61/517,582 | 2011-04-21 | ||
| PCT/EP2012/001737 WO2012143144A1 (en) | 2011-04-21 | 2012-04-23 | Pyrazolo [4, 3-d] pyrimidines useful as kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014511885A JP2014511885A (ja) | 2014-05-19 |
| JP2014511885A5 true JP2014511885A5 (https=) | 2016-09-29 |
| JP6222776B2 JP6222776B2 (ja) | 2017-11-01 |
Family
ID=46017783
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505544A Active JP6222776B2 (ja) | 2011-04-21 | 2012-04-23 | キナ−ゼ・インヒビタ−として有用なピラゾロ［４，３−ｄ］ピリミジン |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9802937B2 (https=) |
| EP (1) | EP2699579B1 (https=) |
| JP (1) | JP6222776B2 (https=) |
| KR (1) | KR101649611B1 (https=) |
| CN (1) | CN103492389B (https=) |
| AP (1) | AP2013007253A0 (https=) |
| AU (1) | AU2012244550C1 (https=) |
| BR (1) | BR112013026521A2 (https=) |
| CA (1) | CA2831634C (https=) |
| CL (1) | CL2013003051A1 (https=) |
| CO (1) | CO6831982A2 (https=) |
| CR (1) | CR20130536A (https=) |
| CU (1) | CU20130143A7 (https=) |
| EA (1) | EA029040B1 (https=) |
| EC (1) | ECSP13012982A (https=) |
| GT (1) | GT201300255A (https=) |
| IL (1) | IL228968A (https=) |
| MA (1) | MA35124B1 (https=) |
| MX (1) | MX363696B (https=) |
| PE (1) | PE20140928A1 (https=) |
| PH (1) | PH12013502185A1 (https=) |
| SG (1) | SG194549A1 (https=) |
| TN (1) | TN2013000419A1 (https=) |
| TW (1) | TWI606049B (https=) |
| WO (1) | WO2012143144A1 (https=) |
| ZA (1) | ZA201307839B (https=) |
Families Citing this family (62)
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| EP2691399B1 (en) * | 2011-03-28 | 2016-07-13 | F.Hoffmann-La Roche Ag | Thiazolopyrimidine compounds |
| MX363696B (es) | 2011-04-21 | 2019-03-28 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas. |
| BR112013027096A2 (pt) | 2011-04-21 | 2016-12-27 | Gilead Sciences Inc | compostos de benzotiazol e seu uso farmacêutico |
| WO2013103724A1 (en) | 2012-01-04 | 2013-07-11 | Gilead Sciences, Inc. | 2- (tert - butoxy) -2- (7 -methylquinolin- 6 - yl) acetic acid derivatives for treating aids |
| US9284323B2 (en) | 2012-01-04 | 2016-03-15 | Gilead Sciences, Inc. | Naphthalene acetic acid derivatives against HIV infection |
| AR090650A1 (es) | 2012-04-12 | 2014-11-26 | Alcon Res Ltd | Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo |
| US20120323214A1 (en) * | 2012-05-16 | 2012-12-20 | Totada R Shantha | Alzheimer's disease treatment with multiple therapeutic agents delivered to the olfactory region through a special delivery catheter and iontophoresis |
| WO2014001973A1 (en) | 2012-06-29 | 2014-01-03 | Pfizer Inc. | NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS |
| WO2014060112A1 (en) * | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
| WO2014134774A1 (en) | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| US9440952B2 (en) | 2013-03-04 | 2016-09-13 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134776A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| WO2014134772A1 (en) * | 2013-03-04 | 2014-09-12 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| TW201534597A (zh) | 2013-06-20 | 2015-09-16 | Ab Science | 作為選擇性蛋白質激酶抑制劑之苯并咪唑衍生物 |
| WO2015026683A1 (en) * | 2013-08-22 | 2015-02-26 | Merck Sharp & Dohme Corp. | Compounds inhibiting leucine-rich repeat kinase enzyme activity |
| CN105828823B (zh) | 2013-10-18 | 2019-06-14 | 美国印第安纳大学研究和技术公司 | 乙型肝炎病毒组装效应物 |
| JP6487921B2 (ja) | 2013-12-17 | 2019-03-20 | ファイザー・インク | ＬＲＲＫ２阻害薬としての新規の３，４−二置換−１Ｈ−ピロロ［２，３−ｂ］ピリジンおよび４，５−二置換−７Ｈ−ピロロ［２，３−ｃ］ピリダジン |
| KR20160106622A (ko) | 2014-01-29 | 2016-09-12 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 화합물 |
| ES2717757T3 (es) * | 2014-01-29 | 2019-06-25 | Glaxosmithkline Ip Dev Ltd | Compuestos |
| EA201691831A1 (ru) | 2014-04-25 | 2017-02-28 | Пфайзер Инк. | Гетероароматические соединения и их применение в качестве допаминовых d1 лигандов |
| EP3166637B1 (en) | 2014-07-10 | 2020-01-29 | The J. David Gladstone Institutes | Compositions and methods for treating dengue virus infection |
| AU2016219102B2 (en) * | 2015-02-13 | 2020-10-15 | Dana-Farber Cancer Institute, Inc. | LRRK2 inhibitors and methods of making and using the same |
| AU2016249021A1 (en) | 2015-04-17 | 2017-10-19 | Assembly Biosciences, Inc. | Hepatitis B viral assembly effectors |
| CA3028355A1 (en) * | 2015-06-26 | 2016-12-29 | Kadmon Corporation, Llc | Glucose uptake inhibitors |
| US10729691B2 (en) | 2015-06-26 | 2020-08-04 | Kadmon Corporation, Llc | Treatment of infectious diseases with glucose uptake inhibitors |
| KR102161364B1 (ko) | 2015-09-14 | 2020-09-29 | 화이자 인코포레이티드 | LRRK2 억제제로서 이미다조[4,5-c]퀴놀린 및 이미다조[4,5-c][1,5]나프티리딘 유도체 |
| US9762007B2 (en) | 2016-02-10 | 2017-09-12 | Dish Network L.L.C. | Push on connector |
| TW201811799A (zh) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | 吡唑并嘧啶化合物及其用途 |
| WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
| US10280164B2 (en) | 2016-09-09 | 2019-05-07 | Incyte Corporation | Pyrazolopyridone compounds and uses thereof |
| UA125650C2 (uk) | 2016-09-09 | 2022-05-11 | Інсайт Корпорейшн | Регулятори нрk1 на основі похідних піразолопіридину та їх застосування для лікування раку |
| CN109996546B (zh) | 2016-09-30 | 2023-06-27 | 阿沙纳生物科学公司 | P2x3和/或p2x2/3化合物及方法 |
| CN106667990A (zh) * | 2016-11-17 | 2017-05-17 | 郑州郑先医药科技有限公司 | 一种治疗风湿病的药物 |
| CN106620315A (zh) * | 2016-11-17 | 2017-05-10 | 郑州郑先医药科技有限公司 | 一种用于治疗风湿病的药物组合物 |
| US20180153922A1 (en) | 2016-12-06 | 2018-06-07 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease |
| CN106580974A (zh) * | 2016-12-06 | 2017-04-26 | 郑州郑先医药科技有限公司 | 一种治疗脊髓损伤的西药组合物及其应用 |
| US12539297B2 (en) | 2017-02-07 | 2026-02-03 | Oncocross Co., Ltd. | Composition for inhibiting cancer metastasis and treating cancer |
| US11364237B2 (en) | 2017-02-07 | 2022-06-21 | Oncocross Co., Ltd. | Composition for inhibiting cancer metastasis and treating cancer |
| US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
| WO2018195397A2 (en) * | 2017-04-21 | 2018-10-25 | Kyn Therapeutics | Indole ahr inhibitors and uses thereof |
| US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
| CN108178760B (zh) * | 2017-12-27 | 2020-02-18 | 安徽医科大学 | 一种嘧啶并吡唑杂环化合物、制备方法、用途 |
| US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
| US10800761B2 (en) | 2018-02-20 | 2020-10-13 | Incyte Corporation | Carboxamide compounds and uses thereof |
| WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
| WO2019162964A1 (en) * | 2018-02-23 | 2019-08-29 | Indian Institute Of Science | Anti-tubercular composition, and combinatorial implementations thereof |
| US10689386B2 (en) | 2018-03-07 | 2020-06-23 | Duquesne University Of The Holy Spirit | Pyrazolo[4,3-d]pyrimidines as antitumor agents |
| US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
| US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
| ES2973117T3 (es) | 2018-09-25 | 2024-06-18 | Incyte Corp | Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR |
| CN109867800B (zh) * | 2019-04-01 | 2021-04-09 | 江西理工大学 | 一种镉基金属-有机框架及其制备方法 |
| KR102702945B1 (ko) | 2019-05-21 | 2024-09-05 | 보로노이 주식회사 | N을 포함하는 헤테로아릴 유도체 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물 |
| WO2020247756A1 (en) * | 2019-06-05 | 2020-12-10 | Forcyte Biotechnologies, Inc. | Small molecules to relax uterine smooth muscle contractions |
| EP3993764A4 (en) | 2019-07-05 | 2023-08-23 | Icahn School of Medicine at Mount Sinai | HAIR LOSS PREVENTION METHODS |
| MX2022001562A (es) | 2019-08-06 | 2022-04-26 | Incyte Corp | Formas solidas de un inhibidor de la cinasa 1 del progenitor hematopoyetico (hpk1). |
| CN110876752B (zh) * | 2019-11-18 | 2021-04-30 | 暨南大学 | 长链非编码rna nron功能基序在制备抑制骨吸收及防治骨质疏松药物中的应用 |
| PT4065582T (pt) | 2019-11-26 | 2025-05-22 | Ikena Oncology Inc | Derivados polimórficos do carbazol e utilizações dos mesmos |
| US12569481B2 (en) | 2020-06-12 | 2026-03-10 | Vanderbilt University | Methods of treatment for gastrointestinal motility disorders |
| CA3202773A1 (en) * | 2020-10-26 | 2022-05-05 | Neuron23, Inc. | Methods of treatment and diagnosis of parkinson's disease associated with wild-type lrrk2 |
| WO2023032987A1 (ja) * | 2021-08-31 | 2023-03-09 | 日本たばこ産業株式会社 | ６－アミノピラゾロピリミジン化合物及びその医薬用途 |
| WO2023076404A1 (en) | 2021-10-27 | 2023-05-04 | Aria Pharmaceuticals, Inc. | Methods for treating systemic lupus erythematosus |
| JP2025539787A (ja) * | 2022-11-16 | 2025-12-09 | ヴァーンウィ セラピューティクス，インコーポレイテッド | Ｔｙｋ２阻害剤 |
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| US4469868A (en) * | 1982-05-24 | 1984-09-04 | Warner-Lambert Company | Alkylimidazo[1,2-c]pyrazolo[3,4-e]pyrimidines |
| GB8306481D0 (en) * | 1983-03-09 | 1983-04-13 | Beecham Group Plc | Compounds |
| US5360720A (en) | 1993-10-08 | 1994-11-01 | Alcon Laboratories, Inc. | Method of preparing human conjunctival mast cells for mast cell stabilization assays |
| US5723608A (en) * | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| DE19942474A1 (de) * | 1999-09-06 | 2001-03-15 | Merck Patent Gmbh | Pyrazolo[4,3-d]pyrimidine |
| DE10113710A1 (de) | 2001-03-16 | 2002-09-26 | Joerg Rademann | Oxoammoniumsalze sowie deren Verwendung |
| GB0106661D0 (en) * | 2001-03-16 | 2001-05-09 | Pfizer Ltd | Pharmaceutically active compounds |
| ATE478872T1 (de) | 2002-03-28 | 2010-09-15 | Ustav Ex Botan Av Cr V V I I O | Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung |
| US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| US7226919B2 (en) | 2002-12-18 | 2007-06-05 | Vertex Pharmaceuticals Inc. | Compositions useful as inhibitors of protein kinases |
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| BRPI0609225A2 (pt) | 2005-05-12 | 2010-03-09 | Pfizer | formas cristalinas anidras de n-[1-(2-etoxietil)-5-(n-etil-n-metilamino)-7-(4-metilpiridi n-2-il-amino)-1h-pirazolo[4,3-d]pirimidina-3-carbonil] metanossulfonamida, composição farmacêutica compreendendo as mesmas e uso das mesmas |
| EP1903045A1 (en) | 2005-05-27 | 2008-03-26 | Mitsubishi Tanabe Pharma Corporation | Pyrazolopyrimidine derivative |
| JP2007055940A (ja) | 2005-08-24 | 2007-03-08 | Astellas Pharma Inc | ピラゾロピリミジン誘導体 |
| NL2000291C2 (nl) | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| US20100298557A1 (en) * | 2006-12-28 | 2010-11-25 | Taisho Pharmaceutical Co., Ltd | Pyrazolopyrimidine compound |
| JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ，インコーポレーテッド | ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法 |
| EA021293B1 (ru) | 2008-12-08 | 2015-05-29 | Джилид Коннектикут, Инк. | ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| WO2010118367A2 (en) | 2009-04-10 | 2010-10-14 | Progenics Pharmaceuticals, Inc. | Antiviral pyrimidines |
| KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Ｅｇｆｒ 억제제 및 질환 치료방법 |
| MX363696B (es) | 2011-04-21 | 2019-03-28 | Origenis Gmbh | Pirazolo[4,3-d]pirimidinas utiles como inhibidores de cinasas. |
| AR090650A1 (es) | 2012-04-12 | 2014-11-26 | Alcon Res Ltd | Tratamiento para respuestas inflamatorias inducidas por microbios en el ojo |
-
2012
- 2012-04-23 MX MX2013012294A patent/MX363696B/es unknown
- 2012-04-23 BR BR112013026521A patent/BR112013026521A2/pt not_active Application Discontinuation
- 2012-04-23 TW TW101114348A patent/TWI606049B/zh active
- 2012-04-23 EP EP12717198.1A patent/EP2699579B1/en active Active
- 2012-04-23 JP JP2014505544A patent/JP6222776B2/ja active Active
- 2012-04-23 SG SG2013077920A patent/SG194549A1/en unknown
- 2012-04-23 EA EA201301184A patent/EA029040B1/ru unknown
- 2012-04-23 CA CA2831634A patent/CA2831634C/en active Active
- 2012-04-23 PH PH1/2013/502185A patent/PH12013502185A1/en unknown
- 2012-04-23 PE PE2013002376A patent/PE20140928A1/es active IP Right Grant
- 2012-04-23 WO PCT/EP2012/001737 patent/WO2012143144A1/en not_active Ceased
- 2012-04-23 KR KR1020137030320A patent/KR101649611B1/ko active Active
- 2012-04-23 US US13/506,510 patent/US9802937B2/en active Active
- 2012-04-23 AU AU2012244550A patent/AU2012244550C1/en active Active
- 2012-04-23 CN CN201280019429.4A patent/CN103492389B/zh active Active
- 2012-04-23 AP AP2013007253A patent/AP2013007253A0/xx unknown
-
2013
- 2013-10-14 TN TNP2013000419A patent/TN2013000419A1/fr unknown
- 2013-10-18 GT GT201300255A patent/GT201300255A/es unknown
- 2013-10-20 IL IL228968A patent/IL228968A/en active IP Right Grant
- 2013-10-21 ZA ZA2013/07839A patent/ZA201307839B/en unknown
- 2013-10-21 CL CL2013003051A patent/CL2013003051A1/es unknown
- 2013-10-21 CU CU2013000143A patent/CU20130143A7/es unknown
- 2013-10-21 CO CO13249372A patent/CO6831982A2/es unknown
- 2013-10-21 EC ECSP13012982 patent/ECSP13012982A/es unknown
- 2013-10-21 CR CR20130536A patent/CR20130536A/es unknown
- 2013-11-14 MA MA36430A patent/MA35124B1/fr unknown
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